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Rho

Rho protein functions as a hexamer of a single polypeptide chain with 419 residues, which is the product of the rho gene. It is an RNA-binding protein with the capacity to hydrolyze ATP and other nucleoside triphosphates.
Cat. No. Product name CAS No. Purity Chemical Structure
T30778 CCG-257081 1922098-90-5 98%
CCG-257081 is an inhibitor of cardiac myosin-related transcription factor and serum response factor (MRTF/SRF) that acts by inhibiting the Rho/MRTF/SRF pathway.C...
TP2327L Y16 acetate(429653-73-6 free base) TP2327L 98%
Y16 is a G-protein–coupled Rho GEFs inhibitor; works synergistically with Rhosin/G04 in inhibiting LARG-RhoA interaction, RhoA activation, and RhoA-mediated sign...
TP2130L Rac1 Inhibitor F56, control peptide acetate TP2130L 98%
Rac1 Inhibitor F56, control peptide acetate is a control peptide version of Rac1 Inhibitor; comprises residues 45-60 of Rac1 with Trp56 replaced by Phe. Does not...
T12452 Digeranyl bisphosphonate 878143-03-4 98%
Digeranyl bisphosphonate is a potent geranylgeranyl pyrophosphate (GGPP) synthase inhibitor that inhibits geranyl pyrophosphorylation of Rac1.Digeranyl bisphosph...
T16746 Rhosin 1173671-63-0 98%
Rhosin is an effective and specific RhoA subfamily Rho GTPases inhibitor, which specifically binds to RhoA to inhibit RhoA-GEF interaction (Kd: ~ 0.4 uM). Rhosin...
T7391 SAR407899 923359-38-0 98%
SAR407899 is Rho kinase inhibitor potently inhibits endothelin-1-induced constriction of renal resistance arteries.
T22062 CCG-100602 1207113-88-9 98%
CCG-100602 inhibits RhoA/C-mediated, SRF-driven luciferase expression in PC-3 prostate cancer cells (IC50 :9.8 µM).
T1237 Azathioprine 446-86-6 98%
Azathioprine, an immunosuppressive agent, inhibits purine synthesis and GTP-binding protein Rac1 activation.
T22991 ML-099 496775-95-2 98%
pan activator of Ras-related GTPases
T6342 NSC 23766 trihydrochloride 1177865-17-6 98%
NSC 23766 is an inhibitor of Rac GTPase targeting Rac activation by GEFs (IC50: ~50 μM); no inhibitory for the closely related targets, RhoA or Cdc42.
T25450 GGTI 2147 191102-87-1 98%
GGTI 2147 decreased Rac1 activity, down-regulated p65 expression, and ameliorated OGD/R-induced neuronal apoptosis.
T15602 ITX3 347323-96-0 98%
ITX3 is a specific, non-toxic, active and selective TrioN RhoGEF inhibitor with IC50 of 76 μM. ITX3 has anticancer effects, inhibits trion mediated GTP exchange ...
TP2131L Rac1 Inhibitor W56 acetate(1095179-01-3 free base) TP2131L 98%
Peptide comprising residues 45-60 of the guanine nucleotide exchange factor (GEF) recognition/activation site of Rac1; selectively inhibits Rac1 interaction with...
T16745 Rhosin hydrochloride 1281870-42-5 98%
Rhosin hydrochloride is an effective and specific RhoA subfamily Rho GTPases inhibitor, which specifically binds to RhoA to inhibit RhoA-GEF interaction (Kd: ~ 0...
T4306 CCG-203971 1443437-74-8 98%
CCG-203971 is an inhibitor of SRE activation in the prostate cancer cell line PC-3 (IC50: 6.4 μM), with 87% inhibition of SRE activation achieved at 100 μM. This...
T7764 CCG-222740 1922098-69-8 98%
CCG-222740 is an inhibitor of Rho/MRTF pathway
T61448 AZA1 1071098-42-4 98%
AZA1 is a potent dual inhibitor of Rac1 and Cdc42. AZA1 induced apoptosis of prostate cancer cells and inhibited cell proliferation, migration and invasion.
T26193 SKLB-163 1255099-06-9 98%
SKLB-163 is an anticancer agent that acts by downregulating RhoGDI, decreasing phosphorylated Akt and p44/42 MAPK, and activating JNK-1 signaling pathway and cas...
