PD-1/PD-L1

PD-1 inhibitors and PD-L1 inhibitors are a group of checkpoint inhibitor anticancer drugs that block the activity of PD-1 and PDL1 immune checkpoint proteins present on the surface of cells. Immune checkpoint inhibitors are emerging as a front-line treatment for several types of cancer.

Cat. No.	Product name	CAS No.	Purity
T35396	Spartalizumab (anti-PD-1)		98%

T35394	Sintilimab (anti-PD-1)		98%

T9616	PD-1/PD-L1-IN-10	2487550-41-2	98%
PD-1/PD-L1-IN-10 is an orally active PD-1/PD-L1 inhibitor (IC50 of 2.7 nM) with potent anticancer efficacy.
T36487	Evixapodlin	2374856-75-2	98%
Evixapodlin is a human PD-1/PD-L1 protein/protein interaction inhibitor (IC50: 0.213).Evixapodlin has anticancer and antiviral activities.
T9902	Atezolizumab	1380723-44-3	98%
Atezolizumab anti-PD-L1) is a fully humanized IgG1 monoclonal antibody that blocks the interaction of PD-L1 with both PD-1 and B7.1 but not the interaction of PD...
T9907	Nivolumab	946414-94-4	98%
Nivolumab anti-PD-1) is a genetically engineered fully human immunoglobulin Ig) G4 monoclonal antibody directed against the negative immunoregulatory human cell ...
TP1076L	AUNP-12 acetate		98%
AUNP-12 acetate is a polypeptide inhibitor of PD-1 that is equivalent to PD-1 and PD-2 in inhibiting lymphocyte proliferation and effector fuction, in addition t...
T9359	PDL-1 cpd 10	2767424-13-3	98%
PDL-1 cpd 10 is a novel small molecule PD-L1 inhititor.
T36899	INCB086550	2230911-59-6	98%
INCB086550 (example 24) is a PD-1/PD-L1 inhibitor, with an IC50 <= 10 nM.
T12379	PD-1-IN-22	2349372-98-9	98%
PD-1-IN-22 is a potent programmed cell death-1 (PD-1)/programmed cell death-ligand 1 (PD-L1) interaction inhibitor(IC50 of 92.3 nM).
T8470	BMS-1001	2113650-03-4	98%
BMS-1001 is a potent inhibitor of PD-1/PD-L1 interaction(IC50 : 2.25 nM, in a homogenous time-resolved fluorescence binding assay).
T9908	Pembrolizumab	1374853-91-4	98%
Pembrolizumab is a humanized monoclonal antibody inhibiting the PD-1 receptor and the first in the class of agents called the HER2 dimerization inhibitors that i...
T26859	BMS-8	1675201-90-7	98%
BMS-8 is a novel inhibitor of the PD-1/PD-L1 interaction.
T3146	BMS-202	1675203-84-5	98%
PD1-PDL1 inhibitor 2 is an inhibitor of the PD-1 (Programmed death- 1) /PD-Ll (Programmed death-ligand 1) protein/protein interaction, extracted from patent WO/2...
T5697	BMS-1166	1818314-88-3	98%
BMS-1166 is a potent PD-1/PD-L1 interaction inhibitor.
T0844	Sulfamethoxypyridazine	80-35-3	98%
Sulfamethoxypyridazine is a sulfanilamide antibacterial agent.
T6S0071	Fraxinellone	28808-62-0	98%
1. Fraxinellone significantly reduced weight loss and diarrhea in mice and alleviated the macroscopic and microscopic signs of the disease. 2. Fraxinellone exhib...
T9651	PD-1/PD-L1-IN-9	2628506-54-5	98%
PD-1/PD-L1-IN-9 is a potent and orally active inhibitor of PD-1/PD-L1 interaction, IC50 = 3.8 nM. PD-1/PD-L1-IN-9 can enhance the killing activity of tumor cells...
T4696	BMS202 hydrochloride (1675203-84-5(free base))	T4696	98%
PD-1/PD-L1 inhibitor 2 is a small-molecule PD-1/PD-L1 interaction inhibitor (IC50: 18 nM). Biophysical studies demonstrate that BMS202 binds directly to PD-L1. B...
T10565	BMS-1001 hydrochloride	2113650-04-5	98%
BMS-1001 hydrochloride is an orally active inhibitor of human PD-1/PD-L1 immune checkpoint with low-toxicity in cells.BMS-1001 alleviates the inhibitory effect o...

