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Results for "

nk receptor

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    82
    TargetMol | Inhibitors_Agonists
  • Peptide Products
    36
    TargetMol | Peptide_Products
  • Inhibitory Antibodies
    2
    TargetMol | Inhibitory_Antibodies
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    78
    TargetMol | Recombinant_Protein
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    TargetMol | Antibody_Products
Aprepitant
MK-869, MK-0869, L-754030, Aprepitant`
T1743170729-80-3
Aprepitant is a Substance P/Neurokinin-1 Receptor Antagonist. The mechanism of action of aprepitant is as a Neurokinin 1 Antagonist, and Cytochrome P450 3A4 Inhibitor, and Cytochrome P450 2C9 Inducer, and Cytochrome P450 3A4 Inducer.
  • $48
In Stock
Size
QTY
Vapreotide acetate
RC-160 acetate, BMY-41606 acetate
T13306L849479-74-9
Vapreotide acetate (BMY-41606 acetate) is an antagonist of the neurokinin-1 (NK1) receptor (IC50: 330 nM).
  • $30
In Stock
Size
QTY
Fosaprepitant dimeglumine
MK-0517, L785298, Fosaprepitant dimeglumine salt
T1790265121-04-8
Fosaprepitant dimeglumine (MK-0517) is the dimeglumine salt form of fosaprepitant, a water-soluble, N-phosphorylated prodrug of aprepitant with antiemetic activity. Upon intravenous administration and rapid conversion to aprepitant, this agent selectively binds to human substance P/neurokinin 1 (NK1) receptors in the central nervous system (CNS), inhibiting receptor binding of endogenous substance P and preventing substance P-induced emesis.
  • $45
Backorder
Size
QTY
Rolapitant
SCH619734
T3716552292-08-7
Rolapitant (SCH619734) Hydrochloride is the hydrochloride salt form of rolapitant, an orally bioavailable, centrally-acting, selective, neurokinin 1 receptor (NK1-receptor) antagonist with potential antiemetic activity. Upon oral administration, rolapitant competitively binds to and blocks the activity of the NK1-receptor in the central nervous system, thereby inhibiting the binding of the endogenous ligand, substance P (SP). This may prevent both SP-induced emesis and chemotherapy-induced nausea and vomiting (CINV). The interaction of SP with the NK1-receptor plays a key role in the induction of nausea and vomiting caused by emetogenic cancer chemotherapy. Compared to other NK1-receptor antagonists, rolapitant has both a more rapid onset of action and a much longer half-life.
  • $43
In Stock
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QTY
Elinzanetant
T38144929046-33-3
Elinzanetant is a dual antagonist of neurokinin (NK) receptors 1 and 3 and modulates reproductive hormone secretion.
  • $97
In Stock
Size
QTY
Substance P (7-11)
Substance P 7-11(TFA)
T755451165-05-0
Substance P (7-11) (Substance P 7-11(TFA)) is a C-terminal fragment of Substance P .
  • $39
In Stock
Size
QTY
TargetMol | Inhibitor Sale
Senktide
T7633106128-89-6
Senktide is an agonist of tachykinin NK3 receptor.
  • $56
In Stock
Size
QTY
L-732138
T8235148451-96-1
L-732138 is a potent and competitive antagonist of neurokinin-1 (NK-1) receptor(IC50 : 2.3 nM)
  • $43
In Stock
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QTY
Substance P
Neurokinin P
TP108733507-63-0
Substance P (Neurokinin P) (SP) is an undecapeptide (a peptide composed of a chain of 11 amino acid residues) member of the tachykinin neuropeptide family.
  • $52
In Stock
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[Lys5,MeLeu9,Nle10]-NKA(4-10)
TP1883137565-28-7
Highy selective and potent NK2 receptor agonist (IC50 = 6.1 nM). Induces contraction of the rat fundus and bladder (EC50 values are 117 and 10 nM respectively).
  • $103
In Stock
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MEN11467
T12000214487-46-4In house
MEN11467 is a novel, orally available, potent and selective peptidomimetic tachykinin NK 1 receptor antagonist for the study of acute colon cancer.
