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Search Results for " osteosarcoma "

34

Compounds

11

Natural Products

16

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T70841 Osteosarcoma-IN-D14
Osteosarcoma-IN-D14 is an inhibitor of migration and invasion of osteosarcoma cells mediated by p53, regulating EMT-related genes.
T21876 DC_AC50 Apoptosis , Others
DC_AC50 is a dual inhibitor of Atox1 and CCS (copper chaperones). Inhibiting intracellular copper chaperones as a means of reducing/preventing acquired chemotherapy resistance.DC_AC50 binding to Atox1 and CCS and reducin...
T70839 S 14063
S 14063 is a potent 5-HT1A receptor antagonist devoid of beta-adrenoceptor blocking properties.
T9102 WM-3835 Apoptosis , Histone Methyltransferase , Histone Acetyltransferase
WM-3835 is a novel and high-specific small molecule inhibitor of Lysine Acetyltransferase 7 (KAT7, MYST2, HBO1) , able to potently suppressed OS cell proliferation and migration, and leads to apoptosis activation.
T14364 AZ-Dyrk1B-33 3-(2-Methyl-4-pyrimidinyl)-1-(phenylmethyl)-1H-pyrrolo[2,3-c]pyridine DYRK
AZ-Dyrk1B-33 (3-(2-Methyl-4-pyrimidinyl)-1-(phenylmethyl)-1H-pyrrolo[2,3-c]pyridine) is a potent and selective Dyrk1B kinase inhibitor with an IC50 of 7 nM.
T13174 TMPyP4 tosylate TMP 1363 DNA/RNA Synthesis , Telomerase
TMPyP4 tosylate (TMP 1363) is a quadruplex-specific ligand and is a telomerase inhibitor with antitumor effects in osteosarcoma cell lines.
T77448 Naxitamab Naxitamab-gqgk,Humanized 3F8,Hu3F8 Others
Naxitamab (Hu3F8) is a humanized monoclonal antibody against GD2 (hu3F8). Naxitamab has antitumor activity and can be used to study neuroblastoma, osteosarcoma, and other GD2-positive cancers.
T0484 Deracoxib SC 46,SC 046,SC 59046 Apoptosis , COX
Deracoxib (SC 46) is a non-steroidal, non-narcotic anti-inflammatory drug. It is also a selective cyclooxygenase-2 inhibitor, and IC50 Value: 70 to 150 μM(inhibition of 3 osteosarcoma cell lines).
T60039 KSQ-4279 USP1-IN-1 PARP , DUB
KSQ-4279 (USP1-IN-1) is an inhibitor of USP1 and PARP.KSQ-4279 has anticancer activity and is used in the study of non-small cell lung cancer, osteosarcoma, ovarian, breast, glioblastoma, bladder, uterine and pancreatic ...
T26869 BMS-986122 BMS 986122 Opioid Receptor
BMS-986122 (BMS 986122) is a positive allosteric modulator of μ-opioid receptors that increases β-arrestin recruitment stimulated by endomorphin 1 in U2OS-OPRM1 human osteosarcoma cells expressing μ-opioid receptors (EC5...
T12037 Mifamurtide L-MTP-PE,MTP-PE,CGP 19835 Others
Mifamurtide is a drug against osteosarcoma, is an immunomodulator with antitumor effects.
T19559 Seocalcitol EB 1089 Others
Seocalcitol is an analog of vitamin D, binds vitamin D receptor protein from human osteosarcoma MG-63 cells(Kd : 0.27 nM).
T26610 AM-6761 AM 6761,AM6761
AM-6761 is a potent inhibitor of the MDM2-p53 interaction. In the SJSA-1 osteosarcoma xenograft model, AM-6761 shows excellent antitumor activity with an ED50 of 11 mg/kg.
TP2332L Mifamurtide sodium Muramyl tripeptide,CGP 19835A,L-MTP-PE,Mepact,Junovan
Mifamurtide sodium is a drug against osteosarcoma, a kind of bone cancer mainly affecting children and young adults. It was approved in Europe in March 2009.
