Search Result

Search Results for " ampk "

Targets

118

Compounds

Natural Products

Recombinant Proteins

Libraries

Cat No.	Product Name	Synonyms	Targets
T60675L	AMPK activator 2 hydrochloride( 2410961-69-0 Free base)	AMPK activator 2 hydrochloride( 2410961-69-0 Free base)	AMPK
	AMPK activator 2 hydrochloride is a fluoroguanidine-containing derivative that up-regulates the AMPK signaling pathway and down-regulates mTOR/4EBP1/p70S6K.AMPK activator 2 hydrochloride inhibits the proliferation and mi...		AMPK
T78791	AMPK activator 12		AMPK
	AMPK activator 12 is an AMPK activator and GDF15 inducer that elevates the expression level of GDF15 protein in human hepatocytes, which can be used for cancer research.		AMPK
T62745	AMPK-IN-3		VEGFR , AMPK
	AMPK-IN-3 is a novel, selective and potent AMPK inhibitor with inhibitory effects on AMPK (α2), AMPK (α1) and KDR, with IC50 values of 60.7, 107 and 3820 nM, respectively.AMPK-IN-3 showed anticancer activity in K562 cell...		VEGFR , AMPK
T62238	AMPK activator 4		AMPK
	AMPK activator 4 is a potent and selective AMPK activator that does not inhibit mitochondrial complex I. AMPK activator 4 selectively activates AMPK in muscle tissue and dose-dependently improves glucose tolerance in nor...		AMPK
T22567	AMPK activator		Others
	AMPK activator		Others
T70862	AMPK Activator SC4
	SC4 is a potent, direct AMPK activator. SC4 preferentially activates α2 complexes and stimulates skeletal muscle glucose uptake.
T23734	AMPK activator C2	Compound 2,Compound-2,C2
	AMPK activator C2 is an AMPK allosteric activator.
T10069	AMPK activator 1		Others
	AMPK activator 1 is an AMPK activator(compound No.1-75, EC50: <0.1μM).		Others
T72690	AMPK activator 9
	AMPK Activator 9 (ZM-6), a potent activator of AMPK (α2β1γ1), demonstrates an EC50 of 1.1 µM, indicating its strong efficacy in activating AMPK. This compound holds promise for type 2 diabetes research, highlighting its ...
T63177	AMPK activator 8
	AMPK activator 8 (Compound 2) is an AMP-activated protein kinase (AMPK) activator that acts on rAMPK α1β1γ1 (EC50: 11 nM), rAMPK α2β1γ1 (EC50: 27 nM), rAMPK α1β2γ1 (EC50: 4 nM), rAMPK α2β2 AMPK activator 8 can be used to...
T83127	AMPK activator 13		AMPK
	AMPK Activator 13 is a potent activator of the AMPK pathway, effectively inhibiting mitotic clonal expansion in 3T3-L1 cells and enhancing mitochondrial oxygen consumption rates. This compound is utilized in the study of...		AMPK
T60675	AMPK activator 2		AMPK
	AMPK activator 2 is a chloroformin derivative with potential anticancer activity, which can up-regulate AMPK signaling pathway and down-regulate mTOR/4EBP1/p70S6K, and inhibit proliferation and migration of human cancer ...		AMPK
T73224	AMPK-IN-1
	AMPK-IN-1 is an activator of the AMP-activated protein kinase (AMPK) enzyme, specifically targeting the α2β2γ1 isoform with an EC50 of 551 nM. It induces phosphorylation of eEF2 independent of the mTORC1 pathway.
T62052	AMPK activator 6
	AMPK activator 6 (Compound GC) activates the AMPK pathway and reduces lipid content in HepG2 and 3T3-L1 cells. AMPK activator 6 significantly suppresses the increase of total cholesterol (TC), low-density lipoprotein-C (...
T79226	AMPK activator 11		Mitochondrial Metabolism
	AMPK Activator 11 is a nanomolar potent inhibitor of cell proliferation in various colorectal carcinomas (CRCs), acting through the selective activation of AMP-activated protein kinase (AMPK) and enhancement of oxidative...		Mitochondrial Metabolism
T63117	AMPK activator 7
	AMPK activator 7 (compound I-3-24) is an AMPK activator (EC50: 8.8 nM). AMPK activator 7 can be used in studies involving AMPK disorders, particularly type 2 diabetes, hyperglycaemia, metabolic syndrome, obesity, hyperch...
T83125	AMPK-α1β1γ1 activator 1		AMPK
	AMPK-α1β1γ1 activator 1 (M1), an acyl glucuronide metabolite derived from an Indole-3-carboxylic Acid-based AMPK activator, selectively activates the β1 isoforms of human AMPK with an EC50 of 38.1 nM through direct bindi...		AMPK
T79649	CB1R/AMPK modulator 1		Cannabinoid Receptor
	Compound 38-S is an orally active CB1R/AMPK modulator with a K i of 0.81 nM and an IC50 of 3.9 nM for CB1R. This compound activates AMPK and has been shown to decrease food intake and body weight, in addition to enhancin...		Cannabinoid Receptor
T7362	O-304		AMPK
	O-304 is a pan-activator of AMP-activated protein kinase (AMPK).		AMPK
T5187	MK-3903	MK 3903	AMPK
	MK-3903 is a potent and selective AMPK activator (EC50: 8 nM).		AMPK
T2374	HTH-01-015		AMPK
	HTH-01-015 is a selective NUAK1 inhibitor (IC50=100 nM).		AMPK
T16099	MK8722		AMPK
	MK8722 is an effective and systemic activator of pan-AMPK.		AMPK
T11947	MARK4 inhibitor 1		Apoptosis , Others , AMPK
	MARK4 inhibitor 1 inhibits cancer cell proliferation, metastasis and induces apoptosis. MARK4 inhibitor 1 is a potent microtubule affinity-regulating kinase 4 (MARK4) inhibitor, with an IC50 of 1.54 μM.		Apoptosis , Others , AMPK
T13411	ZLN024		AMPK
	ZLN024 is an activator of AMPK allosteric. ZLN024 allosterically stimulates active AMPK heterotrimers and the inactive α1 subunit truncations α1 (1-394) and α1 (1-335) but not α1 (1-312).		AMPK
T6291	WZ4003		AMPK
	WZ4003, a highly selective NUAK kinase inhibitor, is with IC50 of 20 nM and 100 nM for NUAK1 and NUAK2, respectively. It is no significant inhibition on 139 other kinases.		AMPK
T8432	ASP4132		AMPK
	ASP4132 is an orally active AMPK activator (EC50 : 18 nM), has anti-cancer activity.		AMPK
T13173	TMPA		Others , AMPK
