T30778 |
CCG-257081
|
1922098-90-5
|
98%
|
|
CCG-257081 is an inhibitor of cardiac myosin-related transcription factor and serum response factor (MRTF/SRF) that acts by inhibiting the Rho/MRTF/SRF pathway.C...
|
TP2327L |
Y16 acetate(429653-73-6 free base)
|
TP2327L
|
98%
|
|
Y16 is a G-protein–coupled Rho GEFs inhibitor; works synergistically with Rhosin/G04 in inhibiting LARG-RhoA interaction, RhoA activation, and RhoA-mediated sign...
|
TP2130L |
Rac1 Inhibitor F56, control peptide acetate
|
TP2130L
|
98%
|
|
Rac1 Inhibitor F56, control peptide acetate is a control peptide version of Rac1 Inhibitor; comprises residues 45-60 of Rac1 with Trp56 replaced by Phe. Does not...
|
T12452 |
Digeranyl bisphosphonate
|
878143-03-4
|
98%
|
|
Digeranyl bisphosphonate is a potent geranylgeranyl pyrophosphate (GGPP) synthase inhibitor that inhibits geranyl pyrophosphorylation of Rac1.Digeranyl bisphosph...
|
T16746 |
Rhosin
|
1173671-63-0
|
98%
|
|
Rhosin is an effective and specific RhoA subfamily Rho GTPases inhibitor, which specifically binds to RhoA to inhibit RhoA-GEF interaction (Kd: ~ 0.4 uM). Rhosin...
|
T7391 |
SAR407899
|
923359-38-0
|
98%
|
|
SAR407899 is Rho kinase inhibitor potently inhibits endothelin-1-induced constriction of renal resistance arteries.
|
T22062 |
CCG-100602
|
1207113-88-9
|
98%
|
|
CCG-100602 inhibits RhoA/C-mediated, SRF-driven luciferase expression in PC-3 prostate cancer cells (IC50 :9.8 µM).
|
T1237 |
Azathioprine
|
446-86-6
|
98%
|
|
Azathioprine, an immunosuppressive agent, inhibits purine synthesis and GTP-binding protein Rac1 activation.
|
T22991 |
ML-099
|
496775-95-2
|
98%
|
|
pan activator of Ras-related GTPases
|
T6342 |
NSC 23766 trihydrochloride
|
1177865-17-6
|
98%
|
|
NSC 23766 is an inhibitor of Rac GTPase targeting Rac activation by GEFs (IC50: ~50 μM); no inhibitory for the closely related targets, RhoA or Cdc42.
|
T25450 |
GGTI 2147
|
191102-87-1
|
98%
|
|
GGTI 2147 decreased Rac1 activity, down-regulated p65 expression, and ameliorated OGD/R-induced neuronal apoptosis.
|
T15602 |
ITX3
|
347323-96-0
|
98%
|
|
ITX3 is a specific, non-toxic, active and selective TrioN RhoGEF inhibitor with IC50 of 76 μM. ITX3 has anticancer effects, inhibits trion mediated GTP exchange ...
|
TP2131L |
Rac1 Inhibitor W56 acetate(1095179-01-3 free base)
|
TP2131L
|
98%
|
|
Peptide comprising residues 45-60 of the guanine nucleotide exchange factor (GEF) recognition/activation site of Rac1; selectively inhibits Rac1 interaction with...
|
T16745 |
Rhosin hydrochloride
|
1281870-42-5
|
98%
|
|
Rhosin hydrochloride is an effective and specific RhoA subfamily Rho GTPases inhibitor, which specifically binds to RhoA to inhibit RhoA-GEF interaction (Kd: ~ 0...
|
T4306 |
CCG-203971
|
1443437-74-8
|
98%
|
|
CCG-203971 is an inhibitor of SRE activation in the prostate cancer cell line PC-3 (IC50: 6.4 μM), with 87% inhibition of SRE activation achieved at 100 μM. This...
|
T7764 |
CCG-222740
|
1922098-69-8
|
98%
|
|
CCG-222740 is an inhibitor of Rho/MRTF pathway
|
T61448 |
AZA1
|
1071098-42-4
|
98%
|
|
AZA1 is a potent dual inhibitor of Rac1 and Cdc42. AZA1 induced apoptosis of prostate cancer cells and inhibited cell proliferation, migration and invasion.
|
T26193 |
SKLB-163
|
1255099-06-9
|
98%
|
|
SKLB-163 is an anticancer agent that acts by downregulating RhoGDI, decreasing phosphorylated Akt and p44/42 MAPK, and activating JNK-1 signaling pathway and cas...
|
T3553 |
Y16
|
429653-73-6
|
98%
|
|
Y16 is a G-protein–coupled Rho GEFs inhibitor; works synergistically with Rhosin/G04 in inhibiting LARG-RhoA interaction, RhoA activation, and RhoA-mediated sign...
|
T8473 |
MLS000532223
|
16616-39-0
|
98%
|
|
MLS000532223 is a selectiveRho family GTPases inhibitor(EC50 : 16 μM to 120 μM).
|