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  • Xanthine Oxidase
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Results for "

xanthine oxidase

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    103
    TargetMol | Inhibitors_Agonists
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    4
    TargetMol | Peptide_Products
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    34
    TargetMol | Natural_Products
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Xanthine oxidase
XOD, XO
T761049002-17-9
Xanthine oxidase (XO) is an enzyme involved in purine catabolism and conversion to uric acid, generating reactive oxygen species, used in the study of cardiovascular diseases.
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7-10 days
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Xanthine oxidase-IN-11
T78985
Xanthine Oxidase-IN-11, an analog of XO8, is an inhibitor of xanthine oxidase (XO) [1].
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Xanthine oxidase-IN-12
T80767
Xanthine oxidase-IN-12 (Compound 11), an inhibitor of xanthine oxidase (XO), has an IC50 value of 91 nM and exhibits antioxidant properties, also reducing intracellular reactive oxygen species (ROS) [1].
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Tigulixostat
LC350189
T606251287766-55-5In house
Tigulixostat (LC350189) is a novel xanthine oxidase inhibitor (XOI) that reduces uric acid production and may be used in studies of gout-related diseases.
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6-8 weeks
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Baicalein
5,6,7-Trihydroxyflavone
T2858491-67-8
Baicalein (5,6,7-Trihydroxyflavone) is a xanthine oxidase inhibitor.
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TargetMol | Citations Cited
Phytic acid
myo-Inositol, hexakis(dihydrogen phosphate), inositol polyphosphate, Inositol hexaphosphate, inositol hexakisphosphate, Fytic Acid
T297183-86-3
Phytic acid (Fytic Acid) is a complexing agent for removal of traces of heavy metal ions. It acts also as a hypocalcemic agent.
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URAT1&XO inhibitor 2
T791771239488-96-0
Compound BDEO (URAT1&XO inhibitor 2) serves as a dual-action inhibitor targeting both xanthine oxidase (XO) and URAT1, demonstrating an IC50 value of 3.3 μM for XO inhibition. It effectively impedes uric acid uptake in HEK293 cells with URAT1 expression, evidenced by a Ki of 0.145 μM. In hyperuricemic mice models, the compound has been shown to reduce serum urate levels and uric acid excretion, indicating potential utility for hyperuricemia research [1].
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6-8 weeks
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Antioxidant agent-13
T79331
Compound 5f (Antioxidant agent-13) is an antioxidant that demonstrates inhibition of DPPH and FRAP with half maximal inhibitory concentrations (IC50s) of 80.33 µM and 85.69 µM, respectively. Additionally, it inhibits the enzymes lipoxygenase (LOX) and xanthine oxidase (XO) with IC50s of 16.85 µM and 23.01 µM, respectively [1].
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URAT1&XO inhibitor 1
T791752669726-78-5
URAT1&XO Inhibitor 1 (compound 29) serves as a dual inhibitor with IC50 values of approximately 10 μM for URAT1 and 1.01 μM for Xanthine Oxidase. It induces a hypouricemic effect in the potassium oxonate-induced hyperuricemic rat model and is utilized in research pertaining to hyperuricemia [1].
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8-10 weeks
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Forsythoside F
Arenarioside
TMA095894130-58-2
Forsythoside F (Arenarioside) is a natural compound with GI50 values ranging from 10 to 16 μM against B16F10 cells.
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Xanthine oxidase-IN-1
4-(3-Cyano-5,6-difluoroindol-1-yl)-2-hydroxybenzoic acid
T105091071970-13-2In house
Xanthine oxidase-IN-1 is an effective inhibitor of xanthine oxidase with an IC50 value of 6.5 nM. It plays a central role in purine catabolism through the degradation of bioactive nucleotides facilitated by nucleic acid and nucleotide intermediates.
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8-10weeks
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TargetMol | Inhibitor Sale
Xanthine oxidoreductase-IN-5
T721661026652-90-3
Xanthine oxidoreductase-IN-5 is an orally active inhibitor of xanthine oxidoreductase (XOR) with an IC50 of 55 nM. Xanthine oxidoreductase-IN-5 may be used in studies of acute hyperuricemia.
