SR-18292 is an inhibitor of PPAR gamma coactivator-1α (PGC-1α), which increases PGC-1α acetylation, suppresses gluconeogenic gene expression and reduces glucose production in hepatocytes.

ZLN005 is an effective and tissue-specific transcriptional activator of PGC-1α.

D-Mannitol (Mannitol) is a diuretic and renal diagnostic aid related to sorbitol. It has little significant energy value as it is largely eliminated from the body before any metabolism can take place. It can be used to treat oliguria associated with kidney failure or other manifestations of inadequate renal function and has been used for determination of glomerular filtration rate. D-Mannitol is also commonly used as a research tool in cell biological studies, usually to control osmolarity.

Phoenixin-20 (TFA) (PNX-20 (TFA)) is a bioactive peptide that stimulates hypothalamo-pituitary-gonadal hormones, regulates mammalian reproductive processes, enhances neuronal mitochondrial biogenesis via the CREB-PGC-1α pathway, and exhibits anxiolytic properties [1] [2] [3].

Metaxalone (Methaxalonum) (marketed by King Pharmaceuticals under the brand name Skelaxin ) is a muscle relaxant used to relax muscles and relieve pain caused by strains, sprains, and other musculoskeletal conditions.

ERRα antagonist-1 (ERR+/- antagonist-1) is a high-affinity, selective antagonist of the estrogen-related receptor α (ERRα). It effectively prevents the interaction of ERRα with both Proliferator-activated Receptor γ Coactivator-1α (PGC-1α) and PGC-1β, displaying IC50 values of 170 nM and 180 nM, respectively. Notably, ERRα antagonist-1 does not interfere with the interactions involving ERRβ or ERRγ and the PGC-1α and PGC-1β coactivators. Furthermore, it does not affect the interaction between either ERα or ERβ and PGC-1α or SRC-1.

Ac-SVVVRT-NH2, a PGC-1α modulator, enhances the activity of the human PGC-1α promoter (114%), elevates PGC-1α mRNA levels (125%), and promotes intracellular lipid accumulation (128%) in subcutaneous human adipocytes. This compound has potential applications in research related to diseases influenced by PGC-1α.

11-Oxoisomogroside V is a triterpenoid glycoside isolated from luo han guo (Siraitia grosvenorii) that exhibits antioxidant and anti-inflammatory activity. 11-Oxoisomogroside V activates the transcriptional activity of PGC-1α. 11-Oxoisomogroside V increases luciferase activity.

ZLN005 (hydrochloride) is an activator of the peroxisome proliferator-activated receptor-gamma coactivator 1-alpha (PGC-1α). It enhances the expression of PGC-1α and downstream genes in skeletal muscle cells, leading to improved glucose utilization and fatty acid oxidation. In diabetic db/db mice, ZLN005 (hydrochloride) elevates the transcription of PGC-1α and downstream genes in skeletal muscle, boosts fat oxidation, and enhances glucose tolerance, pyruvate tolerance, and insulin sensitivity.

Medioresinol possesses antioxidative, a lesishmanicidal activity and cardiovascular disease risk reduction, it has antiamyloidogenic activity via reduction in the amount of α²-secretase, it is a potentially valuable antiamyloidogenic agent for the prevent

AdipoR agonist 1 (Compound 112254), acting as an agonist for the adiponectin receptor (AdipoR), stimulates transcriptional regulators including peroxisome proliferator-activated receptors (PPARs), peroxisome proliferator-activated receptor gamma coactivator 1α (PGC-1α), sirtuin 1 (SIRT1), and adenylate-activated protein kinase (AMPK). It is employed in the field of preventive doping research.

Acetyl hexapeptide 38, breast enhancement peptide, is a kind of acetylated hexapeptide, can significantly stimulate the use of the site of fat synthesis, increase the volume of the chest or cheek, shape the perfect body

D-Mannitol (Standard) is the standard substance of D-Mannitol, suitable for quantitative analysis, quality control, and biochemical experiments, etc. D-Mannitol is a diuretic and a renal diagnostic auxiliary agent with weak renal vascular dilation activity.