	TMPA is a nuclear receptor Nur77 and LKB1 interaction antagonist.		Others , AMPK
T2468	A-769662	A 769662	AMPK , Fatty Acid Synthase
	A-769662 is an effective, reversible AMPK activator(EC50=0.8 μM).		AMPK , Fatty Acid Synthase
T4427	PF-06409577	PF 06409577	AMPK
	PF-06409577 is an effective, orally active, and specific allosteric activator of AMPK (EC50: 7 nM, for α1β1γ1).		AMPK
T10789	Chitosan oligosaccharide	COS	AMPK
	Chitosan oligosaccharide (COS) is an oligomer of β-(1→4)-linked D-glucosamine. It has the ability to activate AMPK and simultaneously inhibit inflammatory signaling pathways, including NF-κB and MAPK.		AMPK
T6854	GSK621		Apoptosis , AMPK , Autophagy
	GSK621 is a specific and potent AMPK activator.		Apoptosis , AMPK , Autophagy
T41162	ZLN 024 hydrochloride		AMPK
	ZLN 024 hydrochloride is an AMPK allosteric activator and stimulates the inactive α1 subunit truncations α1 (1-394) and α1 (1-335) but not α1 (1-312).		AMPK
T7955	EB-3D		Apoptosis , AMPK , AChR
	EB-3D is a potent and selective choline kinase alpha 1 (ChoKα1) inhibitor(IC50 : 1 μM).with anti-cancer activity.		Apoptosis , AMPK , AChR
T6285	GSK-690693	GSK690693	Serine Protease , Akt , PKC , AMPK , Autophagy
	GSK-690693 is a pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 2 nM/13 nM/9 nM, also sensitive to the AGC kinase family: PKA, PrkX and PKC isozymes. Phase 1.		Serine Protease , Akt , PKC , AMPK , Autophagy
T3546	STO-609	STO 609	CaMK , AMPK , Autophagy
	STO-609 is a specific and cell-permeable inhibitor of the Ca2+/calmodulin-dependent protein kinase kinase (CaM-KK) for recombinant CaM-KKα/KKβ (Ki: 80/15 ng/mL).		CaMK , AMPK , Autophagy
T6816	DASA-58		PKM
	DASA-58 is a specific and potent Pyruvate kinase M2 (PKM2) activator.		PKM
TQ0028	EX229	Compound 991,C991	AMPK
	EX229 (C991) is an allosteric activator of AMPK, with Kds of 0.06 μM, 0.06 μM and 0.51 μM for α1β1γ1, α2β1γ1, and α1β2γ1, respectively.		AMPK
T8476	RSVA405	RSVA 405	AMPK , STAT , Autophagy
	RSVA405 is an AMPK activator (EC50 = 1 μM), and is STAT3 inhibitor		AMPK , STAT , Autophagy
T1453	Phenformin hydrochloride	Phenformin HCl,Phenethylbiguanide hydrochloride	Potassium Channel , AMPK , Autophagy
	Phenformin hydrochloride (Phenformin HCl) is an agent belonging to the biguanide class of antidiabetics with antihyperglycemic activity.		Potassium Channel , AMPK , Autophagy
T70860	Banoxantrone	AQ4N
	Banoxantrone (AQ4N), a hypoxia-selective cytotoxin prototype, undergoes reduction to AQ4, effectively inhibiting topoisomerase II. It selectively targets and eradicates hypoxic cells through an iNOS-dependent mechanism. ...
T8526	Metformin	1,1-Dimethylbiguanide	Mitophagy , AMPK , Autophagy
	Metformin (1,1-Dimethylbiguanide) is an AMPK activator with blood-brain barrier permeability. Metformin may improve glycemic control by increasing insulin sensitivity and decreasing intestinal glucose uptake, and is comm...		Mitophagy , AMPK , Autophagy
T3625	Bempedoic acid	ETC1002,ESP-55016,ETC 1002,ETC-1002	ATP Citrate Lyase , AMPK
	Bempedoic acid (ETC1002) is an orally available, once-daily LDL-C lowering small molecule designed to lower elevated levels of LDL-C and to avoid side effects associated with existing LDL-C lowering therapies. Bempedoic ...		ATP Citrate Lyase , AMPK
T0860	Mefloquine hydrochloride	Mefloquin hydrochloride,Mefloquine HCl	Potassium Channel , SARS-CoV , Reactive Oxygen Species , Parasite , Autophagy
	Mefloquine hydrochloride (Mefloquin hydrochloride) is a quinoline derivative used for the prevention and therapy of P. falciparum malaria.
T1477	AICAR	NSC105823,AICA Riboside,Acadesine,AICAR (Acadesine)	Mitophagy , YAP , AMPK , Autophagy
	AICAR (NSC105823) is an AMP-activated protein kinase activator which is used for the treatment of acute lymphoblastic leukemia and may have applications in treating other disorders such as diabetes.		Mitophagy , YAP , AMPK , Autophagy
T1977	Dorsomorphin	Compound C,BML-275	AMPK , Autophagy , TGF-beta/Smad
	Dorsomorphin (BML-275) is an AMPK inhibitor (Ki=109 nM) that is selective and ATP-competitive. Dorsomorphin inhibits the BMP type I receptors ALK2, ALK3, and ALK6. Dorsomorphin induces autophagy, and possesses antitumor ...		AMPK , Autophagy , TGF-beta/Smad
T16156	MT 63-78		Apoptosis , AMPK , mTOR
	MT 63-78 is a specific and effective direct AMPK activator (EC50: 25 μM). MT 63-78 blocks prostate cancer growth by inhibiting the lipogenesis and mTORC1 pathways. MT 63-78 has antitumor effects. MT 63–78 also causes cel...		Apoptosis , AMPK , mTOR
T19659	Annaosanchun	YC6,YC-6,YC 6	Others , AMPK
	Annaosanchun (YC-6) is potentially for the treatment of acute ischemic stroke (AIS).		Others , AMPK
T10035	10,12-Tricosadiynoic acid	TDA,TCDA	Acyltransferase
	10,12-Tricosadiynoic acid is a highly selective and orally active inhibitor of acyl-CoA oxidase-1 (ACOX1). It can treat the high-fat diet- or obesity-induced metabolic diseases by improving mitochondrial lipid and ROS me...		Acyltransferase
T0858	Flufenamic acid	Arlef,Nichisedan,Achless	Potassium Channel , Calcium Channel , Chloride channel , COX , AMPK , Parasite
	Flufenamic acid (Arlef) is an anthranilic acid derivative with analgesic, anti-inflammatory, and antipyretic properties. It is used in musculoskeletal and joint disorders and administered by mouth and topically.
T6920	ON123300		FGFR , c-RET , JAK , CDK , PDGFR , Src , AMPK
	ON123300 is a potent and multi-targeted kinase inhibitor for CDK4/Ark5/PDGFRβ/FGFR1/RET/Fyn (IC50: 3.9/5/26/26/9.2/11 nM).		FGFR , c-RET , JAK , CDK , PDGFR , Src , AMPK

