Search Result

Search Results for " cdk2 "

187

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
TP1875	CDK2
	CDK2, a eukaryotic S/T protein kinase family member, catalyzes the phosphoryl transfer from ATP γ-phosphate to the hydroxyl of serine or threonine (denoted as S0/T0) in a protein substrate.
T36933	Cdk2 Inhibitor II	Cdk2 Inhibitor II,CDK2-IN-3	CDK
	Cdk2 Inhibitor II is a selective and potent CDK2 inhibitor50 at 60 nM.		CDK
T14916	CDK2-IN-4		CDK
	CDK2-IN-4 is a potent and selective inhibitor of CDK2 with an IC50 of 44 nM for CDK2/cyclin A. It shows 2,000-fold selectivity over CDK1/cyclin B with IC50 of 86 uM.		CDK
TP1875L	CDK2 acetate(255064-79-0 free base)		Others
	CDK2 acetate is a member of the eukaryotic S/T protein kinase family and its function is to catalyze the phosphoryl transfer of ATP γ-phosphate to serine or threonine hydroxyl (denoted as S0/T0) in a protein substrate.		Others
T40160	CDK2-IN-7	CDK2-IN-7
	CDK2-IN-7 is a CDK2 inhibitor for treating cancer ( IC 50 < 50 nM).
T35555	GSK-3/CDK5/CDK2-IN-1	GSK-3/CDK5/CDK2-IN-1
	GSK-3/CDK5/CDK2-IN-1 is an imidazole derivative compound that inhibits cdk5, cdk2, and GSK-3.it has demonstrated applications in cancer research and the study of neurodegenerative diseases [1].
T3195	CVT-313	CVT 313,Cdk2 Inhibitor III,CVT313,NG26	CDK
	CVT-313 (NG-26) is a potent, selective, reversible, and ATP-competitive inhibitor.		CDK
T60154	CDK2-IN-13
	CDK2-IN-13 is a potent Cyclin-dependent kinase 2 (CDK2) inhibitor (IC50 value: 12 µM).CDK2-IN-13 is involved in cell cycle regulation and can arrest the cell cycle. CDK2-IN-13 prevents cell division and proliferation, in...
TP2192	Cdk2/Cyclin Inhibitory Peptide I		Others
	Cyclin-dependent kinase 2 also known as cell division protein kinase 2. The protein encoded by this gene is a member of the cyclin-dependent kinase family of Ser/Thr protein kinases. This protein kinase is highly similar...		Others
T12552	PROTAC CDK2/9 Degrader-1		CDK
	PROTAC CDK2/9 Degrader-1 is a potent CDK2 and CDK9 dual degrader(DC50 of 62 nM and 33 nM).		CDK
T62038	CDK2-IN-8
	CDK2-IN-8 is a potent CDK2 inhibitor (IC50= 1.74 μM). CDK2-IN-8 exhibits antiproliferative activity. CDK2-IN-8 can be used for the research of melanoma.
T62668	CDK2-IN-12
	CDK2-IN-12 (compound 10b) is a potent inhibitor of CDK2 (IC50: 11.6 μM). CDK2-IN-12 exhibits inhibition of hCA subtypes I, II, IX and XII with KI values of 3534, 638.4, 44.3 and 48.8 nM, respectively. CDK2-IN-12 shows CD...
T82759	CDK2-IN-20		CDK
	CDK2-IN-20 (compound 3b), a CDK2 inhibitor, exhibits cytotoxic effects on tumor cells with an IC50 ranging from 5.52-17.09 µM. It arrests the MCF-7 cell cycle at the S phase and induces apoptosis [1].		CDK
T79729	EGFR/CDK2-IN-4		EGFR
	EGFR/CDK2-IN-4 (compound 4c) is a dual inhibitor targeting EGFR and CDK-2, demonstrating IC50 values of 89.6 nM for EGFR and 165.4 nM for CDK-2. It prompts apoptosis in MCF-7 cells and causes S phase cell cycle arrest, e...		EGFR
T62567	CDK2-IN-9
	CDK2-IN-9 is a potent inhibitor of CDK2 (IC50: 0.63 μM) with anti-proliferative effects. CDK2-IN-9 is capable of blocking the cell cycle in S and G2/M phases and inducing apoptosis. CDK2-IN-9 has potential for melanoma r...
T62337	CDK2-IN-11
	CDK2-IN-11 (compound 9d) is a potent inhibitor of CDK2 (IC50: 6.4 μM) and acts on hCA II (Ki: 23.4 nM), hCA IX (Ki: 56.3 nM) and hCA XII (Ki: 44.3 nM). CDK2-IN-11 can be used in anticancer studies.
T79648	CDK2-IN-19		CDK
	CDK2-IN-19 (Compound 32) is a selective, orally active inhibitor of CDK2 (K i: 0.18 nM) that exhibits anticancer activity in mice with OVCAR3 tumors [1].		CDK
