Rho

Rho protein functions as a hexamer of a single polypeptide chain with 419 residues, which is the product of the rho gene. It is an RNA-binding protein with the capacity to hydrolyze ATP and other nucleoside triphosphates.

Cat. No.	Product name	CAS No.	Purity
T30778	CCG-257081	1922098-90-5	98%
T30778	CCG-257081 is an inhibitor of cardiac myosin-related transcription factor and serum response factor (MRTF/SRF) that acts by inhibiting the Rho/MRTF/SRF pathway.C...
TP2327L	Y16 acetate(429653-73-6 free base)	TP2327L	98%
TP2327L	Y16 is a G-protein–coupled Rho GEFs inhibitor; works synergistically with Rhosin/G04 in inhibiting LARG-RhoA interaction, RhoA activation, and RhoA-mediated sign...
TP2130L	Rac1 Inhibitor F56, control peptide acetate	TP2130L	98%
TP2130L	Rac1 Inhibitor F56, control peptide acetate is a control peptide version of Rac1 Inhibitor; comprises residues 45-60 of Rac1 with Trp56 replaced by Phe. Does not...
T12452	Digeranyl bisphosphonate	878143-03-4	98%
T12452	Digeranyl bisphosphonate is a potent geranylgeranyl pyrophosphate (GGPP) synthase inhibitor that inhibits geranyl pyrophosphorylation of Rac1.Digeranyl bisphosph...
T16746	Rhosin	1173671-63-0	98%
T16746	Rhosin is an effective and specific RhoA subfamily Rho GTPases inhibitor, which specifically binds to RhoA to inhibit RhoA-GEF interaction (Kd: ~ 0.4 uM). Rhosin...
T7391	SAR407899	923359-38-0	98%
T7391	SAR407899 is Rho kinase inhibitor potently inhibits endothelin-1-induced constriction of renal resistance arteries.
T22062	CCG-100602	1207113-88-9	98%
T22062	CCG-100602 inhibits RhoA/C-mediated, SRF-driven luciferase expression in PC-3 prostate cancer cells (IC50 :9.8 µM).
T1237	Azathioprine	446-86-6	98%
T1237	Azathioprine, an immunosuppressive agent, inhibits purine synthesis and GTP-binding protein Rac1 activation.
T22991	ML-099	496775-95-2	98%
T22991	pan activator of Ras-related GTPases
T6342	NSC 23766 trihydrochloride	1177865-17-6	98%
T6342	NSC 23766 is an inhibitor of Rac GTPase targeting Rac activation by GEFs (IC50: ~50 μM); no inhibitory for the closely related targets, RhoA or Cdc42.
T25450	GGTI 2147	191102-87-1	98%
T25450	GGTI 2147 decreased Rac1 activity, down-regulated p65 expression, and ameliorated OGD/R-induced neuronal apoptosis.
T15602	ITX3	347323-96-0	98%
T15602	ITX3 is a specific, non-toxic, active and selective TrioN RhoGEF inhibitor with IC50 of 76 μM. ITX3 has anticancer effects, inhibits trion mediated GTP exchange ...
TP2131L	Rac1 Inhibitor W56 acetate(1095179-01-3 free base)	TP2131L	98%
TP2131L	Peptide comprising residues 45-60 of the guanine nucleotide exchange factor (GEF) recognition/activation site of Rac1; selectively inhibits Rac1 interaction with...
T16745	Rhosin hydrochloride	1281870-42-5	98%
T16745	Rhosin hydrochloride is an effective and specific RhoA subfamily Rho GTPases inhibitor, which specifically binds to RhoA to inhibit RhoA-GEF interaction (Kd: ~ 0...
T4306	CCG-203971	1443437-74-8	98%
T4306	CCG-203971 is an inhibitor of SRE activation in the prostate cancer cell line PC-3 (IC50: 6.4 μM), with 87% inhibition of SRE activation achieved at 100 μM. This...
T7764	CCG-222740	1922098-69-8	98%
T7764	CCG-222740 is an inhibitor of Rho/MRTF pathway
T61448	AZA1	1071098-42-4	98%
T61448	AZA1 is a potent dual inhibitor of Rac1 and Cdc42. AZA1 induced apoptosis of prostate cancer cells and inhibited cell proliferation, migration and invasion.
T26193	SKLB-163	1255099-06-9	98%
T26193	SKLB-163 is an anticancer agent that acts by downregulating RhoGDI, decreasing phosphorylated Akt and p44/42 MAPK, and activating JNK-1 signaling pathway and cas...
T3553	Y16	429653-73-6	98%
T3553	Y16 is a G-protein–coupled Rho GEFs inhibitor; works synergistically with Rhosin/G04 in inhibiting LARG-RhoA interaction, RhoA activation, and RhoA-mediated sign...
T8473	MLS000532223	16616-39-0	98%
T8473	MLS000532223 is a selectiveRho family GTPases inhibitor(EC50 : 16 μM to 120 μM).