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mTOR

The mammalian target of rapamycin (mTOR), sometimes also referred to as the mechanistic target of rapamycin and FK506-binding protein 12-rapamycin-associated protein 1 (FRAP1), is a kinase that in humans is encoded by the MTOR gene. mTOR is a member of the phosphatidylinositol 3-kinase-related kinase family of protein kinases.mTOR links with other proteins and serves as a core component of two distinct protein complexes, mTOR complex 1 and mTOR complex 2, which regulate different cellular processes. In particular, as a core component of both complexes, mTOR functions as a serine/threonine protein kinase that regulates cell growth, cell proliferation, cell motility, cell survival, protein synthesis, autophagy, and transcription. As a core component of mTORC2, mTOR also functions as a tyrosine protein kinase that promotes the activation of insulin receptors and insulin-like growth factor 1 receptors. mTORC2 has also been implicated in the control and maintenance of the actin cytoskeleton.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T2434 LY 303511 154447-38-8 99.91%
LY 303511
LY303511, an inactive analogue of LY294002, is a mTOR inhibitor and no inhibition for PI3-K.
T79211 MTOR inhibitor-11 3033409-32-1 98%
mTOR inhibitor-11
mTOR inhibitor-11 (Compound 9) is a brain-penetrant compound capable of inhibiting mTOR with an IC50 of 21 nM for pS6. It also exhibits inhibitory activity again...
T79212 MTOR inhibitor-12 98%
mTOR inhibitor-12
mTOR inhibitor-12 (Compound 11), a selective, brain-penetrant mTOR inhibitor, exhibits no genotoxicity risk and is utilized in research pertaining to central ner...
T80546 Thioether-cyclized helix B peptide, CHBP 1453840-35-1 98%
Thioether-cyclized helix B peptide, CHBP
Thioether-cyclized helix B peptide (CHBP) enhances metabolic stability and exerts renoprotective effects by promoting autophagy through the inhibition of mTOR C1...
T80547 Thioether-cyclized helix B peptide, CHBP TFA 98%
Thioether-cyclized helix B peptide, CHBP TFA
Thioether-cyclized helix B peptide, CHBP (TFA), is the trifluoroacetic (TFA) salt of CHBP. This form enhances metabolic stability and exhibits renoprotective eff...
T81743 MTORC1-IN-1 98%
mTORC1-IN-1
mTORC1-IN-1 (T1), a rapamycin homologue (rapalog) and selective inhibitor of mTORC1, controls cell growth and metabolism, with implications in various diseases s...
T81744 MTOR inhibitor-14 98%
mTOR inhibitor-14
mTOR Inhibitor-14 (compound 14c) is a potent inhibitor of mTOR with minimal inhibition of CYP2C8 and has demonstrated the capability to inhibit tumor growth [1]....
T11328 FT-1518 1313026-58-2 98%
FT-1518
FT-1518 ,exhibits antitumor activity, is a new generation selective, potent and oral bioavailable mTORC1 and mTORC2 inhibitor.
TN3310 9,9'-Di-O-(E)-feruloylsecoisolariciresinol 56973-66-1 98%
9,9'-Di-O-(E)-feruloylsecoisolariciresinol
1,4-O-Diferuloylsecoisolariciresinol(9,9'-Di-O-(E)-feruloylsecoisolariciresinol),and pierreione B, two novel inhibitors of mTOR signaling, have strong anticancer...
TN4788 Pierreione B 1292766-21-2 98%
Pierreione B
Pierreione B is an inhibitor of mTOR signaling with strong anticancer activity. Pierreione A and Pierreione B demonstrate solid tumor selectivity with minimal cy...
T11742L K-7174 dihydrochloride 191089-60-8 98%
K-7174 dihydrochloride
K-7174 dihydrochloride is a novel cell adhesion inhibitor; inhibits the expression of vascular cell adhesion molecule-1 (VCAM-1) induced by either IL-1β or TNF-α...
TN2328 Zeylenone 193410-84-3 98%
Zeylenone
Zeylenone, a cyclohexene oxide from Uvaria grandiflora, has antitumour and antiproliferative activity, inhibiting cervical cancer cell proliferation and inducing...
TN4382 Kazinol A 99624-28-9 98%
Kazinol A
Kazinol A shows strong inhibition of arachidonic acid (AA)-induced platelet aggregation. It also exhibits potent inhibition with IC50 values ranging 0.6-164 M ag...
TN5050 Sprengerinin C 88861-91-0 98%
Sprengerinin C
Sprengerinin C exerts anti-tumorigenic effects in hepatocellular carcinoma via inhibition of proliferation and angiogenesis and induction of apoptosis, it can st...
T12124 MTOR inhibitor-2 2219323-96-1 98%
mTOR inhibitor-2
mTOR inhibitor-2 is an inhibitor of selective and oral mTOR (IC50 of 7 nM).
T77629 FD274 2641899-38-7 98%
FD274
FD274 is a potent dual PI3K/mTOR inhibitor with inhibitory effects on PI3Kα/β/γ/δ and mTOR, with IC50s of 0.65 nM, 1.57 nM, 0.65 nM, 0.42 nM, and 2.03 nM, respec...
