Search Result

Search Results for " non-nucleoside "

Targets

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T9103	BVDV-IN-1		DNA/RNA Synthesis
	BVDV-IN-1 is a non-nucleoside inhibitor (NNI) of bovine viral diarrhea virus (BVDV), with an EC50 of 1.8 μM. It directly binds to a hydrophobic pocket of the BVDV RdRp. It has antiviral activity against BVDV resistant to...		DNA/RNA Synthesis
T6729	Lomibuvir	VX-222,VCH-222	HCV Protease
	Lomibuvir (VCH-222) (VX-222) is a selective, non-nucleoside allosteric inhibitor of HCV NS5B polymerase (RdRp) with a Kd of 17 nM. Lomibuvir inhibits the 1b/Con1 HCV subgenomic replicon with an EC 50 of 5.2 nM. Lomibuvir...		HCV Protease
T2330	Rilpivirine	TMC278,R278474,DB08864	HIV Protease , Reverse Transcriptase
	Rilpivirine (R278474) is a diarylpyrimidine derivative and reverse transcriptase inhibitor with antiviral activity against HIV-1 that is used in the treatment of HIV infections.		HIV Protease , Reverse Transcriptase
T7700	Lersivirine	Lersivirine(UK 453061),UK-453061	HIV Protease , Reverse Transcriptase
	Lersivirine (UK-453061)(UK 453061) is a second-generation non-nucleoside reverse transcriptase inhibitor (NNRTI) under development for HIV infection therapy.		HIV Protease , Reverse Transcriptase
T2393	Efavirenz	EFV,DMP 266,Sustiva,Stocrin,L-743726	HIV Protease , Reverse Transcriptase , Autophagy
	Efavirenz (DMP 266) is a Human Immunodeficiency Virus 1 Non-Nucleoside Analog Reverse Transcriptase Inhibitor. The mechanism of action of efavirenz is as a Non-Nucleoside Reverse Transcriptase Inhibitor, and Cytochrome P...		HIV Protease , Reverse Transcriptase , Autophagy
T3172	Trovirdine	LY300046	HIV Protease
	Trovirdine (LY300046) is a thiourea non-nucleoside reverse transcriptase inhibitor.		HIV Protease
T1815	Dapivirine	R147681,TMC120	Apoptosis , HIV Protease , Reverse Transcriptase , Autophagy
	Dapivirine (R147681) is a diarylpyrimidine non-nucleoside reverse transcriptase inhibitor.
T68103L	Mk-6186 HCl	Mk-6186 HCl（1034474-19-5 Free base)	HIV Protease , Reverse Transcriptase
	MK-6186 HCl, a novel non-nucleoside reverse transcriptase inhibitor with antiviral activity, can be used to study HIV.		HIV Protease , Reverse Transcriptase
T68103	MK-6186		Reverse Transcriptase
	MK-6186 is a novel non-nucleoside reverse transcriptase inhibitor with antiviral activity for the study of viral infections.		Reverse Transcriptase
T31860	Fosdevirine	GSK-2248761A,IDX 899,GSK 2248761A,GSK 2248761,GSK-2248761,IDX-12899,GSK2248761,FDV,GSK2248761A	HIV Protease
	Fosdevirine (GSK2248761) is a selective and potent non-nucleoside reverse transcriptase (NNRTI) inhibitor with anti-HIV activity for the study of neurological related disorders such as late-onset epilepsy.		HIV Protease
T67788	BAY-43-9695		HCV Protease
	BAY-43-9695 is a non-nucleoside compound with anti-human cytomegalovirus (HCMV) activity. It is the major metabolite of BAY-38-4766.		HCV Protease
T67804	KM-023		HIV Protease
	KM-023 is a new second-generation non-nucleoside reverse transcriptase inhibitor for the study of human immunodeficiency virus (HIV) type 1 infection.		HIV Protease
T3632	Doravirine	MK-1439	HIV Protease , Reverse Transcriptase
	Doravirine (MK-1439) is a non-nucleoside reverse transcriptase inhibitor, used in the treatment of HIV/AIDS.		HIV Protease , Reverse Transcriptase
T7212	Delavirdine mesylate	U 90152 (mesylate),BHAP-U 90152 (mesylate),Delavirdine (mesylate)	HIV Protease , Reverse Transcriptase
