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mita

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    101
    TargetMol | Inhibitors_Agonists
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    9
    TargetMol | Inhibitory_Antibodies
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    1
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    TargetMol | Inhibitors_Agonists
C-176
STING inhibitor 1, C176
T5154314054-00-7
C-176 (STING inhibitor 1) is a STING inhibitor with selectivity and blood-brain barrier permeability. C-176 inhibits STING-mediated IFNβ production and possesses anti-inflammatory activity.
  • $30
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TargetMol | Inhibitor Hot
H-151
T5674941987-60-6
H-151 is a highly potent and selective STING antagonist. H-151 covalently binds to Cys91 of STING and inhibits palmitoylation of Cys91, thereby inhibiting STING activity. H-151 can be used in the study of autoinflammatory diseases in vivo and ex vivo.
  • $30
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TargetMol | Inhibitor Hot
Vadimezan
NSC 640488, DMXAA, ASA-404, 5,6-Dimethylxanthenone-4-acetic Acid
T6273117570-53-3
Vadimezan (DMXAA) is a vascular disrupting agent, a murine STING agonist, and an inducer of cytokines such as type I IFN. Vadimezan has antitumor activity and induces a rapid cessation of blood flow in tumors without affecting blood flow in normal tissues.
  • $37
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TargetMol | Inhibitor Hot
Omaveloxolone
RTA-408
T69191474034-05-3
Omaveloxolone (RTA-408) (RTA-408) is a synthetic triterpenoid that activates the cytoprotective transcription factor Nrf2 and inhibits NF-κB signaling. Phase 2.
  • $38
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TargetMol | Inhibitor Hot
SN-011
GUN35901, [1,1'-Biphenyl]-4-carboxamide, N-[3-[[(4-fluorophenyl)sulfonyl]amino]-4-hydroxyphenyl]-
T91372249435-90-1
SN-011 (GUN35901) is a STING inhibitor, which inhibited the activation of the STING signal pathway and to prevent or treat a STING- mediated disease. It is a demethyl analogue of DUN99845.
  • $48
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TargetMol | Inhibitor Hot
diABZI STING agonist-1 trihydrochloride
T55162138299-34-8In house
diABZI STING agonist-1 (trihydrochloride) is a stimulator of interferon genes (STING) receptor agonist.
  • $175
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SN-008
T95542249106-01-0In house
SN-008 is a less active analog SN-011 which is a STING antagonist. SN-008 can be used as a negative control.
  • $56
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CCCP
Carbonyl Cyanide m-Chlorophenylhydrazone, Carbonyl cyanide 3-chlorophenylhydrazone
T7081555-60-2
CCCP (Carbonyl Cyanide m-Chlorophenylhydrazone) is an oxidative phosphorylation (OXPHOS) inhibitor and mitochondrial proton carrier uncoupler. CCCP inhibits the activation of STING and its downstream signaling molecules TBK1 and IRF3.
  • $41
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ADU-S100 ammonium salt
ML RR-S2 CDA ammonium salt, MIW815 ammonium salt
T10252L21638750-96-5
ADU-S100 ammonium salt is an activator of stimulator of interferon genes (STING). ADU-S100 ammonium salt leads to potent and systemic tumor regression and immunity.
  • $797
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STING agonist-4
T130152138300-40-8
STING agonist-4 is an agonist of stimulator of Interferon Genes (STING) receptor(IC50 of 20 nM).
  • $163
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ChX710
T136132438721-44-7
ChX710 activates the type I interferon response to cytosolic DNA by priming specific Interferon-Stimulated Genes (ISGs), inducing the ISRE promoter sequence, and facilitating the phosphorylation of Interferon Regulatory Factor (IRF) 3.
  • $55
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SR-717
T86552375421-09-1
SR-717 is a cGAMP analog, a non-nucleoside STING agonist that induces a closed activation conformation of STING. SR-717 has antitumor activity and promotes activation of immune cells and cross-presentation of antigens.
