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Results for "

seizures

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    75
    TargetMol | Inhibitors_Agonists
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    1
    TargetMol | Compound_Libraries
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    1
    TargetMol | Peptide_Products
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Licarbazepine
​10,11-hydroxy-10,11 Dihydrocarbamezer
T780629331-92-8
Licarbazepine (10,11-hydroxy-10,11 Dihydrocarbamezer) is the pharmacologically active metabolite of oxcarbazepine, a drug indicated for the treatment of partial seizures and bipolar disorders.
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Fluzinamide
AHR-8559
T1530276263-13-3In house
Fluzinamide (AHR-8559) has anticonvulsant effects on ignited amygdala seizures.
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6-8 weeks
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Losigamone
ADD-137022, AO33, AO 33, ADD 137022, AO-33, ADD137022;Losigamone
T27845112856-44-7In house
Losigamone (AO-33), an agonist of the GABA receptor, can be utilized in studies on the treatment of partial seizures.
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6-8weeks
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Denzimol
T6805473931-96-1In house
Denzimol is a novel anticonvulsant compound.Denzimol is selective for tonic seizures.
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Dulozafone
F1933
T6805875616-02-3In house
Dulozafone (F1933) has an anti- showed anticonvulsant activity in a brain amygdala ignition model and protected fully ignited rats from generalized seizures.
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Levetiracetam
UCB L059, SIB-S1
T0192102767-28-2
Levetiracetam (SIB-S1) is a relatively unique anticonvulsant that is typically used in combination with other antiepileptic medications for partial onset seizures. Levetiracetam has been linked to rare instances of serum aminotransferase and alkaline phosphatase elevations during treatment and to rare cases of clinically apparent drug induced liver disease.
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Zonisamide
AD 810, CI 912
T026768291-97-4
Zonisamide (AD 810), a sulfonamide anticonvulsant, is approved for use as an adjunctive treatment in adults with partial-onset seizures. It may inhibit a carbonic anhydrase although this is not one of the main mechanisms of action. Zonisamide may act by blocking repetitive firing of voltage-gated sodium channels results in a reduction of T-type calcium channel currents, or by binding allosterically to GABA receptors. This latter action may lower the uptake of the inhibitory neurotransmitter GABA while increasing the uptake of the excitatory neurotransmitter glutamate.
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Topiramate
RWJ 17021, McN 4853
T067597240-79-4
Topiramate (RWJ 17021) is a unique antiseizure medication that is used in the treatment of partial and generalized seizures. Topiramate has been rarely associated with hepatic injury and largely when used in combination with other anticonvulsant medications.
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Ethosuximide
Zarontin
T072877-67-8
Ethosuximide (Zarontin) is an anticonvulsant, blocks the low voltage-activated T-type calcium channel used in the treatment of absence seizures unaccompanied by other types of seizures.
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Beclamide
N-Benzyl-3-chloropropionamide, Chlorakon, Chloracon
T1249501-68-8
Beclamide (Chlorakon) (N-benzyl-B-chloropropionamide) is a drug that possesses anticonvulsant activity. It is no longer used. It has been used as a sedative and as an anticonvulsant. It was studied in the 1950s for its anticonvulsant properties, as a treatment for generalized tonic-clonic seizures. It was not effective for absence seizures.
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Eslicarbazepine Acetate
Zebinix, Aptiom, BIA 2-093, Exalief, Stedesa
T3285236395-14-5
Eslicarbazepine Acetate (Zebinix) is an anticonvulsant medication approved for use in Europe, the United States and Canada as an adjunctive therapy for partial-onset seizures that are not adequately controlled with conventional therapy.
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Magnesium sulfate
T408647487-88-9
Magnesium sulfate is the preferred anticonvulsant for preventing and controlling eclamptic seizures. Additionally, it is extensively utilized as a tocolytic agent.