T70983 Zoledronate disodium
Zoledronate disodium is an inhibitor of osteoclastogenesis and macrophage recruitment, decreasing bone turnover and stabilizing the bone matrix, exhibiting diverse anti-tumor effects in osteosarcoma.
T35408 (±)10(11)-EDP Ethanolamide
(±)10(11)-EDP ethanolamide is an ω-3 endocannabinoid epoxide and cannabinoid (CB) receptor agonist (EC50s = 0.43 and 22.5 nM for CB1 and CB2 receptors, respectively). It is produced though direct epoxygenation of docosah...
T35682 2-deoxy-2-fluoro-D-Glucose
2-deoxy-2-fluoro-D-Glucose (2-FG) is a derivative of glucose with anticancer activity.1It inhibits the growth of 143B osteosarcoma cells grown under normoxic and hypoxic conditions when used at concentrations of 6 and 24...
T76377 Cdk2/Cyclin Inhibitory Peptide II
Cdk2/Cyclin Inhibitory Peptide II (Tat-LDL), a CDK2 inhibitor, kills U2OS osteosarcoma cells in a dose-dependent manner [1] .
T60975 Antitumor agent-50
Antitumor agent-50 (compound 1a) is a thiazolidinone. Antitumor agent-50 is an effective antitumor agent that has the potential for the research of osteosarcoma (OS) [1].
T81353 Pterostilbene-isothiocyanate PTER-ITC
Pterostilbene-isothiocyanate (PTER-ITC) demonstrates strong anticancer properties in vitro, particularly disrupting the interaction between β-catenin and TCF-4 in human osteosarcoma cells [1].
T62480 Antitumor agent-51
Antitumor agent-51 is effective and selective in inhibiting the growth and migration of osteosarcoma cells, acting on MNNG/HOS cells (IC50: 21.9 nM). antitumor agent-51 is less toxic and extremely bioavailable.
TP2046 TAT-cyclo-CLLFVY
Selective HIF-1 dimerization inhibitor. Blocks protein-protein interaction of recombinant HIF-1α, but not HIF-2α, with HIF-1β (IC50 = 1.3 μM). Inhibits hypoxia-induced HIF-1 activity, and decreases VEGF and CAIX expressi...
T76759 Robatumumab
Robatumumab (Sch 717454) is an anti-human IGF-1R ( insulin-like growth factor receptor-1 ) antibody. Robatumumab shows anti-tumor activity and anti-proliferative activity to cancer cells. Robatumumab can be used in osteo...
T82327 GEM–IB
Gemcitabine-ibandronate (GEM–IB), a conjugate of gemcitabine (GEM)-5'-phosphate with ibandronate (IB), exhibits efficacy both as a monotherapy and synergistically with Docetaxel (DTX), resulting in diminished tumor burde...
T62872 PDGFR-IN-1
PDGFR-IN-1 (compound 7m) is an orally active PDGFR (platelet-derived growth factor receptor) inhibitor that acts on PDGFRα (IC50: 2.4 nM) and PDGFRβ (IC50: 0.9 nM). PDGFR-IN-1 exhibits strong anti-tumour effects and low ...
T68511 KRH102140
KRH102140 is a potent activator of PHD2. KRH102140, which has a structure similar to KRH102053. KRH102140 more efficiently suppressed HIF-1α than KRH102053 in human osteosarcoma cells under hypoxia. Furthermore, KRH10214...
T35683 2-deoxy-D-Glucose-13C6 2-deoxy-D-Glucose-13C6
2-deoxy-D-Glucose-13C6is intended for use as an internal standard for the quantification of 2-deoxy-D-glucose by GC- or LC-MS. 2-deoxy-D-Glucose is a glucose antimetabolite and an inhibitor of glycolysis.1,2It inhibits h...
T76997 Socazolimab
Socazolimab (ZKAB001) is an anti- PD-L1 monoclonal antibody. Socazolimab has lasting safety and efficacy in the treatment of recurrent or metastatic cervical cancer . Socazolimab also has potential applications in small ...
