al1

AL-1 is a GLYCOINOSITOL PHOSPHOLIPID MEMBRANE ANCHOR containing ephrin found in developing tectum. It can mediate the bundling of cortical axons and repel the axonal growth of retinal ganglia axons. It exists in a variety of adult tissues of BRAIN; HEART;

LYPLAL1-IN-1 is a selective covalent small-molecule inhibitor of Lysophospholipase-like 1 (IC50: 0.006 μM). LYPLAL1-IN-1 also enhances glucose production.

SirReal1-O-propargyl is a selective Sirtuin 2 inhibitor (IC50=2.4 μM) and PROTAC ligand. Its propargyl group enables click chemistry reactions such as CuAAc.

ST6GAL1-IN-1 (compound 4e) is a potent selective inhibitor of ST6GAL1, with an IC50 value of 20.0 μM. It demonstrates anti-metastatic activity by effectively inhibiting the migration of MDA-MB-231 cells. Furthermore, ST6GAL1-IN-1 is capable of suppressing tumor growth and metastasis in vivo.

AL12180 is a bioactive chemical.

Potent and selective CLK inhibitor (IC50 values are 28, 88 and 510 nM for CLK4, 1 and 2, respectively). Exhibits no significant activity at CLK3, DYRK, CDK or GSK3 at a concentration of 10 μM. Inhibits growth of a range of cancer cell lines in vitro at subnanomolar concentrations. Walter et al (2018) Molecular structures of cdc2-like kinases in complex with a new inhibitor chemotype. PLoS One 13 e0196761 PMID:29723265

AAL1 is an inhibitor of dark-grown Arabidopsis thaliana seedlings, functioning through auxin receptor Transport Inhibitor Response1 (TIR1) and depending on auxin influx and efflux carriers.

P4pal10, a PAR 4 antagonist, inhibits thrombin-mediated aggregation of mouse platelets in vivo and significantly diminishes Carrageenan-induced edema and granulocyte infiltration [1].

{Val1}- exendin-3/4 is the first n-terminal 1-28 residue of exendin-4 peptide.

P4pal10 TFA, the TFA salt form of P4pal10, serves as an antagonist of the protease-activated receptor 4 (PAR4). This compound inhibits platelet aggregation and thrombin generation induced by tissue factor (TF), exhibiting anticoagulant and antithrombotic activities. Additionally, P4pal10 TFA alleviates carrageenan-induced edema and neutrophil infiltration, and ameliorates damage in rat myocardial ischemia/reperfusion (I/R) models.

Gal1-β-3GlcNAc-β-PNP (Galactosyl-N-acetylglucosaminyl-β-p-nitrophenyl) is a biochemical reagent used in glycobiology studies. Research in glycobiology focuses on the structure, synthesis, biology, and evolution of sugars, encompassing carbohydrate chemistry, glycan formation and degradation enzymology, protein-glycan recognition, and the role of glycans in biological systems. This field is closely linked to fundamental research, biomedicine, and biotechnology.

Gal1-β-3GlcNAc1-β-Ome is a type of biochemical reagent used in glycobiology research. Glycobiology explores the structure, synthesis, biology, and evolution of sugars. This field encompasses carbohydrate chemistry, glycan formation and degradation enzymology, protein-glycan recognition, and the role of glycans in biological systems. It closely relates to fundamental research, biomedicine, and biotechnology.

Gal1-b-4GlcNAc-α-PNP is a reagent used in biochemical reactions.

Gal1-β-4GlcNAc-β-Bn (Benzyl β-D-galactopyranosyl-(1→4)-β-D-N-acetylglucosamine) is a biochemical reagent employed in glycobiology research. Glycobiology focuses on exploring the structure, synthesis, biology, and evolution of sugars, encompassing areas such as carbohydrate chemistry, glycan formation and degradation enzymology, protein-glycan recognition, and the roles of glycans within biological systems. This field is closely linked to fundamental research, biomedicine, and biotechnology.

Fuc1-α-2Gal1-β-3GlcNAc-β-PNP is a biochemical reagent utilized in glycoscience research. This field examines the structure, synthesis, biology, and evolution of sugars, encompassing studies in carbohydrate chemistry, glycans formation and degradation, protein-glycan interactions, as well as the role of glycans in biological systems. It closely relates to fundamental research, biomedicine, and biotechnology.

Gal1-β-4GlcNAc1-β-6Gal is a biochemical reagent used in glycoscience research. Glycoscience examines the structure, synthesis, biology, and evolution of sugars. It encompasses carbohydrate chemistry, glycoconjugate formation and degradation enzymology, protein-glycan recognition, and the roles of glycans in biological systems. This field is closely linked to fundamental research, biomedicine, and biotechnology.

BMS-906024 (Osugacestat) is an orally available and selective inhibitor of γ-secretase, a small molecule Notch inhibitor.BMS-906024 has broad-spectrum antitumour activity against a variety of human cancer xenografts.BMS-906024 prevents the activation of all four Notch receptors, and is active against Notch1, -2, -3 and -4 receptors. BMS-906024 prevents the activation of all four Notch receptors, with IC50s of 1.6, 0.7, 3.4 and 2.9 nM for Notch1, -2, -3 and -4 receptors, respectively.

KP136 (AL136) is an orally active anti-allergic compound that inhibits histamine release and is used in studies of asthma and allergic edema.

AL 1965 has anti-neuropathic effects.

Alconil (Al 1567) is an aldose reductase inhibitor that may be used to study chronic obstructive pulmonary disease (COPD) and diabetes.

Idelalisib (GS-1101) is a small molecule inhibitor of the PI3K catalytic subunit p110δ (IC50: 2.5 nM). The selectivity for p110δ is 40- to 300-fold than p110α/β/γ.

Imirestat (HOE 843) is an aldose reductase inhibitor that can be used in diabetes research.

Acalisib (CAL-120) (GS-9820) is a potent and selective inhibitor of PI3Kδ.

iKIX1 is an Pdr1-dependent gene activation. It re-sensitizes drug-resistant C. glabrata to azole antifungals in vitro and in animal models for disseminated and urinary tract C. glabrata infection.