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mapk-2

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    129
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p38 MAPK-IN-2
T11241635725-16-5
p38 MAPK-IN-2 is a potent inhibitor of p38 kinase.
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6-8 weeks
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NF-κB/MAPK-IN-2
T204242
NF-κB MAPK-IN-2 (compound 14) is a potent inhibitor of NF-κB and MAPK pathways. It effectively reduces the protein expression levels of p-p65, p-IκB, p-p38, p-JNK, and p-ERK. This compound decreases the release of TNF-α and IL-6 induced by LPS and inhibits the nuclear translocation of p65 and c-Fos. NF-κB MAPK-IN-2 shows potential for research in sepsis.
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p44/42 MAPK (Erk1/2) (137F5) Rabbit mAb #4695R
T64587
p44 42 MAPK (Erk1 2) (137F5) Rabbit mAb #4695R is a useful organic compound for research related to life sciences and the catalog number is T64587.
    7-10 days
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    Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) (20G11) Rabbit mAb #4376R
    T64608
    Phospho-p44 42 MAPK (Erk1 2) (Thr202 Tyr204) (20G11) Rabbit mAb #4376R is a useful organic compound for research related to life sciences and the catalog number is T64608.
      7-10 days
      Inquiry
      MAPK-IN-2
      T79572
      MAPK-IN-2 (compound 3h) is an efficacious MAPK inhibitor with antineoplastic properties that significantly hinders proliferation across various cancer cell lines. It demonstrates robust suppression of the MAPK pathway (EGFR WT IC50 = 281 nM, c-MET IC50 = 205 nM, B-RAF WT IC50 = 112 nM, CDK4 6 IC50 = 95 and 184 nM, respectively) and exhibits pronounced activity against mutated forms of EGFR and B-RAF (EGFR T790M IC50 = 69 nM and B-RAF V600E IC50 = 83 nM) [1].
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      4-6 weeks
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      PD98059
      PD 98059
      T2623167869-21-8
      PD98059 is an MEK inhibitor that inhibits MEK1 and MEK2 (IC50=2 50 μM) and is non-ATP-competitive. PD98059 is also antagonistic as a ligand for AHR. PD98059 inhibits autophagy.
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      TargetMol | Inhibitor Hot
      Dehydrocorydaline
      Dehydrocorydalin, 13-Methylpalmatine
      T5S235830045-16-0
      1. Dehydrocorydaline (13-Methylpalmatine) exerts anti-metastatic potential via suppression of MMPs and Bcl-2 signaling in NSC-LC cells. 2. Dehydrocorydaline stimulates p38 MAPK activation, which can enhance heterodimerization of MyoD and E proteins, thus resulting in MyoD activation and myoblast differentiation. 3. Dehydrocorydaline shows antiplatelet effects, it inhibits thrombin-induced platelet aggregation in a low dose ( IC50= 34.914 ug mL). 4. Dehydrocorydaline has anti-inflammatory and antinociceptive effects. 5. Dehydrocorydaline inhibits MCF-7 cell proliferation by inducing apoptosis mediated by regulating Bax Bcl-2, activating caspases as well as cleaving PARP.
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      Mirdametinib
      PD325901, PD0325901
      T6189391210-10-9
      Mirdametinib (PD325901) is an MEK inhibitor (IC50=0.33 nM) with selective, non-ATP-competitive, and oral activity. Mirdametinib exhibits antitumor activity by inhibiting p-ERK1 2 expression and inducing apoptosis.
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      TargetMol | Inhibitor Hot
      EF24
      EF-24, EF 24, 3,5-Bis[(2-fluorophenyl)Methylene]-4-piperidinone
      T27242342808-40-6In house
      EF24 (3,5-Bis[(2-fluorophenyl)Methylene]-4-piperidinone) treatment increases the levels of activated caspase 3 and 9, and decreases the phosphorylated forms of MEK1 and ERK. EF24 shows potent anti-tumor activity in oral squamous cell carcinoma (OSCC) via deactivation of the MAPK ERK signaling pathway.
