streptococcus

Isobavachromene is an inhibitor of NADH-Ubiquinone oxidoreductase and ornithine decarboxylase. Isobavachromene has antifungal activity.

Sapienic acid sodium is a fatty acid with variable antimicrobial activities against Gram-positive and Gram-negative bacteria found on the skin and in the oral cavity.

Cefuroxime Sodium is the sodium salt form of cefuroxime and a semi-synthetic, broad-spectrum, beta-lactamase resistant, second-generation cephalosporin antibiotic with bactericidal activity. Cefuroxime sodium (Cefuroxime sodium salt) inhibits bacterial cell wall synthesis by inactivating penicillin binding proteins (PBPs) thereby interfering with the final transpeptidation step required for cross-linking of peptidoglycan units which are a component of the cell wall. Lack of cross-linking results in a reduction of cell wall stability and leads to cell lysis.

Sapienic acid, a fatty acid commonly found on the skin and in the mucosa, is active against Streptococcus sanguinis, Streptococcus mitis, and Fusobacterium nucleatum, with MBC values of 31.3 μg/mL, 375.0 μg/mL, and 93.8 μg/mL, respectively.

Oritavancin diphosphate (LY333328 diphosphate) is a novel semisynthetic glycopeptide antibiotic developed for treating serious Gram-positive bacterial infections.

Tebipenem Pivoxil (Orapenem) , an orally activity carbapenem antibiotic, is utilized in treating otolaryngologic and respiratory infections.

L-Tyrosine Decarboxylase, Streptococcus faecalis (EC 4.1.1.25), is a carboxy-lyase enzyme capable of cleaving carbon-carbon bonds. The L-Tyrosine Decarboxylase Apoenzyme plays a role in tyrosine metabolism and alkaloid biosynthesis. This apoenzyme uses pyridoxal phosphate as a cofactor and works with a substrate, L-tyrosine, to produce two products: tyramine and carbon dioxide.

Glycerol 3-phosphate Oxidase, Streptococcus thermophilus (EC 1.1.3.21), is a type of oxidoreductase enzyme that acts on the CH-OH group of donor molecules using oxygen as the acceptor. This enzyme plays a role in glycerophospholipid metabolism and utilizes the cofactor FAD. Its substrates are sn-glycerol-3-phosphate and O₂, leading to the production of glycerophosphate and H₂O₂.

O-Glycanase, Streptococcus pneumoniae, acts on core disaccharides containing N-acetylgalactosamine.

L-Phenylalanine decarboxylase, Streptococcus faecalis (EC 4.1.1.53), is a member of the lyase enzyme family, with the ability to cleave carbon-carbon bonds. This enzyme plays a role in the metabolism of phenylalanine, utilizing the substrate L-phenylalanine and producing two products: phenylethylamine and CO2.

α2-3 Neuraminidase S, Streptococcus pneumoniae, is a glycoside hydrolase enzyme capable of hydrolyzing the glycosidic bonds of neuraminic acid.

Topoisomerase IV, Streptococcus pneumoniae (EC 5.99.1.), is produced by overexpressing its subunit in Escherichia coli.

L-Tyrosine Decarboxylase Apoenzyme, found in Streptococcus faecalis (EC 4.1.1.25), functions as a carboxy-lyase, facilitating the cleavage of carbon-carbon bonds. This enzyme is involved in tyrosine metabolism and the biosynthesis of alkaloids. It utilizes the cofactor pyridoxal phosphate and has a substrate, L-tyrosine, which it converts to the products tyramine and carbon dioxide.

Transcarbamylase, Streptococcus faecalis Ornithine (EC 2.1.3.3), is an enzyme that catalyzes the reaction between carbamoyl phosphate (CP) and ornithine (Orn) to produce citrulline (Cit) and phosphate (Pi).

Streptokinase, an enzyme from Streptococcus hemolyticus (EC 3.4.99.0), is secreted by various streptococci. It binds to and activates human plasminogen. The complex formed between streptokinase and human plasminogen can activate additional unbound plasminogen by cleaving specific bonds, resulting in the production of plasmin.

Gentamicin sulfate (SCH9724) is a broad-spectrum, orally administered aminoglycoside antibiotic that exhibits inhibitory activity against aerobic Gram-negative bacteria by interfering with mRNA translation.

Solithromycin (OP-1068) is an orally bioavailable antimicrobial agent that inhibits cell viability, protein synthesis, and growth rate of Streptococcus pneumoniae, Staphylococcus aureus, Staphylococcus aureus, and Haemophilus influenzae with IC50 values of 7.5 ng/mL, 40 ng/mL, and 125 ng/mL, respectively.Solithromycin inhibits protein biosynthesis by binding to the large 50S subunit of the ribosome.

Cefuroxime (Cephuroxime) is an orally active second-generation cephalosporin antibiotic with antimicrobial activity that inhibits both Gram-positive and Gram-negative bacteria, and is used in the study of soft tissue infections.

Moxifloxacin (Avelox) is a fourth-generation fluoroquinolone that has been shown to be effective against Gram-positive, Gram-negative, and atypical strains, as well as multi-drug resistant Streptococcus pneumoniae.

Linezolid (PNU-100766), the first of the oxazolidinone class, is a synthetic antibiotic used for the therapy of infections resulted from multi-resistant bacteria including methicillin-resistant Staphylococcus aureus (MRSA) and streptococcus. The drug takes effect as the inhibitor of the initiation of bacterial protein synthesis.

D-Cysteine, the D-isomer of cysteine, is a powerful inhibitor of E. coli growth and is mediated by D-amino acid oxidase to produce H2S, serving as a neuroprotective agent against cerebellar ataxia. Additionally, D-cysteine can inhibit the growth and cariogenicity of a two-species biofilm formed by Streptococcus mutans and Streptococcus hemoglobin.

3,5-Dimethylbenzaldehyde has broad-spectrum antimicrobial activity, inhibiting Bacillus subtilis, Pseudomonas albicans, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Streptococcus pneumoniae.

Delafloxacin (WQ-3034) (RX-3341, ABT-492) is a fluoroquinolone antibiotic agent. It has potent inhibitory against levofloxacin-resistant Streptococcus pneumoniae strains (MIC: 0.0078-0.125 μg/ml).

Copper(Ⅱ) Sulfate (Cupric sulfate) has a variety of antibacterial activities and has inhibitory activity against Staphylococcus aureus, Streptococcus pneumoniae, Pseudomonas aeruginosa, Plasmodium falciparum, etc.