Chk

Checkpoint kinase 1, commonly referred to as Chk1, is a serine/threonine-specific protein kinase that, in humans, is encoded by the CHEK1 gene. Chk1 coordinates the DNA damage response (DDR) and cell cycle checkpoint response. Activation of Chk1 results in the initiation of cell cycle checkpoints, cell cycle arrest, DNA repair and cell death to prevent damaged cells from progressing through the cell cycle.

Cat. No.	Product name	CAS No.	Purity
T10792	CHK1-IN-4	2120398-41-4	98%
T10792	CHK1-IN-4 is a potent inhibitor of checkpoint kinase 1 (chk1) and potently inhibits chk1 phosphorylation in the tumor cells with anti-tumor activity.
T14904	CCT244747	1404095-34-6	98%
T14904	CCT244747 is a CHK1 inhibitor (IC50: 7.7 nM) and also abrogates G2 checkpoint (IC50: 29 nM).
T10718	CCT241533	1262849-73-9	98%
T10718	CCT241533 is an effective and selective ATP competitive inhibitor of CHK2 (Ki: 1.16 nM; IC50: 3 nM).
T10793	CHK1 inhibitor	2097938-64-0	98%
T10793	CHK1 inhibitor (GDC-0575 analog) is a CHK1 inhibitor.
T13148	CHK-IN-1	1278405-51-8	98%
T13148	CHK-IN-1 is a CHK1 and CHK2 inhibitor, has anti-proliferative activities.
T16848	SB-218078	135897-06-2	98%
T16848	SB-218078 is less potently inhibits Cdc2 (IC50: 250 nM) and PKC (IC50: 1000 nM). SB-218078 is a potent, ATP-competitive, and cell-permeable checkpoint kinase 1 i...
T10790	CHK1-IN-2	912367-45-4	98%
T10790	CHK1-IN-2 is an inhibitor of checkpoint kinase 1 (CHK1; IC50: 6 nM).
T16165	Myriocin	35891-70-4	98%
T16165	Myriocin is a fungal metabolite isolated from Myriococcum albomyces, Isaria sinclairi and Mycelia sterilia. Myriocin also is an effective inhibitor of serine-pal...
T17223	VER-00158411	1174664-88-0	98%
T17223	VER-00158411 is a checkpoint kinase 1 and CHK2 inhibitor (IC50: 4.4 nM and 4.5 nM, respectively).
TN1458	Buddlejasaponin IV	139523-30-1	98%
TN1458	Buddlejasaponin IV has analgesic and anti-inflammatory effects, the inhibitions of the expressions of iNOS, COX-2, TNF-alpha, IL-1beta and IL-6 by blocking NF-ka...
T10406	Tuvusertib	1613200-51-3	98%
T10406	Tuvusertib is an orally available ataxia telangiectasia and Rad3-related (ATR) kinase inhibitor (Ki< 1 µΜ) with selective and potentially antitumor activity.Tuvu...
T10791	CHK1-IN-3	2097252-39-4	98%
T10791	CHK1-IN-3 is an inhibitor of checkpoint kinase 1 (CHK1; IC50: 0.4 nM).
T4310	Prexasertib	1234015-52-1	98%
T4310	Prexasertib is an inhibitor of checkpoint kinase 1 (chk1) with potential antineoplastic activity.
T21331	SAR-020106	1184843-57-9	98%
T21331	SAR-020106 is a potent, ATP-competitive, and selective CHK1 inhibitor with an IC50 of 13.3 nmol/L on the isolated human enzyme.
T27407	GDC0575 monohydrochloride	1196504-54-7	98%
T27407	GDC-0575 is a potent and selective inhibitor of cell cycle checkpoint kinase 1 (Chk1) with an IC50 of 1.2 nM. GDC-0575 specifically binds to and inhibits Chk1; t...
T7300	GDC-0575	1196541-47-5	98%
T7300	GDC-0575 is a highly-selective oral small-molecule Chk1 inhibitor(IC50 of 1.2 nM).
T10792L	CHK1-IN-4 hydrochloride		98%
T10792L	CHK1-IN-4 hydrochloride is a potent inhibitor of checkpoint kinase 1 (chk1). CHK1-IN-4 hydrochloride potently inhibits chk1 phosphorylation in the tumor cells. C...
T14072	A-443654	552325-16-3	98%
T14072	A-443654 is a pan-Akt inhibitor. It has equal potency against Akt1, Akt2, or Akt3 within cells (Ki=160 pM).
T6028	PF 477736	952021-60-2	98%
T6028	PF-477736 is a specifc, effective and ATP-competitive Chk1 inhibitor (Ki: 0.49 nM ) and also inhibits FGFR3, Aurora-A, VEGFR2, Flt3, Fms (CSF1R), Ret and Yes.
T6350	CHIR-124	405168-58-3	98%
T6350	CHIR-124 is an effective Chk1 inhibitor (IC50: 0.3 nM). It has 2, 000-fold selectivity against Chk2, 500- to 5, 000-fold less activity against Cdc2 and CDK2/4.