l 45

L-45 is the first potent and cell-active bromodomain (Brd) inhibitor of p300/CBP-associated factor (PCAF) (Kd: 126±15 nM).

Poloxamer 125 L45 is a block copolymer of polyethylene oxide and polypropylene oxide with an average molecular weight of 2400. It forms a thermoreversible hydrogel and is used as a food additive and as a drug delivery vehicle in cosmetics, pharmaceuticals, and tissue engineering.

BI-L 45XX, an anti-inflammatory benzimidazole derivative, has inhibitory effects on neutrophil function.

Gadopentetate dimeglumine is used in magnetic resonance imaging (MRI) to allow blood vessels, organs and other non-bone tissues to be visualized more clearly.Gadopentetate dimeglumine induces atrophy of spermatogonia.

Gemcitabine hydrochloride (LY 188011 hydrochloride) is a synthetic cytosine nucleoside derivative and an inhibitor of DNA synthesis. Gemcitabine has antitumor and antimetabolic activities. Gemcitabine induces autophagy and apoptosis.

1-benzyl-2-ethyl-4,5,6,7-tetrahydro-1H-indol-4-one is an inhibitor Bromodomain-containing protein 4 (human).

Deflazacort (MDL 458) is a glucocorticoid served as an immunosuppressant and anti-inflammatory. It can be used to treat autoimmune diseases due to inhibiting the immune system. It can also be acted in the therapy of some types of Ys. Deflazacort can help to prevent and to treat the rejection of transplanted organs.

3-(1,3-benzodioxol-5-yl)-4,5,7-trimethoxy-2H-chromen-2-one is a useful organic compound for research related to life sciences and the catalog number is T131588.

XJTU-L453, a PI3Kα inhibitor, exhibits an IC50 of 0.4 nM. It inhibits the proliferation of breast cancer cell lines T47D and MCF7, with IC50 values of 0.2 μM and 0.5 μM respectively. Additionally, XJTU-L453 disrupts the PI3K pathway, leading to cell cycle arrest and cell apoptosis (apoptosis). It also demonstrates antitumor activity in MCF7 xenograft mice.

Z944 is a T-type calcium channel antagonist with potential applications in pain management. In both epileptic and non-epileptic rats, Z944 disrupts prepulse inhibition. Additionally, it corrects cross-modal sensory and visual recognition memory deficits in Strasbourg genetic absence epilepsy rats. In a neuropathic pain rat model, Z944 restores cortical synchrony and thalamocortical connectivity. In the amygdala kindling model, it delays seizure progression.

BBL454 (Compound 43) is an agonist of the cholecystokinin 2B (CCK2B) receptor. It induces hyperactivity and enhances memory in rat models, while showing weak activity on peripheral CCK2 receptors and no anxiogenic effects. In anesthetized rat models, BBL454 increases gastric acid secretion. It is applicable to diabetes research.

L458-BPyne is a γ-secretase modulator photoaffinity probe that acts by identifying distinct allosteric binding sites on presenilin. It also can be exploited to reduce levels of pathogenic Aβ species.

m-Anisidine, N,N-dimethyl-4-((5-phenylpentyl)oxy)- is a bioactive chemical.

m-Anisidine, N-methyl-4-((5-phenylpentyl)oxy)- is a bioactive chemical.

(R)-N,N-diethyl-4,5,6,7-tetrahydrodiindeno[7,1-de:1',7'-fg][1,3,2]dioxaphosphocin-12-amine is a useful organic compound for research related to life sciences and the catalog number is T64487.

2,6-Bis((4S,5S)-4,5-diphenyl-4,5-dihydro-1H-imidazol-2-yl)pyridine is a useful organic compound for research related to life sciences. The catalog number is T64503 and the CAS number is 1221973-02-9.

N-(2-Bromo-6-fluorophenyl)-4,5-dihydro-1H-imidazol-2-amine hydrochloride is a useful organic compound for research related to life sciences and the catalog number is T64522.

(11aR)-N,N-Bis((S)-1-phenylethyl)-4,5,6,7-tetrahydrodiindeno[7,1-de:1',7'-fg][1,3,2]dioxaphosphocin-12-amine is a useful organic compound for research related to life sciences and the catalog number is T64794.

Ethyl 4-(5-(bis(2-hydroxyethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoate is a useful organic compound for research related to life sciences. The catalog number is T65581 and the CAS number is 3543-74-6.

1-(4-Methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid is a useful organic compound for research related to life sciences. The catalog number is T66214 and the CAS number is 503614-92-4.

2-Phenyl-4,5-dihydro-1H-imidazole is a useful organic compound for research related to life sciences. The catalog number is T66274 and the CAS number is 936-49-2.

Methyl 4,5-dichlorothiophene-2-carboxylate is a useful organic compound for research related to life sciences. The catalog number is T66373 and the CAS number is 89281-29-8.

2-(Pyridin-3-yl)-4,5-dihydrooxazole is a useful organic compound for research related to life sciences. The catalog number is T66524 and the CAS number is 40055-37-6.

MK-0359 besylate is a Phosphodiesterase-4 (PDE4) inhibitor.