Compounds

AMPK activator 2 hydrochloride( 2410961-69-0 Free base)

T60675L

Synonym: AMPK activator 2 hydrochloride( 2410961-69-0 Free base)

Target: VEGFR, AMPK

Synonym: Compound 2,Compound-2,C2

Target: Mitochondrial Metabolism

AMPK-α1β1γ1 activator 1

T83125

Synonym:

Target: AMPK

CB1R/AMPK modulator 1

T79649

Synonym:

Target: Cannabinoid Receptor

Target: Apoptosis, Others, AMPK

Target: Others, AMPK

A-769662

T2468

Synonym: A 769662

Target: AMPK, Fatty Acid Synthase

Chitosan oligosaccharide

Target: Apoptosis, AMPK, Autophagy

ZLN 024 hydrochloride

Target: Apoptosis, AMPK, AChR

GSK-690693

T6285

Synonym: GSK690693

Target: Serine Protease, Akt, PKC, AMPK, Autophagy

STO-609

T3546

Synonym: STO 609

Target: CaMK, AMPK, Autophagy

Synonym: Compound 991,C991

Target: AMPK, STAT, Autophagy

Phenformin hydrochloride

T1453

Synonym: Phenformin HCl,Phenethylbiguanide hydrochloride

Target: Potassium Channel, AMPK, Autophagy

Synonym: 1,1-Dimethylbiguanide

Target: Mitophagy, AMPK, Autophagy

Bempedoic acid

T3625

Synonym: ETC1002,ESP-55016,ETC 1002,ETC-1002

Target: ATP Citrate Lyase, AMPK

Mefloquine hydrochloride

T0860

Synonym: Mefloquin hydrochloride,Mefloquine HCl

Target: Potassium Channel, SARS-CoV, Reactive Oxygen Species, Parasite, Autophagy

AICAR

T1477

Synonym: NSC105823,AICA Riboside,Acadesine,AICAR (Acadesine)

Target: Mitophagy, YAP, AMPK, Autophagy

Dorsomorphin

T1977

Synonym: Compound C,BML-275

Target: AMPK, Autophagy, TGF-beta/Smad

MT 63-78

T16156

Synonym:

Target: Apoptosis, AMPK, mTOR

Annaosanchun

T19659

Synonym: YC6,YC-6,YC 6

Target: Others, AMPK

10,12-Tricosadiynoic acid

T10035

Synonym: TDA,TCDA

Target: Acyltransferase

Flufenamic acid

T0858

Synonym: Arlef,Nichisedan,Achless

Target: Potassium Channel, Calcium Channel, Chloride channel, COX, AMPK, Parasite

