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Search Results for " insulin (human) "

83

Compounds

37

Recombinant Proteins

1

Libraries

Cat No. Product Name
T8221 Insulin (human) INSULIN,Insulin(human) IGF-1R
Insulin (human) is a polypeptide hormone that regulates the level of glucose.
T6793 BRD7552 Others
BRD7552 is an inducer of transcription factor PDX1, which increases insulin expression. BRD7552 increases PDX1 expressio...
T9266 Fatostatin Lipid , Fatty Acid Synthase
Fatostatin is a specific inhibitor of SREBP activation, it impairs the activation of SREBP-1 and SREBP-2. Fatostatin bin...
T8233 BRD3308 Apoptosis , HIV Protease , HDAC
BRD3308 is a highly selective inhibitor of HDAC3(IC50 of 54 nM), attenuating PE-mediated phosphorylation of ERK but not ...
T7714 Temocapil Tyrosinase
Temocapril is an inhibitor of tyrosine kinase.
T6832 Fatostatin hydrobromide Fatostatin HBr,Fatostatin A,Fatostatin A HBr,Fatostatin NPC1L1 , Fatty Acid Synthase
Fatostatin hydrobromide (Fatostatin A HBr) ia an inhibitor of sterol regulatory element binding protein (SREBP). It impa...
T6698 Temocapril hydrochloride CS-622 HCl,Acecol,Temocapril HCl,CS-622 RAAS
Temocapril hydrochloride (CS-622 HCl), the hydrochloride of Temocapril, is a long-acting ACE inhibitor used for the ther...
T21761 HNMPA IGF-1R
HNMPA is a membrane impermeable inhibitor of insulin receptor tyrosine kinase. HNMPA inhibits tyrosine and serine autop...
T76664 Adropin (34-76) (human, mouse, rat)
Adropin (34-76) (human, mouse, rat) is a peptide that attenuates liver fibrosis and insulin resistance independent of ob...
TP1863L Glucagon (19-29), human acetate Glucagon Receptor
Glucagon (19-29), human acetate a COOH-terminal fragment processed from glucagon, is a potent and efficient inhibitor of...
TP2018L GIP (human) acetate GIP (human) acetate(100040-31-1 Free base) IGF-1R
GIP (human) acetate is a stimulator of glucose-dependent insulin secretion and a weak inhibitor of gastric acid secretio...
TP2312 MOTS-c(Human) Acetate(1627580-64-6 free) Others , AMPK
MOTS-c(Human) Acetate is a mitochondrial-derived peptide. MOTS-c(human) acetate induces the accumulation of AMP analog A...
T72947 JBSNF-000028 JBSNF-000028 free base Others
JBSNF-000028 is an orally active and potent nicotinamide N-methyltransferase (NNMT) inhibitor with inhibitory effects on...
T12853 SBI-477 Others
SBI-477 is a chemical probe stimulated insulin signaling by deactivating the transcription factor MondoA. SBI-477 coordi...
T15810 LY2922470 GPR
LY2922470 reduces glucose levels along with significant enhancements in insulin and GLP-1, which is the potential for th...
T6017 Linsitinib OSI-906 IGF-1R
OSI-906 (Linsitinib (OSI-906)) is an orally bioavailable small molecule inhibitor of the insulin-like growth factor 1 re...
T3S0027 Picropodophyllotoxin AXL 1717,Picropodophyllin IGF-1R
Picropodophyllotoxin (AXL 1717) is a cyclolignan alkaloid found in the mayapple plant family (Podophyllum peltatum), and...
TP1664 Proinsulin C-Peptide (55-89), human
Human proinsulin, the single-chain peptide precursor of insulin, consists of the insulin A and B chains connected by the...
T77037 Insulin efsitora alfa
Insulin efsitora alfa (LY-3209590) is a selective agonist of insulin receptor (IR) . Insulin efsitora alfa is a fusion p...
TP1584 GIP (1-30) amide,human GIP (1-30) amide (Human)
GIP (1-30) amide (Human) is an insulin-dependent glucose-dependent polypeptide.The sugar-dependent insulin polypeptide (...
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Cat No. Product Name Species Source
TMPY-00395 Insulin Protein, Human, Recombinant Human Yeast
INS (Insulin) is a Protein Coding gene. This gene encodes insulin, a peptide hormone that plays a vital role in the regulation of carbohydrate and lipid metabolism. After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. The binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. Diseases associated with ...
TMPY-01146 Insulin Receptor Protein, Human, Recombinant (long isoform, His) Human HEK293
INSR (Insulin receptor), also known as CD22, is a transmembrane receptor that is activated by insulin. INSR belongs to the protein kinase superfamily and exists as a tetramer consisting of two alpha subunits and two beta subunits linked by disulfide bonds. The alpha and beta subunits are encoded by a single INSR gene, and the beta subunits pass through the cellular membrane. As the receptor for insulin with tyrosine-protein kinase activity, INSR associates with downstream mediators upon binding ...
TMPY-04395 Insulin Receptor Protein, Human, Recombinant (His & GST) Human Baculovirus-Insect Cells
