nk receptor

Substance P (Neurokinin P) (SP) is an undecapeptide (a peptide composed of a chain of 11 amino acid residues) member of the tachykinin neuropeptide family.

Highy selective and potent NK2 receptor agonist (IC50 = 6.1 nM). Induces contraction of the rat fundus and bladder (EC50 values are 117 and 10 nM respectively).

gamma-preprotachykinin amide (72-92) acetate is a 21 amino acid peptide belonging to the tachykinin (TK) family and including neurokinin A (NKA) in its C-terminal sequence. gamma-preprotachykinin amide (72-92) acetate possesses higher affinity than NKA for central NK-2 receptors; it shows lower affinity for NK-1 receptors, however, it potently stimulates salivary secretion, which is mediated by NK-1 receptor activation.

R 396 acetate is an NK-2 Tachykinin Receptor Antagonist.

Substance P(1-7) (Substance P 1-7) is the major bioactive metabolite formed after proteolytic degradation of the tachykinin substance P (SP),with anti-inflammatory, anti-nociceptive and anti-hyperalgesic effects

MEN 10207 acetate is a selective antagonist for NK-2 tachykinin receptor.

Substance P(1-4) Acetate is a neurokinin receptor (NK-R) antagonist that inhibits the formation of PV EEC, affecting the proliferation and differentiation of PV CD36+ erythroid progenitor cells.

(β-Ala8)-Neurokinin A (4-10), a neuropeptide, is a potent and selective agonist for the NK-2 tachykinin receptor [1].

Substance P (6-11), the C-terminal hexapeptideamide of Substance P, exhibits affinity for the NK-1 tachykinin receptor, leading to motoneuron depolarization and a hypotensive effect [1] [2].

HCV Peptide (35-44), a core protein of Hepatitis C Virus at positions 35 to 44, functions as an HLA-A2-restricted CTL epitope and inhibits NK cell activity through the KIR2DL2 3 receptor and synergistically through the CD94:NKG2A receptor [1].

Men 10376 TFA is a selective antagonist of the tachykinin NK-2 receptor, exhibiting a K_i value of 4.4 μM for the NK-2 receptor in rat small intestine [1].

Vapreotide acetate (BMY-41606 acetate) is an antagonist of the neurokinin-1 (NK1) receptor (IC50: 330 nM).

R 396 (Acleu-asp-gln-trp-phe-glynh2) is a linear hexapeptide and is also an NK-2 tachykinin receptor antagonist.

Potent and selective tachykinin NK1 receptor agonist (EC50 = 2 nM in guinea pig vas deferens).

[Sar9]-Substance P acetate is one of NK-1 receptor agonist. The action of SP on progesterone metabolism was mimicked by the rNK1-specific agonist [Sar-9,Met(O2)11]-SP.

GR 83074 is a potent and selective antagonist of the NK-2 (Neurokinin Receptor) with a 340-fold selectivity over NK-1 and a pK_B value of 8.23. It does not act as an antagonist for NK-3, affirming its specificity [1].

Substance P (7-11) (Substance P 7-11(TFA)) is a C-terminal fragment of Substance P .

[Sar9]-Substance P is one of NK-1 receptor agonist. The action of SP on progesterone metabolism was mimicked by the rNK1-specific agonist [Sar-9,Met(O2)11]-SP.

Eledoisin Related Peptide (Eledoisin RP) is a tachykinin receptor ligand.

Men 10376 is a selective antagonist of tachykinin NK-2 receptor. It has a Ki of 4.4 μM for rat small intestine NK-2 receptor.

Biotin-Neurokinin A, a biotinylated form of Neurokinin A (Substance K), functions as a peptide neurotransmitter within the tachykinin family, primarily engaging the NK-2 receptor. It serves as a significant mediator in the physiological processes of human airway and gastrointestinal tissues [1].

[Lys5,MeLeu9,Nle10]Neurokinin A(4-10) (LMN-NKA), a Neurokinin A analogue, is a selective and potent NK2 receptor (NK2R) agonist with prokinetic activity, making it valuable for researching smooth muscle contractions across various tissues through NK-2 receptor engagement [1][2][3].

Neurokinin A (4-10) TFA is a tachykinin NK2 receptor agonist [1].

dCNP binds to NPR-B C receptors (NPR-B C receptor), initiating the cGMP signaling pathway and regulating vascular function. It exhibits anti-hypoxic effects by downregulating hypoxia-related genes such as HIF1α and HIF2α. Additionally, dCNP inhibits tumor stroma induction, demonstrating antifibrotic properties. It also enhances immune response by upregulating CTL, NK cells, and conventional type 1 dendritic cells in tumors.