dp1

Flibanserin (Girosa) is a serotonergic antidepressant used to treat hypoactive sexual desire disorder. Flibanserin has been associated with a low rate of minor serum aminotransferase elevations during treatment but has not been linked to instances of clinically apparent acute liver injury.

BW 245C is a selective prostaglandin-like DP receptor (DP1) agonist, a prostaglandin analogue with inhibitory effects on the aggregation response of collagen, which can be used to study diseases such as stroke.

DP-1, a Ganetespib degradation product, represents a fragment derived from SDC-TRAP-0063. Ganetespib itself functions as an inhibitor of heat shock protein 90 (HSP90), exhibiting notable anti-tumor properties.

Anisotropine Methylbromide is an anticholinergic agent and has been used for relief of gastrointestinal spasm and for the suppression of gastric acid secretion.

Treprostinil (Orenitram) is a potent DP1, IP and EP2 agonist (EC50: 0.6/1.9/6.2 nM).

Treprostinil Sodium (UT-15) is a potent DP1, IP and EP2 agonist (EC50: 0.6/1.9/6.2 nM).

Asapiprant (S-555739) is a potent and selective DP1 receptor antagonist (Ki: 0.44 nM). It exhibited high affinity and selectivity for the DP1 receptor.

Treprostinil diethanolamine (UT-15C) is a potent agonist of EP2, DP1, and IP, with values of 3.6, 4.4, and 32.1 nM for EP2, DP1, and IP, respectively, and 212, 826, 2505, and 4680 nM for EP1, EP4, EP3, and FPKi, respectively. Treprostinil diethanolamine contributes to the upregulation of cAMP, maintaining vascular homeostasis and causing vasodilation in human pulmonary arteries.

DP-1 hydrochloride is a degradation product of SDC-TRAP-0063, a fragment of Ganetespib, a heat shock protein 90 (HSP90) inhibitor with antitumor activity.

Laropiprant (MK-0524) is a potent and selective antagonist of prostaglandin D2 (PGD2) receptor (DP) such as and DP/DP1 receptor(Ki = 0.57 nM) and TP Receptor(Ki = 2.95 nM).

L 888607 is an effective and selective CRTH2 agonist (Ki: 0.8 nM).

L 888607 Racemate is a selective antagonist of the prostaglandin D2 receptor subtype 1 (DP1) with Ki values of 132 nM and 17 nM for DP1 and the thromboxane A2 receptor (TP), respectively.

TDP1 Inhibitor-1 is a potent inhibitor of Tyrosyl-DNA Phosphodiesterase 1 (TDP1) with an IC50 of 7 μM.

Fructo-oligosaccharide DP11/GF10 is a fructooligosaccharide (FOS) with a high degree of polymerization of approximately 11. It consists of multiple fructose units linearly linked via β(2→1) glycosidic bonds, with a glucose residue at the terminal end of the molecule. Fructo-oligosaccharide DP11/GF10 belongs to prebiotic substrates and can be selectively utilized by gut microbiota to modulate the structure and metabolic activity of the intestinal flora.

Fructo-oligosaccharide DP12/GF11 is a fructooligosaccharide (FOS) with a high degree of polymerization of 12. It consists of 11 fructose units linearly linked via β(2→1) glycosidic bonds, with a glucose residue at the terminal end of the molecule. It can be selectively fermented by beneficial gut bacteria, thereby influencing the composition and metabolic function of the intestinal microecology.

TDP1 Inhibitor-3 (Compound 4E) is a TDP1 inhibitor with an IC50 value of 0.63 μM.

LMDP10 is an orally active 3-aminoquinazoline derivative that activates the Keap1-Nrf2 pathway. It binds to Keap1, inhibiting the Keap1-Nrf2 interaction and subsequently activating the Nrf2 pathway. This leads to increased levels of Nrf2, SOD, and GSH, while reducing MDA and TNF-α levels. As a result, LMDP10 alleviates neurodegeneration and improves memory in Alzheimer's disease (AD) rat models. LMDP10 is applicable for Alzheimer's disease (AD) research.

TDP1-IN-4 (Compound 33) is an inhibitor of tyrosyl-DNA phosphodiesterase 1 (TDP1) with an IC50 of 0.90 μM. It demonstrates strong synergistic effects with Camptothecin in SK-Mel-2 cells, but not in cancer cells (A549, HCT-116, and MCF-7 cells) or non-cancerous Ges-1 cells. TDP1-IN-4 is applicable in cancer chemotherapy and radiotherapy research.

TDP1 Inhibitor-2 is a potent inhibitor of TDP1 (tyrosyl-DNA phosphodiesterase 1) (IC50: 99 nM) and inhibits SCAN1 (spinal cerebellar ataxia syndrome with axonal neuropathy) (IC50: 3.5 μM).

MDP1, derived from Melittin, disrupts the membrane integrity of both Gram-positive and Gram-negative bacteria, leading to bacterial death through membrane damage. This compound exhibits potent antibacterial activity against multidrug-resistant (MDR) and reference strains of S. aureus, E. coli, and P. aeruginosa [1].

MDP1 acetate, a derivative of Melittin, compromises membrane integrity of both Gram-positive and Gram-negative bacteria leading to bacterial death through membrane damage. MDP1 acetate exhibits antibacterial activity against multidrug-resistant and reference strains of S. aureus, E. coli, and P. aeruginosa. MDP1 acetate is used in antimicrobial membrane biology research systems to investigate peptide-induced membrane disruption, bacterial permeability changes, and antimicrobial peptide mechanism profiling.

SDP116, a synthetic peptide derivative of the GPR116 Stachel sequence, exhibits ADGRF5 agonistic activity [1].

Fructo-oligosaccharide DP14, an oligosaccharide derived from Atractylodes lancea [1], represents a specific polysaccharide subclass with a degree of polymerization of 14.

Fructo-oligosaccharide DP13 is a high-degree polymerization fructan that belongs to the inulin-type polysaccharides. It can be isolated from Morinda officinalis.