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Cat No. | Product Name | Synonyms | Targets |
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T8708 | Paroxetine | Serotonin Transporter | |
Paroxetine is a inhibitor of serotonin uptake that is effective in the treatment of depression. | |||
T0300 | Pargyline | Pargylamine,Paragyline | MAO , Monoamine Oxidase |
Pargyline (Pargylamine) is a monoamine oxidase inhibitor with antihypertensive properties. | |||
T1997 | JNJ-31020028 | JNJ 31020028 | Neuropeptide Y Receptor |
JNJ-31020028 is a selective brain penetrant antagonist of neuropeptide Y2 receptor with high affinity(pIC50=8.07, human; pIC50=8.22, rat); it exhibits >100-fold selectivity for Y2 versus human Y1/Y4/Y5 receptors. | |||
T22453 | Venlafaxine | Wy 45030 | Serotonin Transporter |
Venlafaxine (Wy 45030), an arylalkanolamine serotonin-norepinephrine reuptake inhibitor (SNRI), is used to treat major generalised anxiety disorder (GAD), depressive disorder (MDD), panic disorder and social phobia. | |||
T1578 | Pargyline hydrochloride | Pargylamine hydrochloride | MAO , Monoamine Oxidase |
Pargyline hydrochloride (Pargylamine hydrochloride) is an irreversible monoamine oxidase(MAO) inhibitor with antihypertensive properties. | |||
T0766 | Promazine hydrochloride | Romtiazin hydrochloride,Sinophenin hydrochloride | Dopamine Receptor , 5-HT Receptor , Adrenergic Receptor , AChR |
Promazine hydrochloride (Romtiazin hydrochloride) is a phenothiazine with actions similar to CHLORPROMAZINE but with less antipsychotic activity. It is primarily used in short-term treatment of disturbed behavior and as ... | |||
T4274 | Melitracen hydrochloride | Thymeol hydrochloride,Melixeran | Dopamine Receptor , 5-HT Receptor |
Melitracen hydrochloride (Thymeol hydrochloride) , an antidepressant, is used as potential dopamine D1/2 receptor antagonist to treat depression. | |||
T0472 | Venlafaxine hydrochloride | Venlafaxine HCl,Wy 45030 hydrochloride | 5-HT Receptor , Serotonin Transporter |
Venlafaxine hydrochloride (Wy 45030 hydrochloride) is a cyclohexanol and phenylethylamine derivative that functions as a SEROTONIN AND NORADRENALINE REUPTAKE INHIBITOR (SNRI) and is used as an ANTIDEPRESSIVE AGENT. | |||
T1050 | Prazosin hydrochloride | Prazosin hydrochloride,Prazosin HCl,cp-12299-1,Peripress,Vasoflex,Minipress | Potassium Channel , MRP , Adrenergic Receptor , ABC , Autophagy |
Prazosin hydrochloride (Vasoflex) reduces peripheral resistance and relaxes vascular smooth muscles as a selective adrenergic alpha-1 antagonist by a mechanism not completely known. Prazosin hydrochloride is a synthetic ... | |||
T3275 | Nefazodone hydrochloride | Dutonin,MJ-13754-1,Serzone,BMY-13754-1,BMY-13754 | 5-HT Receptor , Adrenergic Receptor |
Nefazodone hydrochloride (Serzone) is a serotoninergic modulating antidepressant that is used in therapy of depression, aggressive behavior and panic disorder. | |||
T0031L | Ziprasidone hydrochloride | CP-88059 hydrochloride,CP-88059,Ziprasidone HCl | Dopamine Receptor , 5-HT Receptor , Adrenergic Receptor , Norepinephrine , Histamine Receptor |
Ziprasidone hydrochloride (CP-88059 hydrochloride) is a united 5-HT (serotonin) and dopamine receptor antagonist which shows potent effects of antipsychotic activity. | |||
T68186 | Aminomenthylnorepinephrine | ||
Aminomenthylnorepinephrine is a partial agonist of the beta-adrenoreceptor that causes irreversible inactivation. | |||