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      Aspirin
      ASA, Acetylsalicylic Acid, Acetylsalicylate
      T000550-78-2
      Aspirin (Acetylsalicylic Acid) is a COX inhibitor that inhibits COX1 and COX2 (IC50=5 210 μg mL) with selective, irreversible, and oral activity. Aspirin is also a histone deacetylase inhibitor that up-regulates the cell cycle blocking protein, p21. Aspirin has a variety of activities. Aspirin has anti-inflammatory, antipyretic and analgesic, and antiplatelet aggregation activities.
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      Amiodarone hydrochloride
      Nexterone, Amiodarone HCl, Amiodar HCl
      T149619774-82-4
      Amiodarone hydrochloride (Amiodarone HCl) is an antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibiting POTASSIUM CHANNELS and VOLTAGE-GATED SODIUM CHANNELS. There is a resulting decrease in heart rate and in vascular resistance.
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      Afatinib Dimaleate
      BIBW2992, BIBW 2992MA2, Afatinib (BIBW2992) Dimaleate, Afatinib
      T1773850140-73-7
      Afatinib Dimaleate (BIBW 2992MA2) is an orally bioavailable anilino-quinazoline derivative and inhibitor of the receptor tyrosine kinase (RTK) epidermal growth factor receptor (ErbB; EGFR) family, with antineoplastic activity.
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      3'-Hydroxypterostilbene
      3'-HPT
      T2S2382475231-21-1
      3'-Hydroxypterostilbene (3'-HPT), a natural pterostilbene analogue, effectively inhibits the growth of human colon cancer cells with IC50s of 9.0, 40.2, and 70.9 μM for COLO 205, HCT-116, and HT-29 cells, respectively, by inducing apoptosis and autophagy. 3'-Hydroxypterostilbene inhibits the p38MAPK , and PI3K Akt mTOR p70S6K pathways and activates the ERK1 2, JNK1 2 MAPK pathways[1].
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      Fumaric acid
      Trans-Butenedioic acid, Lichenic acid, Fumarate, Donitic acid, Allomaleic acid, 2-Butenedioic acid
      T3763110-17-8
      Fumaric acid (2-Butenedioic acid) attenuates the eotaxin-1 expression in TNF-α-stimulated fibroblasts by suppressing p38 MAPK-dependent NF-κB signaling. Fumaric acid has recently been identified as an oncometabolite or an endogenous, cancer-causing metabolite. High levels of this organic acid can be found in tumors or biofluids surrounding tumors. Its oncogenic action appears due to its ability to inhibit prolyl hydroxylase-containing enzymes.
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      Nisin Z
      T76264137061-46-2
      Nisin Z has anti-inflammatory activity and reduces pro-inflammatory cytokine release by inhibiting activation of the ERK1 2 and p38 mitogen-activated protein kinase (MAPK) signaling pathways, attenuating lipopolysaccharide-induced mastitis through inhibition of the ERK1 2 and p38 mitogen-activated protein kinase signaling pathways.
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      7-10 days
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      Rineterkib
      ERK-IN-1
      T112241715025-32-3
      Rineterkib (ERK-IN-1) is an inhibitor of RAF and ERK1 2 activating mutations in the MAPK pathway.
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      10-14 weeks
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      LXH254
      T118981800398-38-2
      LXH254 is a B C RAF inhibitor with IC50 values of 0.2 nM and 0.07 nM for inhibiting BRAF and CRAF.
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      Lawsone methyl ether
      2-Methoxy-1,4-naphthoquinone, 2-Methoxy-p-naphthoquinone, 2-Methoxynaphthoquinone
      T30082348-82-5
      Lawsone methyl ether (2-Methoxy-1,4-naphthoquinone) induces apoptosis in A549 cells independently of cell cycle arrest, mediated by JNK and p38 MAPK signaling pathways. These pathways are activated due to oxidative DNA damage from increased ROS generation in MNQ-treated A549 cells.
