modification

N-Succinimidyl-S-acetylthioacetate (SATA) is a protein modification agent that introduces thiol-groups into protein molecules and adds sulfhydryl groups in a protected form to proteins and other amine-containing molecules for later reaction with sulfhydryl reactive crosslinkers such as Sulfo-SMCC, Sulfo-MBS, etc.

Cemdisiran, an investigational N-acetylgalactosamine-conjugated RNAi (RNA interference) agent with terminal sugar modification, is a small interfering RNA (siRNA) designed to specifically target and suppress the C5 mRNA, thereby reducing the liver's production of the complement component C5 [1].

Leptomycin B (LMB) is a potent inhibitor of the nuclear export of proteins and is a potent antifungal antibiotic blocking the eukaryotic cell cycle. Leptomycin B inactivates CRM1 exportin 1 by covalent modification at a cysteine residue.

Triparanol (NSC-65345) interferes with posttranslational modification of Hedgehog signaling molecules as well as the sterol sensing domain of its receptor PTCH1, leading to down-regulation of Hedgehog signaling. Triparanol suppresses human tumor growth and is an antilipemic agent with high ophthalmic toxicity.

VRT-532 (CFpot-532) is an effective modulator of CFTR and is commonly used in studies of cystic fibrosis (CF) caused by CFTR defects. Modification of CFTR by this small molecule modulator can increase arylsulfatase B (ARSB), which is necessary to reduce the accumulation of sulphate glycosaminosaccharide (gag), thus reducing the accumulation of 4-chondroitin sulfate in cystic fibrosis.

Compound FL0001, with CAS No. 479553-01-0, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound FL0001 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Compound FL0002, with CAS No. 189089-90-5, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound FL0002 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Compound FL0003, with CAS No. 1067193-34-3, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound FL0003 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Compound FL0004, with CAS No. 800402-07-7, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound FL0004 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

AZETIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER, with CAS No. 159749-28-7, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. AZETIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Compound FL0036, with CAS No. 142733-64-0, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound FL0036 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Compound FL0044, with CAS No. 345965-52-8, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound FL0044 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Compound FL0066, with CAS No. 927679-54-7, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound FL0066 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Compound FL0101, with CAS No. 396074-50-3, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound FL0101 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Compound FL0105, with CAS No. 117642-16-7, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound FL0105 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Compound FL0107, with CAS No. 171049-41-5, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound FL0107 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Compound FL0108, with CAS No. 20348-21-4, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound FL0108 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Compound FL0113, with CAS No. 1017783-09-3, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound FL0113 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Compound FL0122, with CAS No. 193537-14-3, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound FL0122 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Compound FL0148, with CAS No. 1694-06-0, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound FL0148 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Compound FL0151, with CAS No. 1788054-84-1, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound FL0151 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Compound FL0152, with CAS No. 120737-78-2, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound FL0152 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Compound FL0153, with CAS No. 278788-66-2, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound FL0153 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Compound FL0165, with CAS No. 398491-59-3, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound FL0165 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.