ca 4

Combretastatin A4 (CA4) is a microtubule-targeting agent that binds β-tubulin (Kd: 0.4 μM).

PAF antagonist

Pca 4233 belongs to a class of selective PAF-receptor antagonists.

Trombodipine (PCA-4230) is a platelet aggregation inhibitor with antithrombotic activity and protection against Listeria monocytogenes.

(R)-Naproxen, an anti-inflammatory agent, has antipyretic and analgesic properties. Both the acid and its sodium salt are used in the therapy of acute gout or dysmenorrhea, musculoskeletal disorders, rheumatoid arthritis and other rheumatic.

3,7-dimethylocta-2,6-dienyl 5,9,13-trimethyltetradeca-4,8,12-enoate is a useful research compound for many research applications, including the fields of chemistry and life sciences, among others.

(-)-Agelastatin A is a member of the pyrrole-aminoimidazole marine alkaloid (PAI) family, capable of inhibiting β-catenin, GSK-3β, and osteopontin (OPN), exhibiting antiproliferative activity against various cancers such as leukaemia and breast cancer, and possessing a certain ability to penetrate the central nervous system (CNS).

IRAK4-IN-7 (CA-4948) is a selective and potent IRAK4 kinase inhibitor with in vivo activity in a TLR4-induced cytokine release model.

BRM/BRG1 ATP Inhibitor-1 is an allosteric dual Brahma homolog (BRM)/SWI/SNF related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 (SMARCA2) and BRG1/SMARCA4 ATPase activity inhibitor (IC50s<0.005 μM).

(2S,3R,4S,5S,6R)-2-{[(2R,3R,4S,5S,6R)-2-(deca-4,6,8-triyn-1-yloxy)-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl]oxy}-6-(hydroxymethyl)oxane-3,4,5-triol is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

2,3,4,5-tetrahydroxypentyl (4E,8E,12E)-3,7-dihydroxy-2,4,6,8,10,12,14,16-octamethyl-11-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}octadeca-4,8,12-trienoate is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

(4E,8E)-10-(4,6-dihydroxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoic acid is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

6-carbamimidamido-2-[(4E,6E,12E,14E)-3-hydroxy-2-(hydroxymethyl)-8,10,16-trimethyloctadeca-4,6,12,14-tetraenamido]hexanoic acid is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

10-{[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}deca-4,6-diynoic acid is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

(4E,8Z)-2-hydroxy-9-(hydroxymethyl)-2,6-dimethyl-6-(4-methylpent-3-en-1-yl)-10-oxo-12-oxabicyclo[9.1.0]dodeca-4,8-dien-3-yl 3-methylbut-2-enoate is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

(4E,8E,12E,16E)-2,3,7,11,15-pentahydroxy-4,6,8,10,12,14,16-heptamethyloctadeca-4,8,12,16-tetraenoic acid is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

(4E,6E)-2-(hydroxymethyl)-3-(3-methoxy-3-oxopropyl)deca-4,6-dienoic acid is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

5,11,17,19-tetrahydroxy-15-methyl-2-oxapentacyclo[9.8.0.0^{1,3}.0^{4,9}.0^{12,17}]nonadeca-4,6,8-triene-10,13-dione is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

ACBI1 is a potent PROTAC degrader of BAF ATPase subunits SMARCA2 and SMARCA4, also degrades the polybromo-associated BAF (PBAF) complex member PBRM1, with DC50s of 6 nM, 11 nM and 32 nM for SMARCA2, SMARCA4 and PBRM1 in MV-4-11 cells, respectively. ACBI1 is composed of a bromodomain ligand, a linker, and the E3 ubiquitin ligase VHL. ACBI1 can induce anti-proliferative effects and apoptosis.

ML141 (CID-2950007) is an effective, specific and reversible non-competitive inhibitor of Rho family GTPase cdc42 (IC50: 200 nM).

Antibiotic A 40104A is an antibiotic.

Boc-A 410099.1 amide-alkylC4-amine, a functionalized IAP ligand for PROTACs, consists of an IAP ligand and an amide-alkylC4 linker terminating in an amine group, enabling it to form conjugates with target protein ligands.

GNE-064 is a selective, orally active and highly soluble inhibitor of SMARCA4, SMARCA2 and PBRM1 bromodomains 5. GNE-064 inhibits SMARCA4 with an IC50 of 0.035 μM and inhibits SMARCA2 with an EC50 of 0.10 μM. GNE-064 possess Kds with 0.01, 0.016, 0.018 and 0.049 μM for SMARCA4, SMARCA2, PBRM1 bromodomains 5 and PBRM1 bromodomains 2, repectively. GNE-064 can be used as a chemical probe for the research of drug synthesis.

Nutlin-3a is the active enantiomer of Nutlin-3, an MDM2 antagonist that inhibits MDM2-p53 interaction (Ki=90 nM) and activates p53. Nutlin-3a binds preferentially to the p53-binding pocket of MDM2, leading to stabilization of p53 and activation of the p53 pathway. Nutlin-3a has antitumor activity.