p300

Expression system: E. coli
Length: 1286-1662, Partial
Activity: Not Tested

Expression system: P. pastoris (Yeast)
Length: 2-349, Full Length of Mature Protein
Activity: Not Tested

Signal transducer and activator of transcription 6 (STAT6) is a transcription factor that is activated by interleukin-4 (IL-4)-induced tyrosine phosphorylation and mediates most of the IL-4-induced gene expression. STAT6 plays a central role in exerting interleukin-4 (IL-4) mediated biological responses and is found to induce the expression of BCL2L1 BCL-XL, which is responsible for the anti-apoptotic activity of IL4. Transcriptional activation by STAT6 requires the interaction with coactivators like p300 and the CREB-binding protein (CBP). NF-κB and tyrosine-phosphorylated Stat6 can directly bind each other in vitro and in vivo, which suggests that the direct interaction between Stat6 and NF-κB may provide a basis for synergistic activation of transcription by IL-4 and activators of NF-κB.

Expression system: E. coli
Length: 1-325, Full Length of Isoform 2
Activity: Not Tested

Expression system: E. coli
Length: 36-84, Partial
Activity: Not Tested