Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty

Microtubule Associated

Microtubule-associated proteins (MAPs) are proteins that interact with the microtubules of the cellular cytoskeleton. MAPs bind to the tubulin subunits that make up microtubules to regulate their stability. A large variety of MAPs have been identified in many different cell types, and they have been found to carry out a wide range of functions. These include both stabilizing and destabilizing microtubules, guiding microtubules towards specific cellular locations, cross-linking microtubules and mediating the interactions of microtubules with other proteins in the cell.

Eribulin mesylate
T13687441045-17-6
Eribulin mesylate (E7389 mesylate) (E7389 mesylate) inhibits the proliferation of cancer cells by binding microtubule proteins and microtubules. Eribulin mesylate (E7389 mesylate) is a microtubule targeting agent that is used in the treatment of metastatic breast cancer.
  • $430
In Stock
Size
QTY
TargetMol | Inhibitor Hot
C004019
T678342417159-57-8In house
C004019 is a small molecule PROTAC capable of targeting tau for selective protein degradation from the cell, while recruiting tau and E3 ligase (Vhl) for selective enhancement of tau ubiquitination and proteollyzation. C004019 is a candidate for AD and related tau protein diseases.
  • $263
In Stock
Size
QTY
TargetMol | Inhibitor Hot
Mertansine
T1992139504-50-0
Mertansine is a tubulin inhibitor and an antibody-conjugable maytansinoid alkaloid. The IC50 of Mertansine against HCT-15 and A431 cells is 0.750 and 0.04nM.
  • $30
In Stock
Size
QTY
TargetMol | Inhibitor Hot
TargetMol | Citations Cited
Valecobulin hydrochloride
T132781240321-53-2
Valecobulin hydrochloride (CKD-516 hydrochloride) is the valine prodrug and vasoblocker of S516. Valecobulin hydrochloride (CKD-516 hydrochloride) has a potent inhibitory effect on β-tubulin polymerization and has significant anti-tumor activity against solid tumors in mice and humans.
  • $81
In Stock
Size
QTY
TargetMol | Inhibitor Sale
LY3372689
T616612241514-56-5In house
LY3372689 (Formulaic Ia) is an orally active O-GlcNAcase (OGA) enzyme inhibitor targeting tau protein-based disorders, including Alzheimer's disease.
  • $100
In Stock
Size
QTY
TargetMol | Inhibitor Hot
Sovilnesib
T399942410796-79-9
Sovilnesib is a kinesin-like protein KIF18A inhibitor. Sovilnesib can be used for the cancer research.
  • $97
In Stock
Size
QTY
Nocodazole
T280231430-18-9
Nocodazole (Oncodazole) is a reversible inhibitor of microtubule polymerization and an inhibitor of Bcr-Abl. Nocodazole has antitumor activity, blocks the cell cycle and induces apoptosis.
  • $31
In Stock
Size
QTY
TargetMol | Citations Cited
Docetaxel
T1034114977-28-5
Docetaxel (RP-56976), a semi-synthetic analog of paclitaxel, is a microtubule depolymerization inhibitor (IC50=0.2 μM) that attenuates the effects of bcl-2 and bcl-xL gene expression and exhibits apoptosis-inducing, anti-tumor activity.
  • $30
In Stock
Size
QTY
TargetMol | Citations Cited
Sabizabulin
T172281332881-26-1In house
Sabizabulin (ABI-231) is a potent, orally bioavailable α- and β-tubulin inhibitor that is active against melanoma and prostate cancer cell lines. Sabizabulin inhibits tumor growth and metastatic phenotypes of cervical cancer cells by targeting HPV E6 and E7 and is also being studied in prostate cancer.
  • $148
In Stock
Size
QTY
Glembatumumab vedotin
T741781182215-65-1
Glembatumumab vedotin (CDX-011) is an antibody-drug conjugate with potent anticancer effects, utilized in the study of triple negative breast cancer (TNBC).
