hts

HTS01037 is a fatty acid-binding inhibitor and a competitive antagonist of protein-protein interactions mediated by AFABP/aP2 (Ki: 0.67 μM).

NB001 (HTS 09836) is an adenyl cyclase 1 inhibitor that affects both neural and non-neural pain.

LY-364947 (HTS466284) is a potent ATP-competitive inhibitor of TGFβR-I.

(R)-HTS-3, a lysophosphatidylcholinacyltransferase 3 (LPCAT3) inhibitor, remodels polyunsaturated phospholipid content in human cells and reduces RSL3-induced ferroptosis in cancer cells.

HTS05585 (Compound Hit-1) is a selective inhibitor of macrophage migration inhibitory factor (MIF) with a Kd value of 0.29 μM determined by microscale thermophoresis (MST) and confirmed through isothermal titration calorimetry (ITC) at 0.32 μM. It suppresses the release of pro-inflammatory factors (TNF-α, IL-6, IL-1β) in macrophages induced by LPS, making it a promising candidate for the study of inflammatory diseases such as sepsis.

HTS07545 is a potent sulfide:quinone oxidoreductase inhibitor (IC50: 30 nM) that reduces the rate of hydrogen sulfide (H2S) decomposition and has been used in heart failure studies.

HTS07944 (HTS07944SC, C3) acts as a modulator of the laminin receptor (37 LR) and exhibits anticancer activity by activating Caspase3/7.

Phtstllap is a luteinizing hormone-releasing factor

APE1-IN-1 is a potent inhibitor of purine/pyrimidine endonuclease 1 (APE1) that crosses the blood-brain barrier, exhibits potential antitumor activity, and enhances the cytotoxicity of the alkylating agent [methyl methanesulfonate] on cancer cells.

Nimodipine (BAY-e 9736), a 1, 4-dihydropyridine calcium channel blocker, acts primarily on vascular smooth muscle cells.

Dihydrotanshinone I (DHTS) is a natural compound extracted from Salvia miltiorrhiza Bunge used for treating of cardiovascular diseases.

N-Cyclohexyl-4-[1-(1-piperazinyl)-2,6-naphthyridin-3-yl]-2-pyridinamine is a novel 2,6-naphthyridine identified by high throughput screen (HTS) as a dual protein kinase C/D (PKC/PKD) inhibitor[1].

NSC 80538 is an inhibitor of MEK Kinase PB1 Domains in multiplex HTS assays.

C-215 is a novel inhibitor of mycobacterial membrane protein large 3 (MmpL3).

CCT251236 is a cell-based phenotypic high-throughput screening (HTS) chemical probe developed to screen for inhibitors of the HSF1 stress pathway.CCT251236 exhibits antimyeloma activity and inhibits HSF1.

Methylbenzoprim is an innovative multifunctional thymidylate synthase (TYMS) inhibitor. It exhibits greater antitumor activity compared to current fluoropyrimidines and antifolates, without inducing TYMS overexpression. In pancreatic xenograft tumor models and hTS/Ink4a/Arf null genetically engineered mouse models, Methylbenzoprim effectively prolongs survival.

L 650719 is a bioactive chemical.

GSK2200150A is an anti-tuberculosis (TB) agent identified by high-throughput screening (HTS) campaign.