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Results for "

nonpeptide

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    75
    TargetMol | Inhibitors_Agonists
  • Natural Products
    1
    TargetMol | Natural_Products
Lanepitant
LY303870, LY-303870, LY 303870
T25615170566-84-4In house
Lanepitant (LY303870) is a nonpeptide neurokinin-1 (NK-1) antagonist with analgesic activity that inhibits neurogenic dura mater inflammation and is used for the prevention of migraine.
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L-162,313
L-162313, L 162,313, L162,313
T27762151488-11-8In house
L-162,313 is an ANG II receptor agonist, a nonpeptide that mimics the biological actions of angiotensin II and induces an increase in MAP.
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6-8 weeks
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Nebentan potassium
YM598
T36008342005-82-7In house
Nebentan potassium (YM598) is an orally active and selective nonpeptide endothelin receptor (ETA receptor) antagonist.Nebentan potassium inhibits pulmonary arterial hypertension and may be useful in the study of neurologic and cardiovascular diseases.
  • Inquiry Price
7-10 days
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AM-8123
T394422049973-02-4In house
AM-8123 is an orally available nonpeptide APJ agonist.AM-8123 reduces collagen load and improves cardiac function. AM-8123 ameliorates myocardial infarction in rats and can be used to study cardiovascular diseases such as heart failure.
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SB273005
T6657205678-31-5In house
SB273005 is an orally active and potent nonpeptide integrin αvβ3 antagonist that inhibits αvβ3 and αvβ5 and reduces the production of Th2 cells and the cytokine IL-10 in pregnant mice.
  • Inquiry Price
4-6 weeks
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Aliskiren hemifumarate
CGP 60536, SPP 100, CGP60536B
T1520173334-58-2
Aliskiren hemifumarate (CGP60536B) is an orally active nonpeptide renin inhibitor with antihypertensive activity.
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Eltrombopag Olamine
Promacta Olamine, Revolade, Eltrombopag diethanolamine salt, SB497115, SB-497115GR
T6825496775-62-3
Eltrombopag Olamine (Eltrombopag diethanolamine salt) is an orally active small-molecule, nonpeptide thrombopoietin receptor agonist that stimulates megakaryopoiesis. It binds to and activates the transmembrane domain of the platelet thrombopoietin receptor (TPO-R or CD110), promoting the proliferation and differentiation of megakaryocytic cells and enhancing platelet production.
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SCH79797 dihydrochloride
T128701216720-69-2
SCH79797 dihydrochloride is an effective and selective antagonist of protease activated receptor 1 (PAR1) with an IC50 of 70 nM and a Ki of 35 nM. SCH79797 dihydrochloride has antiproliferative and pro-apoptotic effects.
  • Inquiry Price
6-8 weeks
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TargetMol | Inhibitor Sale
BMS 182874 hydrochloride
T217901215703-04-0
BMS 182874 hydrochloride is a nonpeptide endothelin (El) receptor antagonist.
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TargetMol | Inhibitor Sale
(R)-Elagolix
NBI-56418
T11174834153-87-6
(R)-Elagolix (NBI-56418) is a short-acting, nonpeptide, GnRH antagonist with an IC50 and Ki of 0.25 and 3.7 nM, respectively. administered orally, that unlike injectable depot GnRH agonists and antagonists, produces a dose-dependent suppression of ovarian estrogen production, that is, from partial suppression at lower doses to full suppression at higher doses.
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Ivachtin
Caspase-3 Inhibitor VII
T11696745046-84-8
Ivachtin (Caspase-3 Inhibitor VII) is a nonpeptide, noncompetitive and reversibl caspase-3 inhibitor(IC50 = 23 nM) and is a modest inhibitor of the remaining caspases.
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L-368,899 hydrochloride
L-368899 hydrochloride, L-368,899 HCl
T11794160312-62-9
L-368,899 hydrochloride is an orally available and selective nonpeptide oxytocin receptor (OXTR) antagonist for the prevention of preterm labor.L-368,899 hydrochloride prevents oxytocin-induced anti-anomalous pain and anti-nausea, and may be useful for the study of depression.
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7-10 days
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LIT-001 free base
T118562245072-20-0
LIT-001 free base improves social interaction in a mouse model of autism. LIT-001 free base is the first nonpeptide oxytocin receptor (OT-R) agonist (EC50=55 nM; Ki=226 nM).
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10-14 weeks
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LIT-001
T118572245072-21-1
LIT-001 improves social interaction in a mouse model of autism.It is the first nonpeptide oxytocin receptor agonist with EC50 of 55 nM and Ki of 226 nM.
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LMD-009
T11862950195-51-4
LMD-009 mediates chemotaxis, inositol phosphate accumulation, and calcium release in high potencies with EC50s from 11 to 87 nM. LMD-009 is a selective CCR8 nonpeptide agonist.
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8-10 weeks
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OT-R antagonist 2
Oxytocin receptor antagonist 2
T12331364071-16-9
OT-R antagonist 2 is a nonpeptide, low molecular weight antagonist of OT-R (oxytocin receptor).
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3-6 months
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OT-R antagonist 1
Oxytocin receptor antagonist 1
T12331L364071-17-0
OT-R antagonist 1 inhibits oxytocin-evoked intracellular Ca2+ mobilization (IC50 = 8 nM). OT-R antagonist 1 is a new effective and selective nonpeptide low molecular weight OT-R antagonist.
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3-6 months
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Proglumide hemicalcium
T1254485068-56-0
Proglumide hemicalcium is a antagonist of nonpeptide and orally active cholecystokinin (CCK)-A B receptors, has antiepileptic and antioxidant activities.
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3-6 months
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A-192621
T14068195529-54-5
A-192621 is a potent, nonpeptide, orally active, and selective endothelin B (ETB) receptor antagonist with an IC50 of 4.5 nM and a Ki of 8.8 nM. A-192621 promotes apoptosis in PASMCs and elevates both arterial blood pressure and plasma ET-1 levels[1][2][3]. Its selectivity is 636-fold higher for ETB than ETA (IC50 of 4280 nM and Ki of 5600 nM).
    7-10 days
    Inquiry
    AVE 0991 sodium salt
    T14354306288-04-0
    AVE 0991 competes for high-affinity binding of [125I]-Ang-(1-7) to bovine aortic endothelial cell membranes, with IC50 of 21±35 nM. AVE 0991 sodium salt is a nonpeptide and orally active Ang-(1-7) receptor Mas agonist.
    • Inquiry Price
    7-10 days
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    Devazepide
    L-364,718, MK-329
    T15101103420-77-5
    Devazepide is a competitive and orally active nonpeptide antagonist of cholecystokinin (CCK) receptor (IC50s: 81 pM, 45 pM, and 245 nM for rat pancreatic, bovine gallbladder and guinea pig brain CCK receptors, respectively).
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    7-10 days
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    FR167344 free base
    T15347215258-13-2
    FR167344 free base is an orally active, nonpeptide antagonist of the bradykinin receptor B2, exhibiting high-affinity binding (IC50: 65 nM) and showing no binding affinity for the B1 receptor.
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    3-6 months
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    L-159282
    MK 996
    T15680157263-00-8
    L-159282 is an orally active and nonpeptide angiotensin II receptor antagonist. It also has anti-hypertensive activity.
    • Inquiry Price
    6-8 weeks
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    mk-0429
    L-000845704
    T16085227963-15-7
    MK-0429 is an orally active, selective, and nonpeptide antagonist of αvβ3 integrin (IC50: 80 nM).
    • Inquiry Price
    7-10 days
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