T25398 | Ethylnorepinephrine hydrochloride | Butanefrine hydrochloride,Bronkephrine | |
Ethylnorepinephrine hydrochloride is a unique bronchodilator. | |||
T6963 | Reboxetine mesylate | FCE20124 mesylate,Edronax,PNU155950E mesylate,PNU 155950E | Adrenergic Receptor , Norepinephrine |
Reboxetine mesylate (FCE20124 mesylate) is a norepinephrine reuptake inhibitor (Ki: 8.2 nM). | |||
T7061 | Duloxetine | Serotonin Transporter | |
Duloxetine is an inhibitor of serotonin-norepinephrine reuptake(Ki of 4.6 nM),with treatment of major depressive disorder and generalized anxiety disorder. | |||
T2092 | Amitifadine hydrochloride | DOV-21947 hydrochloride,EB-1010 hydrochloride | Dopamine Receptor , 5-HT Receptor , Serotonin Transporter , Norepinephrine |
Amitifadine hydrochloride (EB-1010 hydrochloride) is a triple reuptake inhibitor (TRI) or serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI). | |||
T5380 | Ansofaxine hydrochloride | LPM570065,LY03005 | Dopamine Receptor , 5-HT Receptor , Norepinephrine |
Ansofaxine hydrochloride (LY03005) is a serotonin-norepinephrine-dopamine reuptake inhibitor (IC50s: 723, 763 and 491 nM, respectively). | |||
T3526 | Dasotraline hydrochloride | SEP-225289 hydrochloride | Dopamine Receptor , 5-HT Receptor , Serotonin Transporter , Norepinephrine |
Dasotraline hydrochloride (SEP-225289 hydrochloride) (SEP-225289 hydrochloride) is a triple reuptake inhibitor that inhibits dopamine, norepinephrine, and serotonin transporters with IC50 values of 4, 6, and 11 nM, respe... | |||
T28380 | PF-184298 | PF184298,PF 184298 | Dopamine Receptor , 5-HT Receptor |
PF-184298 is a serotonin and norepinephrine monoamine reuptake inhibitor (SNRI) that inhibits dopamine reuptake. | |||
T11087 | DOV-216,303 Free Base | DOV-216303 | Dopamine Receptor , Serotonin Transporter , Norepinephrine |
DOV-216,303 Free Base (DOV-216303) is an inhibitor of serotonin, norepinephrine, and dopamine reuptake with with IC50s of 14, 20 and 78 nM. DOV-216,303 Free Base exhibits antidepressant effects. | |||
T6188 | Desvenlafaxine succinate hydrate | O-Desmethylvenlafaxine succinate hydrate,WY 45233 Succinate,Desvenlafaxine Succinate | 5-HT Receptor , Serotonin Transporter , Norepinephrine |
Desvenlafaxine succinate hydrate (WY 45233 Succinate) is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI). | |||
T10758L | Centanafadine hydrochloride | EB-1020 hydrochloride | Dopamine Receptor , Serotonin Transporter , Adrenergic Receptor , Norepinephrine |
Centanafadine hydrochloride (EB-1020 hydrochloride) is a dual inhibitor of norepinephrine (NE)/dopamine (DA) transporter, also inhibits serotonin transporter (IC50s: 6 nM, 38 nM, and 83 nM for human NE, DA, and serotonin... | |||
T9395 | (1S,4R)-N-Desmethyl Sertraline Hydrochloride | Others | |
(1S,4R)-N-DesmethylSertralineHydrochloride is a Serotonin transporter and Norepinephrine transporter inhibitor with IC50 of 19 nM and 35 nM, respectively. | |||
T0871 | Noradrenaline bitartrate | Adrenergic Receptor | |
Norepinephrine bitartrate acts directly on the α- and β-adrenergic receptors. Norepinephrine Bitartrate is a bitartrate salt of norepinephrine, a synthetic phenylethylamine that mimics the sympathomimetic actions of the ... | |||
T0869 | Atomoxetine hydrochloride | Tomoxetine hydrochloride,(R)-Tomoxetine hydrochloride,LY 139603,Atomoxetine HCl,LY 139603 HCl | Dopamine Receptor , 5-HT Receptor , Norepinephrine |