	Delavirdine mesylate (BHAP-U 90152 (mesylate)) is a non-nucleoside reverse transcriptase inhibitor (NNRTI).		HIV Protease , Reverse Transcriptase
T1595	Nevirapine	NSC 641530,BI-RG 587,NVP	HIV Protease , Reverse Transcriptase
	Nevirapine (NVP) is a benzodiazepine non-nucleoside reverse transcriptase inhibitor. In combination with other antiretroviral drugs, nevirapine reduces HIV viral loads and increases CD4 counts, thereby retarding or preve...		HIV Protease , Reverse Transcriptase
T3489	Dasabuvir	ABT-333	HCV Protease
	Dasabuvir (ABT-333) is a non-nucleoside inhibitor of the hepatitis C virus (HCV) non-structural protein 5B (NS5B), an RNA-dependent RNA polymerase, with potential activity against HCV. Upon administration and after intra...		HCV Protease
T31860L	(Iso)-Fosdevirine	(Iso)-Fosdevirine（Iso-1018450-26-4）,(Iso)-GSK2248761	HIV Protease
	(Iso)-Fosdevirine ( (Iso)-GSK2248761) is a selective and potent non-nucleoside reverse transcriptase (NNRTI) inhibitor with anti-HIV activity for the study of neurological disorders such as late-onset epilepsy.		HIV Protease
T29037	UC-781	NSC 675186,UC781,UC 781	Antiviral , HIV Protease
	UC-781 (NSC-675186) is a potent and selective inhibitor of human immunodeficiency virus HIV-1 non-nucleoside reverse transcriptase (NNRTI) I with a C50 value of 5 nM.UC-781 exhibits both antiviral activity and drug resis...		Antiviral , HIV Protease
T2551	Etravirine	TMC125,R165335	HIV Protease , Reverse Transcriptase
	Etravirine (R165335) is a diarylpyrimidine non-nucleoside reverse transcriptase inhibitor. Etravirine is designed to be active against HIV isolates with mutations that confer resistance to the two most commonly prescribe...		HIV Protease , Reverse Transcriptase
T8655	SR-717		STING
	SR-717 is a cGAMP analog, a non-nucleoside STING agonist that induces a "closed" activation conformation of STING. SR-717 has antitumor activity and promotes activation of immune cells and cross-presentation of antigens.		STING
T28762	Setrobuvir	RO-5466731,ANA-598,RG7790,ANA598,RG-7790	HCV Protease , SARS-CoV , DNA/RNA Synthesis
	Setrobuvir (ANA-598) is an orally active non-nucleoside HCV NS5B polymerase inhibitor with inhibitory effects on de novo RNA synthesis and primer extension with IC50s between 4 and 5 nM. setrobuvir shows good binding aff...		HCV Protease , SARS-CoV , DNA/RNA Synthesis
T38237	2′-O-Methylcytidine		Nucleoside Antimetabolite/Analog , HCV Protease
	2'-O-Methylcytidine is a nucleoside derivative and an inhibitor of hepatitis C virus (HCV) non-structural protein 5B (NS5B; IC50= 3.8 μM).1It inhibits HCV replication in a replicon assay (IC50= 21.2 μM). 1.Migliaccio, G....		Nucleoside Antimetabolite/Analog , HCV Protease
T27625	IQP-0528	SJ-3991,SJ3991,IQP0528	Antiviral , HIV Protease , Reverse Transcriptase
	IQP-0528 is a potent non-nucleoside reverse transcriptase inhibitor (NNRTI) that has potential for the treatment of HIV infection by blocking viral entry and shows antiviral activity as a microbicidal gel. . IQP-0528 sho...		Antiviral , HIV Protease , Reverse Transcriptase
T21537L	TMC647055 Choline Hydroxide Salt	TMC647055 Choline Hydroxide Salt (1204416-97-6 free base)	HCV Protease
	TMC647055 Choline Hydroxide Salt is a novel and potent non-nucleoside inhibitor of the HCV NS5B polymerase which potentially for the treatment of HCV infection. It has nanomolar cellular potency (EC(50) of 82 nM) with mi...		HCV Protease
T28204	NSC-176377	NSC 176377
