streptococcus

Isobavachromene is an inhibitor of NADH-Ubiquinone oxidoreductase and ornithine decarboxylase. Isobavachromene has antifungal activity.

Sapienic acid sodium is a fatty acid with variable antimicrobial activities against Gram-positive and Gram-negative bacteria found on the skin and in the oral cavity.

D-Cysteine, the D-isomer of cysteine, is a powerful inhibitor of E. coli growth and is mediated by D-amino acid oxidase to produce H2S, serving as a neuroprotective agent against cerebellar ataxia. Additionally, D-cysteine can inhibit the growth and cariogenicity of a two-species biofilm formed by Streptococcus mutans and Streptococcus hemoglobin.

Gentamicin sulfate (SCH9724) is a wide-spectrum, aminoglycoside antibiotic used to inhibit protein synthesis in sensitive organisms.

Sapienic acid, a fatty acid commonly found on the skin and in the mucosa, is active against Streptococcus sanguinis, Streptococcus mitis, and Fusobacterium nucleatum, with MBC values of 31.3 μg/mL, 375.0 μg/mL, and 93.8 μg/mL, respectively.

Macelignan (Anwuligan) is a lignan isolated from nutmeg with antimicrobial and anticariogenic activity against Streptococcus mutans and other streptococcus species.

Erlose (Fructomaltose) is a sucrose derivative found in honeydew from two aphid species, preventing tooth decay caused by oral bacteria, mainly Streptococcus mutans.

7-Hydroxyflavanone shows antimicrobial activity against Streptococcus pneumoniae clinical isolates.

Oleanolic aldehyde, an antimicrobial agent, effectively hinders the growth of oral pathogens Streptococcus mutans and Porphyromonas gingivalis, implicated in dental caries and periodontal disease. The compound exhibits minimum inhibitory concentrations (MICs) of 488 µg/mL and 250 µg/mL against these bacteria respectively [1].

Paulomenol A exhibits activity against Gram-positive bacteria, including Staphylococcus aureus, Streptococcus pyogenes, and Streptococcus pneumoniae.

Paulomenol B exhibits activity against Gram-positive bacteria, including Staphylococcus aureus, Streptococcus pyogenes, and Streptococcus pneumoniae.

Nocathiacin III (Nocathiacine III) exhibits strong resistance against Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA), penicillin-resistant Streptococcus pneumoniae (PRSP), and multidrug-resistant Enterococcus faecium (MREF).

Nocathiacin I (Nocathiacine I) exhibits strong resistance against Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA), penicillin-resistant Streptococcus pneumoniae (PRSP), and multidrug-resistant Enterococcus faecium (MREF).

Memnopeptide A is a terpenoid peptide that activates SERCA2. Memnopeptide A exhibits mild resistance against Gram-positive bacteria, such as Staphylococcus aureus and Streptococcus pyogenes.

Citreamicin alpha (LL-E 19085-alpha) is an antibiotic that has been evaluated for its in vitro antibacterial activity against 429 clinical isolates of Gram-positive cocci using the agar dilution method. This study included 313 strains of staphylococci and 116 strains of streptococci. Its in vitro efficacy was compared with ampicillin, amoxicillin, cephalothin, erythromycin, and vancomycin. For staphylococci, Citreamicin alpha demonstrated MIC values ranging from 0.12 to 4.0 μg/ml, and for Streptococcus pyogenes, the MIC values ranged from 0.03 to 0.12 μg/ml. Conversely, enterococci presented relative resistance, requiring 2.0 μg/ml to inhibit 64% of 62 tested strains. The antibiotic's in vitro efficacy significantly surpassed that of ampicillin, amoxicillin, cephalothin, and erythromycin, while it was comparable to or slightly less effective than vancomycin.

Martinomycin is an antibiotic that inhibits Staphylococcus spp., Streptococcus spp., and Enterococcus spp., with a MIC range of 0.06 to 0.5 μg/mL.

Chalcomycin is a macrolide antibiotic effective against Gram-positive Staphylococcus aureus and Streptococcus pyogenes. It protects mice from infections caused by various Staphylococcus and Streptococcus strains and exhibits no significant toxicity (LD50>2500 mg/kg).

Protorubradirin is an antibiotic that can be isolated from the non-pigmented Streptomyces achromogenes var. rubradiris alongside Rubradirin. It exhibits inhibitory activity against HIV reverse transcriptase. In vitro studies show that Protorubradirin also inhibits strains of Staphylococcus aureus and Streptococcus. In infected mice, subcutaneous administration of Protorubradirin demonstrates in vivo efficacy against antibiotic-resistant Staphylococcus aureus strains. However, oral administration may significantly reduce its activity compared to Rubradirin, possibly due to its C-nitroso sugar decomposing more rapidly in acidic gastric conditions.

(-)-Asimilobine shows antioxidative, anti-acetylcholinesterase (AChE), anti-α±-glucosidase, anti-leishmanial and anti-fungal activities; it displays weak inhibition against Streptococcus mutans (ATCC 25175), with a minimum inhibition concentration (MIC) o

Erythrabyssin II actives against several strains of Staphylococcus and Streptococcus with an MIC range of 0.78-1.56 microg/ml. It inhibits bacterial neuraminidase in a dose-dependent manner with significant inhibition (IC(50)=0.09-3.25 μM).

Gancaonin G shows antibacterial effects on the MRSA strains with MIC values of 16 microg/ml, it also shows more moderate antibacterial activity against Streptococcus mutans.

Kushenol C is a good 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenger, and it exhibits inhibitory activity against Sodium-dependent glucose cotransporter 2(SGLT2). Kushenol C shows antimicrobial activity against Staphylococcus aureus and Streptococcus mutan

Lysicamine shows significant antioxidant capacity in the ORAC(FL) assay and it is active against S. epidermidis and C. dubliniensis, with MIC values in the range 12.5-100 microg mL(-1). Lysicamine has antimicrobial and anti-inflammation activity, the mini

Psoromic acid is a selective and covalent rab-prenylation inhibitor targeting autoinhibited RabGGTase, it shows antibacterial activities against Streptococcus gordonii and Porphyromonas gingivalis, and it is an effective and safe natural drug plausible fo