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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T18230 | MAC glucuronide linker-1 | Others | |
MAC glucuronide linker-1 is a nonclaevable ADC linker for antibody-drug-conjugations (ADCs). | |||
TN1966 | N-(3-Methoxybenzyl)Oleamide | N-Benzyloleamide,MAC 18:1 | Antioxidant |
N-(3-Methoxybenzyl)Oleamide (MAC 18:1), an agmatine isolated from Lepidium meyenii, has pharmacological effects on exercise-induced fatigue, which may be related to the modulation of energy metabolism and improvement of ... | |||
T3638 | Leukadherin-1 | Integrin , Complement System | |
Leukadherin-1 is an allosteric activator of CD11b/CD18. Increasing CD11b/CD18-dependent cell adhesion to fibrinogen, Decreasing leukocyte motility and transendothelial migration; reduces inflammation. | |||
T76844 | Abciximab | C7E3 | Integrin |
Abciximab (C7E3) is a mouse/human chimeric monoclonal antibody that is a potent glycoprotein IIb/IIIa inhibitor. Abciximab has anti-platelet aggregation and leukocyte adhesion, acting by binding to glycoproteins IIb/IIIa... | |||
T67749 | Fuzapladib | IS-741 | Phospholipase |
Fuzapladib (IS-741) (IS-741) is a phospholipase A2 inhibitor that can inhibits the expression of Mac-1, a cell adhesion molecule. Fuzapladib blocks activation of adhesion molecules (integrin) expressed on the inflammator... | |||
T10863 | Complement C5-IN-1 | Complement System | |
Complement C5-IN-1 is a small-molecule inhibitor of complement component 5 protein (C5). | |||
T24207 | JNJ-28610244 | JNJ 28610244 | |
JNJ-28610244 is a specific agonist of the H4 receptor. It acts by blocking Mac-1-dependent activation of p38 MAPK. | |||
T18722 | MAC glucuronide α-hydroxy lactone-linked SN-38 | Others | |
MAC glucuronide α-hydroxy lactone-linked SN-38 (Topoisomerase I inhibitor) is a cytotoxic drug linker that maintains a stabilized lactone form, showing efficacy against L540cy and Ramos cells, with IC50 values of 99 and ... | |||
T18721 | MAC-VC-PABC-ST7612AA1 | Others | |
MAC-VC-PABC-ST7612AA1 is a part of antibody drug conjugates (ADCs) charged with HDAC inhibitor by a linker, shows antitumor activity[1]. | |||
T18231 | MAC glucuronide linker-2 | Others | |
MAC glucuronide linker-2 is an ADC linker employed in the synthesis of ADCs, offering cleavability [1]. | |||
T22202 | IMAC2 | ||
iMAC2, a potent MAC (Membrane Attack Complex) inhibitor, exhibits an IC50 of 28 nM and an LD50 of 15,000 nM, demonstrating significant efficacy in inhibiting MAC. Additionally, iMAC2 effectively suppresses apoptosis by b... | |||
T16898 | Complement factor D-IN-1 | Others | |
Complement factor D-IN-1 is an effective and selective small-molecule reversible factor d inhibitor (IC50s: 0.006 and 0.05 μM in FD Thioesterolytic Fluorescent Assay and a MAC Deposition Assay, respectively). | |||
T18538 | MAC glucuronide phenol-linked SN-38 | Others | |
MAC glucuronide phenol-linked SN-38, a pH-sensitive lactone and DNA topoisomerase I inhibitor drug linker, exhibits cytotoxicity in L540cy and Ramos cells, with IC50 values of 113 ng/mL and 67 ng/mL, respectively[1]. | |||
T80682 | γ-Fibrinogen 377-395 TFA | ||
γ-Fibrinogen377-395 TFA is an inhibitory peptide derived from fibrinogen, which also functions as a fibrinogen epitope. It effectively blocks microglial activation and impedes fibrin-Mac-1 interactions in vitro. Addition... | |||
T80683 | γ-Fibrinogen 377-395 | ||
γ-Fibrinogen377-395 is a peptide derived from fibrinogen, functioning both as an inhibitory molecule and an epitope. It inhibits microglial activation, disrupts fibrin-Mac-1 interactions in vitro, and mitigates experimen... | |||
T71212 | Lornoxicam-d4 | ||
Lornoxicam-d4 is intended for use as an internal standard for the quantification of lornoxicam by GC- or LC-MS. Lornoxicam is a COX inhibitor and non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory and an... | |||
T38309 | LL-37 amide (trifluoroacetate salt) | ||
LL-37 is a cationic and α-helical antimicrobial peptide expressed in human bone marrow, testis, granulocytes, and gingival epithelium and is upregulated in psoriatic lesions. It inhibits growth of Gram-positive E. coli D... |