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6-8 weeks
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TargetMol | Inhibitor Sale
Xanthine oxidoreductase-IN-3
T72165651769-78-7
Xanthine oxidoreductase-IN-3 is an orally active xanthine oxidoreductase (XOR) inhibitor with an IC50 of 26.3 nM, suitable for use in acute hyperuricemia studies.
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6-8 weeks
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TargetMol | Inhibitor Sale
Xanthine oxidoreductase-IN-4
T720781026587-58-5
Xanthine oxidoreductase-IN-4 is an orally active xanthine oxidoreductase (XOR) inhibitor with an IC50 value of 29.3 nM, useful for studying hyperuricemia.
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6-8 weeks
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TargetMol | Inhibitor Sale
6-Formylpterin
Pterin-6-aldehyde, 6 Formylpterin
T35976712-30-1
6-Formylpterin (Pterin-6-aldehyde) is an inhibitor of Xanthine Oxidase (Ki ~0.6 nM) with potent neuroprotective effects against transient IRI in gerbils.6-Formylpterin induces intracellular ROS generation in HL-60 cells as well as apoptosis ( 6-Formylpterin inhibits the expression of iNOS, produces hydrogen peroxide intracellularly and restores the impaired bactericidal activity of human neutrophils.
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7-10 days
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Xanthine oxidase-IN-16
T200654
Xanthine oxidase-IN-16 is an effective orally active inhibitor of xanthine oxidase (XO), demonstrating significant therapeutic efficacy in rats with hyperuricemia and an IC50 of 102 nM.
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xanthine oxidase-in-6
T72409
Xanthine oxidase-IN-6, a potent and orally active mixed-type inhibitor of xanthine oxidase (XOD), demonstrates significant anti-hyperuricemia and renal protective activity with an IC50 value of 1.37 µM.
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6-8 weeks
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Xanthine oxidase-IN-10
XO8 analog
T78984851429-65-7
Xanthine oxidase-IN-10 (XO8 analog) is an inhibitor of xanthine oxidase (XO) used in gout research.
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8-10 weeks
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Xanthine oxidase-IN-8
T755042571069-66-2
Xanthine oxidase-IN-8 (Icarisids J) (Compound 7) acts as an inhibitor of xanthine oxidase with an inhibitory concentration (IC50) of 29.71 μM [1].
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Xanthine oxidase-IN-9
T755052571069-61-7
Xanthine Oxidase-IN-9 (also known as Icarisids E or Compound 2) effectively inhibits xanthine oxidase (XOD) with an IC50 value of 31.81 μM [1].
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Xanthine oxidase-IN-4
T606322642137-96-8
Xanthine oxidase-IN-4 (compound 19a) is an orally active and potent xanthine oxidase (XO) inhibitor with an IC50 of 0.039 μM, suitable for research in hyperuricemia and gout. Xanthine oxidase-IN-4 demonstrates hypouricemic potency in potassium oxonate-induced hyperuricemia rats. [1].
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6-8 weeks
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Xanthine oxidase-IN-7
T606262411698-59-2
Xanthine oxidase-IN-7 (compound 1h) is a potent, orally active xanthine oxidase (XO) inhibitor with an IC50 of 0.36 μM, effectively reducing serum uric acid levels and showing potential for hyperuricemia and gout research [1].
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6-8 weeks
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Xanthine oxidase-IN-5
T610922276711-87-4
Xanthine oxidase-IN-5, a powerful and orally active inhibitor of xanthine oxidase (XO), exhibits an IC50 value of 0.70 μM. It possesses favorable drug-like characteristics, with ligand efficiency (LE) and lipophilic ligand efficiency (LLE) values of 0.33 and 3.41, respectively. Moreover, Xanthine oxidase-IN-5 showcases significant hypouricemic effects in a hyperuricemic rat model [1].
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6-8 weeks
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CC15009
T2004452482713-67-5
CC15009 is a potent inhibitor of xanthine oxidoreductase (XOR), demonstrating an IC50 value of 0.237 nM. It effectively inhibits the oxidative subtype of XOR, thereby reducing the generation of the byproduct ROS and exhibiting antioxidant activity. CC15009 has shown a favorable dose-dependent uric acid-lowering effect in two different XOR substrate-induced hyperuricemia mouse models.
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4-6 weeks
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