INSR (Insulin receptor), also known as CD22, is a transmembrane receptor that is activated by insulin. INSR belongs to the protein kinase superfamily and exists as a tetramer consisting of two alpha subunits and two beta subunits linked by disulfide bonds. The alpha and beta subunits are encoded by a single INSR gene, and the beta subunits pass through the cellular membrane. As the receptor for insulin with tyrosine-protein kinase activity, INSR associates with downstream mediators upon binding ...
TMPY-01149 Insulin Receptor Protein, Human, Recombinant (short isoform, His) Human HEK293
INSR (Insulin receptor), also known as CD22, is a transmembrane receptor that is activated by insulin. INSR belongs to the protein kinase superfamily and exists as a tetramer consisting of two alpha subunits and two beta subunits linked by disulfide bonds. The alpha and beta subunits are encoded by a single INSR gene, and the beta subunits pass through the cellular membrane. As the receptor for insulin with tyrosine-protein kinase activity, INSR associates with downstream mediators upon binding ...
TMPY-05283 Insulin Receptor Protein, Human, Recombinant (long isoform, His), Biotinylated Human HEK293
INSR (Insulin receptor), also known as CD22, is a transmembrane receptor that is activated by insulin. INSR belongs to the protein kinase superfamily and exists as a tetramer consisting of two alpha subunits and two beta subunits linked by disulfide bonds. The alpha and beta subunits are encoded by a single INSR gene, and the beta subunits pass through the cellular membrane. As the receptor for insulin with tyrosine-protein kinase activity, INSR associates with downstream mediators upon binding ...
TMPY-00545 Dermcidin Protein, Human, Recombinant (hFc) Human HEK293
Hepatocellular carcinoma (HCC) is a major contributor to cancer-related deaths due to its often late stage diagnosis, and dermcidin (DCD) may have the potential to be used as a serum biomarker for HCC for more timely diagnoses. Human dermcidin (DCD) is an antimicrobial peptide secreted constitutively by sweat glands. And the role of DCD in ischemic heart disease has drawn increasing attention in particular its relationship with insulin secretion and glycemic control, nitric oxide (NO) synthesis ...
TMPY-04699 GAD65 Protein, Human, Recombinant (GST) Human Baculovirus-Insect Cells
Glutamate decarboxylase 2, also known as glutamate decarboxylase 65 kDa isoform, 65 kDa glutamic acid decarboxylase, GAD2 and GAD65, is a member of thegroup II decarboxylase family. GAD2 is identified as a major autoantigen in insulin-dependent diabetes. GAD2 is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T ...
TMPY-00835 IGFBP-3 Protein, Human, Recombinant (His) Human HEK293
The Insulin-like Growth Factor (IGF) signaling system plays a central role in cellular growth, differentiation, and proliferation. IGFBP3 is the most abundant IGF binding protein in human serum and is a growth inhibitory, apoptosis-inducing molecule, capable of acting via IGF-dependent and IGF-independent mechanisms. It appears to function both by cell cycle blockade and the induction of apoptosis. IGFBP3 can be transported to the nucleus by an importin beta mediated mechanism, where it has been...
TMPY-00566 CCL18 Protein, Human, Recombinant (His) Human Yeast
CCL18 is a chemotactic cytokine involved in the pathogenesis and progression of various disorders, including cancer. Proof showed high levels of CCL18 in the serum of epithelial ovarian carcinoma patients suggesting its potential as a circulating biomarker. CCL18 chemokine has an important role in chemokine-mediated tumor metastasis, and may serve as a potential predictor for poor survival outcomes for ovarian cancer. (CCL18) is predominantly secreted by M2-tumor associated macrophages (TAMs) a...
TMPY-06479 Cathepsin H Protein, Human, Recombinant (His) Human HEK293
Proinflammatory cytokines decreased the expression of CTSH in human islets and primary rat beta-cells, and overexpression of CTSH protected insulin-secreting cells against cytokine-induced apoptosis.
TMPK-00751 FSTL3 Protein, Human, Recombinant (His) Human HEK293
Follistatin-like 3 (FSTL3) is a novel cytokine that regulates insulin sensitivity and counteracts activin/myostatin signalling. In the present study, regulation of FSTL3 in renal dysfunction was investigated in both human chronic kidney disease (CKD) and acute kidney dysfunction (AKD). Furthermore, mFSTL3 expression was analysed in insulin-sensitive tissues in a mouse model of CKD.
TMPY-04081 Cathepsin H Protein, Mouse, Recombinant (His) Mouse HEK293