  • $718
In Stock
Size
QTY
CRT-0105950
T239171661845-86-8
CRT-0105950 is a potent LIMK inhibitor with high affinity for both LIMK1 and LIMK2.CRT-0105950 inhibits filamentous cutin phosphorylation and promotes α-microtubulin acetylation in cells.CRT-0105950 can be used in the study of renal carcinoma.
  • $59
In Stock
Size
QTY
Ixabepilone
T6864219989-84-1
Ixabepilone (Azaepothilone B) is an orally bioavailable microtubule inhibitor. It binds to tubulin and promotes tubulin polymerization and microtubule stabilization, thereby arresting cells in the G2-M phase of the cell cycle and inducing tumor cell apoptosis.
  • $52
In Stock
Size
QTY
TargetMol | Inhibitor Sale
TargetMol | Citations Cited
VCMMAE
T4232646502-53-6
VCMMAE (mc-vc-PAB-MMAE) is a drug-linker conjugate for ADC with potent antitumor activity.
  • $30
In Stock
Size
QTY
TargetMol | Inhibitor Sale
JH-VIII-157-02
T156121639422-97-1
JH-VIII-157-02 is an inhibitor of ALK and inhibits echinoderm microtubule-associated protein-like 4-ALK (EML4-ALK) with IC50s of 2 nM for EML4-ALK G1202R, EML4-ALKwt, EML4-ALK C1156Y, EML4-ALK F1174L, and EML4-ALK F1174L.
  • $118
In Stock
Size
QTY
Rosabulin
T16788501948-05-6
v Rosabulin (STA 5312) is an orally active microtubule inhibitor with potency. Rosabulin inhibits microtubule assembly and has broad-spectrum antitumor activity.
  • $98
In Stock
Size
QTY
Sabeluzole
T28655104383-17-7In house
Sabeluzole (R-58735) has antiepileptic and cognitive enhancing effects, inhibits neurotoxin-induced tau expression and cell death.Sabeluzole is protective against chlordiazepoxide-induced habituation disorders and may be useful in the study of Alzheimer's disease.
  • $64 TargetMol
In Stock
Size
QTY
Soblidotin
T14350149606-27-9
Soblidotin (TZT-1027) (Auristatin PE) is an inhibitor of tubulin polymerization. It is also a novel synthetic Dolastatin 10 derivative.
  • $113
In Stock
Size
QTY
AK301
T26585314022-97-4In house
AK301 is a potent and selective inhibitor of tubulin polymerization and an effective sensitizer of cancer cells to apoptotic ligands (EC50 < 200 nM). Colon cancer cells arrested in mitosis with AK301 readily underwent a p53-dependent apoptosis following compound withdrawal and arrest release.
  • $350
In Stock
Size
QTY
Batabulin
T10460195533-53-0
Batabulin (T138067) is an antitumor compound that binds covalently and selectively to a subset of the β-tubulin isotypes, disrupting microtubule polymerization. This disruption affects cell morphology, induces cell-cycle arrest, and ultimately leads to apoptotic cell death.
  • $43
In Stock
Size
QTY
Flubendazole
T000931430-15-6
Flubendazole (Flumoxane) is available OTC in Europe that is an anthelmintic using to treat worm infection in humans.
  • $50
In Stock
Size
QTY
cemadotin free base
T70407159776-69-9In house
Cemadotin free base(LU103793 free base) is a novel anti-limiting peptide , an analog of Dolastatin 15, a naturally occurring cytotoxic peptide that blocks mitosis and inhibits microtubules (tubulin) with a Ki of 1 μM. Cemadotin is used in research against cancer.
  • $190
In Stock
Size
QTY
Cabazitaxel
T2543183133-96-2
Cabazitaxel (taxoid XRP6258) is a taxane and antineoplastic agent which is currently used in the therapy of castration-resistant metastatic prostate cancer after failure of docetaxel.
  • $51
In Stock
Size
QTY
TargetMol | Citations Cited
Monomethyl auristatin E
T6897474645-27-7
Monomethyl auristatin E (MMAE) (MMAE), an antimitotic agent, inhibits cell division by blocking the polymerization of tubulin and also has inhibition of antibody-drug conjugates (ADCs) activity.