Cat. No.

Product name

CAS No.

Purity

Chemical Structure

T35396

Spartalizumab (anti-PD-1)

98%

T35394

Sintilimab (anti-PD-1)

98%

T9616

PD-1/PD-L1-IN-10

2487550-41-2

98%

PD-1/PD-L1-IN-10 is an orally active PD-1/PD-L1 inhibitor (IC50 of 2.7 nM) with potent anticancer efficacy.

T36487

Evixapodlin

2374856-75-2

98%

Evixapodlin is a human PD-1/PD-L1 protein/protein interaction inhibitor (IC50: 0.213).Evixapodlin has anticancer and antiviral activities.

T9902

Atezolizumab

1380723-44-3

98%

Atezolizumab anti-PD-L1) is a fully humanized IgG1 monoclonal antibody that blocks the interaction of PD-L1 with both PD-1 and B7.1 but not the interaction of PD...

T9907

Nivolumab

946414-94-4

98%

Nivolumab anti-PD-1) is a genetically engineered fully human immunoglobulin Ig) G4 monoclonal antibody directed against the negative immunoregulatory human cell ...

TP1076L

AUNP-12 acetate

98%

AUNP-12 acetate is a polypeptide inhibitor of PD-1 that is equivalent to PD-1 and PD-2 in inhibiting lymphocyte proliferation and effector fuction, in addition t...

T9359

PDL-1 cpd 10

2767424-13-3

98%

PDL-1 cpd 10 is a novel small molecule PD-L1 inhititor.

T36899

INCB086550

2230911-59-6

98%

INCB086550 (example 24) is a PD-1/PD-L1 inhibitor, with an IC50 <= 10 nM.

T12379

PD-1-IN-22

2349372-98-9

98%

PD-1-IN-22 is a potent programmed cell death-1 (PD-1)/programmed cell death-ligand 1 (PD-L1) interaction inhibitor(IC50 of 92.3 nM).

T8470

BMS-1001

2113650-03-4

98%

BMS-1001 is a potent inhibitor of PD-1/PD-L1 interaction(IC50 : 2.25 nM, in a homogenous time-resolved fluorescence binding assay).

T9908

Pembrolizumab

1374853-91-4

98%

Pembrolizumab is a humanized monoclonal antibody inhibiting the PD-1 receptor and the first in the class of agents called the HER2 dimerization inhibitors that i...

T26859

BMS-8

1675201-90-7

98%

BMS-8 is a novel inhibitor of the PD-1/PD-L1 interaction.

T3146

BMS-202

1675203-84-5

98%

PD1-PDL1 inhibitor 2 is an inhibitor of the PD-1 (Programmed death- 1) /PD-Ll (Programmed death-ligand 1) protein/protein interaction, extracted from patent WO/2...

T5697

BMS-1166

1818314-88-3

98%

BMS-1166 is a potent PD-1/PD-L1 interaction inhibitor.

T0844

Sulfamethoxypyridazine

80-35-3

98%

Sulfamethoxypyridazine is a sulfanilamide antibacterial agent.

T6S0071

Fraxinellone

28808-62-0

98%

1. Fraxinellone significantly reduced weight loss and diarrhea in mice and alleviated the macroscopic and microscopic signs of the disease. 2. Fraxinellone exhib...

T9651

PD-1/PD-L1-IN-9

2628506-54-5

98%

PD-1/PD-L1-IN-9 is a potent and orally active inhibitor of PD-1/PD-L1 interaction, IC50 = 3.8 nM. PD-1/PD-L1-IN-9 can enhance the killing activity of tumor cells...

T4696

BMS202 hydrochloride (1675203-84-5(free base))