T79727	EGFR/CDK2-IN-2		EGFR
	EGFR/CDK2-IN-2 (compound 6a) serves as a dual inhibitor targeting both EGFR and CDK-2, exhibiting IC50 values of 19.6 nM and 87.9 nM, respectively. It promotes apoptosis in MCF-7 cells and halts cell cycle progression du...		EGFR
T76377	Cdk2/Cyclin Inhibitory Peptide II
	Cdk2/Cyclin Inhibitory Peptide II (Tat-LDL), a CDK2 inhibitor, demonstrates dose-dependent cytotoxic effects on U2OS osteosarcoma cells [1].
T72844	EGFR/CDK2-IN-1
	EGFR/CDK2-IN-1, an inhibitor of both EGFR and CDK2, demonstrates effective cytotoxicity towards MCF7 and HepG2 cells, suggesting its potential application in cancer research.
T78813	CDK2/Bcl2-IN-1		CDK
	CDK2/Bcl2-IN-1 (compound 1) is a saponin-based inhibitor of CDK-2 (IC50=117.6 nM) that exhibits potent cytotoxic effects on cancer cells. Additionally, it inhibits Bcl-2 and promotes apoptosis in A549 lung cancer cells [...		CDK
T79728	EGFR/CDK2-IN-3		EGFR
	EGFR/CDK2-IN-3 (compound 4b) serves as a dual inhibitor targeting both EGFR and CDK-2, exhibiting IC50 values of 71.7 nM and 113.7 nM, respectively. It prompts apoptosis in MCF-7 cells and halts the cell cycle in the S p...		EGFR
T63209	HDAC1/2 and CDK2-IN-1
	HDAC1/2 and CDK2-IN-1 (compound 14d) are potent inhibitors of HDAC1, HDAC2 and CDK2 with IC50 values of 70.7, 23.1 and 0.80 μM, respectively. HDAC1/2 and CDK2-IN-1 are able to block the cell cycle and induce apoptosis. T...
T2029	Bohemine		ERK , CDK
	Bohemine is a cyclin-dependent kinase inhibitor.		ERK , CDK
T9615	CK7		CDK
	CK7, a Cdk2/9 inhibitor, is instrumental in the synthesis of Nek1 inhibitors BSc5231 and BSc5367.		CDK
T21588	Olomoucine		ERK , CDK
	Olomoucine is an ATP competitive inhibitor of Cdk2/cyclin A, Cdc2/CyclinB, CDK2/CyclinE, CDK5/p35, and ERK1/p44 MAP kinase with IC50s of 7, 7, 7, 3 and 25 µM, respectively. Olomoucine regulates cell cycle and exhibits an...		ERK , CDK
T6612	NU6027		ATM/ATR , DNA-PK , CDK
	NU6027 is a potent ATR/CDK inhibitor, inhibits CDK1/2, ATR and DNA-PK with Ki of 2.5 μM/1.3 μM, 0.4 μM and 2.2 μM, enter cells more readily than the 6-aminopurine-based inhibitors.		ATM/ATR , DNA-PK , CDK
T6866	AUZ 454	K03861	CDK
	AUZ 454 (K03861) is a type II CDK2 inhibitor with Kd of 50 nM, 18.6 nM, 15.4 nM, and 9.7 nM for CDK2(WT), CDK2(C118L), CDK2(A144C), and CDK2(C118L/A144C), respectlvely.		CDK
T7426	ALSTERPAULLONE		Apoptosis , GSK-3 , CDK
	Alsterpaullone is a Cyclin-Dependent Kinase Inhibitor, Mediated Toxicity in HeLa Cells Through Apoptosis-Inducing Effec		Apoptosis , GSK-3 , CDK
T2028	NG 52	NG52,NG-52,Compound 52	CDK
	NG 52 (NG-52) is a cell-permeable, reversible, and ATP-compatible inhibitor of the cell cycle-regulating kinase Cdc28p and the related Pho85p kinase.		CDK
T4327	Prexasertib dihydrochloride	LY2606368 (dihydrochloride),Prexasertib HCl,LY2606368	Apoptosis , Chk , S6 Kinase
	Prexasertib dihydrochloride (LY2606368) is an ATP-competitive CHK1 inhibitor (Ki: 0.9 nmol/L). in the cell-free assay, its IC50 values are 8 nM and 9 nM for CHK2 and RSK, respectively.		Apoptosis , Chk , S6 Kinase
T4205	AG-494	Tyrphostin AG-494,AG 494,Tyrphostin B48	EGFR , CDK
	AG-494 (Tyrphostin B48) is an inhibitor of epidermal growth factor receptor kinase.		EGFR , CDK
T7167	Purvalanol B	NG 95	CDK , Parasite
	Purvalanol B (NG 95) is a CDK inhibitor that inhibits Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p35, and Cdk2/cyclin B (IC50s = 6, 9, 6, and 6 nM, respectively)		CDK , Parasite
T4310	Prexasertib	LY2606368	Apoptosis , Chk