ON123300

T6920

Synonym:

Target: FGFR, c-RET, JAK, CDK, PDGFR, Src, AMPK

Cat No.	Product Name	Synonyms	Targets
TN1828	Kahweol		Apoptosis , NF-κB , AMPK
	Kahweol has anticarcinogenic, anti-angiogenic,and anti-inflammatory activities, it can block the LPS-induced activation of NF-kappaB by preventing IkappaB degradation and inhibiting IkappaB kinase activity.		Apoptosis , NF-κB , AMPK
TN1836	Kudinoside D		LDL , AMPK , PPAR
	Kudinoside D exerts anti-adipogenic effects through modulation of adipogenic transcription factors via AMPK signaling pathway.		LDL , AMPK , PPAR
TN1100	Nepodin		transporter , COX , AMPK , Parasite
	Nepodin has antimalarial, and anti-inflammatory activities, it shows significant cyclooxygenase (COX) inhibitory activity. Nepodin has an antidiabetic effect, which is at least partly mediated by stimulation of GLUT4 tra...		transporter , COX , AMPK , Parasite
T3889	Platycodin D		Prostaglandin Receptor , AMPK
	Platycodin D may stimulate TNF-α synthesis or inhibit degradation of TNF-α mRNA. Platycodin D (10/30 μM) suppresses prostaglandin E2 production in rat peritoneal macrophages stimulated by the protein kinase C activator 1...		Prostaglandin Receptor , AMPK
T7327	7-Methoxyisoflavone		AMPK
	7-Methoxyisoflavone is an activator of adenosine monophosphate-activated protein kinase (AMPK).		AMPK
T4S0800	Demethyleneberberine		P450 , NOS , NF-κB , HIF , AMPK
	Demethyleneberberine, which is composed of a potential antioxidant structure, could penetrate the membrane of mitochondria and accumulate in mitochondria either in vitro or in vivo.Demethyleneberberine suppresses CYP2E1,...		P450 , NOS , NF-κB , HIF , AMPK
T3904	Gomisin J		Calcium Channel , AMPK
	Gomisin J is a natural product and have vasodilatory activity. Gomisin J suppresses lipid accumulation by regulating the expression of lipogenic and lipolytic enzymes and inflammatory molecules through activation of AMPK...		Calcium Channel , AMPK
T3881	Vaccarin		Integrin , Akt , PERK , AMPK
	Vaccarin is a major flavonoid glycoside in Vaccariae semen, its biotransformation pathways involves methylation, hydroxylation, glycosylation and deglycosylation.		Integrin , Akt , PERK , AMPK
T5497	AMAROGENTIN		Apoptosis , AMPK
	Amarogentin is mainly extracted from Swertia and Gentiana roots. It plays cemopreventive/therapeutic role during liver carcinogenesis through modulation of cell cycle and apoptosis		Apoptosis , AMPK
T3405	[6]-Gingerol	6-Gingerol,gingerol,(S)-(+)-[6]Gingerol	Apoptosis , AMPK
	[6]-Gingerol ((S)-(+)-[6]Gingerol), an antioxidant, protects HL-60 cells from oxidative stress. It has protective effects for Yous tumors in the pancreas, ovaries, breast tissue, the bowel, among other tissues.		Apoptosis , AMPK
T2S0820	Karanjin		Apoptosis , AMPK
	Karanjin is a flavonoid obtained from the seeds of the karanja tree.Karanjin induces GLUT4 translocation in skeletal muscle cells by increasing AMPK activity. Karanjin can induce cancer cell death through cell cycle arre...		Apoptosis , AMPK
TN1911	Marein		transporter , Akt , HDAC , AMPK
	Marein shows neuroprotective effect on PC12 cell damage induced by methylglyoxal, which is due to a reduction of damage to mitochondria function and activation of the AMPK signal pathway, it may be a potent compound for ...		transporter , Akt , HDAC , AMPK
T5552	Methyl cinnamate		Tyrosinase , Antibacterial , AMPK
	Methyl cinnamate, a tyrosinase inhibitor and a flavoring compound, has antimicrobial, antiadipogenic, vasorelaxant, and anti-inflammatory effects.		Tyrosinase , Antibacterial , AMPK
TN1499	Cimiracemoside C	Cimicifugoside M	AMPK
	Cimiracemoside C (Cimicifugoside M) is an active component of Cimicifuga racemosa. It activates AMPK and has the potential activity against diabetes.		AMPK
T2S0731	Trilobatin	P-Phlorizin	Amylase
	Trilobatin (P-Phlorizin) has anti-oxidant effect, can increase superoxide dismutase (SOD) activity.Trilobatin has anti-inflammatory effect, it potentially inhibits the lipopolysaccharide (LPS)-induced inflammatory respon...		Amylase
T0800	Danthron	Dantron,1,8-Dihydroxyanthraquinone,Chrysazin,Antrapurol	Virus Protease , Antibacterial , AMPK , Autophagy
	Danthron (Antrapurol) is a natural product, regulates glucose, and lipid metabolism by activating AMPK.		Virus Protease , Antibacterial , AMPK , Autophagy
T2750	Ginkgolide C	BN-52022	MMP , Sirtuin , Endogenous Metabolite , AMPK
	Ginkgolide C (BN-52022), a natural product, can enhance the cardiac function of rats in the body.		MMP , Sirtuin , Endogenous Metabolite , AMPK
T19500	Palmitelaidic Acid	trans-Palmitoleic acid,9-trans-Hexadecenoic acid	Glucokinase , AMPK , PPAR
