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Cat No. | Product Name | Synonyms | Targets |
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T70841 | Osteosarcoma-IN-D14 | ||
Osteosarcoma-IN-D14 is an inhibitor of migration and invasion of osteosarcoma cells mediated by p53, regulating EMT-related genes. | |||
T21876 | DC_AC50 | Apoptosis , Others | |
DC_AC50 is a dual inhibitor of Atox1 and CCS (copper chaperones). Inhibiting intracellular copper chaperones as a means of reducing/preventing acquired chemotherapy resistance.DC_AC50 binding to Atox1 and CCS and reducin... | |||
T70839 | S 14063 | ||
S 14063 is a potent 5-HT1A receptor antagonist devoid of beta-adrenoceptor blocking properties. | |||
T9102 | WM-3835 | Apoptosis , Histone Methyltransferase , Histone Acetyltransferase | |
WM-3835 is a novel and high-specific small molecule inhibitor of Lysine Acetyltransferase 7 (KAT7, MYST2, HBO1) , able to potently suppressed OS cell proliferation and migration, and leads to apoptosis activation. | |||
T14364 | AZ-Dyrk1B-33 | 3-(2-Methyl-4-pyrimidinyl)-1-(phenylmethyl)-1H-pyrrolo[2,3-c]pyridine | DYRK |
AZ-Dyrk1B-33 (3-(2-Methyl-4-pyrimidinyl)-1-(phenylmethyl)-1H-pyrrolo[2,3-c]pyridine) is a potent and selective Dyrk1B kinase inhibitor with an IC50 of 7 nM. | |||
T13174 | TMPyP4 tosylate | TMP 1363 | DNA/RNA Synthesis , Telomerase |
TMPyP4 tosylate (TMP 1363) is a quadruplex-specific ligand and is a telomerase inhibitor with antitumor effects in osteosarcoma cell lines. | |||
T77448 | Naxitamab | Naxitamab-gqgk,Humanized 3F8,Hu3F8 | Others |
Naxitamab (Hu3F8) is a humanized monoclonal antibody against GD2 (hu3F8). Naxitamab has antitumor activity and can be used to study neuroblastoma, osteosarcoma, and other GD2-positive cancers. | |||
T0484 | Deracoxib | SC 46,SC 046,SC 59046 | Apoptosis , COX |
Deracoxib (SC 46) is a non-steroidal, non-narcotic anti-inflammatory drug. It is also a selective cyclooxygenase-2 inhibitor, and IC50 Value: 70 to 150 μM(inhibition of 3 osteosarcoma cell lines). | |||
T60039 | KSQ-4279 | USP1-IN-1 | PARP , DUB |
KSQ-4279 (USP1-IN-1) is an inhibitor of USP1 and PARP.KSQ-4279 has anticancer activity and is used in the study of non-small cell lung cancer, osteosarcoma, ovarian, breast, glioblastoma, bladder, uterine and pancreatic ... | |||
T26869 | BMS-986122 | BMS 986122 | Opioid Receptor |
BMS-986122 (BMS 986122) is a positive allosteric modulator of μ-opioid receptors that increases β-arrestin recruitment stimulated by endomorphin 1 in U2OS-OPRM1 human osteosarcoma cells expressing μ-opioid receptors (EC5... | |||
T12037 | Mifamurtide | L-MTP-PE,MTP-PE,CGP 19835 | Others |
Mifamurtide is a drug against osteosarcoma, is an immunomodulator with antitumor effects. | |||
T19559 | Seocalcitol | EB 1089 | Others |
Seocalcitol is an analog of vitamin D, binds vitamin D receptor protein from human osteosarcoma MG-63 cells(Kd : 0.27 nM). | |||
T26610 | AM-6761 | AM 6761,AM6761 | |
AM-6761 is a potent inhibitor of the MDM2-p53 interaction. In the SJSA-1 osteosarcoma xenograft model, AM-6761 shows excellent antitumor activity with an ED50 of 11 mg/kg. | |||
TP2332L | Mifamurtide sodium | Muramyl tripeptide,CGP 19835A,L-MTP-PE,Mepact,Junovan | |
Mifamurtide sodium is a drug against osteosarcoma, a kind of bone cancer mainly affecting children and young adults. It was approved in Europe in March 2009. | |||
