Carboxypeptidase

CPA inhibitor (Carboxypeptidase inhibitor) is a potent carboxypeptidase A (CPA) inhibitor with a Ki of 0.32 μM.

2-Benzylsuccinic acid (DL-Benzylsuccinic acid) is a metabolite produced by bacteria as they process xenobiotic compounds.

2-PMPA (2-(Phosphonomethyl)pentanedioic acid) is a potent and selective inhibitor of glutamate carboxypeptidase II (GCPII) (IC50=300 pM).

Carboxypeptidase C, often utilized in biochemical research, is an enzyme that excises COOH-terminal lysine, arginine, and proline, in addition to various neutral, aliphatic, aromatic, and acidic protein amino acids from peptide chains [1].

CarboxypeptidaseW, Wheat (EC 3.4.16.6) is part of the serine carboxypeptidase family and can be inhibited by diisopropyl fluorophosphate.

Carboxypeptidase G, derived from Pseudomonas sp. (EC 3.4.17.11), is a lysosomal thiol-dependent protease that systematically cleaves γ-glutamylpteroyl-poly-γ-glutamate, resulting in the production of pteroyl-α-glutamate (folic acid) and free glutamate. This enzyme is highly specific for the γ-glutamyl bond but exhibits no specificity towards the C-terminal amino acid of the leaving group. Zn2+ ions can activate Carboxypeptidase G.

Carboxypeptidase G2 (CPG2) Inhibitor (CPG2 Inhibitor) is a new CPG2 Inhibitor with antitumor activity.

Carboxypeptidase B, a peptide exonuclease, specifically degrades peptide chains by progressively hydrolyzing from the C-terminal, releasing free amino acids. It acts exclusively on peptide bonds with basic amino acids (such as arginine and lysine) at the C-terminal residues [1] [2].

Carboxypeptidase A (EC 3.4.2.1), a zinc-containing metalloprotease, catalyzes the hydrolysis of peptide bonds near the C-terminal end of polypeptides and is frequently utilized in biochemical research. As a prototypical enzyme for metalloproteases, it is essential in biological systems [1].

GNE-375 is a selective and potent BRD9 inhibitor (IC50: 5 nM).GNE-375 inhibits BRD4, TAF1, and CECR2, and can be used to study epigenetic resistance.

CeMMEC1 is an inhibitor of BRD4, and also has a great affinity for TAF1(IC50=0.9 μM).

Monosodium 2-sulfoterephthalate (8) is an inhibitor of glutamate carboxypeptidase II.

2-MPPA (GPI-5693) is an orally active, selective, and potent inhibitor of glutamate carboxypeptidase II (GCP II) (IC50: 90 nM) and also a NAALADase inhibitor, used in the study of neurological diseases.

GCPII-IN-1 is a potent inhibitor scaffold targeting glutamate carboxypeptidase II (GCPII), also known as prostate-specific membrane antigen (PSMA). It exhibits a high affinity for GCPII, with a binding affinity (K i ) of 44.3 nanomolar (nM).

GCPII-IN-1 TFA is a scaffold inhibitor of glutamate carboxypeptidase II (GCPII; PSMA) with a Ki of 44.3 nM.

Mergetpa, a carboxypeptidase inhibitor, impedes the conversion of kinins and B2 receptor antagonists into metabolites devoid of the C-terminal arginine [1].

BAY-299 is an effecitve inhibitor of the bromodomain and PHD finger family member BRPF2 and the TATA box binding protein-associated factors TAF1 and TAF1L with IC50s of 67 nM, 8 nM, and 106 nM, respectively.

GEMSA is a potent inhibitor of enkephalin convertase (Ki = 8.8 nM) with analgesic effects[1].

Histargin is an enzyme inhibitor separated from Streptomyces roseoviridis.

CeMMEC13 is an isoquinolinone that selectively inhibits the second bromodomain of TAF1 (IC50 = 2.1 μM).

Spinorphin is a heptapeptide, and is a potent enkephalin-degrading enzymes inhibitor.

CarboxypeptidaseY, Baker's yeast (S. cerevisiae) serves as a biocatalyst and is a crucial enzyme in advanced biocatalyst technology. Enzyme engineering focuses on improving the kinetics of enzyme reactions, substrate selectivity, and performance under challenging conditions, such as low or high pH. Introducing stimulus-responsive modifications to these enzymes also enables dynamic control of their activity.

Meropenem (SM 7338) is a synthetic carbapenem antibiotic with broad-spectrum antibacterial activity. It exerts a bactericidal effect by inhibiting the synthesis of peptidoglycan in the bacterial cell wall and is active against a wide range of Gram-positive, Gram-negative, and anaerobic bacteria. Meropenem is active against both susceptible and resistant Neisseria gonorrhoeae (MIC values of 0.02–0.06 mg/mL), Haemophilus influenzae (MIC: 0.03–0.12 mg/mL), and Klebsiella pneumoniae (MIC: 0.015–0.12 mg/mL). Meropenem can be used for constructing bacterial infection models and screening for antimicrobial activity.

MLN-4760 is an angiotensin-converting (ACE2) inhibitor(human ACE2;IC50=0.44 nM). It also has excellent selectivity (>5000-fold) versus related enzymes including human testicular ACE (IC50, >100 μM) and bovine carboxypeptidase A (CPDA; IC50, 27 μM).