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7-10 days
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Pyrrole-2-carboxylic acid
Minaline, 2-Pyrrolecarboxylic acid
T4716634-97-9
Pyrrole-2-carboxylic acid (Minaline) was first identified as a degradation product of sialic acids, then as a derivative of the oxidation of the D-hydroxyproline isomers by mammalian D-amino acid oxidase. The latter relationship results from the lability of the direct oxidation product, A'-pyrroline-4-hydroxy-2-carboxylic acid, which loses water spontaneously to form the pyrrole. A similar reaction is catalyzed by the more specific allohydroxy-D-proline oxidase of Pseudomonas. In whole animal observations, pyrrole-2-carboxylate (PCA) ' was identified in rat or human urine after administration of the D-isomers of hydroxyproline, a finding ascribable to the action of D-amino acid oxidase. Urinary excretion of N-(pyrrole-2-carboxyl) glycine has been reported in a 5-year-old affected with type II hyperprolinemia; The child has mild developmental delay, recurrent seizures of the grand mal type and EEG alterations.
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DL-Homocysteine thiolactone hydrochloride
DL-Homocysteinethiolactone hydrochloride
T59686038-19-3
DL-Homocysteine thiolactone hydrochloride (DL-Homocysteinethiolactone hydrochloride) is a cysteine derivative that binds to and induces conformational changes in various plasma proteins, slowing coagulation and inducing oxidative stress. It decreases left ventricular systolic blood pressure and cardiac force and induces seizures in vivo.
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Gabapentin hydrochloride
Neurontin HCl, Gabapentin HCl
T650760142-95-2
Gabapentin hydrochloride (Neurontin HCl) is a GABA analogue, used to treat seizures and neuropathic pain.
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Prilocaine
Citanest, Propitocaine, NSC 40027
T6953721-50-6
Prilocaine (NSC-40027) is a local anesthetic of the amino amide type, which acts on the sodium channel on the neuronal membrane and limits the spread of seizures.
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D-Leucine
(R)-Leucine
T9299328-38-1
D-Leucine ((R)-Leucine) potently terminates seizures even after the onset of seizure activity. D-leucine reduces long-term potentiation but had no effect on basal synaptic transmission in vitro.
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L-803087
T11800217480-26-7
L-803087 is a potent and selective agonist of the growth inhibitor sst4 receptor with a Ki value of 0.7 nM for sst4, demonstrating over 280-fold selectivity compared to other growth inhibitory receptors. L-803087 induces AMPA-mediated synaptic responses in the hippocampus in vitro and increases seizures in alginate-induced seizure-busting mice in vivo.
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6-8 weeks
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N-(2-Chloro-6-methylphenyl)-N'-4-pyridinylurea
T1215697627-24-2
N-(2-Chloro-6-methylphenyl)-N'-4-pyridinylurea is an anticonvulsant agent, treatment of generalized tonic-clonic and partial seizures.
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WWL123
T221711338575-41-9
WWL123 is a potent and selective ABHD6 inhibitor (IC50=430 nM). WWL123 crosses the blood-brain-barrier and inhibits ABHD6 in brain parenchyma. ABHD6 blockade by WWL123 exerts an antiepileptic effect in Pentylenetetrazole (PTZ)-induced epileptiform seizures and spontaneous seizures in R6 2 mice.
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VU 0255035
T235081135243-19-4
VU 0255035 is a highly selective, competitive, and brain-penetrant muscarinic M1 receptor antagonist with an IC50 of 130 nM, used to reduce pilocarpine-induced seizures in mice and to examine the role of the M1 receptor in diverse situations.
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6-8 weeks
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Ameltolide
T23717787-93-9
Ameltolide is an anticonvulsant agent. It has been shown to be effective at inhibiting seizures in animal models.
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6-8 weeks
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Benzolamide
CL-11366, W 1803, CL 11366, CL11366, W-1803
T237823368-13-6
Benzolamide (CL 11366) inhibits carbonic anhydrase effectively and low-threshold calcium currents in hippocampal pyramidal neurons.
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Bumetanide
PF 1593, Ro 10-6338
T010828395-03-1
Bumetanide (PF 1593) is a potent sulfamoylanthranilic acid derivative belonging to the class of loop diuretics. In the brain, bumetanide may prevent seizures in neonates by blocking the bumetanide-sensitive sodium-potassium-chloride cotransporter (NKCC1), thereby inhibiting chloride uptake thus, decreasing the internal chloride concentration in neurons and may block the excitatory effect of GABA in neonates.
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