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(56)
By Target- TGF-beta/Smad
- ALK(22)
- Autophagy(5)
- AMPK(3)
- Apoptosis(3)
- NF-κB(3)
- p38 MAPK(3)
- 5-HT Receptor(2)
- COX(2)
- Others(6)
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By Target By Application- ELISA(5)
- Functional assay(5)
- FCM(3)
- FACS(2)
By Natures- Citrus(1)
- Epimedium(1)
- Laggera(1)
- Peucedanum(1)
- Zanthoxylum(1)
By ResearchField- Cancer(41)
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Results for "
tgf-β receptor
" in TargetMol Product Catalog.- Inhibitors & Agonists67
- Compound Libraries3
- Peptide Products4
- Inhibitory Antibodies5
- PROTAC Products1
- Natural Products7
- Recombinant Protein18
- Isotope Products1
- Antibody Products1
- Disease Modeling1
- Oligonucleotides1
- SB-431542SB 431542T1726301836-41-9SB-431542 is an inhibitor of ALK5/TGF-β type I Receptor (IC50=94 nM) and is selective. SB 431542 also has inhibitory activity against ALK4 and ALK7 but not other proteins. SB 431542 can be used for induced differentiation of stem cells.
- $50
SizeQTY
Cited - LDN193189LDN-193189, LDN 193189, DM-3189T19351062368-24-4LDN193189 (LDN-193189) (DM 3189) is a selective BMP signaling inhibitor, inhibiting the transcriptional activity of ALK2 and ALK3 (IC50s: 0.8/0.8/5.3/16.7 nM for ALK1/2/3/6).
- $41
SizeQTY Cited - DMH-1DMH1T19421206711-16-1DMH-1 is a potent and selective Bone Morphogenetic Protein (BMP) inhibitor.
- $53
SizeQTY Cited - DorsomorphinCompound C, BML-275T1977866405-64-3Dorsomorphin (BML-275) is an AMPK inhibitor (Ki=109 nM) that is selective and ATP-competitive. Dorsomorphin inhibits the BMP type I receptors ALK2, ALK3, and ALK6. Dorsomorphin induces autophagy, and possesses antitumor activity.
- $48
SizeQTY Cited - GalunisertibLY2157299T2510700874-72-2Galunisertib (LY2157299) is a TGF-β receptor type I (TGF-βRI) inhibitor (IC50=56 nM) that is selective. Galunisertib has antitumor activity and can be used in combination with PD-1 inhibitors.
- $40
SizeQTY Cited - A 83-01ALK5 Inhibitor IV, A8301T3031909910-43-6A 83-01 (ALK5 Inhibitor IV) is an inhibitor of the TGF-β type I receptors ALK5, ALK4, and ALK7 (IC50=12/45/7.5 nM). A 83-01 promotes the reprogramming of mouse fibroblasts into iPSCs. A 83-01 can be used in organoid cultures.
- $52
SizeQTY Cited - RepSoxSJN 2511, E-616452, ALK5 Inhibitor IIT6337446859-33-2RepSox (ALK5 Inhibitor II) is a TGFβR-1/ALK5 inhibitor that selectively inhibits the binding of ATP to ALK5 and the autophosphorylation of ALK5 (IC50=23/4 nM). RepSox induces adipogenesis in MEFs cells.
- $30
SizeQTY Cited - BMP signaling agonist sb4SB 4T7799100874-08-6BMP signaling agonist sb4 (SB 4) is an agonist of benzoxazole bone morphogenetic protein (BMP) signaling (EC50 :74 nM)
- $39
SizeQTY Cited - ALK2-IN-2T102872254409-25-9In houseALK2-IN-2 is a potent and selective inhibitor of activin receptor-like kinase 2 (ALK2) with an IC50 of 9 nM, demonstrating 700-fold higher inhibition of ALK2 compared to ALK3.
- $39
SizeQTY
- Maohuoside ATN2081128988-55-6Maohuoside A promotes osteogenesis of rat mesenchymal stem cells via BMP and MAPK signaling pathways.
- $50
SizeQTY - R-268712T16708879487-87-3R-268712 is a specific activin receptor-like kinase 5 (ALK5) inhibitor(IC50 of 2.5 nM). It is also an orally active transforming growth factor-β type I receptor inhibitor.
- $39
SizeQTY - SB 525334SB525334T1763356559-20-1SB-525334 is a potent and selective inhibitor of the TGF-β1R and ALK5 (IC50: 14.3 nM).
- $32
SizeQTY Cited - GW788388GW 788388T1800452342-67-5GW788388 is a potent and selective inhibitor of ALK5, and it also inhibits TGF-(beta) type II receptor and activin type II receptor activities.
- $58
SizeQTY - LDN-212854LDN212854, BMP Inhibitor IIIT19001432597-26-6LDN-212854 (BMP Inhibitor III), a novel BMP inhibitor, exhibits greater selectivity for BMP versus the TGF-β type I receptors; possesses differences towards ALK2(IC50=1.3 nM) versus ALK1/3 compared to other inhibitors.
- $42
SizeQTY Cited - ML347LDN 193719T19431062368-49-3ML347 (LDN 193719)(DN193719) is a highly specific ALK1/2 inhibitor ( IC50: 46/32 nM), and the selectivity for ALK2 is >300-fold than ALK3.
- $33
SizeQTY - LY-364947LY 364947, HTS466284T2048396129-53-6LY-364947 (HTS466284) is a potent ATP-competitive inhibitor of TGFβR-I.
- $59
SizeQTY Cited - A 77-01A77-01T2098607737-87-1A 77-01 is a potent inhibitor of the TGF-(beta) type I receptor superfamily activin-like kinase ALK5, with an IC50 of 25 nM.
- $36
SizeQTY - SD-208SD208, ALK5 Inhibitor VT2109627536-09-8SD-208 (ALK5 Inhibitor V), a selective TGF-βRI (ALK5) inhibitor (IC50: 48 nM), is >100-fold selectivity over TGF-βRII.
- $30
SizeQTY Cited - LY2109761T2123700874-71-1LY2109761 is a novel selective TGF-β receptor type I/II (TβRI/II) dual inhibitor with Ki of 38 nM and 300 nM, respectively; shown to negatively affect the phosphorylation of Smad2.
- $39
SizeQTY Cited - ITD-1T22731099644-42-4ITD-1 is a potent and highly selective TGFβ pathway inhibitor.
- $33
SizeQTY - PD-161570PD 161570T23127192705-80-9PD-161570 is a potent and ATP-competitive human FGF-1 receptor inhibitor with an IC50 of 39.9 nM and a Ki of 42 nM. It also inhibits the PDGFR, EGFR, and c-Src tyrosine kinases with IC50 values of 310 nM, 240 nM, and 44 nM, respectively.
- $30
SizeQTY - SB-505124T2462694433-59-5SB505124 is a selective inhibitor of TGFβR for ALK4, ALK5.
- $34
SizeQTY Cited - SJ000291942T4662425613-09-8SJ000291942 is an activator of the canonical bone morphogenetic proteins (BMP) signaling pathway.
- $30
SizeQTY Cited
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