  • $41
In Stock
Size
QTY
TargetMol | Citations Cited
Methylene Blue
T688861-73-4
Methylene Blue (Tetramethylthionine chloride) (IC50 of 1.9 μM) inhibits tau filament formation. And it inhibits soluble guanylyl cyclase. It is also used as a dye in chromoendoscopy.
  • $30
In Stock
Size
QTY
TargetMol | Citations Cited
MMAF
T3256745017-94-1
MMAF (MonoMethyl auristatin F), an antimitotic agent, inhibits cell division by blocking the polymerization of tubulin.
  • $40
In Stock
Size
QTY
Dolastatin 10
TP1180110417-88-4
Dolastatin 10 (DLS 10) is a potent peptide with antimitotic properties, effectively inhibiting tubulin polymerization.
  • $213
In Stock
Size
QTY
TargetMol | Inhibitor Sale
McMMAF
T16031863971-19-1
McMMAF is a protective group-conjugated MMAF. MMAF is a potent tubulin polymerization inhibitor.It is a MMAF derivative having a Maleimidocaproyl linker (MC linker), which is ready to conjugate to antibody or other proteins or biopolymers. Mafodotin is a useful agent for make antibody drug conjugate (ADC) for targeted drug delivery.
  • $51
In Stock
Size
QTY
TAI-1
T66911334921-03-7
TAI-1 is a potent and specific Hec1 inhibitor, which disrupts Hec1-Nek2 protein interaction.
  • $31
In Stock
Size
QTY
Tirbanibulin
T6345897016-82-9
Tirbanibulin (KX2-391) is a highly selective Src kinase inhibitor that has demonstrated efficacy in pre-Clinicalal animal models of colon, pancreatic, prostate and breast cancer. It is a substrate-targeted kinase inhibitor. KX2-391, belongs to an emerging new family of targeted cancer treatments called protein kinase inhibitors.
  • $35
In Stock
Size
QTY
TargetMol | Citations Cited
Eribulin
T13688253128-41-5
Eribulin (B1939) is a nonpaclitaxel microtubule kinetic inhibitor with anticancer activity that inhibits polymerization of microtubule protein subunits by preventing lengthening and shortening of microtubules during cell division.Eribulin is used in the study of metastatic breast cancer and solid tumors.
  • $420
In Stock
Size
QTY
EL-102
T152051233948-61-2
EL-102 is a HIF1α inhibitor with anticancer activity that inhibits microtubule protein polymerization and can be used to study prostate cancer.
  • $89
In Stock
Size
QTY
Lexibulin
T2090917111-44-5
Lexibulin (CYT-997)(CYT-997) is a potent tubulin polymerization inhibitor (IC50: 10-100 nM, in Y cell lines). Lexibulin blocks the formation of the mitotic spindle and leading to cell cycle arrest at the G2/M phase; this may result in disruption of the tumor vasculature and tumor blood flow, and tumor cell death.
  • $43
In Stock
Size
QTY
KX2-361
T9411897016-26-1In house
KX2-361 is a orally bioavailable small molecule dual Src/tubulin inhibitor that provides long term survival in a murine model of glioblastoma
  • $74
In Stock
Size
QTY
TargetMol | Inhibitor Sale
MKC-1
T9831125313-92-0In house
MKC-1 (Ro-31-7453) is an orally bioavailable small-molecule bisindolylmaleimide cell cycle inhibitor with potential antineoplastic activity. MKC-1 and its metabolites inhibit tubulin polymerization, blocking mitotic spindle formation, which may result in apoptosis and tumor cell death.
  • $52
In Stock
Size
QTY
TargetMol | Inhibitor Sale
TN-16
T780033016-12-5
TN-16 is a microtubule polymerization inhibitor (IC50 :0.4-1.7 μM)
  • $33
In Stock
Size
QTY
TargetMol | Inhibitor Sale
DM4
T15141796073-69-3
DM4 (Ravtansine) can be used in the preparation of antibody drug conjugate and it is an antitubulin agent. It can inhibit cell division.
