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IPA

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Catalog No. T219084 Copy Product Info
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IPA is a specific Sec18/NSF inhibitor. It binds competitively to phosphatidic acid, inducing conformational rigidity in Sec18/NSF, which disrupts its essential flexibility and blocks SNARE activation and vacuole membrane fusion. IPA can be utilized to study the activity of Sec18 and the dynamics of SNARE activation.

IPA

Cas No. 200348-48-7
Other Forms of IPA:
3-Indolepropionic acidT5297830-96-6
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Pack SizePriceUSA StockGlobal StockQuantity
10 mgInquiry10-14 weeks10-14 weeks
50 mgInquiry10-14 weeks10-14 weeks
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction

Bioactivity
Description
IPA is a specific Sec18/NSF inhibitor. It binds competitively to phosphatidic acid, inducing conformational rigidity in Sec18/NSF, which disrupts its essential flexibility and blocks SNARE activation and vacuole membrane fusion. IPA can be utilized to study the activity of Sec18 and the dynamics of SNARE activation.
In vitro
IPA binds to purified monomeric Saccharomyces cerevisiae Sec18, as well as the isolated Sec18 D1 and D2 domains, including the D1-D2 recombinant, with the highest binding affinity observed in the D1 domain [IC 50 = 762 nM (Sec18), 220 nM (D1), 641 nM (D2)]. IPA effectively and specifically competes with phosphatidic acid for binding to monomeric Saccharomyces cerevisiae Sec18 and its isolated D1 and D2 domains, without significantly inhibiting the interaction between phosphatidic acid and other phosphatidic acid-binding proteins or the association of Sec18 with PI liposomes. At a concentration of 100 μM, IPA strongly inhibits the binding of monomeric Saccharomyces cerevisiae Sec18 to PA liposomes with varying membrane curvature, showing a slightly stronger inhibitory effect on larger diameter liposomes.
Chemical Properties
Molecular Weight394.37
FormulaC22H18O7
Cas No.200348-48-7
SmilesO=C(O)C1C2C=CC(C1C3=C4C=CC(=O)C(O)=C4OC=5C(O)=C(O)C=CC53)C2C
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 µL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
µL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Related Tags: IPA in vitro | IPA formula | IPA molecular weight
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