  • $75
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MSA-2
T8798129425-81-6
MSA-2 is an orally available non-nucleotide STING agonist. The non-covalent dimer of MSA-2 binds to STING with nanomolar affinity. It shows anti-tumor activity in syngeneic mouse tumor models, synergizes with anti-PD-1, stimulates tumor secretion of interferon-β, induces tumor regression, and has long-lasting anti-tumor immunity. [3]
  • $34
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Ascorbyl palmitate
L-Ascorbyl 6-palmitate, L-Ascorbic acid 6-hexadecanoate, 6-O-Palmitoyl-L-ascorbic acid
T0752137-66-6
Ascorbyl palmitate (L-Ascorbic acid 6-hexadecanoate), an ester formed from ascorbic acid and palmitic acid, produces a fat-soluble form of vitamin C.
  • $30
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Retinyl palmitate
Vitamin A palmitate, Retinyl (Vitamin A) Palmitate, Retinol palmitate
T105979-81-2
Retinyl palmitate (Vitamin A palmitate) is a naturally-occurring phenyl analogue of retinol, with potential antineoplastic and chemopreventive activities.
  • $30
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Chloramphenicol palmitate
T20525530-43-8
Chloramphenicol palmitate is a broad-spectrum antibiotic with activity against gram-positive and gram-negative bacteria. Chloramphenicol palmitate can be used in studies about acting as a bacterial selection agent in transformed cells containing chloramphenicol resistance genes.
  • $33
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Methyl palmitate
Palmitic acid methyl ester, Methyl hexadecanoate
T2S0157112-39-0
Methyl hexadecanoate is an acaricidal compound found in green walnut hulls with anti-inflammatory and antifibrotic properties, inhibiting phagocytic activity and immune response.
  • $42
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Ethyl palmitate
Palmitic acid ethyl ester, Ethyl hexadecanoate, Ethyl cetylate
T2S0164628-97-7
Ethyl palmate (palmitic acid ethyl ester) is a type of fatty acid ethyl ester (FAEE). After human subjects consumed alcohol, its synthesis was higher than other FAEEs. It can be used as a hair and skin conditioner.
  • $29
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Mitapivat
PKR-IN-1
T42231260075-17-9
Mitapivat (PKR-IN-1), also known as PKM2 activator 1020 is a PKM2 activator (pyruvate kinase activator) for the treatment of pyruvate kinase deficiency.
  • $34
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Lomitapide
BMS-201038, AEGR-733
T6267182431-12-5
Lomitapide (AEGR-733) is a small molecule inhibitor of microsomal triglyceride transfer protein (MTP), an enzyme located in the lumen of the endoplasmic reticulum responsible for absorbing dietary lipids and transferring triglycerides onto apolipoprotein B (apo-B) in the assembly of very-low-density lipoprotein.
  • $59
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Propane-1,2,3-triyl tripalmitate
Tripalmitoylglycerol, Tripalmitin, Palmitic Triglyceride, Glycerol Tripalmitate
TWO2727555-44-2
Propane-1,2,3-triyl tripalmitate (Glycerol Tripalmitate) is a triacylglycerol found in dietary fats. In hamsters fed a diet enriched with it, Tripalmitin increases body weight, elevates plasma LDL levels, and reduces hepatic LDL receptor mRNA levels. It inhibits glucose-stimulated insulin secretion and decreases the viability of INS1 cells dose-dependently. Tripalmitin is used in cosmetic products for skin conditioning and as a thickening agent, and it forms lipid matrices of nanoparticles for drug delivery.
  • $38
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Mitapivat sulfate hydrate
AG348 sulfate hydrate, AG 348 sulfate hydrate
T698652151847-10-6
Mitapivat sulfate hydrate (AG 348 sulfate hydrate) is an erythrocyte pyruvate kinase (PK) allosteric activator. It enhances enzyme activity, protein stability, and ATP levels in various PKLR genotypes and can be used in pyruvate kinase deficiency research.
  • $293
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Alimemazine hemitartrate
Alimemazine Tartrate, Methylpromazine Tartrate, Trimeprazine tartrate, Trimeprazine hemitartrate
T32824330-99-8
Alimemazine hemitartrate (Trimeprazine hemitartrate) is aphenothiazine derivative that is used as an antipruritic. It also acts as a sedative, hypnotic, and antiemetic for prevention of motion sickness.
  • $42
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N-(3-Methoxybenzyl)Palmitamide
T12139847361-96-0
N-(3-Methoxybenzyl)Palmitamide is a promising FAAH inhibitor for the treatment of pain, inflammation, and CNS degenerative disorders.
  • $32
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