ro7

RO-7 is a next-generation polymerase (PA) endonuclease inhibitor of influenza A and B viruses.

Ro 7-9767 is a biochemical.

HRO761 (Werner syndrome RecQ helicase-IN-1, Example 42) is a small molecule inhibitor, a potent WRN inhibitor with high efficacy, and can be used for research on cancers such as colon cancer and gastric cancer.

RO7185876 is a selective gamma secretase modulator, which can be used in the study of Alzheimer's disease.

RO7567132 (FAP-LTBR) is a novel bispecific antibody that binds and agonizes LTBR bivalently while binds and antagonizes FAP monovalently, thereby limiting the activation of LTBR to the tumor microenvironment, inducing the formation of local tertiary lymphoid structures (TLS), and reducing systemic toxicity. Its mouse alternative can inhibit breast cancer growth, and the effect is better when combined with atezolizumab. In the mouse colorectal cancer model, it can also enhance immune cell infiltration and TLS-like structure formation.

(9R)-RO7185876 (Compound example 16) is a γ-secretase inhibitor. It reduces the secretion of Αβ42. This compound can be employed in the research of Alzheimer's disease, cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, multi-infarct dementia, senile dementia, or Down syndrome.

RO7122290 is a bispecific antibody-like fusion protein composed of a trimeric ligand for the T-cell co-stimulatory receptor 4-1BB (CD137) and an antigen-binding fragment (Fab) targeting the tumor-associated protein fibroblast activation protein (FAP), with potential immunomodulatory and antitumor activities. It shows promise in the treatment of advanced solid tumors. Molecular weight: 177.78 KD.

RO7196472 is a potent macrocyclic peptide antibiotic that selectively inhibits the activity of Acinetobacter strains. It targets the lipopolysaccharide (LPS) binding site on the inner membrane's LptB2FG complex, inhibiting lipopolysaccharide transport and thereby suppressing the activity of Acinetobacter strains.

(D-Pro7)-Angiotensin I/II (1-7) is a selective peptide-based antagonist of Angiotensin-(1-7). It effectively blocks various biological effects of Ang-(1-7), inhibits the hypertensive response induced by microinjection of Ang-(1-7) into the rostral ventrolateral medulla (RVLM), and eliminates endothelium-dependent vasorelaxation in mice. This compound is useful in cardiovascular disease research.

Risdiplam (RG7916) is a centrally and peripherally distributed and orally administrable small molecule SMN2 pre-mRNA splicing modifier that increases survival motor neuron (SMN) protein levels.

Trontinemab (RG6102) is a human IgG1-κ antibody selectively targeting Aβ precursor protein (APP) with transferrin receptor p90, CD71 (TFRC), inhibits amyloid production, and can be used to study neurological disorders such as Alzheimer's disease.

2,4,5-Trichloro-7H-pyrrolo[2,3-d]pyrimid is a chemical agent.

6-Chloro-7-hydroxy-4-methylcoumarin ,with CAS No. 19492-02-5, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 6-Chloro-7-hydroxy-4-methylcoumarin provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

3-Chloro-7-hydroxy-4-methylcoumarin ,with CAS No. 6174-86-3, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 3-Chloro-7-hydroxy-4-methylcoumarin provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Ornidazole (Tiberal) is a nitroimidazole antiprotozoal agent used in ameba and trichomonas infections. It is partially plasma-bound and also has radiation-sensitizing action.

7-Hydroxycarbostyril (3,4-Dihydro-7-hydroxycarbostyril) (3,4-Dihydro-7-hydroxycarbostyril) is a kind of pharmaceutical intermediate.

GDC-2992 is a selective and orally active androgen receptor (AR) degradator that degrades AR (DC50 = 2.7 nM) and inhibits proliferation (IC50 = 9.7 nM) in VCaP cells, making it suitable for studying castration-resistant prostate cancer (CRPC).

1,8-Naphthyridine,1,2,3,4-tetrahydro-7-methyl- ,with CAS No. 274676-47-0, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 1,8-Naphthyridine,1,2,3,4-tetrahydro-7-methyl- provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

6-Chloro-7-deazapurine-β-D-riboside shows antifungal activity.

4-Chloro-7H-pyrrolo[2,3-d]pyrimidine ,with CAS No. 3680-69-1, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

4-Chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylic acid ,with CAS No. 186519-92-6, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylic acid provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

1,4-Benzodioxin-6-amine, 2,3-dihydro-7-(phenylthio)- ,with CAS No. 1019584-14-5, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 1,4-Benzodioxin-6-amine, 2,3-dihydro-7-(phenylthio)- provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

RO 7-0213 is a novel benzodiazepine (RO7-0213) containing a fully positive quaternary ammonium component.

Canrenone (SC14266) is an aldosterone antagonist with potassium-sparing diuretic activity.