	Palmitelaidic Acid (trans-Palmitoleic acid) is one of the most abundant fatty acids in serum and tissue.		Glucokinase , AMPK , PPAR
T13265	Urolithin B		ERK , NF-κB , Akt , Endogenous Metabolite , JNK , AMPK
	Urolithin B is one of the gut microbial metabolites of ellagitannins and is found in diverse plant foods, including pomegranates, berries, walnuts, tropical fruits, and medicinal herbs. Urolithin B inhibits NF-κB activit...		ERK , NF-κB , Akt , Endogenous Metabolite , JNK , AMPK
T1020	Doxorubicin hydrochloride	Adriamycin,Doxorubicin (Adriamycin) HCl,Hydroxydaunorubicin hydrochloride,NSC 123127	Apoptosis , Mitophagy , HBV , HIV Protease , Topoisomerase , Antibacterial , Antibiotic , AMPK , Autophagy
	Doxorubicin hydrochloride (Adriamycin) belongs to the anthracycline class of antibiotics and is an inhibitor of human DNA topoisomerase I/II (IC50=0.8/2.67 μM). Doxorubicin hydrochloride exhibits cytotoxicity and antitum...
T2851	Daphnetin	7,8-Dihydroxycoumarin,Daphnetol	EGFR , PKA , PKC , Parasite , Autophagy
	Daphnetin (7,8-Dihydroxycoumarin), a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM), and PKC (IC50: 25.01 μM), also exhibit anti-oxidant and anti-...		EGFR , PKA , PKC , Parasite , Autophagy
T1456	Doxorubicin	Hydroxydaunorubicin,Adriamycin	Topoisomerase , AMPK
	Doxorubicin (Adriamycin) is a Topoisomerase II (Top2) inhibitor with antineoplastic activity.		Topoisomerase , AMPK
T8200	Ginkgolide K		AMPK , Autophagy
	Ginkgolide K induces protective autophagy through the AMPK/mTOR/ULK1 signalling pathway. It possesses neuroprotective activity.		AMPK , Autophagy
TN6751	1-HEXACOSANOL		NPC1L1 , AMPK
	Hexacosanol activates AMPK and hepatic autophagy and inhibits SREBP2, resulting in hypocholesterolemic activities and improvement of hepatic steatosis.		NPC1L1 , AMPK
TN1731	Hernandezine		TNF , ROS , P-gp , AMPK
	Hernandezine is an activator of AMPK activator and a selective reversing agent for ABCB1-mediated MDR in cancer cells.		TNF , ROS , P-gp , AMPK
TN2346	Mogrol		ERK , AMPK , STAT
	Mogrol, a biometabolite of mogrosides, functions by inhibiting the ERK1/2 and STAT3 pathways, diminishing CREB activation, and activating AMPK signaling.		ERK , AMPK , STAT
T14149	AICAR phosphate	AICA Riboside phosphate,Acadesine phosphate	Mitophagy , NOS , YAP , AMPK
	AICAR phosphate (Acadesine phosphate) is an AMPK activator and inhibitor of autophagy, YAP, and mitophagy, as well as an adenosine analog that regulates glucose and lipid metabolism, and inhibits the production of pro-in...		Mitophagy , NOS , YAP , AMPK
T2854	Phillyrin	Forsythin	P450 , Influenza Virus , AMPK
	Phillyrin (Forsythin) is a novel AMPK activator, has anti-obesity effects in nutritive obesity mice, it can prevent lipid accumulation in HepG2 cells by blocking the expression of SREBP-1c and FAS through LKB1/AMPK activ...		P450 , Influenza Virus , AMPK
TN1140	Onjisaponin B		AMPK , mTOR , Autophagy
	Onjisaponin B induces autophagy via the AMPK-mTOR signaling pathway, increases the NGF level and accelerates both the removal of mutant huntingtin and A53T α±-synuclein, it may have potential therapeutic effects on Parki...		AMPK , mTOR , Autophagy
T5S2178	Fargesin	(+/-)-Fargesin	Adrenergic Receptor
	1. Fargesin ((+/-)-Fargesin) as a potential β1AR antagonist through cAMP/PKA pathway could protect against myocardial ischemia/reperfusion injury in rats. 2. Fargesin improves dyslipidemia and hyperglycemia by activating...		Adrenergic Receptor
T3863	Chikusetsusaponin IVa	Calenduloside F	AMPK
	Chikusetsusaponin IVa (Calenduloside F) is a novel AMPK activator, can induce insulin secretion from βTC3 cells via GPR4 mediated calcium and PKC pathways, may be developed into a new potential for therapeutic agent used...		AMPK
T3S0137	Bavachalcone		Antibacterial , Antibiotic
	Bavachalcone is a major bioactive compounds isolated from Psoralea corylifolia L. it may be useful as a therapeutic drug for bone resorption-associated diseases.Bavachalcone can protect the endothelial function by increa...		Antibacterial , Antibiotic
T3843	Pinosylvin	3,5-stilbenediol,5-Styrylresorcinol	Apoptosis , Others , Antibacterial , Autophagy
	Pinosylvin (5-Styrylresorcinol) induces autophagy via AMPK activation. Pinosylvin is likely to act as a pro-angiogenic factor.		Apoptosis , Others , Antibacterial , Autophagy
TN1677	Gartanin		BCL , Caspase , JNK
	Gartanin is an androgen receptor degradation enhancer, it is also a potential neuroprotective agent against glutamate-induced oxidative injury partially through increasing Nrf-2-independed HO-1 and AMPK/SIRT1/PGC-1α±sign...		BCL , Caspase , JNK