T70983 | Zoledronate disodium | ||
Zoledronate disodium is an inhibitor of osteoclastogenesis and macrophage recruitment, decreasing bone turnover and stabilizing the bone matrix, exhibiting diverse anti-tumor effects in osteosarcoma. | |||
T35408 | (±)10(11)-EDP Ethanolamide | ||
(±)10(11)-EDP ethanolamide is an ω-3 endocannabinoid epoxide and cannabinoid (CB) receptor agonist (EC50s = 0.43 and 22.5 nM for CB1 and CB2 receptors, respectively). It is produced though direct epoxygenation of docosah... | |||
T35682 | 2-deoxy-2-fluoro-D-Glucose | ||
2-deoxy-2-fluoro-D-Glucose (2-FG) is a derivative of glucose with anticancer activity.1It inhibits the growth of 143B osteosarcoma cells grown under normoxic and hypoxic conditions when used at concentrations of 6 and 24... | |||
T76377 | Cdk2/Cyclin Inhibitory Peptide II | ||
Cdk2/Cyclin Inhibitory Peptide II (Tat-LDL), a CDK2 inhibitor, kills U2OS osteosarcoma cells in a dose-dependent manner [1] . | |||
T60975 | Antitumor agent-50 | ||
Antitumor agent-50 (compound 1a) is a thiazolidinone. Antitumor agent-50 is an effective antitumor agent that has the potential for the research of osteosarcoma (OS) [1]. | |||
T81353 | Pterostilbene-isothiocyanate | PTER-ITC | |
Pterostilbene-isothiocyanate (PTER-ITC) demonstrates strong anticancer properties in vitro, particularly disrupting the interaction between β-catenin and TCF-4 in human osteosarcoma cells [1]. | |||
T62480 | Antitumor agent-51 | ||
Antitumor agent-51 is effective and selective in inhibiting the growth and migration of osteosarcoma cells, acting on MNNG/HOS cells (IC50: 21.9 nM). antitumor agent-51 is less toxic and extremely bioavailable. | |||
TP2046 | TAT-cyclo-CLLFVY | ||
Selective HIF-1 dimerization inhibitor. Blocks protein-protein interaction of recombinant HIF-1α, but not HIF-2α, with HIF-1β (IC50 = 1.3 μM). Inhibits hypoxia-induced HIF-1 activity, and decreases VEGF and CAIX expressi... | |||
T76759 | Robatumumab | ||
Robatumumab (Sch 717454) is an anti-human IGF-1R ( insulin-like growth factor receptor-1 ) antibody. Robatumumab shows anti-tumor activity and anti-proliferative activity to cancer cells. Robatumumab can be used in osteo... | |||
T82327 | GEM–IB | ||
Gemcitabine-ibandronate (GEM–IB), a conjugate of gemcitabine (GEM)-5'-phosphate with ibandronate (IB), exhibits efficacy both as a monotherapy and synergistically with Docetaxel (DTX), resulting in diminished tumor burde... | |||
T62872 | PDGFR-IN-1 | ||
PDGFR-IN-1 (compound 7m) is an orally active PDGFR (platelet-derived growth factor receptor) inhibitor that acts on PDGFRα (IC50: 2.4 nM) and PDGFRβ (IC50: 0.9 nM). PDGFR-IN-1 exhibits strong anti-tumour effects and low ... | |||
T68511 | KRH102140 | ||
KRH102140 is a potent activator of PHD2. KRH102140, which has a structure similar to KRH102053. KRH102140 more efficiently suppressed HIF-1α than KRH102053 in human osteosarcoma cells under hypoxia. Furthermore, KRH10214... | |||
T35683 | 2-deoxy-D-Glucose-13C6 | 2-deoxy-D-Glucose-13C6 | |
2-deoxy-D-Glucose-13C6is intended for use as an internal standard for the quantification of 2-deoxy-D-glucose by GC- or LC-MS. 2-deoxy-D-Glucose is a glucose antimetabolite and an inhibitor of glycolysis.1,2It inhibits h... | |||
T76997 | Socazolimab | ||
