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  • Nucleoside Antimetabolite/Analog
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Results for "

Antimetabolite

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    144
    TargetMol | Inhibitors_Agonists
  • Peptide Products
    1
    TargetMol | Peptide_Products
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    1
    TargetMol | Dye_Reagents
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    TargetMol | PROTAC
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    24
    TargetMol | Natural_Products
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    5
    TargetMol | Inhibitors_Agonists
Floxuridine
NSC 27640, FUDR, Deoxyfluorouridine, 5-Fluorouracil 2'-deoxyriboside
T096450-91-9
Floxuridine (FUDR) is an antimetabolite, floxuridine inhibits thymidylate synthase, resulting in disruption of DNA synthesis and cytotoxicity.
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Gemcitabine
NSC 613327, LY188011
T025195058-81-4
Gemcitabine (LY188011) is a synthetic cytosine nucleoside derivative and an inhibitor of DNA synthesis. Gemcitabine has antitumor and antimetabolic activities. Gemcitabine induces autophagy and apoptosis.
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5-Fluorouracil
NSC 19893, Fluorouracil, 5-FU, 5-Fluoracil
T098451-21-8
5-Fluorouracil (5-FU) is a uracil analog and inhibitor of DNA synthesis, exhibiting antitumor activity by affecting pyrimidine synthesis through thymidylate synthase inhibition; it induces apoptosis and autophagy.
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Decitabine
NSC 127716, Dacogen, 5-Aza-CdR, 5-Aza-2'-deoxycytidine
T15082353-33-5
Decitabine (Deoxycytidine) is a deoxycytidine analog, a DNA methyltransferase inhibitor with oral activity. Decitabine has antitumor activity and antimetabolic activity. Decitabine induces cell cycle arrest and apoptosis.
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Fludarabine
NSC 118218, Fludarabinum, F-ara-A
T103821679-14-1
Fludarabine (Fludarabinum) is a fluorinated purine analog, an inhibitor of nucleic acid synthesis and an inhibitor of STAT1 activation. Fludarabine has antitumor activity and can be used for the treatment of leukemia and lymphoma.
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TargetMol | Inhibitor Hot
1-Methylcytosine
N-Methylcytosine, 4-amino-1-methylpyrimidin-2(1H)-one, 1-methylcytosin
T100191122-47-0In house
1-Methylcytosine (4-amino-1-methylpyrimidin-2(1H)-one) is a methylated form of the cytosine and can be used as the nucleobase of hachimoji DNA paired with isoguanine.
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6-8 weeks
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MBC-11
T11956L332863-86-2In house
MBC-11 is a first-in-class conjugate of the bone-targeting bisphosphonate etidronate covalently linked to the antimetabolite cytarabine (araC), with potential to treat tumor-induced bone disease (TIBD).
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6-8 weeks
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Peldesine
BCX 34
T12399133432-71-0In house
Peldesine (BCX 34) is an effective, competitive, reversible, and orally active inhibitor of purine nucleoside phosphorylase. Peldesine inhibits T-cell proliferation with an IC50 of 800 nM. Peldesine can be used in research on cutaneous T-cell lymphoma, psoriasis and HIV infection.
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6-8 weeks
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Ascamycin
T1432991432-48-3In house
Ascamycin is a 5'-O-sulfonamide ribonucleoside antibiotic produced by Streptomyces spp. It exhibits selective antibacterial activity against Xanthomonas species, inhibiting Xanthomonas citri, Xanthomonas oryzae, and phage with MIC values of 0.4 μg mL, 12.5 μg mL, and 12.5 μg mL respectively.
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6-8 weeks
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TargetMol | Inhibitor Sale
Rabacfosadine
VDC-1101, GS-9219
T16716859209-74-8In house
Rabacfosadine (GS-9219) is a novel dual pre-drug of the acyclic nucleotide phosphonate PMEG to tumor lymphocytes for the study of lymphoma.
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7-10 days
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Netivudine
T6054084558-93-0In house
Netivudine is a potent nucleoside reverse transcriptase inhibitor (NRTIs), a nucleoside analogue with anti-varicella zoster virus activity that can be used to treat human immunodeficiency virus (HIV) infection. Netivudine works by inhibiting reverse transcriptase, which reduces viral load in the body and slows the progression of the disease through its inhibitory effect.
