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Cat No. | Product Name | Synonyms | Targets |
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TP1604L | Thioredoxin reductase peptide acetate | Thioredoxin reductase peptide acetate(950890-23-0 free base) | Others |
Thioredoxin reductase peptide acetate corresponds to residues 53–67 in thioredoxin reductase (TrxR), used in thioredoxin reductase research.Mammalian thioredoxin reductase (TR) catalyzes the reduction of the redox-active... | |||
TP1604 | Thioredoxin reductase peptide | ||
Thioredoxin reductase peptide corresponds to residues 53–67 in thioredoxin reductase (TrxR), used in thioredoxin reductase research.Mammalian thioredoxin reductase (TR) catalyzes the reduction of the redox-active disulfi... | |||
TP1375 | Thioredoxin reductase peptide TFA | ||
Thioredoxin reductase peptide TFA corresponds to residues 53-67 in thioredoxin reductase (TrxR), used in thioredoxin reductase research.. | |||
T13230 | TXNIP-IN-1 | Others | |
TXNIP-IN-1 is an inhibitor of the TXNIP-TRX complex and used in the research of TXNIP-TRX complex associated metabolic disorder (diabetes), cardiovascular disease, or inflammatory disease. | |||
T5481 | TRi-1 | Others | |
TRi-1 is irreversible inhibitor of cytosolic thioredoxin reductase 1 (TXNRD1), with an IC50 of 12 nM. TRi-1 has little mitochondrial toxicity for anticancer therapy | |||
T20168 | Aurothiomalate sodium | Myocrisin,Myocrisine,Miochrysin,Sodium aurothiomalate,Myochrysine,gold sodium thiomalate | Others , PKC |
Sodium aurothiomalate is a gold compound that is used for its immunosuppressive anti-rheumatic effects. Aurothiomalate sodium (Miochrysin) is a potent and selective inhibitor of oncogenic PKC-ι signaling. Aurothiomalate ... | |||
T9118 | KEA1-97 | Apoptosis , Others , Caspase | |
Kea1-97 is a selective disruptor of interaction between thioredoxin and caspase-3 (IC50 = 10 μ M). Kea1-97 destroys the interaction between thioredoxin and caspase 3 and activates caspases without affecting the activity ... | |||
T39664 | Ethaselen | BBSKE | |
Ethaselen (BBSKE), a selective thioredoxin reductase (TrxR) inhibitor, is orally active with IC50s of 0.5 and 0.35 μM for wild-type human TrxR1 and rat TrxR1, respectively. Ethaselen specifically binds to the unique sele... | |||
T4414 | Eprenetapopt | APR-246,PRIMA-1Met | Apoptosis , Others , Ferroptosis , p53 , Autophagy |
Eprenetapopt (PRIMA-1Met) restores wild-type conformation and function to mutant p53, and triggers apoptosis in tumor cells. PRIMA-1MET also targets the selenoprotein thioredoxin reductase 1 (TrxR1), a key regulator of c... | |||
T60446 | LCS3 | Apoptosis , Glutathione reductase | |
LCS3 is a reversible and non-competitive synergistic inhibitor of glutathione disulfide reductase (GSR) and thioredoxin reductase 1 (TXNRD1) with IC50s of 3.3 μM and 3.8 μM, respectively. LCS3 has antitumour activity, in... | |||
T2283 | PX-12 | IV-2,PX12 | Thioredoxin |
PX-12 (PX12) (1-methylpropyl 2-imidazolyl disulfide) is a small-molecule inhibitor of Trx-1 (thioredoxin-1), stimulates apoptosis, down-regulates HIF-1α and vascular endothelial growth factor (VEGF) and inhibits tumor gr... | |||
T29018 | TrxR inhibitor D9 | D9,TrxR-IN-D9 | |
TrxR-IN-D9 is a novel inhibitor of thioredoxin reductase (TrxR). | |||
T23166 | PMX 464 | Others | |
inhibitor of the thioredoxin-thioredoxin reductase (Trx-TrxR) system | |||
T24593 | PAO-PDT | PAO PDT | |
PAO-PDT is a highly selective thioredoxin reductase inhibitor. | |||
T11130 | DVD-445 | Others | |
Dvd-445 has good anti-cancer effect.Dvd-445 is an effective peptide covalent thioredoxin reductase 1 (TrxR1) inhibitor with IC50 value of 0.60 mol/L M. | |||
T28906 | T6603185 | T-6603185,T 6603185 | |
T6603185 is a novel inhibitor of peroxiredoxin (Prx) and thioredoxin (Trx) systems. | |||
T70131 | TPP2a bromide | ||