T36108 YW3-56 (hydrochloride) (technical grade) YW3-56 (hydrochloride) (technical grade)
YW3-56 is an inhibitor of protein arginine deiminase 2 (PAD2) and PAD4 (IC50s = 0.5-1 and 1-5 μM, respectively).1It inhibits the growth of U2OS osteosarcoma cells (IC50= ~2.5 μM) in a p53-dependent mannerviainduction of ...
T74089 Mifamurtide TFA
Mifamurtide TFA (MTP-PE TFA), an analog of the muramyl dipeptide (MDP), is a nonspecific immunomodulator by stimulating the immune response activating macrophages and monocytes. Mifamurtide TFA, an orphan agent, is a spe...
T35468 (±)19(20)-EDP Ethanolamide
(±)19(20)-EDP ethanolamide is an ω-3 endocannabinoid epoxide and cannabinoid (CB) receptor agonist (EC50s = 108 and 280 nM for CB1 and CB2, respectively). It is produced through direct epoxygenation of docosahexaenoyl et...
T83854 BRC4wt TFA
BRC4wt, an acetylated peptide originating from the BRC4 repeat within human BRCA2 (1521-1536), acts as an inhibitor of the BRCA2 and RAD51 protein-protein interaction. When linked to the cationic cell-penetrating peptide...
T83911 CYY292
CYY292 is a chemical compound acting as an inhibitor of PDGFRα, PDGFRβ, FGFR1, -2, and -3, with respective IC50 values of 5.35, 4.6, 28, 28, and 78 nM. It exhibits selectivity over FGFR4 (IC50 > 1,000 nM) while also targ...
T35604 Osteocalcin (1-49) (human) (trifluoroacetate salt)
Osteocalcin (1-49) is a non-collagenous peptide that is secreted by osteoblasts and odontoblasts and comprises 1-2% of the total protein in bone. Secretion of osteocalcin (1-49) is stimulated by 1,25-dihydroxy vitamin D ...

Compounds

Osteosarcoma-IN-D14
T70841
Synonym:
Target:
DC_AC50
T21876
Synonym:
Target: Apoptosis, Others
S 14063
T70839
Synonym:
Target:
WM-3835
T9102
Synonym:
Target: Apoptosis, Histone Methyltransferase, Histone Acetyltransferase
AZ-Dyrk1B-33
T14364
Synonym: 3-(2-Methyl-4-pyrimidinyl)-1-(phenylmethyl)-1H-pyrrolo[2,3-c]pyridine
Target: DYRK
TMPyP4 tosylate
T13174
Synonym: TMP 1363
Target: DNA/RNA Synthesis, Telomerase
Naxitamab
T77448
Synonym: Naxitamab-gqgk,Humanized 3F8,Hu3F8
Target: Others
Deracoxib
T0484
Synonym: SC 46,SC 046,SC 59046
Target: Apoptosis, COX
KSQ-4279
T60039
Synonym: USP1-IN-1
Target: PARP, DUB
BMS-986122
T26869
Synonym: BMS 986122
Target: Opioid Receptor
Mifamurtide
T12037
Synonym: L-MTP-PE,MTP-PE,CGP 19835
Target: Others
Seocalcitol
T19559
Synonym: EB 1089
Target: Others
AM-6761
T26610
Synonym: AM 6761,AM6761
Target:
Mifamurtide sodium
TP2332L
Synonym: Muramyl tripeptide,CGP 19835A,L-MTP-PE,Mepact,Junovan
Target:
Zoledronate disodium
T70983
Synonym:
Target:
(±)10(11)-EDP Ethanolamide
T35408
Synonym:
Target:
2-deoxy-2-fluoro-D-Glucose
T35682
Synonym:
Target:
Cdk2/Cyclin Inhibitory Peptide II
T76377
Synonym:
Target:
Antitumor agent-50
T60975
Synonym:
Target:
Pterostilbene-isothiocyanate
T81353
Synonym: PTER-ITC
Target:
Antitumor agent-51
T62480
Synonym:
Target:
TAT-cyclo-CLLFVY
TP2046
Synonym:
Target:
Robatumumab
T76759
Synonym:
Target:
GEM–IB
T82327
Synonym:
Target:
PDGFR-IN-1