	NSC-176377 is a non-nucleoside reverse transcriptase inhibitor.
T2330L	Rilpivirine HCl	Rilpivirine hydrochloride,TMC278,Rilpivirine,TMC-278,TMC 278. trade name Edurant
	Rilpivirine is a potent non-nucleoside reverse transcriptase inhibitor.
T27542	HI-207	HI207,HI 207
	HI-207 is an inhibitor of non-nucleoside reverse transcriptase.
T23968	DC_501	DC 501,DC501
	DC_501 is a selective non-nucleoside DNA methyltransferase 1 inhibitor.
T25493	HEPT
	HEPT is a non-nucleoside inhibitor of HIV-1 reverse transcription.
T24087	GCA-186	I-EBU-dM,IEBUdM,I EBU dM,GCA 186
	GCA-186 is an effective non-nucleoside HIV-1 reverse transcriptase inhibitor.
T24354	L 738372	L-738,372,L 738,372,L738372,L738,372,L-738372
	L 738372 is a non-nucleoside inhibitor of HIV-1 reverse transcriptase.
T27384	FR-234938	FR 234938
	FR-234938 is a non-nucleoside adenosine deaminase inhibitor with anti-inflammatory activity.
T25501	HI-236	HI 236,D-PBT,D PBT,DPBT
	HI-236 is used as a non-nucleoside HIV-1 reverse-transcriptase inhibitor.
T70794	Nevirapine dimer
	Nevirapine dimer is a non-nucleoside reverse transcriptase inhibitor (NNRTI).
T33435	MK-4965
	MK-4965 is a new type of non-nucleoside reverse transcriptase inhibitor with antiviral activity.
T69435	GW-4511
	GW-4511 is a benzophenone non-nucleoside HIV-1 reverse transcriptase inhibitor.
T26946	Capravirine	S-1153,AG1549,S1153,AG-1549,AG 549
	Capravirine, a non-nucleoside reverse transcriptase inhibitor, is used potentially for the treatment of HIV infection.
T28507	RDEA-427	RDEA 427
	RDEA-427, a non-nucleoside reverse transcriptase inhibitor, is used potentially for the treatment of HIV infection.
T26940	Calanolide A	NSC 675451,NSC675451,NSC-675451
	Calanolide A, a non-nucleoside reverse transcriptase inhibitor, is used potentially for the treatment of HIV infection.
T27512	GW-695634	GW5634,GW695634,GW-5634G,GW-5634
	GW-695634, a non-nucleoside reverse transcriptase inhibitor, is used potentially for the treatment of HIV infection.
T70545	HI-253
	HI-253 is a potent non-nucleoside inhibitor of drug-resistant human immunodeficiency virus (HIV).
T70851	U 88204
	U 88204 is a non-nucleoside HIV-1 reverse transcriptase inhibitor.
T68450	IDX-989
	IDX-989 is an HIV-1 non-nucleoside reverse transcriptase inhibitor.
T71566	MK-7445
	MK-7445 is a conformationally constrained inhibitor of non-nucleoside reverse transcriptase.
T70156	K-5a2
	K-5a2 is a novel human immunodeficiency virus type 1 (HIV-1) non-nucleoside reverse transcriptase inhibitor (NNRTI).
T31369	Deleobuvir	BI207127,BI-207127,BI 207127,BI-207127NA
	Deleobuvir(BI207127) is an inhibitor of non-nucleoside hepatitis C virus NS5B polymerase for the treatment of hepatitis C.
T69796	Nevirapine hemihydrate
	Nevirapine hemihydrate is a non-nucleoside reverse transcriptase inhibitor (NNRTI) studied for potential treatment of HIV-1 infection and AIDS.
T27383	FR-221647
	FR-221647 is a non-nucleoside adenosine deaminase inhibitor, it has moderate activity and good pharmacokinetics compared with the known inhibitors EHNA and pentostatin.
T71517	Nevirapine quinone methide
	Nevirapine quinone methide is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used to treat HIV-1 infection and AIDS.
T24839	Stampidine	HI-113,HI 113,HI113
	Stampidine can prevent the sexual transmission of HIV-1. It exhibited remarkable subnanomolar to low nanomolar in vitro antiretroviral potency against nucleoside reverse transcriptase inhibitor-resistant primary clinical...

