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Results for "

programmed

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    67
    TargetMol | Inhibitors_Agonists
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    TargetMol | Compound_Libraries
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BMS-202
PD1-PDL1 inhibitor 2, PD-1 PD-L1 inhibitor 2
T31461675203-84-5
BMS-202 (PD1-PDL1 inhibitor 2) is an inhibitor of the PD-1 (Programmed death- 1) PD-Ll (Programmed death-ligand 1) protein protein interaction.
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TargetMol | Inhibitor Hot
BMS-1
PD1-PDL1 inhibitor 1, PD-1 PD-L1 inhibitor 1
T36551675201-83-8
BMS-1 (PD-1 PD-L1 inhibitor 1) is an inhibitor of the PD1-PD-L1 protein-protein interaction. It also acts as an immunomodulator. Programmed death ligand 1 (PD-L1) is a protein in humans that is encoded by the CD274 gene and the upregulation of PD-L1 allows Ys to evade the host immune system. High tumor expression of PD-L1 was associated with increased tumor aggressiveness and a 4.5-fold increased risk of death.
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TargetMol | Inhibitor Hot
Polyphyllin I
T389550773-41-6
Polyphyllin D induces apoptosis via the mitochondrial apoptotic pathway as evidenced by decreased Bcl-2 expression levels, disruption of MMP and increased Bax, cytochrome C, and cleaved-caspase-3 levels. Polyphyllin D has an anti-angiogenic effect. Polyphyllin D has toxicity in human RBCs as well as its underlying mechanism for the hemolysis and eryptosis erythroptosis. Polyphyllin D has strong anticancer activity, can overcome drug resistance in R-HepG2 cells and elicit programmed cell death via mitochondrial dysfunction.
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TargetMol | Inhibitor Hot
GSK2593074A
GSK'074
T114841337531-06-2In house
GSK2593074A (GSK'074) is a programmed necrosis inhibitor that displays inhibitory effects on RIP1 and RIP3.
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6-8weeks
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PD-1-IN-17
T123771673560-66-1In house
PD-1-IN-17 is an inhibitor of programmed cell death-1 (PD-1). PD-1-IN-17 inhibits 92% splenocyte proliferation at 100 nM.
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10-14 weeks
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PD-1-IN-22
T123792349372-98-9In house
PD-1-IN-22 is a potent inhibitor of the programmed cell death-1 (PD-1) programmed cell death-ligand 1 (PD-L1) interaction, with an IC50 of 92.3 nM.
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6-8 weeks
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ARB-272572
ARB 272572, ARB272572
T399142368182-63-0In house
ARB-272572 is a potent inhibitor of programmed cell death ligand 1 (PD-L1) signaling that induces PD-L1 homodimer interactions and produces immunostimulatory activity in human primary cells.
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7-10 days
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BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride
T40111L2691796-83-3In house
BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride, a resorcinol di-Ph ether scaffold-based programmed cell death-1 (PD-1) programmed cell death ligand 1 (PD-L1) inhibitor, inhibits the PD-1 PD-L1 interaction with an IC50 of 39.2 nM. It contains the target protein PD-1 PD-L1 ligand and PROTAC linker, which can be used to synthesize PROTAC PD-1 PD-L1 degrader-1 and has anticancer activity. Additionally, it serves as a diluent for the preparation of tablets for direct compression.
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7-10 days
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IMMH 010 maleate
YPD-30 maleate
T839702541982-47-0In house
IMMH 010 maleate (YPD-30 maleate) is an orally available programmed cell death ligand 1 inhibitor with potential antitumor activity for the study of neurological disorders and advanced malignant solid tumors.
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Fmoc-Met-OH
Fmoc-L-Met-OH
T6756871989-28-1
Fmoc-Met-OH (Fmoc-L-Met-OH) is an fmoc-based programmed synthesis of methionine derivatives.
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7-10 days
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2-aminobenzo[d]thiazol-6-ol
T7734626278-79-5
2-aminobenzo[d]thiazol-6-ol has antimicrobial, antioxidant and anticancer properties and may inhibit the activity of certain cancer cell lines by inducing apoptosis or programmed cell death.
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TargetMol | Inhibitor Sale
M50054
T2193654135-60-3
Apoptosis Inhibitor was a novel inhibitor of programmed cell death associate with caspase-3 inhibition.
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Merafloxacin
CI 934
T906691188-00-0
Merafloxacin (CI 934) is a fluoroquinolone antibacterial, which was also identified as a 1 PRF inhibitor of SARS-CoV-2.
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2-amino-4-methyl-1,3-thiazole-5-carbohydrazide
T5001663788-59-0
2-amino-4-methyl-1,3-thiazole-5-carbohydrazide (AMTCH) has antitumor activity and inhibits the growth of cancer cells by inducing apoptosis or programmed cell death. It also has antibacterial and fungal activity.
