f16

F16 ((E)-4-(3-indolylvinyl)-N-methylpyridinium iodide) inhibits the growth of neu-overexpressing cells and the proliferation of mammary epithelial.

2E-3-F16 is an anticancer agent that exhibits tumor cell selectivity between NCI-H446 cancer cells and HBE cells. Additionally, 2E-3-F16 enhances the sensitivity of A549 cells to Cisplatin.

GLF16 HCl is a fluorophore-coupled Sudan Black B analog that allows rapid detection, isolation and real-time tracking of senescent cells by fluorescence microscopy and flow cytometry.

16F16 is a protein disulfide isomerase (PDI) inhibitor.1It inhibits PDI reductase activity in an enzyme assay when used at concentrations ranging from 1 to 100 μg/ml.116F16 reduces PC12 cell apoptosis induced by the misfolded huntingtin protein HTTQ103. It suppresses PDI-dependent mitochondrial outer membrane permeabilization (MOMP) in isolated PC12 cell mitochondria. 16F16 (2, 3, 4, and 10 μM) reduces HTTN90Q73mutant huntingtin-induced medium spinal neuron death and MOMP in rat corticostriatal slices. It also reduces pyramidal neuron death induced by amyloid-β precursor protein (APP) in rat corticostriatal slices. 1.Hoffstrom, B.G., Kaplan, A., Letso, R., et al.Inhibitors of protein disulfide isomerase suppress apoptosis induced by misfolded proteinsNat. Chem. Biol.6(12)900-906(2010)

SF1670 (PTPase CD45 Inhibitor) is a specific PTEN inhibitor with IC50 of 2 μM.

VUF16839 is a high-affinity non-imidazole histamine H3 receptor agonist.

Imupedone (LF 1695) is a synthetic immunomodulator that modulates T lymphocytes and macrophages, induces T-cell differentiation of bone marrow precursor cells, and increases the proliferative response of lymphocytes to mitogens, antigens, and allogeneic cells.13483-84-5

BF-168 is a candidate probe for PET and specifically recognizes both neuritic and diffuse plaques (Ki: 6.4 nM for Aβ1-42).

Nifursemizone (Etafurazone) is an agent with antiprotozoal.

F 16915 can prevent heart failure-induced atrial fibrillation.F 16915 is a docosahexaenoic acid derivative.

Icrocaptide is used potentially for the treatment of acute myocardial infarction.

Orf 1616 is a biochemical.

Reparixin (Repertaxin) is a potent inhibitor of both CXCL8 receptors CXCR1/2, it inhibits weakly CXCR2-mediated cell migration (IC50=100 nM), whereas it strongly blocks CXCR1-mediated chemotaxis (IC50=1 nM).

iCRT 14 is a novel and potent inhibitor of β-catenin-responsive transcription (CRT) with an IC50 of 40.3 nM in assays of Wnt pathway activity.

Carfloglitazar sodium is the salt form of Carfloglitazar, a peroxisome proliferator activating receptor (PPAR) agonist.

Ranibizumab is a humanized monoclonal antibody fragment designed to target and inhibit vascular endothelial growth factor (VEGF), including VEGF110, VEGF121, and VEGF165. Ranibizumab's ability to selectively target and neutralize VEGF-A isoforms has made it a crucial component of research and treatment strategies for wet wet age-related macular degeneration (AMD).