Proinflammatory cytokines decreased the expression of CTSH in human islets and primary rat beta-cells, and overexpression of CTSH protected insulin-secreting cells against cytokine-induced apoptosis.
TMPY-04053 CART Protein, Human, Recombinant Human HEK293
In RNAseq data from human islet donors, CARTPT expression levels correlated with insulin, exocytosis genes and key beta-cell transcription factors.  Insufficient insulin release and hyperglucagonaemia are culprits in type 2 diabetes. Cocaine- and amphetamine-regulated transcript (CART, encoded by Cartpt) affects islet hormone secretion and beta cell survival in vitro in rats, and Cart (-/-) mice have diminished insulin secretion. Established a potential role for cocaine and amphetamine regulated...
TMPY-05014 INSL6 Protein, Human, Recombinant (His) Human HEK293
INSL6 (Insulin-Like 6) is a Protein Coding gene. An important paralog of this gene is RLN1. The protein encoded by this gene contains a classical signature of the insulin superfamily and is significantly similar to relaxin and relaxin-like factor. INSL6 is a newly identified insulin/relaxin family peptide hormone that is predominantly expressed by the male germ cells in testes. It may have a role in sperm development and fertilization. A recent murine study demonstrated that INSL6-knockout resul...
TMPY-03806 CART Protein, Human, Recombinant (mFc) Human HEK293
In RNAseq data from human islet donors, CARTPT expression levels correlated with insulin, exocytosis genes and key beta-cell transcription factors.  Insufficient insulin release and hyperglucagonaemia are culprits in type 2 diabetes. Cocaine- and amphetamine-regulated transcript (CART, encoded by Cartpt) affects islet hormone secretion and beta cell survival in vitro in rats, and Cart (-/-) mice have diminished insulin secretion. Established a potential role for cocaine and amphetamine regulated...
TMPY-05029 INHBE Protein, Human, Recombinant (hFc) Human HEK293
INHBE (Inhibin Subunit Beta E) is a Protein Coding gene. This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate an inhibin beta subunit. INHBE was identified as a novel putative hepatokine with hepatic gene expression that positively correlated with insulin resistance and body mass index in humans. The quantitative real time-PCR analysis also showed an increase in INHBE gene expressi...
TMPJ-01166 IGFBP-7 Protein, Mouse, Recombinant (His) Mouse Human Cells
Insulin-like growth factor-binding protein 7(IGFBP-7) is a secreted glycosylated protein that contains three protein domain modules. IGFBP7 contains an N-terminal IGFBP domain, followed by a Kazal-type serine proteinase inhibitor domain and a C-terminal immunoglobulin-like C2-type domain. Human and mouse IGFBP7 are highly homologous and share 94% aa sequence identity. It is expressed in many normal tissues and in cancer cells. It is abundantly expressed in high endothelial venules (HEVs) of bloo...
TMPJ-00781 LR3-IGF-1 Protein, Mouse, Recombinant (His) Mouse E. coli
Insulin-like growth factor I (IGF1) belongs to the family of insulin-like growth factors that are structurally homologous to proinsulin. Mouse IGF-I is synthesized as two precursor isoforms with alternate N- and C-terminal propeptides. These isoforms are differentially expressed by various tissues. Mature mouse IGF-I shares 94% and 99% aa sequence identity with human and rat IGF-I, respectively, and exhibits cross-species activity. It shares 60% aa sequence identity with mature mouse IGF-II. IG...
TMPY-02519 BLVRB Protein, Human, Recombinant (His) Human E. coli
Biliverdin reductase (hBVR) is a serine/threonine kinase that catalyzes reduction of the heme oxygenase (HO) activity product, biliverdin, to bilirubin. BVR consists of an N-terminal dinucleotide-binding domain (Rossmann-fold) and a C-terminal domain that contains a six-stranded β-sheet that is flanked on one face by several α-helices. The C-terminal and N-terminal domains interact extensively, forming the active site cleft at their interface. Biliverdin reductase (BVR) catalyzes the last step i...
TMPY-04387 AKT2 Protein, Human, Recombinant (His & GST) Human Baculovirus-Insect Cells
AKT (AK mouse plus Transforming or Thymoma) is a frequent oncogene expressed in most tissues which includes three isoforms AKT1, AKT2, and AKT3. Hyperactivation of AKT signaling is a central key in many human cancer progressions, through modulating angiogenesis, tumor growth, and cell migration, invasion, metastasis, and chemoresistance. Among all three isoforms, AKT2 is most related to cancer cell invasion, metastasis, and survival. Amplification and overexpression of AKT2 have been shown in ma...