Atomoxetine hydrochloride (LY 139603) is the hydrochloride salt of atomoxetine, a phenoxy-3-propylamine derivative and selective non-stimulant, norepinephrine reuptake inhibitor with cognitive-enhancing activity. Althou... | |||
T7940 | Milnacipran ((1S-cis) hydrochloride) | Levomilnacipran Hydrochloride | Serotonin Transporter |
Milnacipran (1S-cis) hydrochloride (Levomilnacipran Hydrochloride) is a serotonin-norepinephrine reuptake inhibitor (SNRI), treatment of fibromyalgia. | |||
T7308 | Nomifensine | NOMIFENSINE MALEATE,(±)-Nomifensin | Dopamine Receptor |
Nomifensine ((±)-Nomifensin) is a norepinephrine-dopamine reuptake inhibitor that prevents dopamine reuptake into synaptosomes. | |||
T19893 | Thozalinone | Others | |
Thozalinone is a psychostimulant agent inducing the release of norepinephrine and dopamine. | |||
T33711L | Nolomirole HCl | CHF 1035 HCl,CHF 1035,CHF1035,CHF1035 HCl,CHF-1035 HCl,CHF-1035,Nolomirole Hydrochloride | Dopamine Receptor , Norepinephrine |
Nolomirole HCl (CHF 1035) is a novel selective dopamine agonist with oral activity and inhibitory effects on norepinephrine release, which can be used to study mild chronic heart failure. | |||
T27047 | Clovoxamine fumarate | DU23811 fumarate,DU 23811 fumarate,DU-23811 fumarate | 5-HT Receptor , Serotonin Transporter , Norepinephrine |
Clovoxamine fumarate (DU 23811 fumarate) is a 5-hydroxytryptamine reuptake, serotonin and norepinephrine inhibitor with antidepressant and anticonvulsant activity. | |||
T0204 | Protriptyline hydrochloride | Protriptyline HCl | 5-HT Receptor , AChE |
Protriptyline Hydrochloride is the hydrochloride salt form of protriptyline, a tricyclic secondary amine with an antidepressant property. Protriptyline hydrochloride (Protriptyline HCl) blocks the re-uptake of norepineph... | |||
T13110 | Tedatioxetine hydrobromide | Lu AA 24530 hydrobromide | Dopamine Receptor , 5-HT Receptor , Norepinephrine |
Tedatioxetine hydrobromide (Lu AA 24530 hydrobromide) is a serotonin-norepinephrine-dopamine reuptake inhibitor and an antagonist of 5-HT2A, 5-HT2C, 5-HT3, and α1A-adrenergic receptors, which can be used to treat depress... | |||
T7433 | 2-Phenylethylamine hydrochloride | &beta,-Phenylethylamine hydrochloride,benzeneethanamine hydrochloride,&beta,-aminoethylbenzene hydrochloride | Others |
2-Phenylethylamine hydrochloride (benzeneethanamine hydrochloride) acts as neuromodulator in the central nervous system. It stimulates the release of norepinephrine and dopamine and is metabolized by monoamine oxidases a... | |||
T12232 | Nitroxazepine | CIBA 2330Go | Serotonin Transporter |
Nitroxazepine (CIBA 2330Go) is a serotonin-norepinephrine reuptake inhibitor, and treatment depression. Nitroxazepine is a tricyclic antidepressant (TCA) for the research of depression | |||
T10358 | Netarsudil Dihydrochloride | AR-13324 Dihydrochloride | ROCK |
Netarsudil Dihydrochloride (AR-13324 Dihydrochloride) is an inhibitor of Rho-associated protein kinase (ROCK) and norepinephrine transporter (NET) with effective in intraocular pressure (IOP) reduction. | |||
T2594 | Dextromilnacipran | Levomilnacipran | Serotonin Transporter , Norepinephrine |
Dextromilnacipran (Levomilnacipran) is a selective serotonin and norepinephrine reuptake inhibitor. | |||
T22420 | (S)-Viloxazine Hydrochloride | (S)-Viloxazine HCl | Norepinephrine |
(S)-Viloxazine Hydrochloride, the S-isomer of Viloxazine. Viloxazine is a selective norepinephrine reuptake inhibitor (NRI) that can be used as an antidepressant. | |||