Phoenixin-20 (PNX-20) is a vertebrate bioactive peptide with hormone-like actions, stimulating the hypothalamo-pituitary-gonadal axis to regulate mammalian reproduction, enhancing neuronal mitochondrial biogenesis via the CREB-PGC-1α pathway, and possessing an anxiolytic effect [1] [2] [3].

CPAG-1 is a small molecule activator of the progesterone receptor membrane component 2 (PGRMC2). It facilitates the delivery of mitochondrially-produced heme to the nucleus via PGRMC2 and activates thermogenesis-related genes like Ucp1 and Pgc-1α in brown adipose tissue (BAT), while reducing lipid accumulation in BAT. Additionally, CPAG-1 lowers fasting blood glucose and insulin levels, improving glucose tolerance and insulin sensitivity. It is applicable for research in type 2 diabetes.

MARY1 is a selective 5-HT2BR antagonist with an IC50 of 380 nM and a Ki of 764 nM [human 5-HT2BR]. It promotes mitochondrial biogenesis (MB) in the kidneys and enhances mitochondrial function by increasing mitochondrial respiration capacity, protein levels, and number in renal proximal tubular cells (RPTC). MARY1 induces MB in RPTCs through the 5-HT2BR and dual PI3K/AKT and RAS/MEK/ERK signaling pathways. It is useful for studying kidney diseases related to metabolic and mitochondrial dysfunction.

KL1333 hydrochloride is an orally effective NAD+ modulator that acts as a substrate for NAD(P)H: quinone oxidoreductase 1 (NQO1), leading to increased intracellular NAD+ levels through NADH oxidation. Elevated NAD+ subsequently activates SIRT1 and AMPK, which in turn activate PGC-1α. KL1333 hydrochloride improves energy metabolism and mitochondrial dysfunction in fibroblasts of mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS). It also has a protective effect against cisplatin-induced ototoxicity in cultured mouse cochlea.

Neuroprotective agent 8 (compound AA-9) is an orally active neuroprotective agent that functions through antioxidant stress reduction and anti-inflammatory mechanisms. In a rat model of MCAO ischemic stroke, it activates PGC-1α and inhibits the NLRP3 inflammasome.

Mogroside VI B, a cucurbitane glucoside derived from Siraitia grosvenorii crude extract, exhibits potency in activating PGC-1α transcription [1].

D-Mannitol-d4 (Mannitol-d4) is the deuterium-labeled variant of D-Mannitol. D-Mannitol (Mannitol) is a resistant sugar with oral activity, widely utilized in the food and pharmaceutical industries. It facilitates calcium and magnesium absorption and retention via cecal fermentation and reduces tissue edema as an osmotic diuretic. Additionally, D-Mannitol can enhance brown fat formation, improve insulin action, lower blood glucose levels, and promote the conversion of white adipose cells to brown via β3-adrenergic receptor (β3-AR), PGC1α, and PKA pathways. It is also used to maintain osmotic pressure between plant protoplasts and culture media, protecting cells when the cell wall is weakened or removed.

Metaxalone-D6 is intended for use as an internal standard for the quantification of metaxalone by GC-or LC-MS. Metaxalone (T1610) is a skeletal muscle relaxant. It inhibits the proliferation of, and induces apoptosis in, RAW 264.7 cells in vitro when used at concentrations ranging from 1 to 100 µM. Metaxalone (T1610) also reduces LPS-induced increases in COX-1, COX-2, and NF-kB levels and inhibits LPS-induced production of TNF-α, IL-6, and prostaglandin E2 in RAW 264.7 cells. Formulations containing metaxalone have been used in the treatment of lower back pain.

ZLN005-D4 is the deuterated form of ZLN005. ZLN005 (T1802) acts as a novel activator of the peroxisome proliferator-activated receptor coactivator (PGC-1α).