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      Pyridone 6
      Janus-Associated Kinase Inhibitor I, JAK Inhibitor I, JAK I inhibitor, CMP 6
      T3080457081-03-7
      Pyridone 6 (JAK Inhibitor)(CMP 6) is a potent and selective inhibitor of JAK1 (IC50=15 nM, murine JAK1), JAK2 (IC50=1 nM), JAK3 (Ki=5 nM), and Tyk2 (IC50=1 nM); displaying significantly weaker affinities (130 nM to 10 mM) for other protein tyrosine kinases.
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      Calycosin
      Cyclosin, 3'-Hydroxyformononetin
      T392320575-57-9
      Calycosin (Cyclosin) acts as a selective estrogen receptor modulator. Calycosin induces apoptosis in human ovarian cancer SKOV3 cells by activating caspases and Bcl-2 family proteins. Calycosin suppresses breast cancer cell growth via ERβ-dependent regulation of IGF-1R, p38 MAPK and PI3K Akt pathways. Calycosin has antineoplastic effects against osteosarcoma through inducing apoptosis showing in vitro and in vivo investigations. Calycosin was shown to induce angiogenesis in human umbilical vein endothelial cell cultures (HUVEC) in vitro. Calycosin may be an effective skin-lightening agent that regulates the expression of melanogenic enzymes. Calycosin exhibited tyrosinase inhibitory activity with an IC(50) value of 38.4 microM.
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      TargetMol | Inhibitor Sale
      Cornuside
      7-Galloylsecologanol, 7-O-Galloylsecologanol, Comuside
      T4S2326131189-57-6
      1. Cornuside (Comuside) has immunomodulatory activity . 2. Cornuside suppresses expression levels of cytokine-induced proinflammatory and adhesion molecules in the human endothelial cells. 3. Cornuside can treat myocardial I R and protect the liver from CCl4-induced acute hepatotoxicity, by reducing oxidative stress and suppressing inflammatory responses. 4. Cornuside has anti-inflammatory activity by downregulations of iNOS and COX-2 due to NF-κB inhibition as well as the negative regulation of ERK1 2, p38, and JNK1 2 phosphorylations in RAW 264.7 cells. 5. Cornuside has protective potential against cerebral ischemic injury, may be due to the suppression of intracellular Ca(2+) elevation and caspase-3 activity, and improvements in mitochondrial energy metabolism and antioxidant properties.
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      Theaflavin 3,3′-digallate
      Theaflavin 3,3′-di-O-gallate, Theaflavin 3, TFDG
      T542930462-35-2
      Theaflavin 3,3'-digallate, a major polyphenol found in black tea, is an inducer of oxidative stress which has anti-inflammatory and cancer chemopreventive actions, it reduces tumor angiogenesis by downregulating HIF-1αand VEGF.
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      Atractylenolide II
      2-Atractylenolide, Asterolide
      T5S016873069-14-4
      1. Atractylenolide II (2-Atractylenolide) has antimelanoma effect by inhibiting STAT3 signalling. 2. Atractylenolide II has cytotoxic apoptotic effects may via p38 activation , ERK and Akt inactivation, p53 dependent.
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      Isoquercetin
      3-Glucosylquercetin, Hirsutrin, Isoquercitrin, Quercetin 3-o-glucopyranoside
      T5S0754482-35-9
      1. Isoquercetin (3-Glucosylquercetin) is a potential stimulator of bone mineralization used for prophylaxis of osteoporotic disorders. 2. Isoquercetin may be as a potential therapeutic agent against neurodegeneration in Parkinson's disease. 3. Isoquercetin is an inhibitor of Wnt β-catenin and may be as a potential novel anti-tumoral agent, such as against human pancreati,liver cancer related to opioid receptors and to the activation of the mitogen-activated protein kinase (MAPK) signalling pathway. .
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