TPP2a is a mitochondrial thioredoxin reductase (TrxR) inhibitor. | |||
T34922 | TRFS-red | TRFSred | |
TRFS-red is the first red emission off-on probe for thioredoxin reductase. | |||
T33413 | Mito-TRFS | MitoTRFS | |
Mito-TRFS is the first off-on probe for imaging the mitochondrial thioredoxin reductase (TrxR2) in live cells. | |||
T40946 | Seph-PAO | ||
Seph-PAO, a modified form of polyalphaolefin (PAO) compound, is created by coupling a sepharose fluorophore. Its primary application lies in the detection of thioredoxin reductase (TrxR). | |||
T39048 | Sel-green | ||
Sel-green is a selective selenol fluorescent probe used for quantifying the selenocysteine (Sec) content in the selenoenzyme thioredoxin reductase, as well as imaging endogenous Sec in live HepG2 cells. | |||
T75351 | TP-TRFS | ||
TP-TRFS is a highly selective and the first two-photon fluorescent probe of thioredoxin reductase (TrxR) [1] . | |||
T39915 | Trx-red | Trx-red,NBL-SS perchlorate | |
Trx-red (NBL-SS perchlorate) is a red-emitting fluorescent probe derived from the nile blue fluorophore. It is specifically designed for imaging thioredoxin (Trx) in live cells and in vivo, with excitation and emission w... | |||
T61647 | TrxR-IN-5 | ||
TrxR-IN-5 (compound 4f) is an efficacious inhibitor of TrxR (thioredoxin reductase) with an IC50 of 0.16 μM. By elevating the levels of reactive oxygen species (ROS), TrxR-IN-5 fosters robust antiproliferative impacts. A... | |||
T62021 | TrxR-IN-2 | ||
TrxR-IN-2 is a potential thioredoxin reductase (TrxR) inhibitor. TrxR-IN-2 has research value in the chemotherapy of drug-resistant hepatocellular carcinoma. | |||
T36399 | PAO-Nap | ||
PAO-Nap is a chemically modified version of PAO, in which a naphthalimide fluorophore is attached to the compound using a linker called aminocaproic acid. This modified compound, PAO-Nap, exhibits a selective targeting o... | |||
T79198 | S-Gem | Nucleoside Antimetabolite/Analog | |
S-Gem, a thioredoxin reductase (TrxR)-dependent prodrug of Gemcitabine, is selectively activated by TrxR. Studies indicate that S-Gem exhibits lower cytotoxicity than Gemcitabine [1]. | |||
T73825 | TRFS-green | ||
TRFS-green, a highly selective off-on fluorescent probe, is designed for the specific imaging of thioredoxin reductase (TrxR) in living cells, exhibiting its maximum absorbance at approximately 373 nm [1]. | |||
T62294 | SRI-37330 hydrochloride | ||
SRI-37330 hydrochloride is an orally active thioredoxin-interacting protein (TXNIP) inhibitor. hydrochloride can be used to study type 2 diabetes. | |||
T73512 | ZC0109 | ||
ZC0109, a dual inhibitor targeting IDO1 and Thioredoxin Reductase 1 (TrxR1) with IC50 values of 50 nM and 3.0 μM respectively, effectively promotes ROS accumulation and arrests the cell cycle at the G1/S phase, culminati... | |||
T78158 | MitoCur-1 | Others | |
MitoCur-1, a curcumin analogue, acts as an inhibitor of mitochondrial antioxidative enzyme thioredoxin reductase 2 (TrxR2), possessing electrophilic characteristics with mitochondrial-targeting capabilities. This compoun... | |||
T35811 | CAY10410 | ||
CAY10410 is an analog of prostaglandin D2/prostaglandin J2 (PGD2/PGJ2) with structural modifications intended to give it PPARγ ligand activity and resistance to metabolism. 15-deoxy-δ12,14-PGJ2 has been shown to be a pot... | |||
T83871 | Ferroptocide | ||
Ferroptocide, a thioredoxin (Trx) inhibitor and pleuromutilin derivative, exhibits inhibitory activity against Trx in ES-2 ovarian cancer cells at a concentration of 20 µM and demonstrates cytotoxicity towards these cell... |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T5372 | L-SelenoMethionine | L-(+)-Selenomethionine | Apoptosis , Amino Acids and Derivatives , Endogenous Metabolite |
