atopic — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T14981	Clobetasone butyrate		Glucocorticoid Receptor
	Clobetasone butyrate, a synthetic glucocorticoid with topical anti-inflammatory activity, is effective in treating corticosteroid-responsive dermatoses, such as atopic dermatitis and psoriasis, especially within skin tis...		Glucocorticoid Receptor
T27172	Difamilast		PDE
	Difamilast is an inhibitor of phosphodiesterase IV.		PDE
T7893	Bepotastine	Bepotastine free base	Others , Histamine Receptor
	Bepotastine (Bepotastine free base) free base is a histamine 1 (H1) receptor antagonis.		Others , Histamine Receptor
T6405	Bepotastine Besilate	Talion,TAU 284,Bepreve,Bepotastine Beslilate	Histamine Receptor
	Bepotastine Besilate (TAU 284) is a non-sedating and selective H1 receptor antagonist (pIC50: 5.7).		Histamine Receptor
T4966	Ufenamate	Flufenamic acid butyl ester,Butyl flufenamate	Others
	Ufenamate (Flufenamic acid butyl ester) is an anthranilic acid-based anti-inflammatory drug developed for skin diseases		Others
T2648	Pimecrolimus	SDZ-ASM 981,ASM 981	Others
	Pimecrolimus (SDZ-ASM 981), a calcineurin inhibitor immunosuppressant, binds to the receptor macrophilin-12 (FKBP-12) forming a complex that blocks the calcium-dependent signal transduction cascade mediated by calcineuri...		Others
T2690	Tranilast	MK 341,SB 252218	RAAS , Prostaglandin Receptor
	Tranilast (SB 252218), an antiallergic drug, suppresses lipid mediator and cytokine release from inflammatory cells, therefore utilized in the treatment of allergic disorders.		RAAS , Prostaglandin Receptor
T16792	Rovazolac	ALX-101	Liver X Receptor
	Rovazolac (ALX-101) is a liver x receptor (LXR) modulator used in the study of immune system disorders and atopic dermatitis.		Liver X Receptor
T3987	Lotamilast	E6005,RVT-501	PDE
	Lotamilast (RVT-501) is a phosphodiesterase 4 (PDE-4) inhibitor (IC50: 2.8 nM) potentially for the treatment of atopic dermatitis.		PDE
T29096L	Vapitadine	R 129160	Histamine Receptor
	Vapitadine is a non-sedative antihistamine compound that relieves itching caused by atopic dermatitis.		Histamine Receptor
T77369	Telazorlimab	ISB-830,GBR-830	Immunology/Inflammation related
	Telazorlimab (GBR-830) is a humanized monoclonal antibody that targets the OX40 co-stimulatory receptor on activated T cells. Telazorlimab can be used to treat lupus erythematosus and atopic dermatitis.		Immunology/Inflammation related
T75113	GLPG2534	GLPG-2534	IRAK
	GLPG2534 is an orally active, selective and potent IRAK4 inhibitor with anti-inflammatory activity. GLPG2534 inhibits human and mouse IRAK4 and could be used to study psoriasis and atopic dermatitis.		IRAK
T76775	Fezakinumab	ILV 094	Interleukin
	Fezakinumab is a potent monoclonal antibody to interleukin-22 (IL-22). Fezakinumab can be used to study immune system diseases and inflammation-related conditions such as psoriasis, rheumatoid arthritis and atopic dermat...		Interleukin
TN1236	3',4',7-Trihydroxyisoflavone		MAPK , JNK
	3',4',7-Trihydroxyisoflavone is a soy isoflavone soy glycoside derivative and Cot (Tpl2/MAP3K8) and MKK4 inhibitor with anticancer, antiangiogenic and free radical scavenging properties.3',4',7-Trihydroxyisoflavone enhan...		MAPK , JNK
T76724	Nemolizumab	CIM331	Interleukin
	Nemolizumab (CIM331) is a humanized monoclonal antibody against human interleukin-31 receptor A that inhibits the binding and subsequent signal transduction of interleukin-31 (IL-31) to its receptor. Nemolizumab can be u...		Interleukin
T9043	AS1810722		P450 , STAT
	AS1810722, a fused bicyclic pyrimidine derivative, is an orally active and potent inhibitor of STAT6, demonstrating an IC50 of 1.9 nM. It exhibits effective inhibition of CYP3A4, positioning it as a promising candidate f...		P450 , STAT
T2270	Trans-Tranilast	Tranilast trans-	RAAS
	Trans-Tranilast is an antiallergic drug developed by Kissei Pharmaceuticals. It was approved in 1982 for use in Japan and South Korea for bronchial asthma. Indications for keloid and hypertrophic scar were added in 1993....		RAAS
T2392	Nafamostat mesylate	FUT-175	Apoptosis , Serine/threonin kinase , SARS-CoV , Serine Protease
	Nafamostat mesylate (FUT-175), a synthetic serine protease inhibitor, has been used for the treatment of allergic disorders such as asthma, allergic rhinitis and atopic dermatitis.
T13666	Dupilumab	REGN-668,SAR-231893	IL Receptor
	Dupilumab (REGN-668) is a systemic immunomodulator for AD. Dupilumab is a fully human monoclonal antibody against the alpha subunit of the interleukin-4 receptor, which inhibits downstream signaling of IL-4 and IL-13 and...		IL Receptor
T6S0232	Eriodictyol	Huazhongilexone	Influenza Virus , DNA/RNA Synthesis , Nrf2 , Endogenous Metabolite
	1. Eriodictyol (Huazhongilexone) is a flavonoid with anti-inflammatory and antioxidant activities. 2. Eriodictyol may possess antidiabetic properties through increasing glucose uptake and improving insulin resistance. 3....