GDP

GDP-α-D-mannose disodium gives a competitive inhibition with respect to GTP (Ki 14.7 μM) and an uncompetitive inhibition with respect to mannose-1-P (Ki 115 μM).GDP-α-D-mannose disodium is the donor substrate for mannosyltransferases and the precursor of

GDP366, a dual inhibitor of survivin and Op18, induces cell growth inhibition, cellular senescence, and mitotic catastrophe in human cancer cells.

Guanosine 5'-diphosphate (GDP) as Potential Iron Mobilizer, Preventing the Hepcidin-Ferroportin Interaction and Modulating the Interleukin-6/Stat-3 Pathway.

Adagrasib (MRTX849) is an orally active and selective covalent inhibitor of KRAS G12C. Adagrasib binds to the GDP state of the inactive conformation of KRAS G12C and inhibits KRAS and its downstream signaling. Adagrasib exhibits inhibitory activity against KRAS G12C mutant tumors.

Sotorasib (AMG-510) is an orally active and selective covalent inhibitor of KRAS G12C. Sotorasib binds to the GDP state of the inactive conformation of KRAS G12C and inhibits KRAS and its downstream signaling. Sotorasib exhibits inhibitory activity against KRAS G12C mutant tumors.

Guanosine 5'-diphosphate disodium salt (5'-GDP-Na2) is a nucleoside diphosphate, is a potential iron mobilizer, which prevents the hepcidin-ferroportin interaction and modulating the interleukin-6 (IL-6)/stat-3 pathway.

6-Thioguanosine-5'-O-diphosphate sodium (6-Thio-GDP sodium) (TGDP sodium) is an active metabolite of 6-Mercaptopurine. As a purine analogue, 6-Mercaptopurine acts as an antagonist to endogenous purines and is extensively utilized as both an anti-leukemic and immunosuppressive agent.

Guanosine 5'-diphosphate (GDP) sodium is a nucleoside diphosphate known for activating the adenosine 5'-triphosphate-sensitive K+ channel, serving as a potential iron mobilizer by inhibiting the hepcidin-ferroportin interaction, and modulating the interleukin-6 (IL-6)/stat-3 pathway. It is utilized in research on inflammation-related conditions, including anemia of inflammation (AI).

Guanosine 5'-diphosphate ditromethamine (GDP ditromethamine) is a nucleoside diphosphate that activates ATP-sensitive K+ channels. It acts as a potential iron mobilizer, inhibiting the interaction between hepcidin and ferroportin, and modulating the IL-6/STAT-3 pathway. This compound finds application in inflammation research, such as studying anemia of inflammation (AI).

GDP-D-mannose disodium is a natural product for research related to life sciences and the catalog number is T65209.

GDP-L-fucose disodium, a nucleotide sugar, serves as a crucial substrate for fucose oligosaccharides biosynthesis by providing the fucose moiety. Its formation follows two metabolic pathways: the primary de novo pathway and the secondary remedial pathway [1].

6-T-GDP (6-Thioguanosine 5'-diphosphate) is a metabolite of thiopurine. It inhibits the activity of Rac1, thereby reducing the transcription of inflammatory factors and the expression of cell adhesion molecules, which ultimately suppresses leukocyte migration and the occurrence of tissue inflammation.

2′-OMe-GDP is a nucleotide analog utilized for the synthesis of oligonucleotides.

LNA-GDP is a nucleotide analog utilized in the synthesis of oligonucleotides.

Sp-GDPαS trisodium functions as a modulator of GDP-binding proteins and exhibits greater metabolic stability than GTP.

GDP-L-fucose is a nucleotide sugar widely found in fungi and plants, playing a role in both the slave and secondary remedial metabolic pathways.

Sp-GDPαS acts as a regulator for GDP-binding proteins and exhibits greater metabolic stability than GTP.

GDP-D-Rha6F2 is an inhibitor of GMDS (GDP-mannose-4,6-dehydratase), binding to the active site of GMDS. It effectively inhibits the conversion of GDP-mannose.

Rp-GDPαS (trisodium) is an isomer of the sulfur-containing nucleotide derivative GDP-α-S.

isoGDP (trisodium) is an isomer of GDP. It is the phosphorylated form of crotonoside and acts as an inhibitor of mitochondrial ATPase, with an IC50 of 3 μM.

GGDPS-IN-1 (Compound 37) is an inhibitor of geranylgeranyl diphosphate synthase (GGDPS) with an IC50 of 49.4 nM, disrupting protein geranylgeranylation in myeloma cells.

Gdpflrfamide is a neuropeptide that existed in the snail Lymnaea stagnalis.

RMC-0331 (RM-023) is an orally available and potent SOS1 inhibitor with potential anticancer activity, blocking RAS activation by disrupting RAS-SOS1 interactions.

Guanosine 5'-O-(2-thiodiphosphate) (trisodium) (GDPβS (trisodium)) is a non-hydrolyzable derivative of GDP. It acts as an inhibitor of adenylate cyclase (AC) with a Ki value of 600 nM. In the absence of glutamic-pyruvic transaminase (GPT) in cortical membranes of rodent models, it can partially activate AC, with an EC50 of 400 nM. Furthermore, Guanosine 5'-O-(2-thiodiphosphate) (trisodium) prevents the norepinephrine-induced release of nitric oxide from ventricular myocytes.