T62872
Synonym:
Target:
KRH102140
T68511
Synonym:
Target:
2-deoxy-D-Glucose-13C6
T35683
Synonym: 2-deoxy-D-Glucose-13C6
Target:
Socazolimab
T76997
Synonym:
Target:
YW3-56 (hydrochloride) (technical grade)
T36108
Synonym: YW3-56 (hydrochloride) (technical grade)
Target:
Mifamurtide TFA
T74089
Synonym:
Target:
(±)19(20)-EDP Ethanolamide
T35468
Synonym:
Target:
BRC4wt TFA
T83854
Synonym:
Target:
CYY292
T83911
Synonym:
Target:
Osteocalcin (1-49) (human) (trifluoroacetate salt)
T35604
Synonym:
Target:
Cat No. Product Name Synonyms Targets
T3878 Raddeanin A NSC382873,Anemodeanin A,Raddeanin R3 Apoptosis , HDAC
Raddeanin A (NSC-382873) has moderate inhibitory activity against histone deacetylases (HDACs). Raddeanin A has high antiangiogenic potency, antitumor activity.
T5S0803 Columbamine Columbamin,Dehydroisocorypalmine Others
Columbamine (Columbamin) shows strong activity with IC5 48.1 μM.Columbamine exerts anti-proliferative and anti-vasculogenic effects on metastatic human osteosarcoma U2OS cells with low toxicity.
T5S0053 Coptisine Coptisin Indoleamine 2,3-Dioxygenase (IDO)
1. Coptisine (Coptisin) treatment increases cell viability based on its reversal effect on the enhanced activity of Indoleamine 2, 3-dioxygenase . 2. Coptisine treats myocardial I/R likely through suppressing myocardial ...
T4S1335 Daphnoretin Dephnoretin,Thymelol Influenza Virus , Caspase , PKC
1. Daphnoretin (Thymelol) has strong antiviral activity, mainly on the later phase of the replication cycle. 2. Daphnoretin has anticancer effects on leukemia, osteosarcoma and uterine cervix cancer cells, might through ...
T2S1837 Steviol NSC 226902,Hydroxydehydrostevic acid Others
1. Steviol (NSC-226902), a natural sweetener, it inhibits proliferation of the gastrointestinal cancer cells intensively. 2. Steviol can induce a significant increase in CYP3A29 expression. 3. Steviol inhibits the prolif...
T3923 Calycosin Cyclosin,3'-Hydroxyformononetin Apoptosis , Tyrosinase
Calycosin (Cyclosin) acts as a selective estrogen receptor modulator. Calycosin induces apoptosis in human ovarian cancer SKOV3 cells by activating caspases and Bcl-2 family proteins. Calycosin suppresses breast cancer c...
T6S1141 Ganoderic acid A Apoptosis , NF-κB , Endogenous Metabolite , Autophagy
1. Ganoderic acid A exhibits antitumor activity, mediated through its inhibitory effect on nuclear transcription factor-kappaB and activator protein-1. 2. Ganoderic acid A can induce proliferation inhibition, apoptosis a...
TN4637 Neogrifolin PARP , GSK-3 , Akt , Caspase
Neogrifolin is a potential candidate for osteosarcoma, it can induce concentration- and time-dependent suppression of proliferation and induce apoptosis in U2OS and MG63 osteosarcoma cell lines; it exhibits inhibitory ac...
TN6419 Chamaejasmine
Chamaejasmine could be a candidate drug for osteosarcoma and breast cancer chemoprevention, induces apoptosis in MG63 and HEp-2 cells by Akt inactivation and dephosphorylation of BAD. It inhibits Bcl-2 expression and ind...