TN4356 Jolkinolide A 37905-07-0 98%
Jolkinolide A
Jolkinolide A has anti-tumor activity. It inhibited VEGF expression in A549 cells through the inhibition of the Akt-STAT3-mTOR signaling pathway, and directly in...
TN4213 Hirsutenone 41137-87-5 98%
Hirsutenone
Hirsutenone has potent antioxidant activity, it shows significant free radical scavenging activity and exhibits inhibition effect on the mitochondrial lipid pero...
TN1245 3-Deoxysappanchalcone 112408-67-0 98%
3-Deoxysappanchalcone
3-Deoxysappanchalcone is an effective HO-1 inducer at the translational level.
TN3218 7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one 100667-52-5 98%
7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one
7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one as a beneficial compound to ameliorate the deleterious effects of Aβ on dendrite integrity and cell survival, and may...
LY 303511
T2434
LY303511, an inactive analogue of LY294002, is a mTOR inhibitor and no inhibition for PI3-K.
mTOR inhibitor-11
T79211
mTOR inhibitor-11 (Compound 9) is a brain-penetrant compound capable of inhibiting mTOR with an IC50 of 21 nM for pS6. It also exhibits inhibitory activity again...
mTOR inhibitor-12
T79212
mTOR inhibitor-12 (Compound 11), a selective, brain-penetrant mTOR inhibitor, exhibits no genotoxicity risk and is utilized in research pertaining to central ner...
Thioether-cyclized helix B peptide, CHBP
T80546
Thioether-cyclized helix B peptide (CHBP) enhances metabolic stability and exerts renoprotective effects by promoting autophagy through the inhibition of mTOR C1...
Thioether-cyclized helix B peptide, CHBP TFA
T80547
Thioether-cyclized helix B peptide, CHBP (TFA), is the trifluoroacetic (TFA) salt of CHBP. This form enhances metabolic stability and exhibits renoprotective eff...
mTORC1-IN-1
T81743
mTORC1-IN-1 (T1), a rapamycin homologue (rapalog) and selective inhibitor of mTORC1, controls cell growth and metabolism, with implications in various diseases s...
mTOR inhibitor-14
T81744
mTOR Inhibitor-14 (compound 14c) is a potent inhibitor of mTOR with minimal inhibition of CYP2C8 and has demonstrated the capability to inhibit tumor growth [1]....
FT-1518
T11328
FT-1518 ,exhibits antitumor activity, is a new generation selective, potent and oral bioavailable mTORC1 and mTORC2 inhibitor.
9,9'-Di-O-(E)-feruloylsecoisolariciresinol
TN3310
1,4-O-Diferuloylsecoisolariciresinol(9,9'-Di-O-(E)-feruloylsecoisolariciresinol),and pierreione B, two novel inhibitors of mTOR signaling, have strong anticancer...
Pierreione B
TN4788
Pierreione B is an inhibitor of mTOR signaling with strong anticancer activity. Pierreione A and Pierreione B demonstrate solid tumor selectivity with minimal cy...
K-7174 dihydrochloride
T11742L
K-7174 dihydrochloride is a novel cell adhesion inhibitor; inhibits the expression of vascular cell adhesion molecule-1 (VCAM-1) induced by either IL-1β or TNF-α...
Zeylenone
TN2328
Zeylenone, a cyclohexene oxide from Uvaria grandiflora, has antitumour and antiproliferative activity, inhibiting cervical cancer cell proliferation and inducing...
Kazinol A
TN4382
Kazinol A shows strong inhibition of arachidonic acid (AA)-induced platelet aggregation. It also exhibits potent inhibition with IC50 values ranging 0.6-164 M ag...
Sprengerinin C
TN5050
Sprengerinin C exerts anti-tumorigenic effects in hepatocellular carcinoma via inhibition of proliferation and angiogenesis and induction of apoptosis, it can st...
mTOR inhibitor-2
T12124
mTOR inhibitor-2 is an inhibitor of selective and oral mTOR (IC50 of 7 nM).
FD274
T77629
FD274 is a potent dual PI3K/mTOR inhibitor with inhibitory effects on PI3Kα/β/γ/δ and mTOR, with IC50s of 0.65 nM, 1.57 nM, 0.65 nM, 0.42 nM, and 2.03 nM, respec...
Jolkinolide A
TN4356
Jolkinolide A has anti-tumor activity. It inhibited VEGF expression in A549 cells through the inhibition of the Akt-STAT3-mTOR signaling pathway, and directly in...
Hirsutenone
TN4213
Hirsutenone has potent antioxidant activity, it shows significant free radical scavenging activity and exhibits inhibition effect on the mitochondrial lipid pero...
3-Deoxysappanchalcone
TN1245
3-Deoxysappanchalcone is an effective HO-1 inducer at the translational level.
7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one
TN3218
7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one as a beneficial compound to ameliorate the deleterious effects of Aβ on dendrite integrity and cell survival, and may...
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TargetMol