	Prexasertib (LY2606368) is an inhibitor of checkpoint kinase 1 (chk1) with potential antineoplastic activity.		Apoptosis , Chk
T21503	(E/Z)-Zotiraciclib	(E/Z)-TG02,(E/Z)-SB1317	FLT , JAK , CDK
	(E/Z)-Zotiraciclib ((E/Z)-TG02) inhibits CDK2, JAK2, and FLT3 effectively with IC50s of 13, 73, and 56 nM, respectively.		FLT , JAK , CDK
T8230	PNU112455A hydrochloride	PNU 112455A	CDK
	PNU112455A hydrochloride is an ATP site competetive inhibitor of CDK2 and CDK5,binds to the ATP site of CDK2 and CDK5 with Kms of 3.6 and 3.2 μM, respectively.		CDK
T6081	Milciclib	PHA-848125	Trk receptor , CDK , Autophagy
	Milciclib (PHA-848125) (PHA-848125) is a potent, ATP-competitive CDK inhibitor for CDK2 with IC50 of 45 nM. It is >3-fold more selective for CDK2 than CDK1, 2, 4, 5, and 7. Phase 2.		Trk receptor , CDK , Autophagy
T28218	NU6102	NU-6102,NU 6102	CDK
	NU6102 is a selective and potent ATP-competitive CDK2 inhibitor with antitumor activity against CDK1/cyclinB, CDK2/cyclinA3, CDK1/CDK2, CDK4, DYRK1A , PDK1, and ROCKII, and it can be used to study rectal cancer.		CDK
T2032	WHI-P180	Janex 3	EGFR , VEGFR , c-RET , CDK
	WHI-P180 (Janex 3) is a potent EGFR and Cdk2 inhibitors with IC50 of 4.0 and 1.0 uM, respectively.		EGFR , VEGFR , c-RET , CDK
TQ0053	Fadraciclib	CYC065	CDK
	Fadraciclib (CYC065) is an orally available, second-generation ATP-competitive inhibitor of CDK2/CDK9 kinases (IC50s: 5/26 nM).		CDK
T2059	Purvalanol A	NG-60	Apoptosis , CDK , Autophagy
	Purvalanol A (NG-60) is an effective and cell-permeable CDK inhibitor with IC50 of 70/4/35/850 nM for cdk2-cyclin A/B/E, and cdk4-cyclin D1, respectively.		Apoptosis , CDK , Autophagy
TQ0068	NVP-LCQ195	AT9311,LCQ-195	CDK
	NVP-LCQ195 (LCQ-195) (AT9311) is a potent inhibitor of CDK1, CDK2, CDK3 and CDK5 (IC50: 1-42 nM).		CDK
T6126	JNJ-7706621	JNJ 7706621	Apoptosis , CDK , Aurora Kinase
	JNJ-7706621 is a potent aurora kinase inhibitor, and also inhibits CDK1 and CDK2.		Apoptosis , CDK , Aurora Kinase
T10550	Bisindolylmaleimide X hydrochloride	BIM-X hydrochloride,Ro31-8425 hydrochloride	CDK , PKC
	Bisindolylmaleimide X hydrochloride (BIM-X hydrochloride) is a potent and selective PKC inhibitor. It is also a potent CDK2 antagonist (IC50: 200 nM).		CDK , PKC
T6167	SU9516		Apoptosis , p38 MAPK , CDK , PKC , Autophagy
	SU9516 is a potent CDK2 inhibitor, with an IC50 of 22 nM, and also has inhibitory effects on CDK1 and CDK4, with IC50s of 40 nM and 200 nM, respectively.		Apoptosis , p38 MAPK , CDK , PKC , Autophagy
T4227	SB1317 hydrochloride (1204918-72-8(free base))	TG-02 hydrochloride	FLT , JAK , CDK
	SB1317 hydrochloride (1204918-72-8(free base)) (TG-02 hydrochloride) is an effective inhibitor of CDK2/JAK2/FLT3 (IC50: 13/73/56 nM).		FLT , JAK , CDK
T15335	FN-1501		FLT , CDK
	FN-1501 is a potent FLT3 and CDK inhibitor (IC50s: 2.47, 0.85, 1.96, and 0.28 nM for CDK2/cyclin A, CDK4/cyclin D1, CDK6/cyclin D1 and FLT3, respectively). FN-1501 also has anticancer activity.		FLT , CDK
T2247	KenPaullone	9-Bromopaullone,NSC-664704	GSK-3 , CDK
	KenPaullone (9-Bromopaullone), a potent CDK1, CDK2 and CDK5 inhibitor, as new enhancer for iTreg cell differentiation. Kenpaullone promotes iTreg cell differentiation through increased and prolonged transcription of foxp...		GSK-3 , CDK
T2506	AZD-5438	AZD5438	CDK
	AZD-5438 is an effective inhibitor of CDK, for CDK1(IC50=16 nM), CDK2(IC50=6 nM), CDK9(IC50=20 nM).		CDK
T2095	Seliciclib	Roscovitine,R-roscovitine,CYC202	CDK
	Seliciclib (Roscovitine) is a potent inhibitor of Cdk2/cyclin E (IC50: 0.1 μM). It also inhibits Cdk7/cyclin H, Cdk5/p35, and Cdc2/cyclin B (IC50s: 0.49/0.16/0.65 μM).		CDK