T60330 | Metapramine | ||
Metapramine (19560 RP) is a tricyclic antidepressant[1]. Metapramine inhibits norepinephrine reuptake without affecting the reuptake of serotonin or dopamine [1] [2] [3]. Metapramine is a low-affinity antagonist of the N... | |||
T32737 | Liafensine | BMS820836,BMS 820836,DB104,BMS-820836 | Dopamine Receptor , 5-HT Receptor , Norepinephrine |
Liafensine(BMS-820836) is a novel and selective triple monoamine reuptake inhibitor with inhibitory effects on the reuptake of serotonin, norepinephrine, and dopamine for the study of major depressive disorder and centra... | |||
T22413 | (R)-Viloxazine Hydrochloride | Others | |
(R)-Viloxazine Hydrochloride, the R-isomer of Viloxazine. Viloxazine is a selective norepinephrine reuptake inhibitor (NRI) and can be used as an antidepressant. | |||
T71746 | Pincainide | Others | |
Pincainide is a novel beta-aminoaniline that inhibits, in a dose-dependent manner, diseases caused by abnormal norepinephrine vascular smooth muscle function. | |||
T5954 | Methyldopa hydrate | Alpha-Methyldopa Sesquihydrate,L-(-)-α-Methyldopa hydrate,MK-351 hydrate,Methyldopa Sesquihydrate | Dopamine Receptor , Adrenergic Receptor |
Methyldopa hydrate (MK-351 hydrate) is a DOPA decarboxylase inhibitor and indirect α2-adrenergic receptor agonist used to treat hypertension. It inhibits the sympathetic nervous system, decreases production of dopamine, ... | |||
T2547 | Droxidopa | SM5688,DOPS,L-DOPS | Adrenergic Receptor |
Droxidopa (L-DOPS) is an orally available prodrug of norepinephrine that is used in the treatment of symptomatic orthostatic hypotension due to neurogenic causes of autonomic failure. | |||
T67810 | Tampramine | Norepinephrine | |
Tampramine is a selective norepinephrine reuptake inhibitor that shows a low affinity for adrenergic, histaminergic and muscarinic receptors. Tampramine is a candidate compound for the treatment of forced swimming test (... | |||
T7941 | Imipramine hydrochloride | Imipramine (hydrochloride),Tofranil,G 22355,Imipramine HCl,Melipramine | Serotonin Transporter |
Imipramine hydrochloride (Imipramine HCl) is a first generation tricyclic antidepressant that acts primarily as an inhibitor of serotonin and norepinephrine transporters (Kds = 1.4 and 37 nM, respectively).Imipramine hyd... | |||
T60325 | Viloxazine | Emovit,Viloxazin | 5-HT Receptor , Norepinephrine |
Viloxazine (Viloxazin) (Viloxazin) is a dual-action compound that functions as a norepinephrine reuptake inhibitor and exhibits potent agonistic activity towards 5-HT 2C receptors while acting as an antagonist for 5-HT 2... | |||
T1189 | Milnacipran hydrochloride | Milnacipran HCl,Savella,Dalcipran | Serotonin Transporter , Norepinephrine |
Milnacipran hydrochloride (Savella) is a serotonin and norepinephrine reuptake inhibitor used to treat major depressive disorders. Milnacipran hydrochloride is an enantiomer of milnacipran, which is used to treat fibromy... | |||
T0948 | Adrenalone hydrochloride | Adrenalone HCl | Adrenergic Receptor |
Adrenalone hydrochloride (Adrenalone HCl) is a dopamine β-oxidase inhibitor with a similar structure to the norepinephrine transporter (NET) ligand, with an IC50 of 36.9 μM. It is an adrenergic agonist that acts as a loc... | |||
T7783 | 2-(4-TRIFLUOROMETHYL-PHENYL)-ETHYLAMINE | Others | |
