T10792 |
CHK1-IN-4
|
2120398-41-4
|
98%
|
|
CHK1-IN-4 is a potent inhibitor of checkpoint kinase 1 (chk1) and potently inhibits chk1 phosphorylation in the tumor cells with anti-tumor activity.
|
T14904 |
CCT244747
|
1404095-34-6
|
98%
|
|
CCT244747 is a CHK1 inhibitor (IC50: 7.7 nM) and also abrogates G2 checkpoint (IC50: 29 nM).
|
T10718 |
CCT241533
|
1262849-73-9
|
98%
|
|
CCT241533 is an effective and selective ATP competitive inhibitor of CHK2 (Ki: 1.16 nM; IC50: 3 nM).
|
T10793 |
CHK1 inhibitor
|
2097938-64-0
|
98%
|
|
CHK1 inhibitor (GDC-0575 analog) is a CHK1 inhibitor.
|
T13148 |
CHK-IN-1
|
1278405-51-8
|
98%
|
|
CHK-IN-1 is a CHK1 and CHK2 inhibitor, has anti-proliferative activities.
|
T16848 |
SB-218078
|
135897-06-2
|
98%
|
|
SB-218078 is less potently inhibits Cdc2 (IC50: 250 nM) and PKC (IC50: 1000 nM). SB-218078 is a potent, ATP-competitive, and cell-permeable checkpoint kinase 1 i...
|
T10790 |
CHK1-IN-2
|
912367-45-4
|
98%
|
|
CHK1-IN-2 is an inhibitor of checkpoint kinase 1 (CHK1; IC50: 6 nM).
|
T16165 |
Myriocin
|
35891-70-4
|
98%
|
|
Myriocin is a fungal metabolite isolated from Myriococcum albomyces, Isaria sinclairi and Mycelia sterilia. Myriocin also is an effective inhibitor of serine-pal...
|
T17223 |
VER-00158411
|
1174664-88-0
|
98%
|
|
VER-00158411 is a checkpoint kinase 1 and CHK2 inhibitor (IC50: 4.4 nM and 4.5 nM, respectively).
|
TN1458 |
Buddlejasaponin IV
|
139523-30-1
|
98%
|
|
Buddlejasaponin IV has analgesic and anti-inflammatory effects, the inhibitions of the expressions of iNOS, COX-2, TNF-alpha, IL-1beta and IL-6 by blocking NF-ka...
|
T10406 |
Tuvusertib
|
1613200-51-3
|
98%
|
|
Tuvusertib is an orally available ataxia telangiectasia and Rad3-related (ATR) kinase inhibitor (Ki< 1 µΜ) with selective and potentially antitumor activity.Tuvu...
|
T10791 |
CHK1-IN-3
|
2097252-39-4
|
98%
|
|
CHK1-IN-3 is an inhibitor of checkpoint kinase 1 (CHK1; IC50: 0.4 nM).
|
T4310 |
Prexasertib
|
1234015-52-1
|
98%
|
|
Prexasertib is an inhibitor of checkpoint kinase 1 (chk1) with potential antineoplastic activity.
|
T21331 |
SAR-020106
|
1184843-57-9
|
98%
|
|
SAR-020106 is a potent, ATP-competitive, and selective CHK1 inhibitor with an IC50 of 13.3 nmol/L on the isolated human enzyme.
|
T27407 |
GDC0575 monohydrochloride
|
1196504-54-7
|
98%
|
|
GDC-0575 is a potent and selective inhibitor of cell cycle checkpoint kinase 1 (Chk1) with an IC50 of 1.2 nM. GDC-0575 specifically binds to and inhibits Chk1; t...
|
T7300 |
GDC-0575
|
1196541-47-5
|
98%
|
|
GDC-0575 is a highly-selective oral small-molecule Chk1 inhibitor(IC50 of 1.2 nM).
|
T10792L |
CHK1-IN-4 hydrochloride
|
|
98%
|
|
CHK1-IN-4 hydrochloride is a potent inhibitor of checkpoint kinase 1 (chk1). CHK1-IN-4 hydrochloride potently inhibits chk1 phosphorylation in the tumor cells. C...
|
T14072 |
A-443654
|
552325-16-3
|
98%
|
|
A-443654 is a pan-Akt inhibitor. It has equal potency against Akt1, Akt2, or Akt3 within cells (Ki=160 pM).
|
T6028 |
PF 477736
|
952021-60-2
|
98%
|
|
PF-477736 is a specifc, effective and ATP-competitive Chk1 inhibitor (Ki: 0.49 nM ) and also inhibits FGFR3, Aurora-A, VEGFR2, Flt3, Fms (CSF1R), Ret and Yes.
|
T6350 |
CHIR-124
|
405168-58-3
|
98%
|
|
CHIR-124 is an effective Chk1 inhibitor (IC50: 0.3 nM). It has 2, 000-fold selectivity against Chk2, 500- to 5, 000-fold less activity against Cdc2 and CDK2/4.
|