nb-3

NB-3 is an inhibitor of SARM1, the NAD⁺ hydrolase. NB-3 can block the hydrolysis process of NAD⁺ and form a covalent bond with the reaction product adenosine diphosphate ribose (ADPR). The small-molecule ADPR adduct formed by the binding of NB-3 and ADPR shows excellent activity and exerts neuroprotective effects in nerve injury-related scenarios.

NB-360 is a potent and brain-penetrable inhibitor of BACE1 and BACE2 with IC50s of 5, 5, and 6 nM for mouse and human BACE1 and BACE2. NB-360 exhibits excellent selectivity over the related aspartyl proteases pepsin, cathepsin E, and cathepsin D.

Ellipticine (Elliptisine) is a potent antineoplastic agent exhibiting multiple mechanisms of action, IC50 of 0.67±0.06, 1.25±0.13, 1.25±0.13, 0.67±0.06, 0.27±0.02, 0.49±0.04, 0.44±0.03, and 1.48±0.62 μM for Leukemia HL-60, Breast adenocarcinoma MCF-7, Breast adenocarcinoma MCF-7, Leukemia HL-60, Neuroblastoma IMR-32, Neuroblastoma UKF-NB-4, Neuroblastoma UKF-NB-3, and Glioblastoma U87 mg cell, respectively.

Niacin (Nicotinic acid) is a water-soluble vitamin belonging to the vitamin B family, which occurs in many animal and plant tissues, with antihyperlipidemic activity. Niacin is converted to its active form niacinamide, which is a component of the coenzymes nicotinamide adenine dinucleotide (NAD) and its phosphate form, NADP.

Nicotinamide, a vitamin B3 derivative, is an inhibitor of SIRT1 (IC50=50-180 μM) and SIRT2 (IC50=2 μM). Nicotinamide can be used as a precursor of nicotinamide adenine dinucleotide or NAD+, which can be supplemented by dietary intake and can prevent or treat melanoglossia and pellagra.

Fumonisin B3, a mycotoxin derived from fusarium fungi, is a member of fumonisins.

GQN-B37-Me is an MCL-1 inhibitor that can induce caspase-dependent apoptosis. It exhibits significant cytotoxicity in H929 (IC50= 3.71 μM) and MV-4-11 (IC50= 5.57 μM) cell lines. GQN-B37-Me is useful for leukemia research.

Clostomycin B2 is a bioactive chemical.

Stevastelin B3 is a depsipeptide isolated from Penicillium.

Nicotinamide-D4 is a deuterium-labelled compound of Nicotinamide (TMSM-1731) for isotope tracing. Nicotinamide, a vitamin B3 derivative, inhibits SIRT1 and SIRT2.

iso-Dehydrozingerone is a novel osteoclastogenesis inhibitor, preventing ovariectomy-induced osteoporosis in ddY mice.

KUNB31 is a potent and selective inhibitor of Hsp90β.

Dermaseptin-B3 is an antimicrobial peptide that exhibits inhibitory effects against both Gram-positive and Gram-negative bacterial strains, with minimum inhibitory concentrations (MICs) of 1.3, 2.3, 5.0, 2.6, and 2.3 μM for S. aureus, P. aeruginosa, E. (ATCC 25922), and E. (54127) respectively. Additionally, this compound demonstrates antiproliferative activity against tumor cells [1] [2].

Saikosaponin b3 is isolated from the roots of Bupleurum falcatum L.. Saikosaponin b3 inhibits ACTH-induced lipolysis in the fat cells and exhibits analgesic effects.

Prostaglandin B3 (PGB3) is a secondary alcohol belonging to the prostaglandin B class, characterized by its relatively low affinity for human PPARγ, exhibiting a K_i value greater than 1 mM, in contrast to PGB1 and PGB2, which have K_i values of 26.28 ± 8.7 μM and 77 ± 37.7 μM, respectively [1].

Vitamin B3-d4 (nicotinic acid-d4) is a tetradeuterated stable isotope label of natural vitamin B3 (nicotinic acid) used to track the metabolism of vitamin B3 in the body. Vitamin B3-d4 is commonly used in pharmacokinetic studies of vitamin B3 and for isotope tracing of nicotinic acid metabolic pathways.

GQN-B37-E is an effective selective binder and inhibitor of MCL-1. It binds to the BH3-binding domain of MCL-1. GQN-B37-E demonstrates binding affinity for MCL-1 within the sub-micromolar range (Ki= 0.6 μM), yet shows negligible binding to BCL-2 or BCL-XL.

Niacin (Standard) is the analytical standard of Niacin (Vitamin B3). As an essential water-soluble nutrient and a primary precursor to the coenzymes NAD+ and NADP+, it plays a fundamental role in cellular energy metabolism, gene expression, and the regulation of apoptosis. Niacin acts as an agonist for the GPR109A receptor, modulating lipid profiles and exerting anti-inflammatory effects. It is a cornerstone molecule in research concerning cardiovascular health, metabolic homeostasis, and the mechanisms of aging.

Procyanidin B3 (Standard) is a reference standard for research and analysis in studies involving Procyanidin B3. Procyanidin B3(B3) is a procyanidin dimer that is widely studied due to its high abundance in the human diet and antioxidant activity.

Nicotinic Acid-13C3,15N (Vitamin B3-13C3,15N) (Standard) is a reference standard of Nicotinic Acid-[13C3,15N] (Vitamin B3-[13C3,15N]) intended for quantitative analysis, quality control, and related biochemical research applications.

Nicotinamide-13C6 (Standard) is a reference standard of Nicotinamide-13C6 intended for quantitative analysis, quality control, and related biochemical research applications. Nicotinamide-13C6 is a 13C-labeled form of Nicotinamide. As a vitamin B3, Nicotinamide plays a crucial role in cellular physiology by supporting NAD+ redox homeostasis and serving as a substrate for a class of enzymes that catalyze non-redox reactions. It is also known as a SIRT1 inhibitor.

Vitamin B3-13C6) (Standard) is a reference standard of Vitamin B3-13C6) intended for quantitative analysis, quality control, and related biochemical research applications.

Nicotinamide-15N,13C3 (Standard) is a reference standard of Nicotinamide-15N,13C3 intended for quantitative analysis, quality control, and related biochemical research applications. Nicotinamide-15N,13C3 is a form of nicotinamide labeled with 13C and 15N. Nicotinamide, a vitamin B3, is crucial in cellular physiology by maintaining NAD+ redox balance and supplying NAD+ as a substrate for enzymes catalyzing non-redox reactions. Nicotinamide also acts as an SIRT1 inhibitor.

Vitamin B3-D4 (Standard) is a reference standard of Vitamin B3-D4 intended for quantitative analysis, quality control, and related biochemical research applications. Vitamin B3-d4 (Nicotinic acid-(ring-d4)) is the deuterium substitute for Niacin and is used to track Niacin metabolism in the body.