T3S0195	Nootkatone		AMPK
	1. Nootkatone can provide effective tick control. 2. (+)-Nootkatone has antiallergic, anti-inflammatory, and antiplatelet activities. 3. Nootkatone can prevent obesity and improve physical performance through AMPK activa...		AMPK
T6S1683	Demethoxycurcumin	Curcumin II,Desmethoxycurcumin,Monodemethoxycurcumin	Apoptosis , Antioxidant , Antibacterial , Autophagy
	1. Demethoxycurcumin (Desmethoxycurcumin) has antioxidant activity. 2. Demethoxycurcumin has anti-inflammatory activity. 3. Demethoxycurcumin has anti-proliferative activity. 4. Demethoxycurcumin has anti-acanthamoebic e...		Apoptosis , Antioxidant , Antibacterial , Autophagy
T2978	Mogroside V		AMPK
	Mogroside V is a widely used sweetener, has in vitro AMPK activating effect, it also has anti-inflammatory potential in murine macrophages and a murine ear edema model, and has the potential to protect against LPS-induce...		AMPK
TN1936	Mogroside III-E		IL Receptor , TNF , TLR
	Mogroside III-E is a cucurbitane-type compound isolated from Siraitia grosvenorii, has anti-inflammatory activity, it attenuates LPS-induced acute lung injury in mice partly through regulation of the TLR4/MAPK/NF-κB axis...		IL Receptor , TNF , TLR
T3921	Punicalagin		SARS-CoV , HBV
	Punicalagin is a major ellagitannin found in pomegranates that is reported to produce antioxidant, anti-inflammatory, and anticancer effects. It has been shown to prevent high-fat diet-induced obesity-associated accumula...		SARS-CoV , HBV
T5793	Britannin		Apoptosis , AMPK , Autophagy
	Britannin, a sesquiterpene lactone, inhibits proliferation and induces apoptosis through the mitochondrial signaling pathway in human breast cancer cells.		Apoptosis , AMPK , Autophagy
T3676	Sesamol	1,3-Benzodioxol-5-ol,3,4-Methylenedioxyphenol	Apoptosis , AMPK
	Sesamol (1,3-Benzodioxol-5-ol) could decrease lung inflammation and lipopolysaccharide (LPS)-induced lung injury in rats. Sesamol ameliorates inflammatory and oxidative damage by upregulating AMPK activation and Nrf2 sig...		Apoptosis , AMPK
T3403	Glabridin	Q-100692,KB-289522,LS-176045	Reactive Oxygen Species , Tyrosinase , GABA Receptor , Antibacterial , PPAR
	Glabridin (KB-289522) may serve as an anti-inflammatory agent in diabetes-related vascular dysfunction, through regulating the synthesis and activity of iNOS under high-glucose levels; may possess a therapeutic effect on...
TN2179	Saponarin	Petrocomoside,Saponaretin-7-O-glucoside,Isovitexin-7-O-glucoside	ERK , P450 , NF-κB , AMPK
	Saponarin (Petrocomoside) shows in vitro and in vivo hepatoprotective and antioxidant activity against CCl4-induced liver damage.		ERK , P450 , NF-κB , AMPK
T3220	Euphorbiasteroid	Euphobiasteroid,Euphorbia factor L1	Others , AMPK
	Euphorbiasteroid (Euphobiasteroid) (25-50 μM) decreased differentiation of 3T3-L1 cells via reduction of intracellular triglyceride (TG) accumulation.		Others , AMPK
TQ0207	Sulforaphane		Apoptosis , Nrf2 , HDAC
	Sulforaphane is derived from the consumption of cruciferous vegetables, such as broccoli. It has shown anticancer and cardioprotective activities.		Apoptosis , Nrf2 , HDAC
T4S0878	Prunetin	Prunusetin	ERK , Dehydrogenase , NF-κB
	1. Prunetin (Prunusetin) significantly reduces serum levels of inflammatory cytokines and mortality in mice challenged with lipopolysaccharide. 2. Prunetin mediates anti-obesity/adipogenesis effects by suppressing obesit...		ERK , Dehydrogenase , NF-κB
T6S1784	Brazilin	Natural Red 24,Braziletto,Brasilin,Superbresiline	Apoptosis , Others , AMPK , Autophagy
	1. Brazilin (Braziletto) exhibits anti-hepatotoxic, antiplatelet effects. 2. Brazilin has cancer preventive effect, may inhibit T24 cell growth and trigger cell death through a c-Fos-mediated and tumor cell specific sign...		Apoptosis , Others , AMPK , Autophagy
T10105	3α-Hydroxymogrol		AMPK
	3α-Hydroxymogrol is a triterpenoid isolated from Siraitia grosvenorii Swingle. It is a potent AMPK activator and enhances AMPK phosphorylation.		AMPK
TN1670	Ganodermanondiol		HIV Protease , Nrf2 , AMPK
	Ganodermanondiol exhibits potent cytoprotective effects on t-BHP-induced hepatotoxicity in human liver-derived HepG2 cells, presumably through Nrf2-mediated antioxidant enzymes and AMPK.		HIV Protease , Nrf2 , AMPK
TN6069	Thalidezine
	Thalidezine, a novel AMPK activator, eliminates apoptosis-resistant cancer cells through energy-mediated autophagic cell death, it can inhibit the growth of mouse L1210 cells in vitro. Thalidezine possesses antimicrobial...
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Natural Products