Compounds

Synonym: Cdk2 Inhibitor II,CDK2-IN-3

CDK2 acetate(255064-79-0 free base)

GSK-3/CDK5/CDK2-IN-1

T35555

Synonym: GSK-3/CDK5/CDK2-IN-1

Target:

CVT-313

T3195

Synonym: CVT 313,Cdk2 Inhibitor III,CVT313,NG26

Cdk2/Cyclin Inhibitory Peptide I

TP2192

Synonym:

Target: Others

PROTAC CDK2/9 Degrader-1

Cdk2/Cyclin Inhibitory Peptide II

HDAC1/2 and CDK2-IN-1

Target: ATM/ATR, DNA-PK, CDK

Target: Apoptosis, GSK-3, CDK

NG 52

T2028

Synonym: NG52,NG-52,Compound 52

Target: CDK

Prexasertib dihydrochloride

T4327

Synonym: LY2606368 (dihydrochloride),Prexasertib HCl,LY2606368

Target: Apoptosis, Chk, S6 Kinase

AG-494

T4205

Synonym: Tyrphostin AG-494,AG 494,Tyrphostin B48

Target: CDK, Parasite

Prexasertib

T4310

Synonym: LY2606368

Target: Apoptosis, Chk

(E/Z)-Zotiraciclib

T21503

Synonym: (E/Z)-TG02,(E/Z)-SB1317

Target: FLT, JAK, CDK

PNU112455A hydrochloride

Target: Trk receptor, CDK, Autophagy

NU6102

T28218

Synonym: NU-6102,NU 6102

Target: EGFR, VEGFR, c-RET, CDK

Target: Apoptosis, CDK, Autophagy

NVP-LCQ195

TQ0068

Synonym: AT9311,LCQ-195

Target: Apoptosis, CDK, Aurora Kinase

Bisindolylmaleimide X hydrochloride

T10550

Synonym: BIM-X hydrochloride,Ro31-8425 hydrochloride

Target: Apoptosis, p38 MAPK, CDK, PKC, Autophagy

SB1317 hydrochloride (1204918-72-8(free base))

T4227

Synonym: TG-02 hydrochloride

Target: FLT, JAK, CDK

Synonym: 9-Bromopaullone,NSC-664704

Synonym: Roscovitine,R-roscovitine,CYC202

Target: CDK

Cat No.	Product Name	Synonyms	Targets
TN1299	Desmethylglycitein	6,7,4'-Trihydroxyisoflavone	PI3K , CDK , PKC
	Desmethylglycitein (6,7,4'-Trihydroxyisoflavone) , is a novel inhibitor of PKCα in suppressing solar UV-induced matrix metalloproteinase 1, which has antioxidant, and anti-cancer activities.		PI3K , CDK , PKC
T6S1487	Ginsenoside Rg5		NF-κB , COX , IGF-1R
	1. Ginsenoside Rg5 could be a beneficial agent for the treatment of Alzheimer's disease. 2. Ginsenoside Rg5 suppresses LPS-induced nitric oxide (NO) production and proinflammatory TNF-α secretion. 3. Ginsenoside Rg5 can ...		NF-κB , COX , IGF-1R

