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Rho

Rho protein functions as a hexamer of a single polypeptide chain with 419 residues, which is the product of the rho gene. It is an RNA-binding protein with the capacity to hydrolyze ATP and other nucleoside triphosphates.

  • Y16
    T3553429653-73-6
    Y16 is a G-protein–coupled Rho GEFs inhibitor; works synergistically with Rhosin/G04 in inhibiting LARG-RhoA interaction, RhoA activation, and RhoA-mediated signaling functions.
    • $30
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  • Rhosin hydrochloride
    T167451281870-42-5
    Rhosin hydrochloride is an effective and specific RhoA subfamily Rho GTPases inhibitor, which specifically binds to RhoA to inhibit RhoA-GEF interaction (Kd: ~ 0.4 uM). Rhosin hydrochloride does not interact with Cdc42 or Rac1, nor the GEF, LARG. Rhosin h
    • $162
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  • SKLB-163
    T261931255099-06-9In house
    SKLB-163 acts by downregulating RhoGDI, activating JNK-1 signaling pathway and caspase-3, and reducing phosphorylated Akt and p44/42 MAPK.
    • $137
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  • GGTI 2147
    T25450191102-87-1In house
    GGTI 2147 decreased Rac1 activity, down-regulated p65 expression, and ameliorated OGD/R-induced neuronal apoptosis.
    • $520
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  • Rac1 Inhibitor W56 acetate(1095179-01-3 free base)
    TP2131L
    Rac1 Inhibitor W56 acetate(1095179-01-3 free base) is a peptide comprising residues 45-60 of the guanine nucleotide exchange factor (GEF) recognition/activation site of Rac1. Rac1 Inhibitor W56 acetate(1095179-01-3 free base) selectively inhibits Rac1 interaction with Rac1-specific GEFs TrioN, GEF-H1 and Tiam1.
    • $236
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  • CCG-257081
    T307781922098-90-5In house
    CCG-257081 (MRTF/SRF-IN-1) is an inhibitor of cardiac myosin-related transcription factor and serum response factor (MRTF/SRF) that acts by inhibiting the Rho/MRTF/SRF pathway.CCG-257081 has shown efficacy in preventing bleomycin-induced fibrosis in several mouse models. CCG-257081 can be used in cancer prevention and fibrosis research.
    • $129
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  • Digeranyl bisphosphonate
    T12452878143-03-4In house
    Digeranyl bisphosphonate (DGBP) is a potent geranylgeranyl pyrophosphate (GGPP) synthase inhibitor that inhibits geranyl pyrophosphorylation of Rac1.Digeranyl bisphosphonate induces autophagy but not apoptosis.
    • $263 TargetMol
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  • Zoledronic Acid
    T6739118072-93-8
    Zoledronic Acid (ZOL 446) is a bisphosphonate. Zoledronic Acid (ZOL 446) is used to prevent skeletal fractures in patients with cancers such as multiple myeloma and prostate cancer. It can also be used to treat hypercalcemia of malignancy and can be helpful for treating pain from bone metastases. An annual dose of Zoledronate may also prevent recurring fractures in patients with a previous hip fracture. Zoledronic Acid (ZOL 446) is a single 5 mg infusion for the treatment of Paget's disease of bone. In 2007, the FDA also approved Reclast for the treatment of postmenopausal osteoporosis.
    • $32
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    TargetMol | Citations Cited
  • CCG-1423
    T2014285986-88-1
    CCG-1423, a selective RhoA pathway inhibitor, suppresses SRF-mediated transcription.
    • $32
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  • EHT 1864
    T6483754240-09-0
    EHT 1864 is a effective Rac family GTPase inhibitor for Rac1/Rac1b/Rac2/Rac3 (Kd: 40/50/60/250 nM).
    • $39
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  • Y16 acetate(429653-73-6 free base)
    TP2327L
    Y16 acetate(429653-73-6 free base) is a G-protein–coupled Rho GEFs inhibitor; works synergistically with Rhosin/G04 in inhibiting LARG-RhoA interaction, RhoA activation, and RhoA-mediated signaling functions.
    • $50
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  • (E/Z)-ZINC09659342
    T9986591726-26-0
    (E/Z)-ZINC09659342 is an inhibitor of Lbc-Rho A interaction.
