tnfsf 2

Anti-TNFSF2/TNFa Antibody (hMAK195) is a humanized monoclonal antibody targeting tumor necrosis factor alpha (TNF-α/TNFSF2), serving as a biosimilar to Afelimomab. TNF-α is a critical pro-inflammatory cytokine primarily produced by macrophages and T cells, playing a central role in inflammatory responses, apoptosis, and immune regulation. hMAK195 specifically binds to both soluble and membrane-bound TNF-α, blocking their interaction with cell surface receptors (TNFR1 and TNFR2) and thereby inhibiting the activation of downstream NF-κB and MAPK signaling pathways. This antibody effectively neutralizes TNF-α-induced cytotoxicity and inflammatory cascades, making it a valuable tool for researching sepsis, rheumatoid arthritis, and other inflammatory diseases.

Anti-TNFSF2/TNFa Antibody is a human-derived antibody expressed in CHO cells, targeting TNFSF2/TNFa. It features a huIgG1 heavy chain and a huκ light chain, with an estimated molecular weight (MW) of 145 kDa. For isotype control, refer to HumanIgG1kappa, Isotype Control.

The Anti-Mouse?TNF-alpha/TNFSF2 Antibody (XT3.11) is a rat-derived IgG1 monoclonal antibody targeting TNF-alpha/TNFSF2. The isotype control for this product is RatIgG1kappa, Isotype Control.