2-(4-TRIFLUOROMETHYL-PHENYL)-ETHYLAMINE is a monoamine neurotransmitter. It has been studied for its potential to modulate the activity of various neurotransmitters, including serotonin, dopamine, and norepinephrine. Its... | |||
T15773 | Lofepramine | Gamanil,Amplit,Leo 640,Lopramine | 5-HT Receptor , Norepinephrine |
Lofepramine (Leo 640) is a potent tricyclic antidepressant that is extensively metabolized to desipramine. It inhibits the serotonin and norepinephrine transporters by inhibiting neurons with Kd values of 70 and 5.4 nM, ... |
Cat No. | Product Name | Synonyms | Targets |
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T7044 | Norepinephrine | Levophed,Levonoradrenaline,Aktamin,Nor-Epirenan,Levonor,Arterenol | MMP , Endogenous Metabolite , Adrenergic Receptor , Autophagy |
Norepinephrine (Levophed) can stimulate apoptosis in adult rat ventricular myocytes by activation of the β-adrenergic pathway. It can up-regulate the expression of vascular endothelial growth factor, matrix metalloprotei... | |||
T21066 | Norepinephrine bitartrate salt | Adrenergic Receptor | |
Norepinephrine bitartrate salt is an adrenergic neurotransmitter. | |||
T1064 | Norepinephrine bitartrate monohydrate | Levophed,Noradrenaline bitartrate monohydrate | Endogenous Metabolite , Adrenergic Receptor , Autophagy |
Norepinephrine bitartrate monohydrate (Levophed) is a direct alpha-adrenergic receptors stimulator. | |||
T13655 | DL-Norepinephrine hydrochloride | Lys,DL-lysine | Adrenergic Receptor |
DL-Norepinephrine hydrochloride (DL-lysine) is a high-affinity basic amino acid substrate of amino acid transporter b0 + with a Km value in the range of 100-400 μM. | |||
T60245 | Norepinephrine hydrochloride | ||
Norepinephrine hydrochloride (Levarterenol hydrochloride) is a β1 -selective agonist of the adrenergic receptor with EC 50 of 5.37 μM [1]. | |||
T20173 | Noradrenaline tartrate | NSC 169106,NSC-169106,l-Noradrenaline d-bitartrate,NSC169106,Norepinephrine bitartrate | |
Norepinephrine bitartrate is a precursor of epinephrine. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceru... | |||
T0689 | D-Phenylalanine | Endogenous Metabolite , Monocarboxylate transporter | |
D-Phenylalanine, a necessary aromatic amino acid, is a precursor of thyroxine, dopamine, melanin, and noradrenaline (norepinephrine). | |||
T1045 | Trimipramine maleate | Surmontil maleate | Dopamine Receptor , 5-HT Receptor , Antibacterial , Adrenergic Receptor , Norepinephrine , Histamine Receptor |
Trimipramine maleate (Surmontil maleate) appears to inhibit serotonin transport and norepinephrine uptake by nerve terminals. This increases available norepinephrine or serotonin and prolongs its action. Trimipramine Mal... | |||
T5229 | DL -3,4-Dihydroxymandelic acid | Others | |
3,4-Dihydroxymandelic acid is a minor metabolite of norepinephrine in humans. Patients with neuroblastoma experience elevated levels of 3,4-Dihydroxymandelic acid. | |||
T4761 | Pyridoxal hydrochloride | Others , Endogenous Metabolite | |
The 4-carboxyaldehyde form of vitamin B6 which is converted to pyridoxal phosphate which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. | |||
TQ0135 | 3,4-Dihydroxymandelic acid | Endogenous Metabolite | |
3,4-Dihydroxymandelic acid exists in all living organisms, ranging from bacteria to humans. Within humans, 3,4-dihydroxymandelic acid participates in a number of enzymatic reactions. 3,4-Dihydroxymandelic acid is a metab... | |||
T0973L | Pyridoxine hydrochloride | Pyridoxine HCl,Pyridoxol (hydrochloride),Vitamin B6 (hydrochloride),Vitamin B6 | Nrf2 , Endogenous Metabolite |