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6-8 weeks
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TargetMol | Inhibitor Sale
6-Mercaptopurine
Mercaptopurine, 6-MP
T001050-44-2
6-Mercaptopurine (6-MP) is an antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia.
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Bendamustine hydrochloride
SDX-105, SDX-105 (Cytostasane) HCl, Bendamustine HCl
T00953543-75-7
Bendamustine hydrochloride (EP-3101) (IC50 of 50 μM) is an alkylating agent associated with DNA damage.
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Clofarabine
Clofarex, Evoltra, Clolar
T0297123318-82-1
Clofarabine (Clofarex)m, a second generation purine nucleoside analog with antineoplastic activity, inhibits the enzymatic activities of ribonucleotide reductase (IC50 = 65 nM) and DNA polymerase.
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5,6-Dihydro-5-methyluracil
5, 6-Dihydrothymine, Dihydrothymine
T0532696-04-8
5,6-Dihydro-5-methyluracil (Dihydrothymine) is an intermediate breakdown product of thymine.
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Ganciclovir
RS-21592, BW 759, 2'-Nor-2'-deoxyguanosine
T068882410-32-0
Ganciclovir (2'-Nor-2'-deoxyguanosine) is an ACYCLOVIR analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus. Ganciclovir is used to treat complications from AIDS-associated cytomegalovirus infections.
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Orotic acid
Vitamin B13, 6-Carboxyuracil
T074665-86-1
Orotic acid (Vitamin B13) is an intermediate product in pyrimidine metabolism.
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Adenosine
D-Adenosine, Adenine riboside
T085358-61-7
Adenosine (D-Adenosine) is a natural product, a ribonucleoside consisting of adenine bound to ribose. Adenosine has vasodilatory, antiarrhythmic and analgesic effects.
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Dacarbazine
Imidazole Carboxamide, DTIC-Dome
T11204342-03-4
Dacarbazine (DTIC-Dome) is an antineoplastic agent. It has significant activity against melanomas.
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Cytarabine
Cytosine β-D-arabinofuranoside, Cytosine Arabinoside, Ara-C, Arabinocytidine
T1272147-94-4
Cytarabine (Ara-C) is a nucleoside analog, an inhibitor of DNA synthesis (IC50=16 nM). Cytarabine inhibits DNA polymerase and induces cell cycle arrest, autophagy, and apoptosis. Cytarabine has antitumor activity.
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5-Azacytidine
NSC 102816, Mylosar, Ladakamycin, Azacitidine, 5-AzaC
T1339320-67-2
5-Azacytidine (Ladakamycin) is a cytidine nucleoside analog, a DNA methylation inhibitor with specificity. 5-Azacytidine regulates gene expression by decreasing the level of DNA methylation. 5-Azacytidine induces autophagy and has antitumor activity.
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Tegafur
Fluorafur, FT-207, NSC 148958, FT 207
T137817902-23-7
Tegafur (FT 207) is a congener of the antimetabolite fluorouracil with antineoplastic activity. Tegafur is a prodrug that is gradually converted to fluorouracil in the liver by the cytochrome P-450 enzyme.
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Stavudine
Sanilvudine, NSC 163661, d4T, BMY-27857
T14043056-17-5
Stavudine (BMY-27857), a nucleoside reverse transcriptase inhibitor analog of thymidine, has activity against HIV.
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Capecitabine
Xeloda, RO 09-1978, Capiibine, Capecitibine
T1408154361-50-9
Capecitabine (Capecitibine) is a fluoropyrimidine carbamate belonging to the class of antineoplastic agents called antimetabolites. As a prodrug, capecitabine is selectively activated by tumor cells to its cytotoxic moiety, 5-fluorouracil (5-FU); subsequently, 5-FU is metabolized to two active metabolites, 5-fluoro-2-deoxyuridine monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP) by both tumor cells and normal cells. FdUMP inhibits DNA synthesis and cell division by reducing normal thymidine production, while FUTP inhibits RNA and protein synthesis by competing with uridine triphosphate for incorporation into the RNA strand.
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