T3553 Y16 429653-73-6 98%
Y16 is a G-protein–coupled Rho GEFs inhibitor; works synergistically with Rhosin/G04 in inhibiting LARG-RhoA interaction, RhoA activation, and RhoA-mediated sign...
T8473 MLS000532223 16616-39-0 98%
MLS000532223 is a selectiveRho family GTPases inhibitor(EC50 : 16 μM to 120 μM).
CCG-257081
T30778
CCG-257081 is an inhibitor of cardiac myosin-related transcription factor and serum response factor (MRTF/SRF) that acts by inhibiting the Rho/MRTF/SRF pathway.C...
Y16 acetate(429653-73-6 free base)
TP2327L
Y16 is a G-protein–coupled Rho GEFs inhibitor; works synergistically with Rhosin/G04 in inhibiting LARG-RhoA interaction, RhoA activation, and RhoA-mediated sign...
Rac1 Inhibitor F56, control peptide acetate
TP2130L
Rac1 Inhibitor F56, control peptide acetate is a control peptide version of Rac1 Inhibitor; comprises residues 45-60 of Rac1 with Trp56 replaced by Phe. Does not...
Digeranyl bisphosphonate
T12452
Digeranyl bisphosphonate is a potent geranylgeranyl pyrophosphate (GGPP) synthase inhibitor that inhibits geranyl pyrophosphorylation of Rac1.Digeranyl bisphosph...
Rhosin
T16746
Rhosin is an effective and specific RhoA subfamily Rho GTPases inhibitor, which specifically binds to RhoA to inhibit RhoA-GEF interaction (Kd: ~ 0.4 uM). Rhosin...
SAR407899
T7391
SAR407899 is Rho kinase inhibitor potently inhibits endothelin-1-induced constriction of renal resistance arteries.
CCG-100602
T22062
CCG-100602 inhibits RhoA/C-mediated, SRF-driven luciferase expression in PC-3 prostate cancer cells (IC50 :9.8 µM).
Azathioprine
T1237
Azathioprine, an immunosuppressive agent, inhibits purine synthesis and GTP-binding protein Rac1 activation.
ML-099
T22991
pan activator of Ras-related GTPases
NSC 23766 trihydrochloride
T6342
NSC 23766 is an inhibitor of Rac GTPase targeting Rac activation by GEFs (IC50: ~50 μM); no inhibitory for the closely related targets, RhoA or Cdc42.
GGTI 2147
T25450
GGTI 2147 decreased Rac1 activity, down-regulated p65 expression, and ameliorated OGD/R-induced neuronal apoptosis.
ITX3
T15602
ITX3 is a specific, non-toxic, active and selective TrioN RhoGEF inhibitor with IC50 of 76 μM. ITX3 has anticancer effects, inhibits trion mediated GTP exchange ...
Rac1 Inhibitor W56 acetate(1095179-01-3 free base)
TP2131L
Peptide comprising residues 45-60 of the guanine nucleotide exchange factor (GEF) recognition/activation site of Rac1; selectively inhibits Rac1 interaction with...
Rhosin hydrochloride
T16745
Rhosin hydrochloride is an effective and specific RhoA subfamily Rho GTPases inhibitor, which specifically binds to RhoA to inhibit RhoA-GEF interaction (Kd: ~ 0...
CCG-203971
T4306
CCG-203971 is an inhibitor of SRE activation in the prostate cancer cell line PC-3 (IC50: 6.4 μM), with 87% inhibition of SRE activation achieved at 100 μM. This...
CCG-222740
T7764
CCG-222740 is an inhibitor of Rho/MRTF pathway
AZA1
T61448
AZA1 is a potent dual inhibitor of Rac1 and Cdc42. AZA1 induced apoptosis of prostate cancer cells and inhibited cell proliferation, migration and invasion.
SKLB-163
T26193
SKLB-163 is an anticancer agent that acts by downregulating RhoGDI, decreasing phosphorylated Akt and p44/42 MAPK, and activating JNK-1 signaling pathway and cas...
Y16
T3553
Y16 is a G-protein–coupled Rho GEFs inhibitor; works synergistically with Rhosin/G04 in inhibiting LARG-RhoA interaction, RhoA activation, and RhoA-mediated sign...
MLS000532223
T8473
MLS000532223 is a selectiveRho family GTPases inhibitor(EC50 : 16 μM to 120 μM).
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