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Results for "

c2 8

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    7
    TargetMol | Inhibitors_Agonists
  • PROTAC Products
    5
    TargetMol | PROTAC
  • Recombinant Protein
    5
    TargetMol | Recombinant_Protein
C2-8
C2-8
T38279300670-16-0
C2-8 is an inhibitor of polyglutamine (polyQ) aggregation with IC50s of 25 and 0.05 μM for recombinant HDQ51 and in PC12 cells, respectively. It also limits polyQ aggregation in organotypic hippocampal slice cultures from R6 2 transgenic mice and reduces neurodegeneration dose-dependently in a Drosophila model of Huntington's disease. C2-8 (100 and 200 mg kg) decreases huntingtin aggregate size, reduces neuronal atrophy, and enhances motor performance in a rotarod test in the R6 2 transgenic mouse model of Huntington's disease.
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Palbociclib
PD 0332991
T1785571190-30-2
Palbociclib (PD 0332991) is a CDK inhibitor that inhibits CDK4 and CDK6 (IC50=11 16 nM) and is orally active. Palbociclib has anti-tumorigenic activity and has investigational potential for use in ER-positive and HER2-negative breast cancer.
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Pomalidomide-PEG4-C2-NH2
E3 Ligase Ligand-Linker Conjugates 22, Cereblon Ligand-Linker Conjugates 8
T179162225940-52-1
Pomalidomide-PEG4-C2-NH2 (E3 Ligase Ligand-Linker Conjugates 22) is a synthesized E3 ligase ligand-linker conjugate incorporating the Pomalidomide-based cereblon ligand and 4-unit PEG linker.
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TargetMol | Inhibitor Sale
Cbz-NH-PEG8-C2-acid
T148921334177-87-5
Cbz-NH-PEG8-C2-acid is a PEG-based linker for PROTACs that joins two essential ligands, facilitating selective protein degradation via the ubiquitin-proteasome system within cells.
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7-10 days
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Mal-amido-PEG8-C2-acid
T159611334177-86-4
Mal-amido-PEG8-C2-acid (US2018339985, example 142) is a noncleavable linker for antibody-drug conjugates (ADCs) [1].
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Pomalidomide-PEG3-C2-NH2 (TFA)
Cereblon Ligand-Linker Conjugates 5 (TFA), E3 ligase Ligand-Linker Conjugates 30 (TFA), Pomalidomide-PEG3-C2-NH2 (TFA) (2093416-31-8 free base)
T17882
Pomalidomide-PEG3-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology.
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Pomalidomide-C2-Br
T2035922940940-74-7
Pomalidomide-C2-Br is a conjugate of an E3 ligase ligand and a linker. It is used in the synthesis of PROTACAR Degrader-8.
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