aster

PROTACAster-A degrader-1 (compound NGF3) is an agent that degrades the sterol transport protein Aster-A. Additionally, PROTACAster-A degrader-1 can be utilized as a fluorescent probe.

Aster-A Ligand-3 acts as a ligand for E3 ligase and is utilized in the synthesis of the PROTAC Aster-A degrader.

YN14, a mixture of diastereomers, is a PROTAC (proteolysis-targeting chimera) specifically designed for the KRASG12C protein. It acts as an efficient and selective degrader of KRASG12C, forming a stable KRASG12C:YN14:VHL ternary complex with low binding free energy (ΔG). YN14 exhibits antiproliferative properties, significantly inhibiting the growth of cancer cells with the KRASG12C mutation.

Thalidomide-N-C3-O-C4-O-C3-OH is a conjugate of an E3 ligase ligand and a linker, used in the synthesis of the Aster-APROTAC degrader.