Socazolimab (ZKAB001) is an anti- PD-L1 monoclonal antibody. Socazolimab has lasting safety and efficacy in the treatment of recurrent or metastatic cervical cancer . Socazolimab also has potential applications in small ... | |||
T36108 | YW3-56 (hydrochloride) (technical grade) | YW3-56 (hydrochloride) (technical grade) | |
YW3-56 is an inhibitor of protein arginine deiminase 2 (PAD2) and PAD4 (IC50s = 0.5-1 and 1-5 μM, respectively).1It inhibits the growth of U2OS osteosarcoma cells (IC50= ~2.5 μM) in a p53-dependent mannerviainduction of ... | |||
T74089 | Mifamurtide TFA | ||
Mifamurtide TFA (MTP-PE TFA), an analog of the muramyl dipeptide (MDP), is a nonspecific immunomodulator by stimulating the immune response activating macrophages and monocytes. Mifamurtide TFA, an orphan agent, is a spe... | |||
T35468 | (±)19(20)-EDP Ethanolamide | ||
(±)19(20)-EDP ethanolamide is an ω-3 endocannabinoid epoxide and cannabinoid (CB) receptor agonist (EC50s = 108 and 280 nM for CB1 and CB2, respectively). It is produced through direct epoxygenation of docosahexaenoyl et... | |||
T83854 | BRC4wt TFA | ||
BRC4wt, an acetylated peptide originating from the BRC4 repeat within human BRCA2 (1521-1536), acts as an inhibitor of the BRCA2 and RAD51 protein-protein interaction. When linked to the cationic cell-penetrating peptide... | |||
T83911 | CYY292 | ||
CYY292 is a chemical compound acting as an inhibitor of PDGFRα, PDGFRβ, FGFR1, -2, and -3, with respective IC50 values of 5.35, 4.6, 28, 28, and 78 nM. It exhibits selectivity over FGFR4 (IC50 > 1,000 nM) while also targ... | |||
T35604 | Osteocalcin (1-49) (human) (trifluoroacetate salt) | ||
Osteocalcin (1-49) is a non-collagenous peptide that is secreted by osteoblasts and odontoblasts and comprises 1-2% of the total protein in bone. Secretion of osteocalcin (1-49) is stimulated by 1,25-dihydroxy vitamin D ... |
Cat No. | Product Name | Synonyms | Targets |
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T3878 | Raddeanin A | NSC382873,Anemodeanin A,Raddeanin R3 | Apoptosis , HDAC |
Raddeanin A (NSC-382873) has moderate inhibitory activity against histone deacetylases (HDACs). Raddeanin A has high antiangiogenic potency, antitumor activity. | |||
T5S0803 | Columbamine | Columbamin,Dehydroisocorypalmine | Others |
Columbamine (Columbamin) shows strong activity with IC5 48.1 μM.Columbamine exerts anti-proliferative and anti-vasculogenic effects on metastatic human osteosarcoma U2OS cells with low toxicity. | |||
T5S0053 | Coptisine | Coptisin | Indoleamine 2,3-Dioxygenase (IDO) |
1. Coptisine (Coptisin) treatment increases cell viability based on its reversal effect on the enhanced activity of Indoleamine 2, 3-dioxygenase . 2. Coptisine treats myocardial I/R likely through suppressing myocardial ... | |||
T4S1335 | Daphnoretin | Dephnoretin,Thymelol | Influenza Virus , Caspase , PKC |
1. Daphnoretin (Thymelol) has strong antiviral activity, mainly on the later phase of the replication cycle. 2. Daphnoretin has anticancer effects on leukemia, osteosarcoma and uterine cervix cancer cells, might through ... | |||
T2S1837 | Steviol | NSC 226902,Hydroxydehydrostevic acid | Others |
1. Steviol (NSC-226902), a natural sweetener, it inhibits proliferation of the gastrointestinal cancer cells intensively. 2. Steviol can induce a significant increase in CYP3A29 expression. 3. Steviol inhibits the prolif... | |||
T3923 | Calycosin | Cyclosin,3'-Hydroxyformononetin | Apoptosis , Tyrosinase |