T3425 Polyphyllin G Polyphyllin VII,Polyphyllin VII,Y-0166 Others
Polyphyllin G (Polyphyllin VII), the the main member of polyphyllin family, shows strong anticancer activity against several carcinomas, including lung cancer, breast cancer, colorectal cancer, cervical cancer, hepatocel...
TN3587 Capillarisin MMP , ERK , IL Receptor , BCL , VEGFR , TNF , NOS , NF-κB , TLR , MAPK , COX , DNA/RNA Synthesis , Prostaglandin Receptor , JNK , STAT
Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cells, it inhibits cancer cell growth of osteosarcoma cells by ...

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPY-01462 IL-11R alpha/IL-11RA Protein, Human, Recombinant (His) Human HEK293
Interleukin 11 receptor, alpha subunit (IL11RA/IL-11RA) is a subunit of the interleukin 11 receptor which is a member of the hematopoietic cytokine receptor family. IL11RA/IL-11RA is expressed in some cell lines, includi...
TMPY-01250 IL-11R alpha/IL-11RA Protein, Mouse, Recombinant (His) Mouse HEK293
Interleukin 11 receptor, alpha subunit (IL11RA/IL-11RA) is a subunit of the interleukin 11 receptor which is a member of the hematopoietic cytokine receptor family. IL11RA/IL-11RA is expressed in some cell lines, includi...
TMPY-02671 MFI2 Protein, Mouse, Recombinant (His) Mouse HEK293
MELTF (Melanotransferrin, also known as MFI2) is a Protein Coding gene. The protein encoded by this gene is a cell-surface glycoprotein found on melanoma cells. The protein shares sequence similarity and iron-binding pro...
TMPY-02735 MFI2 Protein, Mouse, Recombinant (hFc) Mouse HEK293
MELTF (Melanotransferrin, also known as MFI2) is a Protein Coding gene. The protein encoded by this gene is a cell-surface glycoprotein found on melanoma cells. The protein shares sequence similarity and iron-binding pro...
TMPY-06607 MFI2 Protein, Human, Recombinant (His) Human HEK293
MELTF (Melanotransferrin, also known as MFI2) is a Protein Coding gene. The protein encoded by this gene is a cell-surface glycoprotein found on melanoma cells. The protein shares sequence similarity and iron-binding pro...
TMPY-03978 TSPAN31 Protein, Human, Recombinant (mFc) Human HEK293
TSPAN31 is a member of the transmembrane 4 superfamily. Most members of this family are cell-surface proteins that are characterized by the presence of four hydrophobic domains. They mediate signal transduction events th...
TMPJ-00692 GAS7 Protein, Human, Recombinant (His) Human E. coli
Growth Arrest-Specific Protein 7 (GAS7) is expressed primarily in terminalaly differentiated brain cells and predominantly in mature cerebellar Purkinje neurons. GAS7 may play a role in neuronal development by promoting ...
TMPJ-00561 SDC2 Protein, Human, Recombinant (His) Human Human Cells
Syndecan-2 is a member of the Syndecans family comprised of type I transmembrane heparan sulfate proteoglycans (HSPG) that are involved in the regulation of many cellular processes. Four sub-types of mammalian Syndecans ...
TMPJ-00799 ANXA2 Protein, Human, Recombinant Human E. coli
Annexin A2 (ANXA2) is a member of the annexin family and has roles in the regulation of cellular growth and in signal transduction pathways. ANXA2 protein is associated with sickle cell osteonecrosis and the expression r...
TMPY-03046 APCDD1 Protein, Human, Recombinant (hFc) Human HEK293
Osteosarcoma (OS) is the most common type of bone tumor in children and adults. The expression of APCDD1, a Wnt antagonist, was reduced in OS tissues and cells compared to adjacent normal tissue and osteoblast cells, res...
TMPJ-00010 CCL8 Protein, Human, Recombinant Human E. coli
Human Chemokine (C-C Motif) Ligand 8 (CCL8) is produced by human MG63 osteosarcoma cells. CCL8 shares 62% and 58% amino acid sequence identity with MCP-1 and MCP-3, respectively. All three MCP proteins are monocyte chemo...
