ha5

HA5 has antimicrobial activity and inhibits the biofilm formation of Streptococcus mutans with an IC50 value of 6.42 μM. HA5 inhibits the production of Streptococcus mutans dextran and the level of eDNA, but it does not inhibit the growth of Streptococcus mutans.

BHA536 is an orally effective inhibitor of PKCα β and the NF-kB signaling pathway. This compound inhibits the proliferation of ABC DLBCL cells harboring CD79 mutations by causing cell cycle arrest in the G1 phase and induces apoptosis in TMD8 cells. Additionally, BHA536 exhibits antitumor activity in mice.

(S)-PHA533533, a cyclin-dependent kinase 2 (CDK2) inhibitor, exhibits antitumor activity and has the capability to induce widespread expression of UBE3A in neurons of Angelman syndrome model mice.