transporters — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T9833	Opiranserin hydrochloride		P2X Receptor , GlyT , 5-HT Receptor
	Opiranserin (VVZ-149) hydrochloride is a dual antagonist of glycine transporter type 2 (GlyT2) and serotonin receptor 2A (5HT2A), with IC50s of 0.86 and 1.3 μM, respectively. It shows antagonistic activity on rP2X3 (IC50...		P2X Receptor , GlyT , 5-HT Receptor
T0760	Cholesterol	Cholesterin,Cholesteryl alcohol	Estrogen Receptor/ERR , MRP , Endogenous Metabolite , ROR
	Cholesterol (cholesteryl alcohol) is a natural product that is the major sterol in mammals and an agonist of estrogen-related receptor α (ERRα). Cholesterol is widely found in the cell membranes of animals and is also us...		Estrogen Receptor/ERR , MRP , Endogenous Metabolite , ROR
T11908	LY2365109 hydrochloride		GlyT
	LY2365109 hydrochloride is a potent and selective GlyT1 inhibitor, with an IC50 of 15.8 nM for glycine uptake in cells over-expressing hGlyT1a.		GlyT
T6788	Bitopertin	Paliflutine,RO4917838,RG1678	GlyT
	Bitopertin (Paliflutine) (RG1678, RO-4917838) is a potent inhibitor of glycine transporter 1 (GlyT1), with Ki of 8.1 nM for human hGlyT1b and IC50 of 22-25 nM in Chinese hamster ovary cells.		GlyT
T6541	Ibutilide Fumarate	Corvert Fumarate,U70226E	Calcium Channel , Sodium Channel
	Ibutilide Fumarate (U70226E) is the fumarate salt form of ibutilide, a class III antiarrhythmic agent. Ibutilide exerts its effect by activating a slow, inward, predominately sodium current rather than by blocking outwar...		Calcium Channel , Sodium Channel
T6975	Sarcosine	Sarcosinic acid,Methylaminoacetic acid,Sarcosin,Methylglycine,N-Methylaminoacetic acid,N-methylglycine	Others , GlyT , Endogenous Metabolite
	Sarcosine (Methylglycine) is a competitive inhibitor of the type I glycine transporter (GlyT1) and an N-methyl-D-aspartate receptor (NMDAR) co-agonist.		Others , GlyT , Endogenous Metabolite
T6352	(-)-Dizocilpine maleate	C13737,(-)-MK 801 (Maleate),(-)-MK 801 Maleate	NMDAR , iGluR
	(-)-Dizocilpine maleate ((-)-MK 801 (Maleate)) is a potent, selective and non-competitive NMDA receptor antagonist with Kd of 37.2 nM in rat brain membranes.		NMDAR , iGluR
T1050	Prazosin hydrochloride	Prazosin hydrochloride,Prazosin HCl,cp-12299-1,Peripress,Vasoflex,Minipress	Potassium Channel , MRP , Adrenergic Receptor , ABC , Autophagy
	Prazosin hydrochloride (Vasoflex) reduces peripheral resistance and relaxes vascular smooth muscles as a selective adrenergic alpha-1 antagonist by a mechanism not completely known. Prazosin hydrochloride is a synthetic ...
T1045	Trimipramine maleate	Surmontil maleate	Dopamine Receptor , 5-HT Receptor , Antibacterial , Adrenergic Receptor , Norepinephrine , Histamine Receptor
	Trimipramine maleate (Surmontil maleate) appears to inhibit serotonin transport and norepinephrine uptake by nerve terminals. This increases available norepinephrine or serotonin and prolongs its action. Trimipramine Mal...
T16399	Opiranserin		P2X Receptor , GlyT , 5-HT Receptor
	Opiranserin is a development as an injectable agent for the treatment of postoperative pain. Opiranserin is a non-opioid and non-NSAID analgesic candidate and is a dual antagonist of glycine transporter type 2 (GlyT2) an...		P2X Receptor , GlyT , 5-HT Receptor
T21102	L-4FPG	L4FPG,L 4FPG	Others
	L-4FPG is a Glycine derivative, inhibits the neutral amino acid transporters ASCT1 and ASCT2.		Others
T3215	JNJ-42165279	JNJ42165279	FAAH , Autophagy
	JNJ-42165279 covalently inactivates the FAAH enzyme but is highly selective with regard to other enzymes, ion channels, transporters, and receptors. JNJ-42165279 (10 μM) exhibits high selectivity against a panel of 50 re...		FAAH , Autophagy
T4921	Oxoadipic acid	2-Oxoadipic acid	Endogenous Metabolite
	Oxoadipic acid (2-Oxoadipic acid) is a key metabolite of the essential amino acids tryptophan and lysine.Important metabolite between the TCA cycle and lysine biosynthesis. Of interest for research on mitochondrial metab...		Endogenous Metabolite
T3526	Dasotraline hydrochloride	SEP-225289 hydrochloride	Dopamine Receptor , 5-HT Receptor , Serotonin Transporter , Norepinephrine
	Dasotraline hydrochloride (SEP-225289 hydrochloride) (SEP-225289 hydrochloride) is a triple reuptake inhibitor that inhibits dopamine, norepinephrine, and serotonin transporters with IC50 values of 4, 6, and 11 nM, respe...
T7941	Imipramine hydrochloride	Imipramine (hydrochloride),Tofranil,G 22355,Imipramine HCl,Melipramine	Serotonin Transporter
	Imipramine hydrochloride (Imipramine HCl) is a first generation tricyclic antidepressant that acts primarily as an inhibitor of serotonin and norepinephrine transporters (Kds = 1.4 and 37 nM, respectively).Imipramine hyd...		Serotonin Transporter
T4927	4-Guanidinobutanoic acid	4-GBA,4-Guanidinobutyric acid	Endogenous Metabolite
	4-Guanidinobutanoic acid (4-GBA) is an L-arginine metabolite that has been used in the intestinal transport tranport studies. It has been specifically use to human proton coupled amino acid transporters hPAT1.		Endogenous Metabolite
T9146	Ms48107	Benzenemethanol, 2-[4-amino-6-[[(4-phenoxyphenyl)methyl]amino]-1,3,5-triazin-2-yl]-3-fluoro-	Others
	MS48107 is a potent, selective positive allosteric modulator of G protein-coupled receptor 68 (GPR68), demonstrating specificity for GPR68 over closely related proton GPCRs, neurotransmitter transporters, and hERG ion ch...		Others
T19649	PF-06273340	PF 6273340,PF 06273340,PF6273340,PF-6273340	Trk receptor
	PF-06273340 is an effective, Selective, and Peripherally Restricted Pan-Trk inhibitor (IC50: Trk-A = 6 nM; Trk-B = 4 nM; Trk-C = 3 nM). PF-06273340 has low metabolic turnover in HLM and hHep is a good substrate for efflu...		Trk receptor
T5061	Lumichrome	7,8-Dimethylalloxazine	Others
	Lumichrome (7,8-Dimethylalloxazine) is a natural metabolite of riboflavin. Lumichrome produced by Rhizobium and other bacterial species induces major developmental changes in plants at nanomolar concentrations. Lumichrom...		Others
T5242	Triarachidin	Triarachin,1,2,3-Trieicosanoyl Glycerol,Glycerol Trieicosanoate	Others , Endogenous Metabolite
	Triarachidin (1,2,3-Trieicosanoyl Glycerol) is a triarachidic acid triglyceride. Triglycerides (TGs) are also known as triacylglycerols or triacylglycerides. TGs are the main constituent of vegetable oil and animal fats....		Others , Endogenous Metabolite