20
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T3594 | ML346 | HSP | |
ML346 is a novel activator of Hsp70. | |||
T2014 | CCG-1423 | CCG1423 | LRRK2 , Rho , Ras |
CCG-1423, a selective RhoA pathway inhibitor, suppresses SRF-mediated transcription. | |||
T11399 | Giredestrant | GDC-9545 | Estrogen Receptor/ERR , Estrogen/progestogen Receptor |
Giredestrant (GDC-9545) potently competes with estradiol for binding and induces a conformational change within the ER ligand binding domain. Giredestrant has anti-tumor activity. Giredestrant, a non-steroidal ER ligand,... | |||
T68165 | Trapencaine | ||
Trapencaine is a newly synthesized carbamate type local anesthetic that induces conformational changes in sodium channels on hypertrophic cell membranes. | |||
T25538 | Iperoxo | Iperoxo iodide | AChR |
Iperoxo (Iperoxo iodide) is an agonist of Muscarinic AChR and can be used to probe activation-related conformational transitions of muscarinic receptors. | |||
T60044 | SPEN-IN-1 | Others | |
SPEN-IN-1 binding suppresses histone H3K27 trimethylation and blocks initiation of X-chromosome inactivation. SPEN-IN-1 binding reduces the conformational space of RepA and displaces cognate interacting protein factors i... | |||
T5968 | DL-Homocysteine thiolactone hydrochloride | DL-Homocysteinethiolactone hydrochloride | Endogenous Metabolite |
DL-Homocysteine thiolactone hydrochloride (DL-Homocysteinethiolactone hydrochloride) is a cysteine derivative that binds to and induces conformational changes in various plasma proteins, slowing coagulation and inducing ... | |||
T50110 | CD532 | Aurora Kinase | |
CD532 is A highly potent Aurora A kinase inhibitor with an IC50 value of 45 nM. CD532 can block Aurora A kinase activity, drive MYCN degradation, and can directly interact with AURKA and induce global conformational tran... | |||
T5104 | BTSA1 | Apoptosis , BCL | |
BTSA1 is a BAX activator that binds with high affinity and specificity to the N-terminal activation site and induces conformational changes to BAX leading to BAX-mediated apoptosis. | |||
T63971 | Canocapavir | ZM-H1505R | HBV |
Canocapavir (ZM-H1505R) is a novel orally available HBV coat protein modulator with antiviral activity that induces conformational changes in the linker region of the HBV core protein, and can be used for the treatment o... | |||
T4647 | M2I-1 | M2I 1 | Others |
M2I-1 a small Mad2 inhibitor-1. the first small molecule inhibitor targeting the binding of Mad2 to Cdc20, an essential proteinprotein interaction (PPI) within the SAC. It can disturbs conformational dynamics of Mad2 cri... | |||
T6760 | APS-2-79 hydrochloride | APS-2-79 HCl,APS-2-79 | MEK , MAPK |
APS-2-79 hydrochloride (APS-2-79 HCl) is a MAPK antagonist that modulating KSR-dependent MAPK signalling by antagonizing RAF heterodimerization as well as the conformational changes required for phosphorylation and activ... | |||
T6778 | BDA-366 | BCL | |
BDA-366, a potent Bcl2 antagonist, selectively binds the Bcl2-BH4 domain with high affinity (Ki = 3.3 nM), inducing a conformational change that nullifies its antiapoptotic function, thereby transforming it into a pro-ap... | |||
T2640 | Rebastinib | DCC2036,DCC 2036,DCC-2036 | Apoptosis , FLT , Bcr-Abl , Src |
DCC-2036 (Rebastinib (DCC-2036)) is a conformational control Bcr-Abl inhibitor for Abl1(WT, IC50: 0.8 nM) and Abl1(T315I, IC50: 4 nM), also inhibits LYN, SRC, HCK, FGR, FLT3, KDR, and Tie-2, and low activity to c-Kit. Re... | |||
T69252 | CPD26 | ||
CPD26 is a novel non-RBD binding modulator to inhibit SARS-CoV-2 by prohibiting the conformational change of the spike (S) protein. | |||
T68898 | Dequalinium Bromide | ||
Dequalinium Bromide is a HIV-1 fusion inhibitor, targeting the membrane-proximal external region of Env spikes, specifically inhibiting the HIV-1 envelope-mediated membrane fusion by blocking CD4-induced conformational c... | |||
T24740 | RS-104966 | ||
RS-104966 is an inhibitor of collagenase that acts by inducing the conformational change in the side-chains of the S1 pocket of MMP-1. | |||
T68310 | CPD7 | ||
CPD7 is a novel non-RBD binding modulator to inhibit SARS-CoV-2 by prohibiting the conformational change of the spike (S) protein. | |||
T76494 | [Phe2]-TRH | ||
'[Phe2]-TRH, a thyrotropin-releasing hormone analogue, exhibits conformational similarity to Leu5-enkephalin [1].' | |||
T71989 | CPD7 HCl | ||
CPD7 HCl is a novel non-RBD binding modulator to inhibit SARS-CoV-2 by prohibiting the conformational change of the spike (S) protein. |