    • $125
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  • Rac1 Inhibitor F56, control peptide acetate
    TP2130L
    Rac1 Inhibitor F56, control peptide acetate is a control peptide version of Rac1 Inhibitor; comprises residues 45-60 of Rac1 with Trp56 replaced by Phe. Does not affect GEF-Rac1 interaction.
    • $412
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  • 1A-116
    T140041430208-73-3
    1A-116 is a specific inhibitor of Rac1 .
    • $46
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  • CCG-100602
    T220621207113-88-9
    CCG-100602 inhibits RhoA/C-mediated, SRF-driven luciferase expression in PC-3 prostate cancer cells (IC50 :9.8 μM).
    • $32
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  • ML-099
    T22991496775-95-2
    pan activator of Ras-related GTPases
    • $41
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  • CCG-203971
    T43061443437-74-8
    CCG-203971 is an inhibitor of SRE activation in the prostate cancer cell line PC-3 (IC50: 6.4 μM), with 87% inhibition of SRE activation achieved at 100 μM. This compound also inhibits PC-3 cell migration (IC50: 4.2 μM), as determined by a scratch wound assay. CCG-203971(CCG203971) causes no cytotoxicity when evaluated by the WST-1 assay. It is well tolerated in normal mice up to doses of 100 mg/kg given intraperitoneally over five days.
    • $48
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  • Rhosin
    T167461173671-63-0
    Rhosin is an effective and specific RhoA subfamily Rho GTPases inhibitor, which specifically binds to RhoA to inhibit RhoA-GEF interaction (Kd: ~ 0.4 uM). Rhosin does not interact with Cdc42 or Rac1, nor the GEF, LARG. Rhosin causes cell apoptosis.
    • $1,520
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  • ITX3
    T15602347323-96-0
    ITX3 is a specific, non-toxic, active and selective TrioN RhoGEF inhibitor with IC50 of 76 μM. ITX3 has anticancer effects, inhibits trion mediated GTP exchange on RhoG and Rac1, inhibits NGF-mediated neurite growth in PC12 cells and REF52 fibroblast structure formation induced by trion.
    • $35
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  • YH-306
    T246421373764-75-0
    YH-306 (TRV055 acetate ) is a modulator of the FAK signaling pathway that acts by suppressing colorectal tumor growth and metastasis.
    • $47
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  • ZINC69391
    T24833303094-67-9
    ZINC69391 (CysHHC10 acetate(1408311-03-4 free base)) is a selective inhibitor of Rac1 with antiproliferative and antimetastatic effects. ZINC69391 interferes with the interaction of Rac1 with Dock180, reduces Rac1-GTP levels and induces apoptosis.
    • $87
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  • NSC 23766 trihydrochloride
    T63421177865-17-6
    NSC 23766 trihydrochloride (Rac1 Inhibitor) is an inhibitor of Rac GTPase targeting Rac activation by GEFs (IC50: ~50 μM); no inhibitory for the closely related targets, RhoA or Cdc42.
    • $52
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  • SAR407899
    T7391923359-38-0
    SAR407899 is Rho kinase inhibitor potently inhibits endothelin-1-induced constriction of renal resistance arteries.
    • $33
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  • EHop-016
    T24271380432-32-5
    EHop-016 is a specific Rac GTPase inhibitor with IC50 of 1.1 μM for Rac1 in MDA-MB-231 and MDA-MB-435 cells, equally effective inhibition for Rac3.
    • $40
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  • Azathioprine
    T1237446-86-6
    Azathioprine (BW 57-322), an immunosuppressive agent, inhibits purine synthesis and GTP-binding protein Rac1 activation.
    • $45
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  • Z62954982
    T371131090893-12-1
    Z62954982 (ZINC08010136) is a selective inhibitor of Rac1, which stunts the growth and branching of neurons.Z62954982 inhibits Rac1 activation and reduces proliferation, p38 phosphorylation, and IL-6 levels in pulmonary arterioles.
    • $38
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  • AZA1
    T614481071098-42-4
    AZA1 (Rac1/Cdc42-IN-1) is a potent dual inhibitor of Rac1 and Cdc42. AZA1 induced apoptosis of prostate cancer cells and inhibited cell proliferation, migration and invasion.
    • $97
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  • CCG-222740
    T77641922098-69-8
    CCG-222740 is an inhibitor of Rho/MRTF pathway
    • $41
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  • MLS000532223
    T847316616-39-0
    MLS000532223 is a selectiveRho family GTPases inhibitor(EC50 : 16 μM to 120 μM).
    • $132
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