anti-influenza

L-Mimosine (Leucenol) is an antineoplastic alanine-substituted pyridine derivative isolated from Leucena glauca and acts as an iron chelator.

Aurintricarboxylic acid (NSC-4056) is a strong inhibitor of topoisomerases and other nucleases. It is a potent inhibitor of ribonuclease and topoisomerase II by preventing the binding of the nucleic acid to the enzyme.

Laninamivir octanoate (CS-8958) is a long acting influenza neuraminidase (NA) inhibitor which shows superior anti-influenza virus activity.

Eleutheroside B1 mediates its anti-influenza activity through POLR2A and N-glycosylation. Eleutheroside B1 inhibits the mRNA expression of several chemokine genes and the influenza nucleoprotein (NP) gene, and exhibits low cytotoxicity. Antiviral and anti

Anti-Influenza agent 9 (Compound 3p) is an ion channel blocker targeting the M2-S31N mutated influenza virus. It exhibits inhibitory activity against both M2-WT and M2-S31N viruses, with EC50 values of 0.92 μM and 0.55 μM, respectively. Anti-Influenza agent 9 is suitable for research in influenza treatment.

Anti-Influenza agent 10 (Compound 41) is an inhibitor of the RNA-dependent RNA polymerase (RdRp) of the influenza A virus. It shows potent antiviral activity against the A/PR/8/34(H1N1) strain, with an IC50 of 0.29 μM and a KD of 4.11 μM. The compound functions by disrupting the interaction between the PA and PB1 subunits, inhibiting the assembly of the viral RdRp complex, and thereby blocking transcription and replication of the viral genome. Anti-Influenza agent 10 also demonstrates significant broad-spectrum efficacy against various influenza strains, such as H3N2, H3N8, and H9N2, with IC50 values of 3.96, 1.91, and 1.45 μM, respectively. It is useful for research on influenza A virus infections.

Anti-Influenza agent 11 (compound L08) serves as an inhibitor of the Influenza Virus and is applicable for research related to influenza virus infections.

Anti-Influenza agent 3 (compound 11h) is a potent anti-influenza agent with low cytotoxicity for MDCK epithelial cells, inhibiting the M2 WT and S31N ion channel conductivity. It has an EC50 value of 3.29 μM for A/HK/68 (H3N2, M2-WT) and 2.45 μM for A/WSN/33 (H1N1, M2-S31N) strain [1].

Anti-Influenza agent 5 (Compound IIB-2), a chalcone-like derivative, serves as an influenza nuclear export inhibitor, effectively inhibiting oseltamivir-resistant strains and hindering viral proliferation by obstructing the export of influenza virus nucleoprotein [1].

Anti-Influenza A virus NP Antibody (H16-L10-4R5 (HB-65)) is a mouse-derived IgG2a kappa antibody designed to target the nucleoprotein of the influenza A virus. The recommended isotype control for this antibody is Mouse IgG2a kappa, Isotype Control.

Anti-Influenza A H10 Hemagglutinin/HA Antibody (8B805) is a Mouse IgG1 monoclonal antibody targeting Influenza Influenza A H10 Hemagglutinin/HA.

Anti-Influenza HA Antibody (3E1) is an antibody. Its expression system is HEK293 cells, the clone number is 3E1, and the isotype control is IgG2, Kappa.

Anti-Influenza NA Antibody (1G01) is an antibody. Its expression system is HEK293 cells, the clone number is 1G01.

Compound 19b, known as Anti-Influenza agent 6, exhibits inhibitory activity against A/WSN/33/H1N1 (EC50= 0.015 μM), Yamagata/16/88 (EC50= 0.073 μM), and Victotis/2/87 (EC50= 0.067 μM).

2'-Deoxy-2'-fluorouridine serves as an intermediate in the synthesis of antiviral agents targeting influenza viruses[1].

Anti-Influenza agent 4 is a potent and selective inhibitor of the influenza virus, effectively inhibiting the A/Parma and A/Roma strains with EC50s of 62 nM and 150 nM, respectively.

Anti-Influenza HA Antibody (CR9114) is an antibody targeting Influenza HA and can be used for infectious disease research.

Rimantadine (1-Rimantadine) (Flumadine) is an anti-influenza virus drug for T. brucei with IC50 of 7 μM.

Acetylcysteine (NAC) is an N-acetyl derivative of cysteine, a ROS inhibitor and mucolytic agent. Acetylcysteine induces apoptosis, can be used to reduce mucus thickness, and has anti-influenza viral activity.

Tunicamycin is a mixture of antibiotics that inhibit N-linked glycosylation by blocking GlcNAc phosphotransferase (GPT). Tunicamycin has antitumor activity, as well as anti-bacterial, anti-fungal, and anti-viral activity.

1. Ginkgetin has anti-influenza virus and anti-fungal activities. 2. Ginkgetin has anti-inflammatory activity, can down-regulates COX-2 induction in vivo against skin inflammatory responses. 3. Ginkgetin is a good STAT3 inhibitor and may be a useful lead

Salcomine (NSC-32965) shows anti-influenza virus activity.

Peramivir (BCX1812) is a highly selective influenza A and B neuraminidase inhibitor with antiviral activity and anti-cytokine effects, which can be used in the study of novel coronavirus and influenza virus infections.

(-)-Arctigenin ((-)-Arctigenin) is found in burdock. (-)-Arctigenin is isolated from Cnicus benedictus, Forsythia viridissima, Arctium lappa, Ipomoea cairica and others (CCD). Arctigenin is a lignan found in certain plants of the Asteraceae, including the Greater burdock (Arctium lappa) and Saussurea heteromalla. It has shown antiviral and anticancer effects. It is the aglycone of arctiin.