a-1 protease inhibitor

Serpin A1 is a prototype member of the Serpin superfamily of the serine protease inhibitors. As one of the most abundant proteinase inhibitors in the circulation, it is synthesized in hepatocytes, and to a lesser extent, in macrophages as well as intestinal epithelial cell lines and secreted as the abundant proteinase inhibitor in the circulation whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Point mutations in the native SerpinA1 variants result in Serpin A1 deficiency, and consequently lead to several clinical complications such as pulmonary emphysema, juvenile hepatitis, cirrhosis, and hepatocellular carcinoma. For example, the Z variants (Glu342 to Lys) forms intracellular inclusion bodies, is not secreted, and leads to a severe SerpinA1 deficiency. Accordingly, Serpin A1 deficiency in circulation is associated with emphysema or liver disease.

Expression system: E. coli
Length: 1-390, Full Length
Activity: Not Tested

Expression system: HEK293 Cells
Length: 20-145, Full Length of Mature Protein
Activity: Not Tested

Plasminogen activator inhibitor-1 (serpin E1) is a serine protease inhibitor which belongs to the serpin family. Serpin E1 acts as 'bait' for tissue plasminogen activator, urokinase, protein C and matriptase-3 TMPRSS7. Its rapid interaction with PLAT may function as a major control point in the regulation of fibrinolysis.

Expression system: HEK293 Cells
Length: 24-79, Partial
Activity: Not Tested

Expression system: HEK293 Cells
Length: 19-261, Full Length of Mature Protein
Activity: Not Tested

Expression system: HEK293 Cells
Length: 20-85, Full Length of Mature Protein
Activity: Not Tested

Expression system: HEK293 Cells
Length: 25-413, Full Length of Mature Protein
Activity: Not Tested

Expression system: HEK293 Cells
Length: 29-282, Partial
Activity: Not Tested

Expression system: HEK293 Cells
Length: 29-282, Partial
Activity: Not Tested

Expression system: HEK293 Cells
Length: 1-423, Full Length
Activity: Enzyme Activity

Expression system: Baculovirus Insect Cells
Length: 1-397, Full Length
Activity: Not Tested

Serpins are the largest and most diverse family of serine protease inhibitors which are involved in a number of fundamental biological processes such as blood coagulation, complement activation, fibrinolysis, angiogenesis, inflammation and tumor suppression and are expressed in a cell-specific manner. Serpins are a group of proteins with similar structures that were first identified as a set of proteins able to inhibit proteases. The acronym serpin was originally coined because many serpins inhibit chymotrypsin-like serine proteases (serine protease inhibitors). Over 1 serpins have been identified.Mouse SerpinB3, also known as Squamous cell carcinoma antigen 1, SCCA-1, SERPINB3, SCCA and SCCA1, is a cytoplasm protein that belongs to the serpin family and Ov-serpin subfamily. SerpinB3 may act as a protease inhibitor to modulate the host immune response against tumor cells. Mouse SerpinB3a and SerpinB3b, but not Serpinb3c, are functional, inhibiting both serine and cysteine proteinases with different inhibitory profiles due to the difference of two amino acids in their reactive site loops. SerpinB3a is ubiquitously expressed in most tissues, whereas expression of SerpinB3b is limited to keratinocytes. SerpinB3a and SerpinB3b may play different roles by inhibiting intrinsic or extrinsic proteinases with different expression distributions and different inhibitory profiles.

Expression system: Baculovirus Insect Cells
Length: 1-415, Full Length
Activity: ELISA

Expression system: HEK293 Cells
Length: 1-576, Full Length
Activity: Not Tested

Expression system: HEK293 Cells
Length: 1-405, Full Length
Activity: Not Tested

Expression system: HEK293 Cells
Length: 1-448, Full Length
Activity: Not Tested

Expression system: HEK293 Cells
Length: 1-414, Full Length
Activity: Enzyme activity

Expression system: HEK293 Cells
Length: 1-247, Full Length
Activity: Enzyme Activity

Expression system: HEK293 Cells
Length: 1-117, Full Length
Activity: Not Tested

Expression system: HEK293 Cells
Length: 1-444, Full length
Activity: Not Tested

Expression system: Baculovirus Insect Cells
Length: 1-1474, Full Length
Activity: Enzyme Activity

Expression system: HEK293 Cells
Length: 1-141, Full Length
Activity: Not Tested

Expression system: E. coli
Length: 2-98, Full Length of Mature Protein
Activity: Enzyme Activity