ro7

HRO761 is a potent Werne r syndrome RecQ DNA deconjugase (WRN) inhibitor that can be used to study cancers such as colon and stomach cancer.

RO7185876 is a selective gamma secretase modulator, which can be used in the study of Alzheimer's disease.

RO7567132 (FAP-LTBR) is a novel bispecific antibody that binds and agonizes LTBR bivalently while binds and antagonizes FAP monovalently, thereby limiting the activation of LTBR to the tumor microenvironment, inducing the formation of local tertiary lymphoid structures (TLS), and reducing systemic toxicity. Its mouse alternative can inhibit breast cancer growth, and the effect is better when combined with atezolizumab. In the mouse colorectal cancer model, it can also enhance immune cell infiltration and TLS-like structure formation.

(9R)-RO7185876 (Compound example 16) is a γ-secretase inhibitor. It reduces the secretion of Αβ42. This compound can be employed in the research of Alzheimer's disease, cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, multi-infarct dementia, senile dementia, or Down syndrome.

RO7122290 is a bispecific antibody-like fusion protein composed of a trimeric ligand for the T-cell co-stimulatory receptor 4-1BB (CD137) and an antigen-binding fragment (Fab) targeting the tumor-associated protein fibroblast activation protein (FAP), with potential immunomodulatory and antitumor activities. It shows promise in the treatment of advanced solid tumors. Molecular weight: 177.78 KD.

RO7196472 is a potent macrocyclic peptide antibiotic that selectively inhibits the activity of Acinetobacter strains. It targets the lipopolysaccharide (LPS) binding site on the inner membrane's LptB2FG complex, inhibiting lipopolysaccharide transport and thereby suppressing the activity of Acinetobacter strains.

RO-7 is a next-generation polymerase (PA) endonuclease inhibitor of influenza A and B viruses.

RO 7-0213 is a novel benzodiazepine (RO7-0213) containing a fully positive quaternary ammonium component.

Ro 7-9767 is a biochemical.