Compounds

BVDV-IN-1

T9103

Synonym:

Target: DNA/RNA Synthesis

Lomibuvir

T6729

Synonym: VX-222,VCH-222

Target: HCV Protease

Rilpivirine

T2330

Synonym: TMC278,R278474,DB08864

Target: HIV Protease, Reverse Transcriptase

Lersivirine

T7700

Synonym: Lersivirine(UK 453061),UK-453061

Target: HIV Protease, Reverse Transcriptase

Efavirenz

T2393

Synonym: EFV,DMP 266,Sustiva,Stocrin,L-743726

Target: HIV Protease, Reverse Transcriptase, Autophagy

Synonym: R147681,TMC120

Target: Apoptosis, HIV Protease, Reverse Transcriptase, Autophagy

Mk-6186 HCl

T68103L

Synonym: Mk-6186 HCl（1034474-19-5 Free base)

Target: HIV Protease, Reverse Transcriptase

MK-6186

T68103

Synonym:

Target: Reverse Transcriptase

Fosdevirine

T31860

Synonym: GSK-2248761A,IDX 899,GSK 2248761A,GSK 2248761,GSK-2248761,IDX-12899,GSK2248761,FDV,GSK2248761A

Target: HIV Protease, Reverse Transcriptase

Delavirdine mesylate

T7212

Synonym: U 90152 (mesylate),BHAP-U 90152 (mesylate),Delavirdine (mesylate)

Target: HIV Protease, Reverse Transcriptase

Nevirapine

T1595

Synonym: NSC 641530,BI-RG 587,NVP

Target: HIV Protease, Reverse Transcriptase

Synonym: (Iso)-Fosdevirine（Iso-1018450-26-4）,(Iso)-GSK2248761

Target: HIV Protease

UC-781

T29037

Synonym: NSC 675186,UC781,UC 781

Target: Antiviral, HIV Protease

Etravirine

T2551

Synonym: TMC125,R165335

Target: HIV Protease, Reverse Transcriptase

Synonym: RO-5466731,ANA-598,RG7790,ANA598,RG-7790

Target: HCV Protease, SARS-CoV, DNA/RNA Synthesis

2′-O-Methylcytidine

T38237

Synonym:

Target: Nucleoside Antimetabolite/Analog, HCV Protease

IQP-0528

T27625

Synonym: SJ-3991,SJ3991,IQP0528

Target: Antiviral, HIV Protease, Reverse Transcriptase

TMC647055 Choline Hydroxide Salt

T21537L

Synonym: TMC647055 Choline Hydroxide Salt (1204416-97-6 free base)

Synonym: Rilpivirine hydrochloride,TMC278,Rilpivirine,TMC-278,TMC 278. trade name Edurant

Target:

HI-207

T27542

Synonym: HI207,HI 207

Target:

DC_501

T23968

Synonym: DC 501,DC501

Synonym: I-EBU-dM,IEBUdM,I EBU dM,GCA 186

Target:

L 738372

T24354

Synonym: L-738,372,L 738,372,L738372,L738,372,L-738372

Synonym: HI 236,D-PBT,D PBT,DPBT

Synonym: S-1153,AG1549,S1153,AG-1549,AG 549

Synonym: NSC 675451,NSC675451,NSC-675451

Target:

GW-695634

T27512

Synonym: GW5634,GW695634,GW-5634G,GW-5634

Synonym: BI207127,BI-207127,BI 207127,BI-207127NA

Target:

Nevirapine hemihydrate

Nevirapine quinone methide

Synonym: HI-113,HI 113,HI113

Target:

Cat No.	Product Name	Synonyms	Targets
T16674	Pseudouridine		Endogenous Metabolite
	Pseudouridine is the most abundant modified nucleoside in non-coding RNAs. It enhances the function of transfer RNA and ribosomal RNA by stabilizing RNA structure.		Endogenous Metabolite

Natural Products

Pseudouridine

T16674

Synonym:

Target: Endogenous Metabolite

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPJ-01308	ITPase Protein, Human, Recombinant (His)	Human	E. coli
	Inosine Triphosphate Pyrophosphatase (ITPase) is a cytoplasmic enzyme that belongs to the HAM1 NTPase family. ITPase hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP) and deoxyinosine triphosphat...
TMPH-01211	DGUOK Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Phosphorylates deoxyguanosine and deoxyadenosine in the mitochondrial matrix, with the highest efficiency for deoxyguanosine. In non-replicating cells, where cytosolic dNTP synthesis is down-regulated, mtDNA synthesis de...
TMPH-00609	DITP/XTP pyrophosphatase Protein, E. coli, Recombinant (His & Myc & SUMO)	E. coli	E. coli
	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinos...
TMPY-03508	XTP3TPA Protein, Human, Recombinant (His)	Human	E. coli
	DCTPP1 hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. It has a strong preference for modified dCTP. DCTPP1’s activity is highest with 5-iodo-dCTP, followed by 5-bromo-d...
TMPH-01801	NME2 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Negativ...