Calycosin (Cyclosin) acts as a selective estrogen receptor modulator. Calycosin induces apoptosis in human ovarian cancer SKOV3 cells by activating caspases and Bcl-2 family proteins. Calycosin suppresses breast cancer c... | |||
T6S1141 | Ganoderic acid A | Apoptosis , NF-κB , Endogenous Metabolite , Autophagy | |
1. Ganoderic acid A exhibits antitumor activity, mediated through its inhibitory effect on nuclear transcription factor-kappaB and activator protein-1. 2. Ganoderic acid A can induce proliferation inhibition, apoptosis a... | |||
TN4637 | Neogrifolin | PARP , GSK-3 , Akt , Caspase | |
Neogrifolin is a potential candidate for osteosarcoma, it can induce concentration- and time-dependent suppression of proliferation and induce apoptosis in U2OS and MG63 osteosarcoma cell lines; it exhibits inhibitory ac... | |||
TN6419 | Chamaejasmine | ||
Chamaejasmine could be a candidate drug for osteosarcoma and breast cancer chemoprevention, induces apoptosis in MG63 and HEp-2 cells by Akt inactivation and dephosphorylation of BAD. It inhibits Bcl-2 expression and ind... | |||
T3425 | Polyphyllin G | Polyphyllin VII,Polyphyllin VII,Y-0166 | Others |
Polyphyllin G (Polyphyllin VII), the the main member of polyphyllin family, shows strong anticancer activity against several carcinomas, including lung cancer, breast cancer, colorectal cancer, cervical cancer, hepatocel... | |||
TN3587 | Capillarisin | MMP , ERK , IL Receptor , BCL , VEGFR , TNF , NOS , NF-κB , TLR , MAPK , COX , DNA/RNA Synthesis , Prostaglandin Receptor , JNK , STAT | |
Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cells, it inhibits cancer cell growth of osteosarcoma cells by ... |
Cat No. | Product Name | Species | Expression System |
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TMPY-01462 | IL-11R alpha/IL-11RA Protein, Human, Recombinant (His) | Human | HEK293 |
Interleukin 11 receptor, alpha subunit (IL11RA/IL-11RA) is a subunit of the interleukin 11 receptor which is a member of the hematopoietic cytokine receptor family. IL11RA/IL-11RA is expressed in some cell lines, includi... | |||
TMPY-01250 | IL-11R alpha/IL-11RA Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Interleukin 11 receptor, alpha subunit (IL11RA/IL-11RA) is a subunit of the interleukin 11 receptor which is a member of the hematopoietic cytokine receptor family. IL11RA/IL-11RA is expressed in some cell lines, includi... | |||
TMPY-02671 | MFI2 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
MELTF (Melanotransferrin, also known as MFI2) is a Protein Coding gene. The protein encoded by this gene is a cell-surface glycoprotein found on melanoma cells. The protein shares sequence similarity and iron-binding pro... | |||
TMPY-02735 | MFI2 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 |
MELTF (Melanotransferrin, also known as MFI2) is a Protein Coding gene. The protein encoded by this gene is a cell-surface glycoprotein found on melanoma cells. The protein shares sequence similarity and iron-binding pro... | |||
TMPY-06607 | MFI2 Protein, Human, Recombinant (His) | Human | HEK293 |
MELTF (Melanotransferrin, also known as MFI2) is a Protein Coding gene. The protein encoded by this gene is a cell-surface glycoprotein found on melanoma cells. The protein shares sequence similarity and iron-binding pro... | |||
