GDP

GDP-α-D-mannose disodium gives a competitive inhibition with respect to GTP (Ki 14.7 μM) and an uncompetitive inhibition with respect to mannose-1-P (Ki 115 μM).GDP-α-D-mannose disodium is the donor substrate for mannosyltransferases and the precursor of

GDP366, a dual inhibitor of survivin and Op18, induces cell growth inhibition, cellular senescence, and mitotic catastrophe in human cancer cells.

2′-Deoxy-GDP trisodium is a guanosine monophosphate (GMP) analog that acts as an inhibitor of hypoxanthine phosphoribosyltransferase (HGPRT), with an IC50 of 12.5 μM. HGPRT is a key enzyme in the purine metabolic pathway of all protozoan parasites.

Guanosine 5'-diphosphate (GDP) as Potential Iron Mobilizer, Preventing the Hepcidin-Ferroportin Interaction and Modulating the Interleukin-6/Stat-3 Pathway.

Adagrasib (MRTX849) is an orally active and selective covalent inhibitor of KRAS G12C. Adagrasib binds to the GDP state of the inactive conformation of KRAS G12C and inhibits KRAS and its downstream signaling. Adagrasib exhibits inhibitory activity against KRAS G12C mutant tumors.

Sotorasib (AMG-510) is an orally active and selective covalent inhibitor of KRAS G12C. Sotorasib binds to the GDP state of the inactive conformation of KRAS G12C and inhibits KRAS and its downstream signaling. Sotorasib exhibits inhibitory activity against KRAS G12C mutant tumors.

Guanosine 5'-diphosphate disodium salt (5'-GDP-Na2) is a nucleoside diphosphate, is a potential iron mobilizer, which prevents the hepcidin-ferroportin interaction and modulating the interleukin-6 (IL-6)/stat-3 pathway.

6-Thioguanosine-5'-O-diphosphate sodium (6-Thio-GDP sodium) (TGDP sodium) is an active metabolite of 6-Mercaptopurine. As a purine analogue, 6-Mercaptopurine acts as an antagonist to endogenous purines and is extensively utilized as both an anti-leukemic and immunosuppressive agent.

Guanosine 5'-diphosphate (GDP) sodium is a nucleoside diphosphate known for activating the adenosine 5'-triphosphate-sensitive K+ channel, serving as a potential iron mobilizer by inhibiting the hepcidin-ferroportin interaction, and modulating the interleukin-6 (IL-6)/stat-3 pathway. It is utilized in research on inflammation-related conditions, including anemia of inflammation (AI).

Guanosine 5'-diphosphate ditromethamine (GDP ditromethamine) is a nucleoside diphosphate that activates ATP-sensitive K+ channels. It acts as a potential iron mobilizer, inhibiting the interaction between hepcidin and ferroportin, and modulating the IL-6/STAT-3 pathway. This compound finds application in inflammation research, such as studying anemia of inflammation (AI).

GDP-D-mannose disodium consists of GDP-α-D-mannose and GDP-β-D-mannose. GDP-α-D-mannose serves as a donor substrate for mannosyltransferases and a precursor for GDP-β-L-fucose biosynthesis. It competitively inhibits GTP with a Ki of 14.7 μM and non-competitively inhibits mannose-1-P with a Ki of 115 μM.

GDP-L-fucose disodium, a nucleotide sugar, serves as a crucial substrate for fucose oligosaccharides biosynthesis by providing the fucose moiety. Its formation follows two metabolic pathways: the primary de novo pathway and the secondary remedial pathway [1].

6-T-GDP (6-Thioguanosine 5'-diphosphate) is a metabolite of thiopurine. It inhibits the activity of Rac1, thereby reducing the transcription of inflammatory factors and the expression of cell adhesion molecules, which ultimately suppresses leukocyte migration and the occurrence of tissue inflammation.

Im-GDP is a monomeric material utilized in the synthesis of nucleic acids.

2'-Deoxy-3',5'-GDP (pdGp) is a monomeric precursor used in the synthesis of nucleic acids.

2′-OMe-GDP is a nucleotide analog utilized for the synthesis of oligonucleotides.

LNA-GDP is a nucleotide analog utilized in the synthesis of oligonucleotides.

Sp-GDPαS trisodium functions as a modulator of GDP-binding proteins and exhibits greater metabolic stability than GTP.

GDP-L-fucose is a nucleotide sugar widely found in fungi and plants, playing a role in both the slave and secondary remedial metabolic pathways.

Sp-GDPαS acts as a regulator for GDP-binding proteins and exhibits greater metabolic stability than GTP.

GDP-D-Rha6F2 is an inhibitor of GMDS (GDP-mannose-4,6-dehydratase), binding to the active site of GMDS. It effectively inhibits the conversion of GDP-mannose.

Rp-GDPαS (trisodium) is an isomer of the sulfur-containing nucleotide derivative GDP-α-S.

3'-OMe-m7GDP is a monomeric material utilized in nucleic acid synthesis.

Im-m7GDP serves as a monomeric precursor used in nucleic acid synthesis.