Natural Products

Desmethylglycitein

TN1299

Synonym: 6,7,4'-Trihydroxyisoflavone

Target: PI3K, CDK, PKC

Ginsenoside Rg5

T6S1487

Synonym:

Target: NF-κB, COX, IGF-1R

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-04542	CDK2 Protein, Human, Recombinant (His)	Human	Baculovirus-Insect Cells
	CDK2 is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinas...
TMPY-02921	CDK2AP2 Protein, Human, Recombinant (His)	Human	E. coli
	CDK2AP2 belongs to the CDK2AP family. Members of this family of proteins are cell-growth suppressors, associating with and influencing the biological activities of important cell cycle regulators in the S phase including...
TMPK-00016	Cpn10/HSPE1 Protein, Human/Mouse/Goat, Recombinant (His & Avi), Biotinylated	Human,Mouse,Goat	E. coli
	Cpn10/HSPE, a 10-kDa heat shock protein, is a novel interacting partner of NPAT. A pool of Cpn10 is colocalized with NPAT foci during G1 and S phases in nuclei.Cpn10 is important for S phase progression and cell prolifer...
TMPY-03535	Cyclin E Protein, Mouse, Recombinant (His & GST)	Mouse	Baculovirus-Insect Cells
	Cyclin E1 is a member of the highly conserved cyclin family and belongs to the E-type cyclin that functions as a regulator of S phase entry and progression in mammalian cells. Cyclin E1 serves as regulatory subunits that...
TMPY-01550	Cyclin E Protein, Human, Recombinant (His)	Human	Baculovirus-Insect Cells
	Cyclin E1 is a member of the highly conserved cyclin family and belongs to the E-type cyclin that functions as a regulator of S phase entry and progression in mammalian cells. Cyclin E1 serves as regulatory subunits that...
TMPY-02777	Cyclin E Protein, Human, Recombinant (His & GST)	Human	Baculovirus-Insect Cells
	Cyclin E1 is a member of the highly conserved cyclin family and belongs to the E-type cyclin that functions as a regulator of S phase entry and progression in mammalian cells. Cyclin E1 serves as regulatory subunits that...
TMPK-00015	Cpn10/HSPE1 Protein, Human/Mouse/Goat, Recombinant (His & Avi)	Human,Mouse,Goat	E. coli
	Cpn10/HSPE, a 10-kDa heat shock protein, is a novel interacting partner of NPAT. A pool of Cpn10 is colocalized with NPAT foci during G1 and S phases in nuclei.Cpn10 is important for S phase progression and cell prolifer...
TMPY-03599	RPRD1B Protein, Human, Recombinant (His)	Human	HEK293
	RPRD1B, together with RPRD1A, can accompany RNAP II from promoter regions to 3'-untranslated regions during transcription in vivo, predominantly interact with phosphorylated RNAP II, and can reduce CTD S5- and S7-phospho...
TMPJ-00972	CDKN1B Protein, Human, Recombinant (His)	Human	E. coli
	Cyclin-Dependent Kinase Inhibitor 1B (CDKN1B) is a Kinesin-related motor protein necessary for mitotic spindle assembly and chromosome segregation. CDKN1B is expressed in all tissues with highest levels observed in skele...
TMPH-02131	SKP2 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle pr...
TMPY-02496	Rad6/UBE2A Protein, Human, Recombinant (His)	Human	E. coli
	Ubiquitin-conjugating enzyme E2 A (also known as HHR6A or UBE2A), encoded by human DNA repair genes HHR6A, belongs to the ubiquitin-conjugating enzymes (E2 enzymes) family and is likely to be involved in postreplication ...
TMPY-01401	Cyclin A1 Protein, Human, Recombinant (His)	Human	Baculovirus-Insect Cells
	Cyclin A1 is a member of the highly conserved cyclin family that is characterized by a dramatic periodicity in protein abundance, and belongs to the A-type cyclin subfamily. The mammalian A-type cyclin family consists of...
TMPH-01552	IRF1 Protein, Human, Recombinant (GST & His)	Human	Baculovirus
	Transcriptional regulator which displays a remarkable functional diversity in the regulation of cellular responses. Regulates transcription of IFN and IFN-inducible genes, host response to viral and bacterial infections,...