Kahweol

TN1828

Synonym:

Target: Apoptosis, NF-κB, AMPK

Kudinoside D

TN1836

Synonym:

Target: LDL, AMPK, PPAR

Nepodin

TN1100

Synonym:

Target: transporter, COX, AMPK, Parasite

Platycodin D

T3889

Synonym:

Target: Prostaglandin Receptor, AMPK

Target: P450, NOS, NF-κB, HIF, AMPK

Gomisin J

T3904

Synonym:

Target: Calcium Channel, AMPK

Vaccarin

T3881

Synonym:

Target: Integrin, Akt, PERK, AMPK

AMAROGENTIN

T5497

Synonym:

Target: Apoptosis, AMPK

[6]-Gingerol

T3405

Synonym: 6-Gingerol,gingerol,(S)-(+)-[6]Gingerol

Target: Apoptosis, AMPK

Karanjin

T2S0820

Synonym:

Target: Apoptosis, AMPK

Marein

TN1911

Synonym:

Target: transporter, Akt, HDAC, AMPK

Methyl cinnamate

T5552

Synonym:

Target: Tyrosinase, Antibacterial, AMPK

Cimiracemoside C

TN1499

Synonym: Cimicifugoside M

Synonym: Dantron,1,8-Dihydroxyanthraquinone,Chrysazin,Antrapurol

Target: Virus Protease, Antibacterial, AMPK, Autophagy

Ginkgolide C

T2750

Synonym: BN-52022

Target: MMP, Sirtuin, Endogenous Metabolite, AMPK

Palmitelaidic Acid

T19500

Synonym: trans-Palmitoleic acid,9-trans-Hexadecenoic acid

Target: Glucokinase, AMPK, PPAR

Urolithin B

T13265

Synonym:

Target: ERK, NF-κB, Akt, Endogenous Metabolite, JNK, AMPK

Doxorubicin hydrochloride

T1020

Synonym: Adriamycin,Doxorubicin (Adriamycin) HCl,Hydroxydaunorubicin hydrochloride,NSC 123127

Target: Apoptosis, Mitophagy, HBV, HIV Protease, Topoisomerase, Antibacterial, Antibiotic, AMPK, Autophagy

Daphnetin

T2851

Synonym: 7,8-Dihydroxycoumarin,Daphnetol

Target: EGFR, PKA, PKC, Parasite, Autophagy

Doxorubicin

T1456

Synonym: Hydroxydaunorubicin,Adriamycin

Target: Topoisomerase, AMPK

Ginkgolide K

T8200

Synonym:

Target: AMPK, Autophagy

1-HEXACOSANOL

TN6751

Synonym:

Target: NPC1L1, AMPK

Hernandezine

TN1731

Synonym:

Target: TNF, ROS, P-gp, AMPK

Mogrol

TN2346

Synonym:

Target: ERK, AMPK, STAT

AICAR phosphate

T14149

Synonym: AICA Riboside phosphate,Acadesine phosphate

Target: Mitophagy, NOS, YAP, AMPK

Phillyrin

T2854

Synonym: Forsythin

Target: P450, Influenza Virus, AMPK

Onjisaponin B

TN1140

Synonym:

Target: AMPK, mTOR, Autophagy

Fargesin

T5S2178

Synonym: (+/-)-Fargesin

Target: Adrenergic Receptor

Chikusetsusaponin IVa

T3863

Synonym: Calenduloside F

Target: Antibacterial, Antibiotic

Pinosylvin

T3843

Synonym: 3,5-stilbenediol,5-Styrylresorcinol

Target: Apoptosis, Others, Antibacterial, Autophagy

Gartanin

TN1677

Synonym:

Target: BCL, Caspase, JNK

Synonym: Curcumin II,Desmethoxycurcumin,Monodemethoxycurcumin

Target: Apoptosis, Antioxidant, Antibacterial, Autophagy

Target: IL Receptor, TNF, TLR

Punicalagin

T3921

Synonym:

Target: SARS-CoV, HBV

Britannin

T5793

Synonym:

Target: Apoptosis, AMPK, Autophagy

Sesamol

T3676

Synonym: 1,3-Benzodioxol-5-ol,3,4-Methylenedioxyphenol

Target: Apoptosis, AMPK

Glabridin

T3403

Synonym: Q-100692,KB-289522,LS-176045

Target: Reactive Oxygen Species, Tyrosinase, GABA Receptor, Antibacterial, PPAR

Saponarin

TN2179

Synonym: Petrocomoside,Saponaretin-7-O-glucoside,Isovitexin-7-O-glucoside

Target: ERK, P450, NF-κB, AMPK

Euphorbiasteroid

T3220

Synonym: Euphobiasteroid,Euphorbia factor L1

Target: Others, AMPK

Sulforaphane

TQ0207

Synonym:

Target: Apoptosis, Nrf2, HDAC

Prunetin

T4S0878

Synonym: Prunusetin

Target: ERK, Dehydrogenase, NF-κB

Brazilin

T6S1784

Synonym: Natural Red 24,Braziletto,Brasilin,Superbresiline

Target: Apoptosis, Others, AMPK, Autophagy

Target: HIV Protease, Nrf2, AMPK

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Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-04451	AMPK (G1/B1/A1) Heterotrimer Protein, Human, Recombinant (His & GST)	Human	Baculovirus-Insect Cells
	AMPK (G1/B1/A1) Heterotrimer Protein, Human, Recombinant (His & GST) is expressed in Baculovirus-Insect Cells
TMPY-04452	AMPK (G1/B2/A1) Heterotrimer Protein, Human, Recombinant (His & GST)	Human	Baculovirus-Insect Cells