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AXC-715 trihydrochloride
T785 trihydrochloride
T722532479276-17-8
AXC-715 trihydrochloride (T785 trihydrochloride) is a TLR7 TLR8 dual agonist for the synthesis of antibody-adjuvanted immunocouplings. The couplings are mostly programmed death ligand 1 (PD-L1) attached to one or more antibody structures of the adjuvant.
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6-8 weeks
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PD-1-IN-17 (TFA) (1673560-66-1 free base)
PD-1-IN-17 (TFA)
T12377L
PD-1-IN-17 TFA is a inhibitor of programmed cell death-1 (PD-1) .
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3-6 months
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CA-170
PD-1-IN-1
T12378L1673534-76-3
PD-1-IN-1 is a programmed cell dealth-1inhibitor. PD-1-IN-1 can be used as an immune modulator.
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8-10 weeks
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PD1-PDL1-IN 1
T123872005454-12-4
PD1-PDL1-IN 1 is a potent inhibitor of programmed cell death 1 (PD-1),and used as immune modulator.
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6-8 weeks
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Lipid C2
T2036103003022-09-8
Lipid C2 is an ionizable cationic lipid utilized in the formation of lipid nanoparticles (LNP) for the delivery of mRNA in vivo. LNPs containing Lipid C2 and encapsulating mRNA reporter genes specifically accumulate in the liver and spleen of mice, while avoiding the heart, lungs, and kidneys. Additionally, LNPs with Lipid C2 that encapsulate mRNA encoding Epstein-Barr virus (EBV) protein Latent Membrane Protein 2 (LMP-2), when combined with anti-programmed cell death protein 1 (PD-1) antibodies, have been shown to reduce tumor size, reverse T cell exhaustion, increase the percentage of CD3+CD8+ central T cells and CD3+CD8+ effector memory T cells in the spleen, and decrease the percentage of CD3+T cells expressing Pd-1 in a CT26 mouse model of EBV-infected colon cancer.
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BG11
T2042613065877-52-0
BG11 promotes the accumulation of Fe2+ and intracellular lipid peroxides, leading to ferroptosis (iron-dependent cell death). It regulates the expression of Bax and Bcl-2 proteins, inducing apoptosis (programmed cell death) in MDA-MB-231 cells. BG11 also causes cell cycle arrest at the G0 G1 and S phases, inhibiting the proliferation of TNBC cancer cells, with IC50 values of 0.49 μM for MDA-MB-231 and 0.52 μM for BT549. Additionally, it reduces cell migration and invasion and demonstrates antitumor effects in mouse models.
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10-14 weeks
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UCD38B HCl
UCD38B hydrochloride,UCD 38 B hydrochloride,UCD-38-B HCl,UCD-38-B Hydrochloride,UCD 38 B HCl
T249201115177-19-9
UCD38B HCl is a cell-permeable intracellular uPA inhibitor that acts by killing proliferative and non-proliferative high-grade glioma cells by programmed necrosis.
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6-8 weeks
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12-Oxo phytodienoic acid
OPDA, 12-Oxo-Phytodienoic acid, 12-oxo PDA, 12-OPDA
T3380885551-10-6
12-Oxo phytodienoic acid (12-oxo PDA) is an endogenous signal converter that increases alkaloid biosynthesis in E. californica cell cultures, increases b. dioica tendril curls, And inhibited jasmonic acid-induced programmed cell death in conditioned A. fru mutants.
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CAY10774
T36034
CAY10774 is an inhibitor of the protein-protein interaction between programmed cell death 1 (PD-1) and its ligand PD-L1 (IC50= 15 nM in a homologous time-resolved fret (HTRF) assay).1It increases the activation of Jurkat cells expressing PD-1 in co-culture with artificial antigen-presenting cells (aAPCs) expressing PD-L1 (EC50= 6.6 μM in a reporter assay). CAY10774 increases surface expression of PD-1 on primary human CD4+and CD8+T cells co-cultured with aAPCs. 1.Konieczny, M., Musielak, B., Kocik, J., et al.Di-bromo-based small-molecule inhibitors of the PD-1/PD-L1 immune checkpointJ. Med. Chem.63(19)11271-11285(2020)
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LH1306
T360462182653-84-3
LH1306 is an inhibitor of the interaction between programmed cell death 1 (PD-1) and its ligand PD-L1 that has an IC50 value of 25 nM in a homologous time-resolved fluorescence (HTRF) assay.1 It increases the activation of Jurkat cells expressing PD-1 in co-culture with U2OS or CHO cells expressing PD-L1 (EC50s = 334 and 4,214 nM, respectively, in reporter assays). |1. Basu, S., Yang, J., Xu, B., et al. Design, synthesis, evaluation, and structural studies of C2-symmetric small molecule inhibitors of programmed cell death-1/programmed death-ligand 1 protein-protein interaction. J. Med. Chem. 62(15), 7250-7263 (2019).
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