  • $31
In Stock
Size
QTY
SB-216
T607572756818-39-8
SB-216 is able to be used for the research of cancer which is a potent inhibitor of tubulin polymerization. SB-216 exhibits strong antiproliferative potency in a panel of human cancer cell lines, including melanoma, breast cancer, and lung cancer [1].
  • $49
In Stock
Size
QTY
TargetMol | Inhibitor Sale
cis-trismethoxy Resveratrol
T3330L94608-23-8In house
cis-trismethoxy Resveratrol ((Z)-3,5,4'-Trimethoxystilbene) inhibits tubulin polymerization (IC50 = 4 μM) and has anti-mitotic effects.
  • $54
In Stock
Size
QTY
BTB-1
T402986030-08-2
BTB-1 (NSC156750) is a novel small molecule inhibitor of the mitotic motor protein Kif18A.
  • $30
In Stock
Size
QTY
Epothilone B
T6075152044-54-7
Epothilone B (EPO 906) is a compound isolated from the myxobacterium Sorangium cellulosum. Similar to paclitaxel, patupilone induces microtubule polymerization and stabilizes microtubules against depolymerization conditions. In addition to promoting tubulin polymerization and stabilization of microtubules, this agent is cytotoxic for cells overexpressing P-glycoprotein, a characteristic that distinguishes it from the taxanes. Patupilone may cause complete cell-cycle arrest.
  • $30
In Stock
Size
QTY
CK-666
T10826442633-00-3
CK-666 is a cell-permeable inhibitor of the actin-related protein Arp2 3 complex, binding to and stabilizing its inactive state, thereby preventing the movement of the Arp2 and Arp3 subunits into the activated filament-like (short pitch) configuration.
  • $34
In Stock
Size
QTY
TargetMol | Inhibitor Sale
TTBK1-IN-2
T600862765453-51-6
TTBK1-IN-2 (N-[4-(4-chlorophenoxy)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine) is an inhibitor of Tau-Tubulin kinase (TTBK1) with IC50s of 0.24 and 4.22 µM. TTBK1-IN-2 reduces TDP-43 phosphorylation both in cell cultures and the spinal cord of transgenic TDP-43 mice.
  • $74
In Stock
Size
QTY
TargetMol | Inhibitor Sale
KHS 101
T49681262770-73-9
KHS101 is a novel inhibitor of transforming acidic coiled-coil protein 3 (TACC3). It is a selective inducer of neuronal differentiation.
  • $37
In Stock
Size
QTY
TargetMol | Inhibitor Sale
TargetMol | Citations Cited
Thiabendazole
T0938148-79-8
Thiabendazole (2-(4-Thiazolyl)benzimidazole) is a benzimidazole derivative with anthelminthic property.
  • $41
In Stock
Size
QTY
Leucomethylene blue mesylate
T70031236208-20-0
Leucomethylene blue mesylate (TRx0237 mesylate) is a second-generation tau protein aggregation inhibitor for the treatment of Alzheimer's disease (AD) and frontotemporal dementia.
  • $50
In Stock
Size
QTY
TargetMol | Citations Cited
AM-5308
T637262410796-89-1
AM-5308 is a kinesin KIF18A inhibitor that can be used to study cancer.
  • $148
In Stock
Size
QTY
Methylene Blue trihydrate
T00067220-79-3
Methylene Blue trihydrate (Basic blue 9) is a compound consisting of dark green crystals or crystalline powder, having a bronze-like luster. Solutions in water or alcohol have a deep blue color. Methylene Blue trihydrate is used as a bacteriologic stain and as an indicator. It inhibits soluble guanylyl cyclase and has been used to treat cyanide poisoning and to lower levels of methemoglobin. It also inhibits tau filament formation (IC50: 1.9μM).
  • $42
In Stock
Size
QTY
Albendazole
T115254965-21-8
Albendazole (SKF-62979) is used as a drug indicated for the treatment of a variety of worm infestations.
  • $40
In Stock
Size
QTY
TargetMol | Inhibitor Sale