TMPJ-00591 CCL8 Protein, Human, Recombinant (His) Human Human Cells
Human Chemokine (C-C Motif) Ligand 8 (CCL8) is produced by human MG63 osteosarcoma cells. CCL8 shares 62% and 58% amino acid sequence identity with MCP-1 and MCP-3, respectively. All three MCP proteins are monocyte chemo...
TMPJ-00164 IGFBP-5 Protein, Human, Recombinant (His & Avi), Biotinylated Human Human Cells
Insulin-Like Growth Factor-Binding Protein 5 (IGFBP-5) is a secreted protein that belongs to the insulin-like growth factor (IGF) binding proteins superfamily. Members of this family prolong the half-life of the IGFs. Th...
TMPY-03900 IL-11R alpha/IL-11RA Protein, Canine, Recombinant Canine HEK293
Interleukin 11 receptor, alpha subunit (IL11RA/IL-11RA) is a subunit of the interleukin 11 receptor which is a member of the hematopoietic cytokine receptor family. IL11RA/IL-11RA is expressed in some cell lines, includi...
TMPY-04097 IL-11R alpha/IL-11RA Protein, Canine, Recombinant (His) Canine HEK293
Interleukin 11 receptor, alpha subunit (IL11RA/IL-11RA) is a subunit of the interleukin 11 receptor which is a member of the hematopoietic cytokine receptor family. IL11RA/IL-11RA is expressed in some cell lines, includi...
TMPY-00304 IL-11R alpha/IL-11RA Protein, Canine, Recombinant (hFc) Canine HEK293
Interleukin 11 receptor, alpha subunit (IL11RA/IL-11RA) is a subunit of the interleukin 11 receptor which is a member of the hematopoietic cytokine receptor family. IL11RA/IL-11RA is expressed in some cell lines, includi...
IL-11R alpha/IL-11RA Protein, Human, Recombinant (His)
TMPY-01462
Species: Human
Expression System: HEK293
IL-11R alpha/IL-11RA Protein, Mouse, Recombinant (His)
TMPY-01250
Species: Mouse
Expression System: HEK293
MFI2 Protein, Mouse, Recombinant (His)
TMPY-02671
Species: Mouse
Expression System: HEK293
MFI2 Protein, Mouse, Recombinant (hFc)
TMPY-02735
Species: Mouse
Expression System: HEK293
MFI2 Protein, Human, Recombinant (His)
TMPY-06607
Species: Human
Expression System: HEK293
TSPAN31 Protein, Human, Recombinant (mFc)
TMPY-03978
Species: Human
Expression System: HEK293
GAS7 Protein, Human, Recombinant (His)
TMPJ-00692
Species: Human
Expression System: E. coli
SDC2 Protein, Human, Recombinant (His)
TMPJ-00561
Species: Human
Expression System: Human Cells
ANXA2 Protein, Human, Recombinant
TMPJ-00799
Species: Human
Expression System: E. coli
APCDD1 Protein, Human, Recombinant (hFc)
TMPY-03046
Species: Human
Expression System: HEK293
CCL8 Protein, Human, Recombinant
TMPJ-00010
Species: Human
Expression System: E. coli
CCL8 Protein, Human, Recombinant (His)
TMPJ-00591
Species: Human
Expression System: Human Cells
IGFBP-5 Protein, Human, Recombinant (His & Avi), Biotinylated
TMPJ-00164
Species: Human
Expression System: Human Cells
IL-11R alpha/IL-11RA Protein, Canine, Recombinant
TMPY-03900
Species: Canine
Expression System: HEK293
IL-11R alpha/IL-11RA Protein, Canine, Recombinant (His)
TMPY-04097
Species: Canine
Expression System: HEK293
IL-11R alpha/IL-11RA Protein, Canine, Recombinant (hFc)
TMPY-00304
Species: Canine
Expression System: HEK293
TargetMol