l 45

BI-L 45XX, an anti-inflammatory benzimidazole derivative, has inhibitory effects on neutrophil function.

(Rac)-SAR131675 is an effective and specific VEGFR-3 inhibitor. It inhibited VEGFR-3 tyrosine kinase activity (IC50: 20 nmol L) and VEGFR-3 autophosphorylation (IC50: 45 nmol L) in HEK cells, respectively. SAR131675 is highly specific for VEGFR-3 versus 107 receptors, enzymes, ion channels, and 65 kinases. SAR131675 is a highly specific VEGFR-3-TK inhibitor with significant antitumoral and antimetastatic activities in vivo through inhibition of lymphangiogenesis and TAM invasion.

L-45 is the first potent and cell-active bromodomain (Brd) inhibitor of p300 CBP-associated factor (PCAF) (Kd: 126±15 nM).

Avilamycin A is an antibiotic.1 It is active against veterinary isolates of C. perfringens (MICs = ≤0.06-0.5 mg/L) and B. hyodysenteriae (MICs = 12.5-100 μg/ml).1,2 Dietary administration of avilamycin A (15 and 30 ppm) reduces mortality in a broiler cockerel model of C. perfringens infection.3 Formulations containing avilamycin A have been used in the prevention of necrotic enteritis in livestock. |1. Watkins, K.L., Shryock, T.R., Dearth, R.N., et al. In-vitro antimicrobial susceptibility of Clostridium perfringens from commercial turkey and broiler chicken origin. Vet. Microbiol. 54(2), 195-200 (1997).|2. Uezato, K., Kinjo, E., and Adachi, Y. In vitro susceptibility of 21 antimicrobial agents to 37 isolates of Brachyspira hyodysenteriae isolated from pigs in Okinawa Prefecture. J. Vet. Med. Sci. 66(3), 307-309 (2004).|3. Paradis, M.A., McMillan, E., Bagg, R., et al. Efficacy of avilamycin for the prevention of necrotic enteritis caused by a pathogenic strain of Clostridium perfringens in broiler chickens. Avian Pathol. 45(3), 365-369 (2016).

UDP-N-acetyl-D-Glucosamine is a natural nucleotide sugar that is used by glycosyltransferases to transfer N-acetyl-D-glucosamine residues to substrates.1It is an important component of antibiotic biosynthesis pathways in fungi and lipopolysaccharide production in bacteria.2,3 1.Roseman, S.Reflections on glycobiologyJ. Biol. Chem.276(45)41527-41542(2001) 2.Kudo, F., and Eguchi, T.Biosynthetic genes for aminoglycoside antibioticsJ. Antibiot. (Tokyo)62(9)471-481(2009) 3.Mulrooney, E.F., Poon, K.K., McNally, D.J., et al.Biosynthesis of UDP-N-acetyl-L-fucosamine, a precursor to the biosynthesis of lipopolysaccharide in Pseudomonas aeruginosa serotype O11J. Biol. Chem.280(20)19535-19542(2005)

Relacatib (SB-462795) is a novel, potent, and orally active inhibitor of human cathepsins K, L, and V, exhibiting high affinity with Ki values of 41 pM, 68 pM, and 53 pM, respectively. It effectively inhibits endogenous cathepsin K in situ in human osteoclasts and human osteoclast-mediated bone resorption with IC50 values of 45 nM and 70 nM, respectively. In vitro studies confirm its inhibitory effect on bone resorption in human tissue, and in vivo studies on cynomolgus monkeys validate its efficacy in reducing bone resorption.

L-Moses (L-45) dihydrochloride is the first potent and selective inhibitor of the p300 CBP-associated factor (PCAF) bromodomain (Brd) with a dissociation constant (Kd) of 126 nM.

L-N-Benzylserine is a useful organic compound for research related to life sciences. The catalog number is T65056 and the CAS number is 17136-45-7.

S-(N-Methylsulfinylbutylthiocarbamoyl)-L-cysteine (SFN-Cys) is an isothiocyanate derivative, functioning as an active metabolite of sulforaphane, a class I and II histone deacetylase (HDAC) inhibitor, and anticancer agent. This compound is generated from sulforaphane through intermediates - DL-sulforaphane glutathione and sulforaphane cysteinylglycine - via the mercapturic acid pathway enzymes. At a concentration of 20 µM, SFN-Cys diminishes invasion and migration of U87MG and U373 MG glioblastoma cells as observed in wound healing and chamber assays. Furthermore, at 45 µM, it significantly lowers the expression of α-tubulin, βIII-tubulin, stathmin 1, and X-linked inhibitor of apoptosis (XIAP), and also reduces cell density in paclitaxel-resistant A549 lung cancer cells (A549/T). Additionally, when used at 30 µM, SFN-Cys prompts apoptosis and cell cycle arrest at the G2/M phase in U87MG and U373 MG cells.

Lucidenic acid L is a natural product for research related to life sciences. The catalog number is TN4458 and the CAS number is 110267-45-3.

HAEGTFTSD acetate is the first N-terminal 1-9 residues of GLP-1 peptide.The GLP-1 (7-36) amide is a product of the preproglucagon gene, which is secreted from intestinal L-cells, in response to the ingestion of food.

MHC class II antigen (45-57) [Homo sapiens] is a peptide with the sequence H2N-Asp-Leu-Asp-Lys-Lys-Glu-Thr-Val-Trp-His-Leu-Glu- Glu-OH, MW= 1868.07. MHC (major histocompatibility complex) class II molecules are found only on antigen-presenting cells and l