avian

Cadherin Peptide, avian Acetate is a peptide with the sequence Leu-Arg-Ala-His-Ala-Val-Asp-Val-Asn-Gly-NH2. Cadherins are a class of type-1 transmembrane proteins.

Harpactira Baviana Venom (Baboon Tarantula Venom), derived from the king baboon spider, modulates Na V 1.8 and induces hyperalgesia [1] [2].

(S)-(-)-O-Demethylbuchenavianine (Compound (S)-(−)-1), a flavonoidal alkaloid, serves as a potent inhibitor of CDKs, exhibiting IC 50 values of 0.03 μM for CDK1 and 0.05 μM for CDK5, respectively.

(R)-(+)-O-Demethylbuchenavianine is a cyclin-dependent kinase (CDK) inhibitor. It inhibits CDK1, CDK5, glycogen synthase kinase 3 (GSK3), cdc2-like kinase (CLK1), and dual-specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) with IC50 values of 1.1 μM, 0.95 μM, >10 μM, >10 μM, and >10 μM, respectively.

(E)-Cinnamamide (trans-Cinnamamide) is the less active isomer of Cinnamamide which is an effective non-lethal chemical repellent suitable for reducing avian pest damage.

N-acetyl-L-methionine is nutritionally and metabolically equivalent to L-methionine. Methionine is a dietary indispensable amino acid required for normal growth and development of humans, other mammals, and avian species. In addition to being a substrate

MBX2329 is a specific inhibitor of HA-mediated viral entry that inhibits H1N1 virus strain high pathogenic avian influenza H5N1 virus strain.

Laninamivir (R 125489) is an effective inhibitor of influenza neuraminidase (NA) (IC50s: 0.90 nM, 1.83 nM, and 3.12 nM for avian H12N5 NA (N5), pH1N1 N1 NA (p09N1) and A/RI/5+/1957 H2N2 N2 (p57N2), respectively).

6′SLN is a characteristic glycan found on the surface of cancer-related extracellular vesicles (EVs) and serves as the primary form of protein glycosylation within EVs. Additionally, 6′SLN, a derivative of sialic acid, interacts with hemagglutinins (HAs) from both human and avian influenza strains, making it relevant in the study of anti-influenza drugs.

Mer-NF5003F (Stachybotrydial; F 1839M) is a sesquiterpene isolated from Stachybotrys, effective in inhibiting avian myeloblastosis virus (AMV) protease with an IC50 of 7.8 μM. It also inhibits sialyltransferases ST6N, ST3O, and ST3N with IC50 values of 0.61, 6.7, and 10 μg/mL, respectively, and fucosyltransferase with an IC50 of 11.3 μg/mL. Additionally, Mer-NF5003F exhibits in vitro activity against herpes simplex virus HSV-1 (IC50=4.32 μg/mL) and multi-drug-resistant Plasmodium falciparum K1 strain (IC50=0.85 μg/mL).

Formycin triphosphate is a fluorescent analog of ATP, exhibiting enhanced fluorescence when binding to enzyme active sites. It acts as a competitive inhibitor of avian liver pyruvate carboxylase (pyruvate carboxylase). Additionally, formycin triphosphate increases atrial natriuretic factor (ANF)-stimulated guanylate cyclase activity with an EC50 of approximately 90 μM and inhibits ATP-stimulated guanylate cyclase activity with an IC50 of around 100 μM.

Riamilovir sodium (Triazavirin) is a novel guanine nucleoside analogue and broad-spectrum antiviral candidate. It completely blocks viral RNA synthesis and transcription by competitively inhibiting viral RNA-dependent RNA polymerase, demonstrating exceptionally potent in vitro neutralizing activity against various strains, including H5N1 avian influenza and multidrug-resistant variants.

Antiviralagent 78 (Compound 27) is an antiviral agent that exhibits inhibitory activity against various viruses. Its IC50 values are 11.22 μM for the 2019 novel coronavirus (2019-nCoV), 78.54 μM for the Ebola virus replicon, and 71.49 μM for the avian influenza virus A/Guangzhou/99. Antiviralagent 78 can be utilized in studies of viral infections.

H5N1 aptamer sodium is a DNA nucleic acid aptamer specifically targeting the H5N1 avian influenza virus.

CL385319 is a potent inhibitor of H5N1 avian influenza A virus infection by blocking viral entry. CL-385319 is effective in inhibiting infection of highly pathogenic H5N1 influenza A virus in Madin-Darby Canine Kidney (MDCK) cells with an IC50 of 27.03±2.

Endochin is an experimental antimalarial. Endochin and analogues thereof are causal prophylactic and potent erythrocytic stage agents in avian models.

Avilamycin A is an antibiotic.1 It is active against veterinary isolates of C. perfringens (MICs = ≤0.06-0.5 mg/L) and B. hyodysenteriae (MICs = 12.5-100 μg/ml).1,2 Dietary administration of avilamycin A (15 and 30 ppm) reduces mortality in a broiler cockerel model of C. perfringens infection.3 Formulations containing avilamycin A have been used in the prevention of necrotic enteritis in livestock. |1. Watkins, K.L., Shryock, T.R., Dearth, R.N., et al. In-vitro antimicrobial susceptibility of Clostridium perfringens from commercial turkey and broiler chicken origin. Vet. Microbiol. 54(2), 195-200 (1997).|2. Uezato, K., Kinjo, E., and Adachi, Y. In vitro susceptibility of 21 antimicrobial agents to 37 isolates of Brachyspira hyodysenteriae isolated from pigs in Okinawa Prefecture. J. Vet. Med. Sci. 66(3), 307-309 (2004).|3. Paradis, M.A., McMillan, E., Bagg, R., et al. Efficacy of avilamycin for the prevention of necrotic enteritis caused by a pathogenic strain of Clostridium perfringens in broiler chickens. Avian Pathol. 45(3), 365-369 (2016).

KIN1148 is a novel small-molecule adjuvant that acts through the RIG-I pathway and IRF-3 transcription factor to stimulate inN/Ate immunity and protection following viral infection. The adjuvant will be developed for an FDA-approved avian inluenza virus v

Y27632 HCl hydrate is an orally effective, ATP-competitive ROCK1/ROCK2 inhibitor (Ki=220 nM/300 nM) that inhibits caspase-3 and suppresses stem cell apoptosis induced by multiple conditions. It is suitable for studying induced pluripotent stem cell (iPSC) culture.

EIDD-2749 (4'-FlU), a ribonucleoside analog, is an orally available RdRp inhibitor with spectroscopic antiviral activity that interrupts the replication of respiratory syncytial virus and SARS-CoV-2.EIDD-2749 attenuates lethal infections of pandemic human and highly pathogenic avian influenza viruses.

[Asp5]-Oxytocin acetate is a neurohypophyseal hormone analogue positioned at the 5-position, noted for its significant biological activity. It stimulates uterine contractions in vitro, an effect that is amplified by the presence of Mg 2+. Furthermore, this compound exhibits rat uteroconstrictor, avian vasodilator, and rat antidiuretic capabilities.

Xenopsin-Related Peptide 2 (XP-2), an avian analog of amphibian Xenopsin, exhibits efficacy in histamine release from isolated rat mast cells comparable to synthetic Bradykinin [1].

Emericid (Lonomycin A) exhibits activity against Gram-positive bacteria and can be employed in the study of avian coccidiosis.

Baicalin methyl ester shows inhibitory effects on the Avian Myeloblastosis Virus reverse transcriptase (AMV-RT).