L-SelenoMethionine (L-(+)-Selenomethionine) is a naturally occurring amino acid. It promotes cell cycle progression and elevates the expression of the antioxidant enzymes thioredoxin reductase, glutathione reductase. |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-00382 | Thioredoxin/TRX Protein, Mouse, Recombinant | Mouse | E. coli |
Thioredoxin/TRX Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 11.7 kDa and the accession number is P10639. | |||
TMPY-02250 | Thioredoxin/TRX Protein, Human, Recombinant | Human | E. coli |
Thioredoxin/TRX Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 11.7 kDa and the accession number is P10599. | |||
TMPY-02084 | Thioredoxin 2/TRX2 Protein, Human, Recombinant (His) | Human | E. coli |
Thioredoxin-2, also known as TXN2, MTRX and TRX2, is a member of the thioredoxin family. Tryparedoxins (TXN) are thioredoxin-related proteins which, as trypanothione:peroxiredoxin oxidoreductases, constitute the trypanot... | |||
TMPY-02723 | TXNL4B Protein, Human, Recombinant (His) | Human | E. coli |
Dim2, also known as TXNL4B, is a member of the DIM1 family. The Dim protein family is composed of two classes, Dim1and Dim2, which share a common thioredoxin-like fold. They were originally identified for their role in c... | |||
TMPH-00739 | Thioredoxin-1 Protein, E. coli, Recombinant (His) | E. coli | E. coli |
Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Thioredoxin-1 Protein, E. coli, Recombinant (His) i... | |||
TMPJ-01404 | TMX2 Protein, Human, Recombinant (His) | Human | E. coli |
TMX2 is a single-pass type I membrane protein and contains 1 thioredoxin domain. Thioredoxin plays an important role in various cellular processes through redox regulation. The Molecular Cloning and characterization of ... | |||
TMPY-02572 | TXNDC17 Protein, Human, Recombinant | Human | E. coli |
Thioredoxin-related protein of 14 kDa (TRP14, also called TXNDC17 for thioredoxin domain containing 17, or TXNL5 for thioredoxin-like 5) is an evolutionarily well-conserved member of the thioredoxin (Trx)-fold protein fa... | |||
TMPJ-01098 | PRDX4 Protein, Human, Recombinant (His) | Human | E. coli |
Peroxiredoxin-4 (PRDX4) is a member of the AhpC/TSA family. PRDX4 is a cytoplasmic protein and contains one thioredoxin domain. PRDX4 exists in homodimer or heterodimer with PRDX1. PRDX4 reduces hydrogen peroxide and alk... | |||
TMPY-06696 | TXNDC15 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
TXNDC15 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 32.96 kDa and the accession number is NP_078991.3. | |||
TMPY-02271 | TRXR1/TXNRD1 Protein, Human, Recombinant (aa 161-647, His) | Human | E. coli |
Thioredoxin reductase 1 (TXNRD1) which is a selenocysteine-containing protein is overexpressed in many malignancies. TXNRD1 plays a key role in regulating cell growth and transformation, and protects cells against oxidat... | |||
TMPY-05058 | TMX1 Protein, Human, Recombinant (mFc) | Human | HEK293 Cells |
As a thiol-based tumor suppressor, TMX1 increases mitochondrial ATP production and apoptosis progression. TMX1 is the first example of a topology-specific client protein redox catalyst acting both in the folding and in t... | |||
TMPY-02797 | TXNL4A Protein, Human, Recombinant (His) | Human | E. coli |
DIM1, also known as TXNL4A, is a member of the Dim protein family. The Dim protein family is composed of two classes, DIM1and Dim2, which share a common thioredoxin-like fold. They were originally identified for their ro... | |||
TMPJ-00720 | TXNDC12 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Thioredoxin Domain-Containing Protein 12 belongs to the thioredoxin superfamily. In this family, proteins possess a thioredoxin fold with a consensus active-site sequence (CxxC) and have roles in redox regulation, defens... | |||
TMPJ-00826 | TXN Protein, Human, Recombinant (His) | Human | E. coli |
Thioredoxin (TXN) is a member of the Thioredoxin family. Thioredoxin exists as a disulfide-linked homodimer and contains one Thioredoxin domain. Thioredoxin is up-regulated by ionizing radiation. Thioredoxin participates... | |||