TMPY-03978 | TSPAN31 Protein, Human, Recombinant (mFc) | Human | HEK293 |
TSPAN31 is a member of the transmembrane 4 superfamily. Most members of this family are cell-surface proteins that are characterized by the presence of four hydrophobic domains. They mediate signal transduction events th... | |||
TMPJ-00692 | GAS7 Protein, Human, Recombinant (His) | Human | E. coli |
Growth Arrest-Specific Protein 7 (GAS7) is expressed primarily in terminalaly differentiated brain cells and predominantly in mature cerebellar Purkinje neurons. GAS7 may play a role in neuronal development by promoting ... | |||
TMPJ-00561 | SDC2 Protein, Human, Recombinant (His) | Human | Human Cells |
Syndecan-2 is a member of the Syndecans family comprised of type I transmembrane heparan sulfate proteoglycans (HSPG) that are involved in the regulation of many cellular processes. Four sub-types of mammalian Syndecans ... | |||
TMPJ-00799 | ANXA2 Protein, Human, Recombinant | Human | E. coli |
Annexin A2 (ANXA2) is a member of the annexin family and has roles in the regulation of cellular growth and in signal transduction pathways. ANXA2 protein is associated with sickle cell osteonecrosis and the expression r... | |||
TMPY-03046 | APCDD1 Protein, Human, Recombinant (hFc) | Human | HEK293 |
Osteosarcoma (OS) is the most common type of bone tumor in children and adults. The expression of APCDD1, a Wnt antagonist, was reduced in OS tissues and cells compared to adjacent normal tissue and osteoblast cells, res... | |||
TMPJ-00010 | CCL8 Protein, Human, Recombinant | Human | E. coli |
Human Chemokine (C-C Motif) Ligand 8 (CCL8) is produced by human MG63 osteosarcoma cells. CCL8 shares 62% and 58% amino acid sequence identity with MCP-1 and MCP-3, respectively. All three MCP proteins are monocyte chemo... | |||
TMPJ-00591 | CCL8 Protein, Human, Recombinant (His) | Human | Human Cells |
Human Chemokine (C-C Motif) Ligand 8 (CCL8) is produced by human MG63 osteosarcoma cells. CCL8 shares 62% and 58% amino acid sequence identity with MCP-1 and MCP-3, respectively. All three MCP proteins are monocyte chemo... | |||
TMPJ-00164 | IGFBP-5 Protein, Human, Recombinant (His & Avi), Biotinylated | Human | Human Cells |
Insulin-Like Growth Factor-Binding Protein 5 (IGFBP-5) is a secreted protein that belongs to the insulin-like growth factor (IGF) binding proteins superfamily. Members of this family prolong the half-life of the IGFs. Th... | |||
TMPY-03900 | IL-11R alpha/IL-11RA Protein, Canine, Recombinant | Canine | HEK293 |
Interleukin 11 receptor, alpha subunit (IL11RA/IL-11RA) is a subunit of the interleukin 11 receptor which is a member of the hematopoietic cytokine receptor family. IL11RA/IL-11RA is expressed in some cell lines, includi... | |||
TMPY-04097 | IL-11R alpha/IL-11RA Protein, Canine, Recombinant (His) | Canine | HEK293 |
Interleukin 11 receptor, alpha subunit (IL11RA/IL-11RA) is a subunit of the interleukin 11 receptor which is a member of the hematopoietic cytokine receptor family. IL11RA/IL-11RA is expressed in some cell lines, includi... | |||
TMPY-00304 | IL-11R alpha/IL-11RA Protein, Canine, Recombinant (hFc) | Canine | HEK293 |
Interleukin 11 receptor, alpha subunit (IL11RA/IL-11RA) is a subunit of the interleukin 11 receptor which is a member of the hematopoietic cytokine receptor family. IL11RA/IL-11RA is expressed in some cell lines, includi... |