guanylate cyclase

Riociguat (BAY 632521) is a stimulator of guanylate cyclase which causes relaxation of vascular smooth muscle and is used to treat severe pulmonary arterial hypertension.

Nitroprusside disodium dihydrate (Sodium Nitroprusside Dihydrate) is a potent vasodilator working through releasing NO spontaneously in blood.

Lificiguat (YC-1) is an nitric oxide (NO)-independent activator of soluble guanylyl cyclase(sGC) and an inhibitor of Hypoxia-inducible factor-1alpha (HIF-1alpha).

Runcaciguat is a soluble guanylate cyclase stimulator. Runcaciguat combines with selective partial adenosine A1 receptor agonists and can be used in studies about cardiovascular and renal diseases.

ODQ is an effective and selective soluble guanylyl cyclase (sGC) inhibitor.

Indusatumab (5F9 Monoclonal antibody) is an anti-human GUCY2C (Guanylate cyclase 2C) monoclonal antibody utilized for synthesizing antibody-drug conjugates.

Uroguanylin (human) serves as a natural ligand for the Guanylyl Cyclase C (GCC) receptor in metastatic colorectal cancer tumors and exhibits anti-tumor effects in an animal model of human colon cancer [1] [2].

Guanylin (mouse, rat), a 15-amino-acid peptide, activates intestinal guanylate cyclase and is employed in diarrhea research [1].

MCUF-651 is a guanylyl cyclase A receptor positive allosteric modulators, EC50=0.45 μM.

Glutaminyl Cyclase Inhibitor 1, a glutaminyl cyclase inhibitor with an IC50 of 0.5 μM, can be utilized for studying neurological disorders.

(Rac)-MGV354 (MGV354) is the racemate of MGV354. MGV354 is a soluble activator of guanylate cyclase (sGC)(EC50s of <0.5 nM, and 5 nM in CHO and GTM-3 E cells, respectively).

Guanylate cyclase-IN-1 (Example 46) is a specific guanylate cyclase inhibitor used in cardiovascular disease research.

sGC activator 2 (Compound 16a) acts as an activator of soluble guanylate cyclase (sGC), enhancing the production of cGMP and exhibiting vasoprotective and anti-inflammatory properties.

Zagociguat (CY6463) is a soluble guanylate cyclase stimulator with central nervous system penetrance, enhancing nitric oxide (NO) signaling and used in the study of neurological diseases.

Uroguanylin (human) (TFA) is the natural ligand for the guanylate cyclase C (GCC) receptor expressed in metastatic colorectal cancer tumors. In animal models of human colon cancer, Uroguanylin (human) (TFA) demonstrates antitumor activity.

PF-07062119 is a humanized immunoglobulin G1 (IgG1) monoclonal antibody designed to target and inhibit GUCY2C.

LY83583 is a soluble guanylate cyclase competitive inhibitor with IC50 of 2 µM.

Sinitrodil (ITF-296) is a guanylate cyclase stimulant that may be used in the treatment of myocardial ischemia and angina pectoris.

Nelociguat (BAY60-4552)(BAY60-4552) is a soluble guanylate cyclase stimulator (sGC stimulator). Soluble guanylate cyclase (sGC) is a key enzyme in the nitric oxide (NO) signalling pathway.

Linaclotide, developed for the treatment of constipation-predominant irritable bowel syndrome (IBS-C) and chronic constipation, is a potent and selective guanylate cyclase C agonist.

NS-2028 is a highly selective soluble Guanylyl Cyclase (sGC) inhibitor (IC50: 30 nM and 200 nM for basal and NO-stimulated enzyme activity) commonly used in nitric oxide signaling pathway research. It inhibits sGC activity in mouse cerebellum homogenates and neuronal NO synthase (IC50: 17 nM and 20 nM), inhibits 3-morpholino-sydnonimine (SIN-1)-elicited cyclic GMP formation in human cultured umbilical vein endothelial cells (IC50: 30 nM), and completely inhibits NO-dependent relaxant responses in non-vascular smooth muscle (1 μM). NS-2028 also decreases vascular endothelial growth factor-induced angiogenesis and permeability.

Olinciguat (IW-1701) is an oral guanylate cyclase (sGC) stimulator. It also has concentration-dependent stimulation of sGC in purified rat and human enzyme assays and a whole-cell assay.

Praliciguat (IW-1973) stimulates sGC in HEK-293 cells (EC50: 197 nM). Praliciguat is an effective and orally active soluble guanylate cyclase stimulator. It also enhances NO signaling and acts as a vasodilator.

Vericiguat (BAY1021189) is a potent and orally available guanylate cyclase stimulator.