TMPJ-00933 | PRDX5 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Peroxisomes are essential organelles that participate in multiple important metabolic processes, including the β-oxidation of fatty acids, plasmalogen synthesis, and the metabolism of reactive oxygen species (ROS). Perox... | |||
TMPH-00072 | 2-Cys Prx A Protein, Arabidopsis thaliana, Recombinant (His) | Arabidopsis thaliana | P. pastoris (Yeast) |
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxide... | |||
TMPH-00078 | Beta-amylase 1, chloroplastic Protein, Arabidopsis thaliana, Recombinant (His & Myc) | Arabidopsis thaliana | E. coli |
Beta-amylase activity. Can use p-nitrophenyl maltopentaoside (PNPG5) as substrate only in reduced form. Can play a minor role in the starch degradation and maltose metabolism in chloroplasts during the night. More active... | |||
TMPJ-01124 | PDIA6 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Protein Disulfide-Isomerase A6 (PDIA6) is a 48.5kDa protein that belongs to the protein disulfide isomerase family (PDI). PDIA6 is an enzyme in the endoplasmic reticulum in eukaryotes which catalyzes the formation and br... | |||
TMPJ-00934 | PRDX3 Protein, Human, Recombinant | Human | E. coli |
Thioredoxin-Dependent Peroxide Reductase Mitochondrial (PRDX3) is an enzyme that belongs to the AhpC/TSA family. Human and mouse PRDX3 genes are highly conserved, and they map to the regions syntenic between mouse and hu... | |||
TMPH-03443 | GPX2 Protein, S. cerevisiae, Recombinant (His & Myc) | Saccharomyces cerevisiae | E. coli |
Glutathione peroxidase-like protein that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress. Plays an important role in the oxidative stress-induced response in the pres... | |||
TMPH-02197 | TXNDC5 Protein, Human, Recombinant | Human | E. coli |
Possesses thioredoxin activity. Has been shown to reduce insulin disulfide bonds. Also complements protein disulfide-isomerase deficiency in yeast. TXNDC5 Protein, Human, Recombinant is expressed in E. coli expression sy... | |||
TMPH-02198 | TXNRD2 Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
Involved in the control of reactive oxygen species levels and the regulation of mitochondrial redox homeostasis. Maintains thioredoxin in a reduced state. May play a role in redox-regulated cell signaling. | |||
TMPJ-00461 | PDIA5 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Protein disulfide-isomerase A5 is a 519 amino acids protein that belongs to the protein disulfide isomerase family.It contains 3 thioredoxin domains.It can catalyze the rearrangement of -S-S- bonds in proteins. | |||
TMPH-02196 | TXNDC5 Protein, Human, Recombinant (GST) | Human | E. coli |
Possesses thioredoxin activity. Has been shown to reduce insulin disulfide bonds. Also complements protein disulfide-isomerase deficiency in yeast. TXNDC5 Protein, Human, Recombinant (GST) is expressed in E. coli express... | |||
TMPJ-01225 | PDILT Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Protein Disulfide-Isomerase-Like Protein of the Testis (PDILT) is a protein that belongs to the protein disulfide isomerase family. Human PDILT is synthesized as a 584 amino acid precursor that contains an 20 amino acid ... | |||
TMPJ-01268 | ERP27 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Endoplasmic reticulum resident protein 27, also known as ER protein 27, C12orf46 and ERP27, is an endoplasmic reticulum luminal protein which is a member of the protein disulfide isomerase family. ERP27 contains one thio... | |||
TMPY-02890 | ERP27 Protein, Human, Recombinant (mFc) | Human | HEK293 Cells |
ERP27 contains 1 thioredoxin domain and is a noncatalytic member of the protein disulfide isomerase family. Protein disulfide isomerases (PDIs) constitute a family of structurally related enzymes which catalyze disulfide... |