Pyridoxine hydrochloride (Vitamin B6) is the 4-methanol form of vitaminB6 which is converted to pyridoxal phosphate which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingo... | |||
T0611 | Vanillylmandelic acid | 4-Hydroxy-3-methoxymandelic acid | Others |
Vanillylmandelic acid (4-Hydroxy-3-methoxymandelic acid), is the end product of catecholamine,epinephrine and norepinephrine metabolism, is commonly used to aid in diagnosis of pheochromocytoma,and which elevation is rel... | |||
T2S1778 | DL-Goitrin | Goitrin | Others |
DL-Goitrin is a potent antithyroid compound found naturally in crucifers. DL-Goitrin is responsible for the induction of glutathione S-transferases. DL-Goitrin is a moderate inhibitor of purified bovine adrenal dopamine ... | |||
T1644 | Dopamine hydrochloride | Dopamine HCl,ASL279 | Ferroptosis , Dopamine Receptor , 5-HT Receptor , Endogenous Metabolite |
Dopamine hydrochloride (ASL279) is a naturally occurring catecholamine formed by decarboxylation of dihydroxyphenylalanine and a precursor of norepinephrine and epinephrine. Dopamine hydrochloride binds to alpha-1- and b... | |||
T0791 | Reserpine | Serpalan,Serpasil,Serpivite | Others , Potassium Channel , MRP , Monoamine Transporter , Autophagy |
Reserpine (Serpalan) is an alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotoni... | |||
TQ0281 | 4-(1,2-Dihydroxyethyl)benzene-1,2-diol | Others | |
4-(1,2-Dihydroxyethyl)benzene-1,2-diol is a normal norepinephrine metabolite. | |||
T33342L | Methyl reserpate | NSC81464,NSC 81464,NSC-81464,Me reserpate | Norepinephrine |
Methyl reserpate (NSC 81464), a yohimbine-type alkaloid derived from the roots and leaves of Rauwolfia vomitoria, inhibits the transport of norepinephrine into chromophobe vesicles. | |||
T3S0964 | Thermopsoside | Chrysoeriol-7-O-glucoside | Others |
Chrysoeriol-7-O-glucoside can strongly inhibit the classical pathway of the complement system.Chrysoeriol-7-O-d-glucoside and luteolin-7-O-d-glucoside can inhibit palmitic acid uptake into small intestinal brush border m... | |||
T75436 | Jatrorrhizine hydroxide | ||
Jatrorrhizine hydroxide, an alkaloid derived from Coptis chinensis, exhibits a range of biological activities including neuroprotective, antimicrobial, antiplasmodial, and antioxidant properties [1]. It acts as a potent ... |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-03852 | Dopamine beta-Hydroxylase Protein, Human, Recombinant (His) | Human | HEK293 |
DBH is a 29 kDa copper-containing oxygenase. It can be detected in noradrenergic nerve terminals of the central and peripheral nervous systems, and is also expressed in chromaffin cells of the adrenal medulla. DBH conta... | |||
TMPY-02948 | SULT1A3 Protein, Human, Recombinant (His) | Human | E. coli |
SULT1A3 belongs to the sulfotransferase 1 family. Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. They are different in their tissue distrib... |
Cat No. | Product Name | ||
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L2700 | Adrenergic Receptor-Targeted Compound Library | 219 compounds | |
A unique collection of 219 bioactive compounds specifically targeting adrenergic receptors, effective tool for screening new drugs or new target identification; | |||
L7110 | Anti-Hypertension Compound Library | 719 compounds | |
719 hypertension-related small molecules for high-throughput and high-content screening. |