    6-8 weeks
    Inquiry
    Bisaramil hydrochloride
    RGH-2957, RGH 2957, NK-1556, NK1556, NK 1556, Bisaramil hcl
    T2682296480-44-3In house
    Bisaramil hydrochloride (Bisaramil) is a novel diazabicyclononane antiarrhythmic compound that inhibits the generation of free radicals.Bisaramil hydrochloride blocks sodium currents and inhibits the slow Ca(2+) action potential induced by isoproterenol in K(+)-depolarized muscle.
    • $293 TargetMol
    In Stock
    Size
    QTY
    Burapitant
    SSR 240600
    T69140537034-22-3In house
    Burapitant (SSR 240600) is a novel non-peptide tachykinin neurokinin 1 (NK) receptor antagonist with anti-coke oven and antidepressant activity.
    • $988
    In Stock
    Size
    QTY
    NKP608
    NKP-608, NKP 608
    TQ0087177707-12-9In house
    NKP608 is a selective and highly effective neurokinin-1 (NK-1) receptor antagonist with anticancer and antianxiety activities, inhibiting the proliferation of human colorectal cancer cells through the Wnt signaling pathway.
    • $152
    In Stock
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    QTY
    Netupitant
    Ro 67-31898 000, CID 6451149
    T6905290297-26-6
    Netupitant (CID 6451149) is a specific neurokinin 1 (NK1) receptor antagonist (Ki: 0.95 nM).
    • $47
    In Stock
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    QTY
    Maropitant
    T7209147116-67-4
    Maropitant is a selective neurokinin (NK1) receptor antagonist.
    • $43
    In Stock
    Size
    QTY
    Fezolinetant
    ESN-364
    T152781629229-37-3
    Fezolinetant (ESN-364) is a neurokinin-3 receptor antagonist that is being investigated for menopausal hot flashes.
    • $73
    In Stock
    Size
    QTY
    gamma-preprotachykinin amide (72-92) acetate
    gamma-preprotachykinin amide (72-92) acetate (114882-65-4 Free base)
    T9417L
    gamma-preprotachykinin amide (72-92) acetate is a 21 amino acid peptide belonging to the tachykinin (TK) family and including neurokinin A (NKA) in its C-terminal sequence. gamma-preprotachykinin amide (72-92) acetate possesses higher affinity than NKA for central NK-2 receptors; it shows lower affinity for NK-1 receptors, however, it potently stimulates salivary secretion, which is mediated by NK-1 receptor activation.
    • $75
    In Stock
    Size
    QTY
    TargetMol | Inhibitor Sale
    Toremifene
    Z-Toremifene, GTx 006
    T013989778-26-7
    Toremifene (GTx 006) is a selective estrogen-receptor modulator (SERM).
    • $35
    In Stock
    Size
    QTY
    TargetMol | Inhibitor Sale
    NK-1 Antagonist 1
    Rolapitant intermediate
    T12233873947-10-5
    NK-1 Antagonist 1 is a NK-1 receptor antagonist.
    • Inquiry Price
    3-6 months
    Size
    QTY
    Men 10376
    Neurokinin-2 receptor antagonist
    T16038135306-85-3
    Men 10376 is a selective antagonist of tachykinin NK-2 receptor. It has a Ki of 4.4 μM for rat small intestine NK-2 receptor.
    • $246
    35 days
    Size
    QTY
    Orvepitant maleate
    GW823296 maleate
    T16406579475-24-4
    Orvepitant maleate is an effective, selective, and well-tolerated neurokinin-1 receptor (NK-1) antagonist (pKi: 10.2 for human neurokinin-1 receptor). Orvepitant maleate has the potential for depressive disorder and chronic refractory cough (CRC) treatmen
    • $2,460
    8-10 weeks
    Size
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    SB-222200
    T16849174635-69-9
    SB-222200 is a selective, reversible, and competitive antagonist of the human NK-3 receptor(Ki=4.4 nM).
    • $33
    In Stock
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    TargetMol | Inhibitor Sale
    Tradipitant
    VLY-686, LY686017
    T17156622370-35-8
    Tradipitant (VLY-686) is an antagonist of neurokinin-1.
    • $55
    In Stock
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    TargetMol | Inhibitor Sale