Recombinant Proteins

Insulin Protein, Human, Recombinant
TMPY-00395
Species: Human
Source: Yeast
Insulin Receptor Protein, Human, Recombinant (long isoform, His)
TMPY-01146
Species: Human
Source: HEK293
Insulin Receptor Protein, Human, Recombinant (His & GST)
TMPY-04395
Species: Human
Source: Baculovirus-Insect Cells
Insulin Receptor Protein, Human, Recombinant (short isoform, His)
TMPY-01149
Species: Human
Source: HEK293
Insulin Receptor Protein, Human, Recombinant (long isoform, His), Biotinylated
TMPY-05283
Species: Human
Source: HEK293
Dermcidin Protein, Human, Recombinant (hFc)
TMPY-00545
Species: Human
Source: HEK293
GAD65 Protein, Human, Recombinant (GST)
TMPY-04699
Species: Human
Source: Baculovirus-Insect Cells
IGFBP-3 Protein, Human, Recombinant (His)
TMPY-00835
Species: Human
Source: HEK293
CCL18 Protein, Human, Recombinant (His)
TMPY-00566
Species: Human
Source: Yeast
Cathepsin H Protein, Human, Recombinant (His)
TMPY-06479
Species: Human
Source: HEK293
FSTL3 Protein, Human, Recombinant (His)
TMPK-00751
Species: Human
Source: HEK293
Cathepsin H Protein, Mouse, Recombinant (His)
TMPY-04081
Species: Mouse
Source: HEK293
CART Protein, Human, Recombinant
TMPY-04053
Species: Human
Source: HEK293
INSL6 Protein, Human, Recombinant (His)
TMPY-05014
Species: Human
Source: HEK293
CART Protein, Human, Recombinant (mFc)
TMPY-03806
Species: Human
Source: HEK293
INHBE Protein, Human, Recombinant (hFc)
TMPY-05029
Species: Human
Source: HEK293
IGFBP-7 Protein, Mouse, Recombinant (His)
TMPJ-01166
Species: Mouse
Source: Human Cells
LR3-IGF-1 Protein, Mouse, Recombinant (His)
TMPJ-00781
Species: Mouse
Source: E. coli
BLVRB Protein, Human, Recombinant (His)
TMPY-02519
Species: Human
Source: E. coli
AKT2 Protein, Human, Recombinant (His & GST)
TMPY-04387
Species: Human
Source: Baculovirus-Insect Cells
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TargetMol