TMPY-04454	AMPK (G1/B1/A2) Heterotrimer Protein, Human, Recombinant (His & GST)	Human	Baculovirus-Insect Cells

TMPY-04453	AMPK (G1/B2/A2) Heterotrimer Protein, Human, Recombinant (His & GST)	Human	Baculovirus-Insect Cells

TMPH-02480	PRKAB1 Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK act...
TMPH-02481	PRKAG1 Protein, Mouse, Recombinant (His)	Mouse	E. coli
	AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK a...
TMPH-02479	PRKAA1 Protein, Mouse, Recombinant (E. coli, His)	Mouse	E. coli
	Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activat...
TMPH-02478	PRKAA1 Protein, Mouse, Recombinant (His)	Mouse	Baculovirus
	Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activat...
TMPH-01796	NR4A1 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3'. May inhibit NF-kappa-B tr...
TMPH-02600	C1QL3 Protein, Mouse, Recombinant (His & Myc)	Mouse	Baculovirus
	May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses. Plays a role in glucose homeostasis. Via AMPK signaling pathway, stimulates glucose uptake in a...
TMPK-00139	Adiponectin Protein, Mouse, Recombinant (hFc)	Mouse	HEK293
	Adiponectin, also known as Acrp30, is an adipocyte-derived protein with wide ranging paracrine and endocrine effects on metabolism and inflammation.Important adipokine involved in the control of fat metabolism and insuli...
TMPH-01003	ATG14 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Required for both basal and inducible autophagy. Determines the localization of the autophagy-specific PI3-kinase complex PI3KC3-C1. Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosphatidyletha...
TMPK-00554	Adiponectin Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293
	Adiponectin, also known as Acrp30, is an adipocyte-derived protein with wide ranging paracrine and endocrine effects on metabolism and inflammation.Important adipokine involved in the control of fat metabolism and insuli...
TMPH-00219	Adiponectin Protein, Bovine, Recombinant (His)	Bovine	Yeast
	Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the l...
TMPH-01689	PLD6 Protein, Human, Recombinant (His)	Human	E. coli
	Presents phospholipase and nuclease activities, depending on the different physiological conditions. Interaction with Mitoguardin (MIGA1 or MIGA2) affects the dimer conformation, facilitating the lipase activity over the...

AMPK (G1/B1/A1) Heterotrimer Protein, Human, Recombinant (His & GST)

TMPY-04451

Species: Human

Expression System: Baculovirus-Insect Cells

AMPK (G1/B2/A1) Heterotrimer Protein, Human, Recombinant (His & GST)

TMPY-04452

Species: Human

Expression System: Baculovirus-Insect Cells

AMPK (G1/B1/A2) Heterotrimer Protein, Human, Recombinant (His & GST)

TMPY-04454

Species: Human

Expression System: Baculovirus-Insect Cells

AMPK (G1/B2/A2) Heterotrimer Protein, Human, Recombinant (His & GST)

TMPY-04453

Species: Human

Expression System: Baculovirus-Insect Cells

PRKAB1 Protein, Mouse, Recombinant (His)

TMPH-02480

Species: Mouse

Expression System: E. coli

PRKAG1 Protein, Mouse, Recombinant (His)

TMPH-02481

Species: Mouse

Expression System: E. coli

PRKAA1 Protein, Mouse, Recombinant (E. coli, His)

TMPH-02479

Species: Mouse

Expression System: E. coli

PRKAA1 Protein, Mouse, Recombinant (His)

TMPH-02478

Species: Mouse

Expression System: Baculovirus

NR4A1 Protein, Human, Recombinant (His & Myc)

TMPH-01796

Species: Human

Expression System: E. coli

C1QL3 Protein, Mouse, Recombinant (His & Myc)

TMPH-02600

Species: Mouse

Expression System: Baculovirus

Adiponectin Protein, Mouse, Recombinant (hFc)

TMPK-00139

Species: Mouse

Expression System: HEK293

ATG14 Protein, Human, Recombinant (His & Myc)

TMPH-01003

Species: Human

Expression System: E. coli

Adiponectin Protein, Cynomolgus, Recombinant (His)

TMPK-00554

Species: Cynomolgus

Expression System: HEK293

Adiponectin Protein, Bovine, Recombinant (His)

TMPH-00219

Species: Bovine

Expression System: Yeast

PLD6 Protein, Human, Recombinant (His)

TMPH-01689

Species: Human

Expression System: E. coli

Cat No.	Product Name
L1120	AMPK-Targeted Compound Library	80 compounds
	80 well-chosen unique AMPK-targeted small molecules；
L2520	Glycometabolism Compound Library	708 compounds
	708 glycometabolism-related comounds, can be used for HTS and HCT;
L2130	Anti-Cancer Metabolism Compound Library	1280 compounds
	A unique collection of 1280 cancer cellular metabolism related compounds for cancer research and high throughput screening (HTS) and high content screening (HCS);

Libraries

AMPK-Targeted Compound Library

L1120

Compounds: 80

Glycometabolism Compound Library

L2520

Compounds: 708

Anti-Cancer Metabolism Compound Library

L2130

Compounds: 1280