Neprilysin

Neprilysin, also known as membrane metallo-endopeptidase (MME), neutral endopeptidase (NEP), cluster of differentiation 10 (CD10), and common acute lymphoblastic leukemia antigen (CALLA) is an enzyme that in humans is encoded by the MME gene. Neprilysin is a zinc-dependent metalloprotease that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. It also degrades the amyloid beta peptide whose abnormal folding and aggregation in neural tissue has been implicated as a cause of Alzheimer's disease. Synthesized as a membrane-bound protein, the neprilysin ectodomain is released into the extracellular domain after it has been transported from the Golgi apparatus to the cell surface.

Cat. No.	Product name	CAS No.	Purity
T6627	Phosphoramidon Disodium	164204-38-0	98%
Phosphoramidon Disodium Salt is a metalloendopeptidase inhibitor, widely used as a biochemical tool.
T19626	LHW090-A7	1308256-94-1	98.26%
LHW090-A7 is an neutral endopeptidase (NEP) inhibitor, and an enzyme responsible for the metabolic inactivation of enkephalins.
T4574	Sacubitril	149709-62-6	98.28%
AHU-377 is a potent NEP inhibitor with an IC50 of 5 nM. AHU-377 is a component of the heart failure medicine LCZ696.
T1176	Racecadotril	81110-73-8	98.86%
Racecadotril has been investigated for the basic science and treatment of Diarrhea, Acute Diarrhea, and Acute Gastroenteritis.
TQ0106	Sacubitrilat	149709-44-4	99.11%
Sacubitrilat (LBQ657) is an effective inhibitor of active neprilysin (NEP).
T4200	Sacubitril hemicalcium salt	1369773-39-6	99.28%
AHU-377 hemicalcium salt is a potent NEP inhibitor with an IC50 of 5 nM. AHU-377 is a component of the heart failure medicine LCZ696.AHU377 is a prodrug of LBQ65...
T7693	Thiorphan	76721-89-6	99.91%
Thiorphan is an neprilysin inhibitor (NEP; IC50 : 0.007 μM).
T2318	Sacubitril/Valsartan	936623-90-4	99.94%
LCZ696 is an orally bioavailable, dual angiotensin II receptor and neprilysin inhibitor for the treatment of hypertension and heart failure.

Cat. No.

Product name

CAS No.

Purity

Chemical Structure

T6627

Phosphoramidon Disodium

164204-38-0

98%

Phosphoramidon Disodium Salt is a metalloendopeptidase inhibitor, widely used as a biochemical tool.

T19626

LHW090-A7

1308256-94-1

98.26%

LHW090-A7 is an neutral endopeptidase (NEP) inhibitor, and an enzyme responsible for the metabolic inactivation of enkephalins.

T4574

Sacubitril

149709-62-6

98.28%

AHU-377 is a potent NEP inhibitor with an IC50 of 5 nM. AHU-377 is a component of the heart failure medicine LCZ696.

T1176

Racecadotril

81110-73-8

98.86%

Racecadotril has been investigated for the basic science and treatment of Diarrhea, Acute Diarrhea, and Acute Gastroenteritis.

TQ0106

Sacubitrilat

149709-44-4

99.11%

Sacubitrilat (LBQ657) is an effective inhibitor of active neprilysin (NEP).

T4200

Sacubitril hemicalcium salt

1369773-39-6

99.28%

AHU-377 hemicalcium salt is a potent NEP inhibitor with an IC50 of 5 nM. AHU-377 is a component of the heart failure medicine LCZ696.AHU377 is a prodrug of LBQ65...

T7693

Thiorphan

76721-89-6

99.91%

Thiorphan is an neprilysin inhibitor (NEP; IC50 : 0.007 μM).

T2318

Sacubitril/Valsartan

936623-90-4

99.94%

LCZ696 is an orally bioavailable, dual angiotensin II receptor and neprilysin inhibitor for the treatment of hypertension and heart failure.