contact

Dimethoate (L-395) is a systemic and contact insecticide for control of cattle grubs and certain other insect pests of farm animals.

N,N'-Diacetyl-L-cystine (DiNAC) is the disulphide dimer of N-acetylcysteine with immunomodulating properties. N,N'-diacetyl-L-cystine also has antiatherosclerotic effects in Watanabe-heritable hyperlipidemic rabbit (WHHL) rabbits. N,N'-diacetyl-L-cystine is also an effective and orally active modulator of contact sensitivity delayed-type hypersensitivity reactions in rodents.

Hexyl nicotinate (AI3 15769) is a cutaneous vasodilator and can be used in research on non-immunologic contact urticaria on the scalp, face, and back.

Prochloraz (Prelude) is a broad-spectrum contact imidazole fungicide. Prochloraz inhibits human placental microsomal aromatase in vitro (IC50 = 40 nM). Prochloraz also acts as an estrogen receptor (IC50s = 25 μM) and androgen receptor (IC50 = 4 μM) antagonist, and activates aryl hydrocarbon receptors (EC50 = 1 μM).

4-Methyl-2-nitrophenol is an organic chemical compound that appears as dark yellow to brown crystals or a fused solid at room temperature. 4-Methyl-2-nitrophenol is primarily used as a versatile intermediate for complex chemical synthesis.4-Methyl-2-nitrophenol is notably toxic by ingestion or skin contact, and it can cause significant skin, eye, and respiratory tract irritation upon exposure.

Methylchloroisothiazolinone Methylisothiazolinone Mixture (Kathon 886MW) is an isothiazolinone preservative that is widely used in cosmetics to inhibit the growth of bacteria, yeasts, and fungi, while potentially causing contact skin sensitization. Methylisothiazolinone activates matrix metalloproteinases (MMPs) in human bronchial epithelial cells to induce apoptosis and inflammation.

Nitrofen is a selective contact herbicide that acts as an inhibitor of protoporphyrinogen oxidase and retinal dehydrogenase.

Diethyl fumarate, a decomposition product of the pesticide Malathion, causes nonimmune contact urticaria on the skin.

Ufenamate (Flufenamic acid butyl ester) is an anthranilic acid-based anti-inflammatory drug developed for the treatment of skin diseases.

Phthalate ester used as plasticizers and additives. Used in toxicology studies as well as risk assessment studies of food contamination that occurs via migration of phthalates into foodstuffs from food-contact materials (FCM).

Tulipalin A (α-methylene-γ-butyrolactone) (2-Methylenebutyrolactone) which has some phytotoxicity is a natural compound extracted from Tulipa gesneriana.

Cymen-ar-ol is a broad spectrum and highly effective bactericide that can contact mucous membrane.

Propanil (CAS 709-98-8) is a widely used contact herbicide predominantly applied in rice production.

4,5-Dichloro-3H-1,2-dithiol-3-one (Dichloro-1,2-dithiacyclopentenone) serves as an inhibitor of the Escherichia coli FabH enzyme, with an inhibition concentration (IC50) of 2.9 µM. Additionally, it is employed as a biocide in the production of paper and cardboard intended for food contact.

Tuaminoheptane was originally developed as a nasal decongestant and belongs to the class of sympathomimetics and vasoconstrictors. It exhibits decongestant and stimulating effects by inhibiting and releasing norepinephrine. Unlike phenethylamine-based norepinephrine releasers, Tuaminoheptane has a unique chemical structure. Additionally, it may cause contact dermatitis due to its potential to irritate the skin by inhibiting volume-regulated anion channels, which limits its effectiveness as a decongestant.

Tuaminoheptane is a sympathomimetic and vasoconstrictor that was once used as a nasal decongestant. It works by inhibiting and accelerating the release of norepinephrine, a mechanism that likely underpins its decongestant and stimulating effects. Unlike other norepinephrine-releasing agents such as phenethylamines, Tuaminoheptane's chemical structure lacks an aromatic ring. Additionally, it acts as a skin irritant and may cause contact dermatitis by inhibiting volume-regulated cation channels, which limits its utility as a decongestant.

Sodium picofosfate is a contact irritant laxative primarily used to alleviate constipation or prepare the colon for a colonoscopy or surgery.

Fludioxonil is employed to manage the growth of axillary buds (suckers) following the topping of tobacco plants. Its mode of action includes a localized systemic effect, contact action, and phytotoxicity.

Triphenyl phosphate can disrupt placental tryptophan metabolism by activating MAOA/ROS/NFκB, leading to abnormal neural behavior. It promotes oxidative stress by inducing inflammatory factors such as nuclear factor κ B (NFκB), interleukin-6, and tumor necrosis factor α. Additionally, triphenyl phosphate may cause allergic contact dermatitis.

4-(2-Octylamino)diphenylamine is an aromatic amine antioxidant known to be toxic to V. fischeri, with an IC50 value of 0.68 mg mL. It induces skin sensitization and contact dermatitis in the murine local lymph node assay and can be used as a rubber additive.

Tetradifon is a broad-spectrum organochlorine acaricide insecticide and a potent inhibitor of the mitochondrial oligomycin sensitivity conferring protein (OSCP)，a subunit of ATP synthase. Tetradifon is utilized for controlling a variety of mite pests and inhibiting energy-related mitochondrial activities including ADP-stimulated respiration and ATPase activity with an IC50 range of 4.5-27 nmoL/mg mitochondrial protein; it exerts oligomycin-like effects by inhibiting oxidative phosphorylation, inducing significant oxidative stress, and interfering with bone metabolism, making it a compound of interest for researching mitochondrial function, bone remodeling mechanisms, and nephrotoxicity.

Hexylamine is a primary aliphatic amine that presents as a flammable, water-white liquid with a strong, unpleasant ammonia-like, fishy odor. Hexylamine is used as a chemical reagent and versatile synthetic intermediate in organic synthesis, including the creation of polypeptides, functionalized materials for CO₂ capture, and lipid nanoparticles for drug delivery, Hexylamine is toxic by inhalation, ingestion, or skin contact, requiring careful handling, storage, and disposal procedures.

Mecrylate polymerizes in contact with moisture. It is used as a tissue adhesive. It also has higher homologs have hemostatic and antibacterial properties.

Bisnorcymserine is a reversible inhibitor of butyrylcholinesterase. The leaving group, bisnoreseroline, interacts in a non-covalent way with Ser(200) and His(440), disrupting the existing interactions within the catalytic triad, and it stacks with Trp(84)